ライフサイエンスコーパス: fear

1 n important causal mechanism for conditioned fear.

2 -based therapeutic approaches acutely reduce fear.

3 y predictive of the subjective experience of fear.

4 ic-vulnerable state could lead to persistent fear.

5 nal stimuli but not responses to conditioned fear.

6 RI) data to assess this issue in the case of fear.

7 ptively overgeneralized and inextinguishable fear.

8 treatment with VEGF inhibitors as previously feared.

9 repeated SRFA if necessary (97.8%), without fear (80.7%).

10 The results call into question fears about the vanishing potential for incidental news

11 Thus, following fear acquisition, hippocampal CA1 place cells sharpen th

12 training is performed immediately following fear acquisition, the extinction memory is weakened.

13 When rating fear, activation in the vmPFC differed between the anxie

14 found to be critical for the recognition of fear and anger.

15 nd pain are mediated by spinal afferents and fear and anxiety (the affective aspects of visceral pain

16 learning mechanisms that might contribute to fear and anxiety disorders transmission in clinically af

17 may represent a novel therapeutic target for fear and anxiety disorders.

18 l circuits and processes thought to underlie fear and anxiety, along with the promise of translationa

19 ion and, in separate studies, for modulating fear and anxiety.

20 tant structure involved in the modulation of fear and anxiety.

21 er volume of three neural regions supporting fear and avoidance responses [bilateral amygdala, nucleu

22 calopride and PF-04995274 attenuated learned fear and decreased stress-induced depressive-like behavi

23 nd an inverted U-shaped relationship between fear and enjoyment, consistent with the theory that the

24 Fear and extinction learning are adaptive processes caus

25 urons in mice during retrieval of contextual fear and extinction memories.

26 learning (where no US is presented), and how fear and extinction memory undergo consolidation one day

27 olecular switch that regulates expression of fear and its extinction.

28 shock delivery induces several days of high fear and low between-session place field stability, foll

29 h and without anxiety disorders while rating fear and memory of ambiguous threats.

30 Although subjective fear and objective physiological responses were correlat

31 Extinction outcomes were self-reported fear and threat expectancy, and neural responses during

32 FOBS items had a good predictive ability for fear and worries about the forthcoming birth (79%) and a

33 within the amygdala network and facilitates fear, and mGluR2 PAMs could be a targeted treatment for

34 have only contributed to unwarranted public fears, and repeating this approach for gene-edited crops

35 examining this divide over time: Deportation fears are high but stable among Latino noncitizens, wher

36 en aiming to assess an individual's level of fear, as relevant measures may not be the same for all i

37 show the same exaggerated remote contextual fear, as well as persistently elevated anxiety-like beha

38 reactivity in early development, with latent fear-associated memories emerging later in adolescence.

39 y and the simultaneously acquired contextual fear association.

40 ing the integration of the RE in circuits of fear, aversion, and defense.

41 ssion Inventory 21), psychological features (Fear-Avoidance Beliefs Questionnaire), lifestyle charact

42 lar regulation of plasticity cascades during fear behavior (context fear retrieval) (n = 16).

43 (safety learning), leading to suppression of fear behavior (fear extinction).

44 However, overactive, relapsing fear behavior in the absence of danger is a hallmark of

45 show that inappropriate, learning-resistant fear behavior results from disruption of brain component

46 tantly, the inhibitor suppressed TMT-induced fear behaviors with a median effective dose (ED(50)) of

47 ear-related behavioural problems, with noise fears being most prevalent.

48 to which contrast normalisation facilitates fear bias effects.

49 h the hypothesis that AMY is not a centre of fear but together with other sub-cortical and cortical s

50 d to danger has contributed to the 'amygdala fear center' meme, a view he does not endorse.

51 racerebral hemorrhage (ICH) is an especially feared complication in patients with brain metastases gi

52 Its most feared complication is intestinal perforation.

53 Infective endocarditis (IE) is the most feared complication of Staphylococcus aureus bacteremia

54 Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controve

55 erative stroke is one of the most severe and feared complications of cardiac surgery.

56 One of the most feared complications of endoscopic retrograde cholangiop

57 increased anxiety-like phenotypes, impaired fear conditioned learning, social behaviors and discrimi

58 as modulated on a trial-by-trial basis using fear-conditioned (CS(+)) stimuli.

59 ated with the release probability of OSNs in fear-conditioned mice.

60 memory processing; these show an increase in fear conditioning (FC), a reduction in prepulse inhibiti

61 eral amygdala (BLA) plays a critical role in fear conditioning and is extremely sensitive to ELS.

62 lable for context encoding during contextual fear conditioning causes maladaptively overgeneralized a

63 anticipatory behavioral responses in an odor fear conditioning in rats, while recording theta (5-15 H

64 CeA Crh-expressing cells (Crh neurons) after fear conditioning or extinction in mice using translatin

65 thy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction

66 ir parent, or a stranger, being exposed to a fear conditioning paradigm, and (2) the subsequent fear

67 monstrated elevated freezing in a contextual fear conditioning paradigm.

68 from surgery, underwent a standard auditory fear conditioning procedure.

69 Fear conditioning produced an immediate and dramatic inc

70 association learning and suggest that trace fear conditioning relies on mechanisms that differ from

71 the level of extinction learning of a trace fear conditioning response, a behavioral paradigm that r

72 Here we show that memory formation through fear conditioning selectively accelerates the degradatio

73 ivity-dependent transcription in response to fear conditioning stress, and the affected genes include

74 the caspase-autophagy pathway is engaged by fear conditioning to facilitate associative fear learnin

75 During fear conditioning, a sensory cue, such as a tone (the co

76 In "trace" fear conditioning, animals learn to associate a neutral

77 us (US)-related information during classical fear conditioning, thereby having an indispensable role

78 In fear conditioning, where a conditioned stimulus predicts

79 cells exhibit long term plasticity following fear conditioning.

80 s in freely behaving mice subjected to trace fear conditioning.

81 circuit plays an essential role in classical fear conditioning.

82 xtinction trials are administered soon after fear conditioning.

83 ed by the unconditioned stimulus (US) during fear conditioning.

84 frontal cortex of rats trained in contextual fear conditioning.

85 in several mouse lines using Barnes maze and fear conditioning.

86 inction memory of rats trained in contextual fear conditioning.

87 out temporal or contextual cues, as in trace fear conditioning.

88 n male and female mice in learned and innate fear contexts without being inherently rewarding or alte

89 e review the rodent literature on early-life fear development to characterize developmental transitio

90 We recently found that males show fear discrimination and females show fear generalization

91 ns core (NAcc) dysfunction in rats receiving fear discrimination consisting of cues for danger, uncer

92 rse experience, when the adult rats received fear discrimination consisting of danger, uncertainty an

93 Despite achieving fear discrimination that was equivalent to controls, vlP

94 ing reduced safety signalling after extended fear discrimination training.

95 toxic NAcc lesions, recovered, and underwent fear discrimination.

96 ts (fear learning), subjects were exposed to fear-eliciting cues without aversive events (safety lear

97 monstrate that Cdc14 Early Anaphase Release (FEAR) ensures robust timing of anaphase, and we verify o

98 recall, in which they rated their levels of fear evoked by, and their explicit memory for, morph sti

99 Fear expression in LB mice was rescued through optogenet

100 roteins associated with PTSD-like heightened fear expression.

101 level, visual-based account of these biases, fear expressions are advantaged in some way due to their

102 irs safety learning, abnormally slowing down fear extinction and exacerbating fear relapse.

103 tex, brain structures critically involved in fear extinction and regulation of stress responses.

104 erchangeable in driving reward behaviors and fear extinction behaviors.

105 Activation of fear extinction engram neurons and natural reward-respon

106 GIRK1/2 channels in the BLA, and facilitates fear extinction in a rodent model.

107 Fear extinction is an active learning process whereby pr

108 Fear extinction is thought to take place when animals fo

109 w sharpened visual processing is affected by fear extinction learning (where no US is presented), and

110 Here we demonstrate that a fear extinction memory engram is formed and stored in a

111 se-dependently impaired the consolidation of fear extinction memory of rats trained in contextual fea

112 is was associated with potentiated recall of fear extinction memory when tested 24 hours after extinc

113 brain is necessary for the consolidation of fear extinction memory.

114 onditioning paradigm, and (2) the subsequent fear extinction process in these children.

115 g), leading to suppression of fear behavior (fear extinction).

116 ated levels of anandamide (AEA) and promotes fear extinction, suggesting that FAAH inhibitors may aid

117 bition of DA neurons in either region slowed fear extinction, with the relevant time period for inhib

118 ion, suggesting that FAAH inhibitors may aid fear extinction-based treatments.

119 nd manipulated VTA DA neurons in mice during fear extinction.

120 anxiety, spatial and contextual memory, and fear extinction.

121 le spatial representation that appears after fear extinction.

122 l VTA have distinct activity profiles during fear extinction: medial VTA activity more closely reflec

123 Hurricane Katrina, we find that bereavement, fearing for loved ones' well-being, and lacking access t

124 after PRF conditioning than fully reinforced fear (FRF) conditioning, despite an equivalent number of

125 tudied (1) how children acquired conditioned fear from observing their parent, or a stranger, being e

126 in a similar safe context erroneously shifts fear from the dangerous to the safe context.

127 cluded longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadeq

128 es show fear discrimination and females show fear generalization involving reduced safety signalling

129 d a stronger neural response associated with fear generalization to the reinforced object category in

130 mong Latino noncitizens, whereas deportation fears have increased substantially among Latino US citiz

131 The conscious experience of fear, he tells us here, is not wired into the amygdala,

132 ess to undergo repeat SRFA with little to no fear in 292 (80.7%) patients.

133 sexes, with (2S,6S)-HNK attenuating learned fear in male mice, and (2R,6R)-HNK preventing stress-ind

134 29S6/SvEv mice, RS-67,333 attenuated learned fear in male, but not female mice.

135 nt methods that lead to reduction in learned fear in rats are dissociated in the cortex.

136 4 might modulate persistent predator-induced fear in rats, a model that captures features of human po

137 GAT1508 effectively extinguished conditioned fear in rodents and lacked cardiac and behavioral side e

138 anied by a brief, more generalized return-of-fear in skin conductance.

139 rat to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hyp

140 ues may provide a novel approach to reducing fear in youths.

141 around parvalbumin (PV) cells, and impaired fear-induced activity of PV interneurons only in the rig

142 effects of social experiences or to inhibit fear-inducing social stimuli in models of anxiety and po

143 women may involve sex differences in learned fear inhibition and medial prefrontal cortex (mPFC) func

144 e indicating that sex differences in learned fear inhibition are associated with altered mPFC functio

145 Fear is a conscious state caused by exposure to real or

146 h the theory that the pursuit of pleasurable fear is a form of play.

147 Fear is adaptive when the level of the response rapidly

148 aversive events are generated, such as when fear is inflated or overexpected, but less so when an ex

149 e similar effects on the neural circuitry of fear is unclear.

150 cortex, a structure generally overlooked in fear, is critical for downregulating fear when novel pre

151 Using the stress-enhanced fear learning (SEFL) model for PTSD, we characterized th

152 on fear sensitization in the stress-enhanced fear learning (SEFL) model of PTSD, as well as associate

153 We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produc

154 change spatial encoding stability throughout fear learning and extinction.SIGNIFICANCE STATEMENT The

155 fear conditioning to facilitate associative fear learning and memory.

156 sted the effects of LB on the development of fear learning and neuronal structures involved in emotio

157 , whose activity was required for contextual fear learning and synaptic potentiation in the vCA1-BA p

158 IGNIFICANCE STATEMENT Powerful mechanisms of fear learning have evolved in animals and humans to enab

159 ear memory task in mice, we demonstrate that fear learning induces oligodendrocyte precursor cells to

160 lay the foundation to examine observational fear learning mechanisms that might contribute to fear a

161 e activated by the tone-footshock pairing of fear learning protocols.

162 We found that contextual fear learning recruits a population of young ABNs that a

163 l neural circuitry typically associated with fear learning requires additional consideration of a mor

164 onic opioid regimens on the sensitization of fear learning seen following traumatic stress in mice.

165 rawal impacted the subsequent enhancement in fear learning seen.

166 reversed to negative valence in a Pavlovian fear learning situation, where CeA ChR2 pairing increase

167 ch, after acquiring fear of aversive events (fear learning), subjects were exposed to fear-eliciting

168 l scrutiny of research on taste-aversion and fear learning, language, and imitation indicates that th

169 ery assessing psychophysiological indices of fear learning, stress reactivity, and stress-induced aff

170 In this variant of fear learning, the association of a cue and shock across

171 ished in all the reviewed domains except for fear learning, where a clear target is yet to be elucida

172 and, unexpectedly, contribute to associative fear learning.

173 ial role for hippocampal input in contextual fear learning.

174 ment is able to robustly augment associative fear learning.

175 tions of neurons that lasted for weeks after fear learning.

176 cquire a response to auditory stimuli during fear learning.

177 cally distinguish between distinct phases of fear learning.

178 the only remaining samples of this once much-feared livestock virus were those held in various labora

179 HCWs feared managing Ebola patients, affecting their willingn

180 al needs, is characterized by persistence of fear memories and maladaptive stress responses.

181 aluated acquisition and retention of context fear memories in rats with prior partial or complete HPC

182 found that neither acquisition nor recall of fear memories to tone and context were altered after rem

183 This includes the formation of fear memories when the anticipation of threat demands le

184 s a brain area critical for the formation of fear memories.

185 rine; and are resistant to the extinction of fear memories.

186 ng trials impaired the formation of auditory fear memories.

187 icity, thereby facilitating the formation of fear memories.

188 mediate encoding and retrieval of contextual fear memories.

189 idation of water maze, as well as contextual fear, memories.

190 bles encode space at a finer scale following fear memory acquisition.

191 ce lacking Tiam1 exhibit enhanced contextual fear memory and context discrimination.

192 ns of prelimbic cortex to the formation of a fear memory and demonstrates the crucial role for hippoc

193 eurons react during learning to encode trace fear memory and how they retrieve a memory.

194 to the PL for the acquisition of trace-cued fear memory and the simultaneously acquired contextual f

195 Here we used long-term contextual fear memory as a paradigm to probe the single-cell gene

196 uring the footshock, reduced the strength of fear memory as tested 1 d later, whereas silencing the V

197 o rescued the seizure-induced alterations of fear memory by restoring the phasic control of eCB signa

198 uroscience and neuropsychiatry literature on fear memory consolidation and extinction, stress, and PT

199 Context fear memory dysregulation is a hallmark symptom of sever

200 ocus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of s

201 Here, we show that contextual fear memory engrams in the mouse dentate gyrus contain f

202 BA neurons contributes to encoding adaptive fear memory for the threat-predictive context.

203 Although the relevance of MLIs during fear memory formation is currently not known, it has bee

204 e neurons projecting to the BA contribute to fear memory formation, by coding for the saliency of the

205 The ability to extinguish conditioned fear memory is critical for adaptive control of fear res

206 ntextual fear memory, the mechanism by which fear memory is encoded in this circuit has not been inve

207 igher in females and that H2A.Z cKO enhanced fear memory only in males.

208 ion of vHC-PrL projectors suppresses context fear memory retrieval and impairs the ability of PrL neu

209 ry and inhibitory PrL neurons during context fear memory retrieval.

210 BLA-mPFC circuitry supports post-extinction fear memory retrieval.

211 Using a contextual fear memory task in mice, we demonstrate that fear learn

212 Zfpm1 mutant mice showed elevated contextual fear memory that was abolished with chronic fluoxetine t

213 In contrast, retention of context fear memory was normal after HPC damage up to 30 d after

214 levated anxiety-like behavior and contextual fear memory, alleviated by chronic fluoxetine treatment.

215 e dopamine has been implicated in contextual fear memory, and Ca(v)1.2 is a downstream target of dopa

216 normal object location memory and contextual fear memory, but impaired long-term object recognition m

217 t ASIC1a has been implicated in nociception, fear memory, mood disorders and ischemia.

218 en implicated in the retrieval of contextual fear memory, the mechanism by which fear memory is encod

219 y recruits BDNF to enhance the expression of fear memory.

220 cient to reinstate a previously extinguished fear memory.

221 rm a new memory that suppresses the original fear memory.

222 to the amygdala are necessary for contextual fear memory.

223 of memory, whereby histone H2A.Z suppresses fear memory.

224 stimuli, contributes to encoding conditioned fear memory.

225 press, but not form, an auditory conditioned fear memory.

226 ned behavioral responses to somatic pain and fear-memory formation.

227 ated with certain behavioral states, such as fear (Monavarfeshani et al., 2017; Salay et al., 2018).

228 behaviors and antagonizes the BLA's original fear neurons.

229 hrough a procedure in which, after acquiring fear of aversive events (fear learning), subjects were e

230 ants of symptoms of mental health disorders: fear of being infected, inability to rest, inability to

231 icity (95%) than sensitivity (70%) to detect fear of childbirth.

232 e against elective pregnancy termination for fear of DOAC embryotoxicity and the recommendation in fa

233 ke, leading to lowered body weight, constant fear of gaining weight, and psychological disturbances o

234 Unnecessary prophylaxis and fear of lawsuits amongst private practice dentists and O

235 relationship between safety emphasis and the fear of medication error reporting among Chinese nurses.

236 phasis, face-saving, power distance, and the fear of medication error reporting were 20.27 (SD=2.36),

237 ned the effect of safety emphasis on nurses' fear of medication error reporting.

238 ship between patient safety emphasis and the fear of medication error reporting.

239 x of Hierarchy of Authority, and the Nurses' Fear of Medication Error Reporting.

240 viduals who report less mindfulness and more fear of pain.SIGNIFICANCE STATEMENT This study demonstra

241 Fear of predation can induce profound changes in the beh

242 tion risk and thus could have been driven by fear of predation over evolutionary time.

243 Three (shortness of breath, fear of progression, and hair problems) of the five mult

244 Four (coughing, shortness of breath, fear of progression, and surgery-related symptoms) of th

245 -item scales (coughing, shortness of breath, fear of progression, hair problems, and surgery-related

246 Among all parents, the fear of retinal detachment was an ongoing concern.

247 Fear of the speculum and feelings of vulnerability durin

248 Fear of transnational terrorism, along with a revitaliza

249 ct and retain the best and brightest without fear of unfair treatment.

250 ble to develop a work culture that minimizes fears of medication error reporting without first addres

251 The word naturally conjures fears of unexpected and freakish changes.

252 induction of a persistent internal state of fear or anxiety.

253 color of an apple to a full-blown feeling of fear or other emotions.

254 PTSD is characterized by fear overgeneralization involving impaired fear regulati

255 in neuropsychiatric conditions.(2-5) Unlike fear, pathological disgust is not improved substantially

256 conditioned stimulus (CS) following a trace fear protocol and reduced the survival of 4-week-old adu

257 on while skin conductance response (SCR) and fear ratings were recorded.

258 PPS enhanced fear reactions to a conditioned stimulus (CS) following

259 fralimbic cortex has a very specific role in fear reduction that depends on the omission of aversive

260 y fear overgeneralization involving impaired fear regulation by safety signals.

261 lum, which predicted susceptibility to later fear reinstatement.

262 lowing down fear extinction and exacerbating fear relapse.

263 A high proportion of pet dogs show fear-related behavioural problems, with noise fears bein

264 g, treating, and even preventing anxiety and fear-related disorders offer great opportunities for suc

265 Anxiety and fear-related disorders peak in prevalence during adolesc

266 Given that risk for fear-related disorders, such as PTSD, is biased toward f

267 eneficial effect was found in other types of fear-related memories.

268 r memory is critical for adaptive control of fear response, and its impairment is a hallmark of emoti

269 entually relapse to the original conditioned fear response.

270 n the adult domestic ferret, such as a muted fear response.

271 is reminiscent of evolutionarily configured fear responses based on threat imminence.

272 l variations of neural regions implicated in fear responses have been well documented in the pathophy

273 entified as the critical hub responsible for fear responses related to stress coping and pathologic s

274 tive than traditional extinction in reducing fear responses; moreover, such effects are long lasting

275 may integrate social information to modulate fear responsivity.

276 icity cascades during fear behavior (context fear retrieval) (n = 16).

277 s freezing to light stimulation alone during fear retrieval.

278 derstood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility we

279 chusetts Bay, Narragansett Bay, and the Cape Fear River Estuary (CFRE), United States.

280 After fear scaling was established, the NAcc was illuminated d

281 (NAcc) in the acquisition and expression of fear scaling.

282 r H2A.Z cKO also has sex-specific effects on fear sensitization in the stress-enhanced fear learning

283 g of four domain (functioning, fatigue/mood, fears/shame, nutrition) and total scores.

284 We studied fear suppression through a procedure in which, after acq

285 onal consideration of a more reactive neural fear system to fully account for this effect.

286 e accuracy of BSE surveillance and spreading fear that BSE might lurk unrecognized in goats.

287 As a result, we fear that there will be a dramatic rising tide of alcoho

288 oned rats were generally impaired in scaling fear to degree of threat, and specifically impaired in r

289 on, generally disrupted the ability to scale fear to degree of threat, and specifically impaired one

290 Our results suggest that shifting from fear to safety through deconditioning-update is a promis

291 e data suggest that mPFC->BNST neurons limit fear to threats with a history of partial association wi

292 mechanism that facilitates the formation of fear traces in the FrA, thus providing a new framework f

293 The biological mechanisms involved in fear transmission within families have been scarcely inv

294 xamines whether and how Latinos' deportation fears vary by citizenship and legal status and over time

295 Our data suggest that children acquire fear vicariously and this can be measured physiologicall

296 Furthermore, conditioned fear was decreased by expression of a non-inhibitable fo

297 oked in fear, is critical for downregulating fear when novel predictions about upcoming aversive even

298 epresentative of the resistant pathogens all fear will emerge in the general population.

299 f anxiety disorders is difficulty regulating fear, with evidence suggesting deficits in extinction le

300 ces of an emotion category, such as anger or fear, yet studies to date have observed more variation t