ライフサイエンスコーパス: fatty acid elongase

1 CoA desaturase-1 (SCD-1) and long chain free fatty acid elongase.

2 ng allene oxide synthase, and DSA15 may be a fatty acid elongase.

3 y with previously identified very long chain fatty acid elongases.

4 phK) inhibitor SKI II, or knockdown of SphK, fatty acid elongase 1 (ELOVL1) and acyl-CoA-binding prot

5 essed sequence tags that encode a homolog of fatty acid elongase 1 (FAE1), a beta-ketoacyl-CoA syntha

6 ng a model for the substrate-binding site of fatty acid elongase-1 3-ketoacyl CoA synthase (FAE1 KCS)

7 Testos group also had a decreased liver fatty acid elongase 2 (ELOVL2) activity.

8 y long-chain fatty acid (VLCFA) synthesis by fatty acid elongase 3 (ELO3) in the regulation of telome

9 alterations in lipid metabolism genes (ELOVL fatty acid elongase 3 and galanin), with parallel reduct

10 2 (Fosl2) and lipid-metabolism-related gene, Fatty acid elongase 4 (Elvol4), and the expression of bo

11 nt and direct AR-mediated induction of ELOVL fatty acid elongase 5 (ELOVL5), an enzyme that catalyzes

12 chain unsaturated FAs, which are products of fatty acid elongase-5 predicted as a key gene.

13 our cells by targeting ATP citrate lyase and fatty acid elongase 6, as well as impairing mitochondria

14 for lipid metabolism during HCMV infection: fatty acid elongase 7 (ELOVL7) and the endoplasmic retic

15 es involved in lipid metabolism, including a fatty acid elongase, a sphingomyelinase, a phosphate acy

16 ncing also caused decreased transcription of fatty acid elongase and ceramide glucosyltransferase, wh

17 which is consistent with an upregulation of fatty acid elongases and/or desaturases in the PUFA synt

18 e 6-phosphate dehydrogenase, very long chain fatty acid elongase, and phospholipase A2 group VI) asso

19 Four enzymes of a fatty acid elongase complex are required for the synthes

20 is either a membrane-bound component of the fatty acid elongase complex or a regulatory protein.

21 Our top hit, a fatty acid elongase (ELOVL6), showed remarkable selectiv

22 Silencing the expression of a fatty acid elongase, ELOVL7, also leads to the regressio

23 related in three-dimensional structure to a fatty acid elongase, ELOVL7.

24 pha, IL-6, and IL-33 inhibited expression of fatty acid elongase enzymes (ELOVL3 and ELOVL4) in HEKs.

25 cturally resembles the ceramide synthase and fatty acid elongase families of coenzyme A-dependent lip

26 RNA interference (RNAi) screen against the fatty acid elongase family members combined with heterol

27 ed greater upregulation of acyltransferases, fatty acid elongases, fatty acid 2-hydroxylase, fatty ac

28 a beta-ketoacyl-CoA synthase (a component of fatty acid elongase) from Lunaria annua.

29 In agreement with increased fatty acid elongase gene expression, VPA increased level

30 An Arabidopsis fatty acid elongase gene, KCS1, with a high degree of se

31 negative regulators of PHS synthesis) and of fatty acid elongase genes FEN1 and SUR4 were decreased,

32 loss of function mutations in either of the fatty acid elongase genes SUR4/ELO3 or FEN1/GNS1/ELO2 ca

33 (a) wax composition and load; (b) microsomal fatty acid elongase, plastidial fatty acid synthase, and

34 ty acids-4 (ELOVL4) has been identified as a fatty acid elongase protein involved in the synthesis of

35 des 3-ketoacyl reductase, a component of the fatty acid elongase required for the biosynthesis of ver

36 Fatty acid elongase substrate specificity is determined

37 way, such as deletion of the very long-chain fatty acid elongase, Sur4, suppress the osmotic growth d

38 al roles for Rvs161p and the very long chain fatty acid elongase, Sur4p, in the localization and/or s

39 ty acyl-CoA reductase (FAR) and an efficient fatty acid elongase system that forms the substrates pre

40 We identify a conserved fatty acid elongase that underlies a mechanism that adju

41 sed up-regulation of FEN1 and SUR4, encoding fatty acid elongases that catalyze the synthesis of very

42 d in mouse hepatocytes for the expression of fatty acid elongases that contribute to a waterproof epi

43 Eukaryotes express a multi-component fatty acid elongase to produce very long chain fatty aci

44 y activating acyl-coenzyme A synthetases and fatty acid elongases to import and activate long-chain f

45 Furthermore, we identified elo-2, a fatty-acid elongase with a known role in defecation cycl