ライフサイエンスコーパス: fear conditioning

1 ed by the unconditioned stimulus (US) during fear conditioning.

2 eyed to the mPFC and amygdala for contextual fear conditioning.

3 in the BLA reduces anxiety-like behavior and fear conditioning.

4 aradigms, e.g., two-way active avoidance and fear conditioning.

5 in an impairment of specifically noise-cued fear conditioning.

6 cells exhibit long term plasticity following fear conditioning.

7 in a mouse model of auditory discriminative fear conditioning.

8 stimulus to lateral amygdala neurons during fear conditioning.

9 ving chemosensory stimuli, such as olfactory fear conditioning.

10 d, including spatial learning and memory and fear conditioning.

11 s in freely behaving mice subjected to trace fear conditioning.

12 utative LA-ACx synaptic pairs after auditory fear conditioning.

13 gy was mediated by this perturbed pattern of fear conditioning.

14 le representations in aversive tasks such as fear conditioning.

15 ponse in laboratory animals during Pavlovian fear conditioning.

16 circuit plays an essential role in classical fear conditioning.

17 sus fro;5XFAD mice using contextual and cued fear conditioning.

18 ontextual) and hippocampal-independent (cue) fear conditioning.

19 arly and late time points following auditory fear conditioning.

20 xtinction trials are administered soon after fear conditioning.

21 cessary for two distinct roles of context in fear conditioning.

22 ant role in regulating Nk3R signaling during fear conditioning.

23 resonance imaging during cued and contextual fear conditioning.

24 prefrontal cortex in extinction of auditory fear conditioning.

25 s were subjected to extinction of contextual fear conditioning.

26 iety paradigms, elevated plus maze (EPM) and fear conditioning.

27 including sexual drive, aggressiveness, and fear conditioning.

28 ry test or for items strongly encoded before fear conditioning.

29 57BL/6J mice after consolidation of auditory fear conditioning.

30 nt fear, we used a mouse model of contextual fear conditioning.

31 tinction training is delivered shortly after fear conditioning.

32 tion, consolidation, and extinction of trace fear conditioning.

33 and local field potentials during Pavlovian fear conditioning.

34 electively attenuated context (but not tone) fear conditioning.

35 inction memory of rats trained in contextual fear conditioning.

36 ntextual complexity is involved, as in trace fear conditioning.

37 frontal cortex of rats trained in contextual fear conditioning.

38 ight chain (TeLC) completely blocks auditory fear conditioning.

39 in several mouse lines using Barnes maze and fear conditioning.

40 t catecholamines regulate several aspects of fear conditioning.

41 ignaling in the hippocampus after contextual fear conditioning.

42 e IPN is involved in fear extinction but not fear conditioning.

43 freezing responses induced by auditory-cued fear conditioning.

44 out temporal or contextual cues, as in trace fear conditioning.

45 e site of spines eliminated previously after fear conditioning.

46 firing properties in response to contextual fear conditioning, a process called "remapping." In the

47 During fear conditioning, a sensory cue, such as a tone (the co

48 ions ("Fos tagging"), we show that olfactory fear conditioning activates sparse and distributed ensem

49 e modeled in animal subjects using Pavlovian fear conditioning, allowing investigation of the underly

50 Trace fear conditioning also significantly enhanced the excita

51 During fear conditioning, amygdala responses evoked by footshoc

52 tion of CeL-projecting PVT neurons prevented fear conditioning, an effect that can be accounted for b

53 of non-NMDA receptor transmission following fear conditioning and a depotentiation upon fear extinct

54 Using classic cued fear conditioning and an extinction paradigm in large co

55 Pavlovian fear conditioning and behavioral pharmacological analyse

56 After associative fear conditioning and during early extinction (EE), when

57 Photoinhibition of CeM projectors impairs fear conditioning and enhances reward conditioning.

58 performed poorly on wire hang and contextual fear conditioning and exhibited a lower seizure threshol

59 to target PL cortex ensembles active during fear conditioning and expressed the inhibitory Gi-DREADD

60 future basic research on sex differences in fear conditioning and extinction but also to exposure-ba

61 ular techniques, we determined whether trace fear conditioning and extinction engages the SR/D-serine

62 the modulation of neural activity following fear conditioning and extinction in both human and anima

63 Here we characterized fear conditioning and extinction in rats selectively bre

64 Taken together, these findings indicate fear conditioning and extinction induce opposing changes

65 The fear conditioning and extinction neurocircuitry has been

66 The effect of fear conditioning and extinction on PVIN-pyramidal neuro

67 Two-day fear conditioning and extinction paradigm.

68 mography scan 4 days before a functional MRI fear conditioning and extinction paradigm.

69 In novel Pavlovian fear conditioning and extinction paradigms, pharmacologi

70 lesion and electrophysiologic studies using fear conditioning and extinction paradigms, there has no

71 ns suggests that an "event boundary" between fear conditioning and extinction protects the conditioni

72 ers and 51 male control subjects underwent a fear conditioning and extinction protocol during functio

73 lled longitudinal study design using a 2-day fear conditioning and extinction protocol.

74 psychophysiological and neural correlates of fear conditioning and extinction recall in anxiety disor

75 in modulating freezing responses related to fear conditioning and extinction remains unclear.

76 esses and the neural circuitry that supports fear conditioning and extinction represent mechanisms th

77 A retrospective analysis of behavior during fear conditioning and extinction revealed that despite n

78 (2) inspiratory breathing load task, and (3) fear conditioning and extinction task.

79 While some cells remapped in both fear conditioning and extinction, others responded predo

80 ty in the amygdala is required for pavlovian fear conditioning and extinction.

81 prefrontal cortex are crucial for modulating fear conditioning and extinction.

82 BLA neurons serve a well-accepted role in fear conditioning and fear extinction.

83 ning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important ro

84 ial learning and memory in context-dependent fear conditioning and in the Barnes circular maze.

85 eral amygdala (BLA) plays a critical role in fear conditioning and is extremely sensitive to ELS.

86 Using an array-based approach after auditory fear conditioning and microRNA (miRNA) sponge-mediated i

87 We observed stronger context fear conditioning and more generalization of fear to a s

88 ry to expectation, our studies of contextual fear conditioning and novel object recognition in I-2 he

89 Using contextual fear conditioning and optogenetic inhibition, we show th

90 Fear conditioning and other elements of basic learning t

91 ted cognitive impairments in both contextual fear conditioning and spatial learning and memory.

92 sed the rates of extinction learning of both fear conditioning and sucrose self-administration.

93 ated by threat-predicting sensory cues after fear conditioning and that activation of these neurons s

94 Rats underwent auditory fear conditioning and then received either immediate (30

95 nce responses to the CS without shock during fear conditioning and to both the CS with shock and CS w

96 e TBI-induced deficits in cue and contextual fear conditioning and water maze retention.

97 er, how exactly these neurons participate in fear conditioning and whether they contribute to the gen

98 ed in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular transport a

99 ficant spatial memory deficits in contextual fear-conditioning and Morris water maze tests compared w

100 h Pavlovian aversive conditioning (so-called fear conditioning), and then behaviors that reduce the f

101 phenotypes, including anxiety-like behavior, fear conditioning, and drug self-administration.

102 ng and memory deficit in object recognition, fear conditioning, and Morris water maze studies.

103 eversed the behavioral deficit in contextual fear conditioning, and reduced brain Abeta levels, plaqu

104 tudy was to examine developmental changes in fear conditioning, and to see whether these changes were

105 In "trace" fear conditioning, animals learn to associate a neutral

106 Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting,

107 splayed a selective impairment in contextual fear conditioning, as both cue fear and spatial learning

108 onsiveness of the amygdala and insula during fear conditioning, as well as hyporesponsiveness of the

109 attribution in morphine place-preference and fear conditioning assays, CBD coadministration reverses

110 Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by qua

111 f the Morris water maze (MWM) and contextual fear conditioning at 85 weeks of age showed that these m

112 After cued fear conditioning, both acute and 2-week administration

113 n-deficient mice exhibited normal contextual fear conditioning but displayed slower extinction learni

114 la, and dorsomedial prefrontal cortex during fear conditioning but negatively correlated with respons

115 components of PNNs were enhanced 4 hr after fear conditioning but were no longer different from the

116 tants are not defective in motor learning or fear conditioning, but do exhibit mild impairment of mot

117 nce did not disrupt the acquisition of trace fear conditioning, but markedly increased the level of f

118 ve been used as conditioned stimuli (CS) for fear conditioning, but researchers have largely neglecte

119 mally in several behavioral tasks, including fear conditioning, but showed enhanced contextual fear e

120 ockout [PS cDKO]) after one-trial contextual fear conditioning by using biochemical, immunohistochemi

121 eurons that were Fos tagged during olfactory fear conditioning causes a decrease in exploratory behav

122 lable for context encoding during contextual fear conditioning causes maladaptively overgeneralized a

123 This led to recall deficit after contextual fear conditioning (cFC) at 2 months of age in APPswe/PS1

124 an extinction training session of contextual fear conditioning (CFC) blocks retrieval but not consoli

125 dritic spines rearrange following contextual fear conditioning (CFC) in the hippocampus and amygdala

126 Extinction of contextual fear conditioning (CFC) in the presence of a familiar no

127 AD mice were tested in a 3-shock contextual fear conditioning (CFC) paradigm to assess memory declin

128 Using a contextual fear conditioning (CFC) paradigm, mice were administered

129 the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (whic

130 osterone (CORT) administration or contextual fear conditioning (CFC).

131 indicate underlying dysfunction in primitive fear conditioning circuits in the cerebellum.

132 M) study of Thy1-YFP mice following auditory fear conditioning complemented by confocal microscopy an

133 In this study, mice underwent trace fear conditioning consisting of an auditory CS paired wi

134 A variant of contextual fear conditioning, context pre-exposure facilitation, al

135 We further show that fear conditioning decreases and fear extinction increase

136 lasping behavior, as well as normalizes cued fear-conditioning defects.

137 We found that fear conditioning drove expression of the immediate earl

138 n of PTSD should include an understanding of fear conditioning, dysregulated circuits, memory reconso

139 Using Pavlovian fear conditioning (electric shock), we quantify generali

140 Mice received two distinct fear conditioning events separated by different interval

141 Moreover, rats that darted during initial fear conditioning exhibited lower freezing during the se

142 In contextual fear conditioning, experimental subjects learn to associ

143 In auditory fear conditioning, experimental subjects learn to associ

144 Parallel trace fear conditioning experiments showed that spine loss pre

145 ication of learning and memory of contextual fear conditioning, expression of CDK5, and enrichment of

146 Participants also underwent a three-day fear conditioning, extinction learning, and extinction r

147 ctivity from the BLA-HPC-mPFC circuit during fear conditioning, extinction, and exposure to an open f

148 Although a few paradigms probed fear conditioning/extinction or utilized peripheral immu

149 at takes place within minutes to hours after fear conditioning fails to produce a long-term extinctio

150 n of immobilization stress (IMO) followed by fear conditioning (FC) a week later.

151 monocular deprivation (MD) or auditory-cued fear conditioning (FC) caused rapid spine elimination in

152 memory processing; these show an increase in fear conditioning (FC), a reduction in prepulse inhibiti

153 oup using novel object recognition (NOR) and fear conditioning (FC).

154 Using three fear-conditioning (FC) paradigms (signaled, unsignaled,

155 healthy participants underwent differential fear conditioning, followed by a generalization test in

156 elated behaviors, as well as cued and social fear conditioning from a translational perspective.

157 nt changes in locomotor activity, contextual fear conditioning, grip strength, and motor learning, ma

158 Fear conditioning has been commonly used as a model of e

159 The hippocampal activity supporting trace fear conditioning has long been mysterious, but a leadin

160 Research in fear conditioning has provided a comprehensive picture o

161 Neural circuits underlying auditory fear conditioning have been extensively studied.

162 Using auditory Pavlovian fear conditioning in a rodent model, we examined the reg

163 n the hippocampus but not PFC impaired trace fear conditioning in adult mice.

164 minate between threat and safety cues during fear conditioning in children.

165 ne how trauma or neural structure relates to fear conditioning in children.

166 vity during contextual, but not during cued, fear conditioning in female participants carrying the PA

167 In addition, context preexposure increased fear conditioning in males and decreased generalization

168 Using auditory fear conditioning in mice, we investigated the role of e

169 anticipatory behavioral responses in an odor fear conditioning in rats, while recording theta (5-15 H

170 on is further supported by studies examining fear conditioning in rodent models.

171 complex 1 (mTORC1) activity after contextual fear conditioning in the CA1 but not CA3 area of the dor

172 PR68 modulator, ogerin, suppressed recall in fear conditioning in wild-type but not in GPR68-knockout

173 ession of PVs during discriminative auditory fear conditioning increased generalization of conditione

174 We found that contextual fear conditioning increased ripple-spindle coupling in m

175 in vivo in the dorsal hippocampus inhibited fear conditioning, indicating that AMPAR diffusion is im

176 Fear conditioning induced both up- and down-regulation o

177 Contextual fear conditioning induced selective strengthening of a s

178 hat can be accounted for by an impairment in fear-conditioning-induced synaptic potentiation onto som

179 econsolidation derives from studies based on fear conditioning instead of avoidance-learning paradigm

180 Our primary analyses demonstrate that human fear conditioning is associated with a consistent and ro

181 Stimulus processing in fear conditioning is constrained by parvalbumin interneu

182 Kim and Cho (2017) now show that fear conditioning is mediated by synapse-specific LTP in

183 Pavlovian fear conditioning is one of the most common and well-und

184 ala (LA) plays an essential role in auditory fear conditioning, it is unknown whether LTP is induced

185 wever, while antagonism of mGluR5 may reduce fear conditioning, it may also reduce fear extinction.

186 ing AEA signaling in the BLA did not prevent fear conditioning itself or fear reinstatement.

187 We find that sub-threshold fear conditioning leads to dopamine receptor D4-dependen

188 have previously demonstrated that olfactory fear conditioning leads to increased odorant-specific re

189 ditory cortex, confocal analysis showed that fear conditioning led to a significantly increased densi

190 remote (28 d) time points after contextually fear conditioning male mice.

191 hat part of the molecular program induced by fear conditioning may initiate homeostatic plasticity.

192 patterns in the hippocampus and deficits in fear conditioning memory.

193 rris water maze) and associative (contextual fear conditioning) memory were observed in lesioned P301

194 studied learning and memory using contextual fear-conditioning, Morris water maze, and novel object r

195 animals and behavioral experiments in which fear conditioning naturally activated the PAG.

196 However, in cued fear conditioning, Neto2(-/-), but not Neto1(-/-) mice,

197 short-term and long-term memories, including fear conditioning, object recognition, object placement,

198 This prior fear conditioning of CSA reduced the prediction error du

199 mp recordings to examine the effect of trace fear conditioning on the intrinsic excitability of layer

200 A1R antagonist), treatment for 7 days before fear conditioning onwards, to attenuate the retrieval of

201 CeA Crh-expressing cells (Crh neurons) after fear conditioning or extinction in mice using translatin

202 ala (3, 10, or 30 mug/side) following either fear conditioning or fear extinction training.

203 JNJ-42165279 did not affect fear conditioning or within-session extinction learning

204 fter either threat conditioning (also called fear conditioning) or conditioned inhibition in adult ra

205 imately three weeks later, learned fear (via fear conditioning) or depressive-like behavior (via tail

206 as not found in animals that did not undergo fear conditioning, or when extinction was conducted outs

207 t anticipation induced by a well-established fear conditioning paradigm applied in both humans and ro

208 ealthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance

209 ate and memory duration using an associative fear conditioning paradigm that trained zebrafish to ass

210 al abuse, or domestic violence), completed a fear conditioning paradigm utilizing blue and yellow bel

211 thy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction

212 ir parent, or a stranger, being exposed to a fear conditioning paradigm, and (2) the subsequent fear

213 This indicates that, under the current fear conditioning paradigm, early-life FGF2 has protecti

214 Recently, in a classical Pavlovian fear conditioning paradigm, Gruene and colleagues descri

215 expressed greater associative learning in a fear conditioning paradigm.

216 agia test, and cognition, using a contextual fear conditioning paradigm.

217 monstrated elevated freezing in a contextual fear conditioning paradigm.

218 ar learning using a combined trace and delay fear conditioning paradigm.

219 provide details for a novel context threat (fear) conditioning paradigm in humans using a commercial

220 sted in the hippocampus-dependent contextual fear-conditioning paradigm in adulthood.

221 wake-behaving mice during training in a cued fear-conditioning paradigm slowed the extinction of lear

222 CeM neurons and reduced fear expression in a fear-conditioning paradigm.

223 its in learning and memory in the contextual fear-conditioning paradigm.

224 zing behavior to the tone was increased in a fear-conditioning paradigm.

225 he parent's SCR during the actual process of fear conditioning predicted higher SCR for the child to

226 community advertisements, to a differential fear conditioning procedure and assessed the relationshi

227 Notably, using a fear conditioning procedure, we found that photostimulat

228 from surgery, underwent a standard auditory fear conditioning procedure.

229 view that they may inform ongoing studies of fear-conditioning processes both in healthy and clinical

230 Fear conditioning produced an immediate and dramatic inc

231 mbined differential intensity-based auditory fear conditioning protocols in mice with C-FOS immunohis

232 Olfactory cue-based fear conditioning provides a framework to address this i

233 During Pavlovian threat (fear) conditioning (PTC), sensory and neuromodulatory in

234 After fear conditioning, PV-INs exhibit nucleus- and target-se

235 Here we demonstrate that aversive fear conditioning rapidly and persistently alters sponta

236 After fear conditioning, rats either received extinction trial

237 netic inhibition of dorsal DG during context fear conditioning, recall, generalization, and extinctio

238 In contrast, trace fear conditioning reduced the excitability of regular sp

239 ce of brain-based markers of overgeneralized fear conditioning related to PTSD.

240 association learning and suggest that trace fear conditioning relies on mechanisms that differ from

241 animal studies, the neurobiological basis of fear conditioning remains only partially understood.

242 Classical Pavlovian fear conditioning remains the most widely employed exper

243 ing on two paradigms: social recognition and fear conditioning, representing approach and avoidance b

244 empirically through case examples from human fear conditioning research, in which the exclusion of 'n

245 del system for stress and anxiety disorders, fear-conditioning research has not yet characterized how

246 the level of extinction learning of a trace fear conditioning response, a behavioral paradigm that r

247 We previously demonstrated that contextual fear conditioning results in hippocampal place cell rema

248 Here we show that memory formation through fear conditioning selectively accelerates the degradatio

249 BLA neuronal activity and function, such as fear conditioning, shifts across the estrous cycle.

250 -GPe circuit, thereby regulating learning in fear conditioning.SIGNIFICANCE STATEMENT The central amy

251 ciently to the basal amygdala for contextual fear conditioning.SIGNIFICANCE STATEMENT This work demon

252 is the first study to demonstrate that trace fear conditioning significantly alters the intrinsic exc

253 Trace fear conditioning significantly enhanced the intrinsic e

254 Fear conditioning significantly increases the eliminatio

255 tonin release in freely behaving mice during fear conditioning, social interaction, and sleep/wake tr

256 ivity-dependent transcription in response to fear conditioning stress, and the affected genes include

257 Animal fear conditioning studies have illuminated neuronal mech

258 discuss whether the inferences we draw from fear conditioning studies operate in the natural world.

259 l models of fear stem largely from Pavlovian fear conditioning studies that focus on how a particular

260 nding motivates a reinterpretation of rodent fear conditioning studies, particularly in females, and

261 frontal cortex as well as amygdala volume in fear conditioning studies.

262 ovide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional ma

263 vations-a scarcely addressed dynamic in fMRI fear-conditioning studies-also suggests the existence of

264 ed in IL after fear extinction compared with fear conditioning, suggesting that EphB2 signaling in IL

265 ase in FTO observed shortly after contextual fear conditioning suggests that FTO normally constrains

266 acquisition and the extinction phases of the fear-conditioning task for the whole brain yielded good

267 nt signal was measured during a differential fear-conditioning task.

268 ormance in the objection location memory and fear conditioning tasks and in a complex spatial environ

269 he formation of stimulus associations during fear-conditioning tasks where the timing of conditioned

270 d improvement in their memory as assessed by fear conditioning test, both in the cue and recall phase

271 group-housed mice exposed to the contextual fear conditioning test, elevated plus maze test, forced

272 ive situations (in the passive avoidance and fear conditioning tests) and an impairment of nonemotion

273 ss for food and subjected to Pavlovian delay fear conditioning, then 28 days later, they underwent a

274 us (US)-related information during classical fear conditioning, thereby having an indispensable role

275 ats with acquisition and extinction of trace fear conditioning to determine how specific neurons chan

276 We used western blot analyses and trace-fear conditioning to determine whether 5 days of VU04095

277 the caspase-autophagy pathway is engaged by fear conditioning to facilitate associative fear learnin

278 g of DG engram neurons 24 h after contextual fear conditioning to identify transcriptome changes spec

279 C57BL/6 mice that combines acute stress with fear conditioning to precipitate traumatic-like memories

280 Furthermore, we used fear conditioning to study learning and memory in these

281 or both, were sleep-deprived at the end of a fear conditioning training session and fear memory was a

282 tressor nonassociatively enhances subsequent fear conditioning training with only a single trial.

283 Next, we found that contextual fear conditioning transiently (0.5 h) decreased Fto leve

284 Here we investigate human Pavlovian fear conditioning under the blood-brain barrier crossing

285 Differential fear conditioning using FPS was tested in n = 63 childre

286 , healthy adult volunteers underwent threat (fear) conditioning using a tone-conditioned stimulus pai

287 e role of GPR171 in anxiety-like behavior or fear conditioning was evaluated following systemic or in

288 iable slowing in a single session of context fear conditioning was found after HPC damage.

289 uced freezing behavior in Tg2576 mice during fear conditioning was partially reversed after subchroni

290 hibitor or vehicle before cue and contextual fear conditioning, water maze training and a spatial wor

291 ific changes in activity, because effects on fear conditioning were assessed in a drug-free state, an

292 Neurons that were active during context fear conditioning were tagged with the long-lasting fluo

293 ories, including novel object recognition or fear conditioning, were not affected by these genetic ma

294 n between auditory sensitivity after TBI and fear conditioning where 75 dB white noise alone evokes a

295 In fear conditioning, where a conditioned stimulus predicts

296 resulted in learning and memory deficits in fear conditioning, whereas CREB deletion in the ventral

297 nd extinction of fear memory during auditory fear conditioning, whereas males exhibited enhanced acti

298 e found cells that remapped primarily during fear conditioning, which could facilitate reacquisition

299 during extinction and in female rats during fear conditioning, which does not involve infralimbic-ba

300 e PVT or Trkb in SOM(+) CeL neurons impaired fear conditioning, while infusion of BDNF into the CeL e