ライフサイエンスコーパス: felodipine

1 water solubility and high hydrophobicity of felodipine.

2 sover design, 18 healthy volunteers ingested felodipine (10 mg) with 1 of the 3 juices (240 mL).

3 h montelukast (2.8 A), troglitazone (2.7 A), felodipine (2.3 A), and 9-cis-retinoic acid (2.6 A) were

4 reatment with a single oral dose of placebo, felodipine (5 mg), metoprolol (50 mg), or enalapril (10

5 closporine for immunosuppression therapy and felodipine, a calcium channel blocker, for blood pressur

6 The in vitro neuroprotective effects of felodipine against vincristine-induced nuclear loss and

7 as amlodipine, isradipine, nicardipine, and felodipine also appear to be effective in patients with

8 Here we report that felodipine, an L-type calcium channel blocker and anti-h

9 It was found that felodipine and copovidone in the 5% dispersion dissolve

10 aded dispersion, partial RDDR values of both felodipine and copovidone were found to be extremely low

11 We used two of these antihypertensives (felodipine and nilvadipine) for administration to mice a

12 The increase in oral availability of felodipine and other commonly used medications when take

13 In the felodipine and placebo groups, mortality (13.8% versus 1

14 sible for enhancing the systemic exposure of felodipine and probably other CYP3A4 substrates that und

15 ete resolution of GE after the withdrawal of felodipine and the control of diabetes.

16 stallized samples of the drugs indomethacin, felodipine, and acetaminophen.

17 We also present felodipine as a specific inhibitor for oncogenic Aurora

18 of transition from amorphous to crystalline felodipine at different locations within the dosage form

19 f numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) f

20 Felodipine can act as a neuroprotectant against glaucoma

21 Felodipine can clear mutant alpha-synuclein in mouse bra

22 Felodipine concentrations in the retina-choroidal tissue

23 The ONH blood flow response to felodipine correlated with tissue concentration-time pro

24 Even high dose of felodipine did not cause any ocular toxicity.

25 High felodipine dosage (780 nmol/eye) improved blood circulat

26 Felodipine exerts a well-tolerated additional sustained

27 omly assigned to double-blind treatment with felodipine extended release (5 mg BID) or placebo for 3

28 (PTX), CRF with the calcium channel blocker felodipine (F), and sham operation of the kidney (SO).

29 ically select oxidation products formed from felodipine (i.e., two chlorine atoms) and bromocriptine

30 Two formulations of poorly water-soluble felodipine in a polymeric matrix of copovidone VA64 whic

31 t juice (GFJ) and the model CYP3A4 substrate felodipine in healthy volunteers using a GFJ devoid of f

32 Felodipine increased ONH blood flow in a dose-dependent

33 d displays a clinical and histologic case of felodipine-influenced GE in an undiagnosed type 2 diabet

34 ative clinical approach to the management of felodipine-influenced gingival enlargement and displays

35 Additionally, felodipine inhibition of LTCCs in primary cultures of mo

36 ls (RGCs) was counted following intravitreal felodipine injection in hypertonic saline-induced OHT ra

37 flowgraphy following intravitreally injected felodipine into normal and ischemic rabbit eyes receivin

38 m for the effect of grapefruit juice on oral felodipine kinetics is its selective downregulation of C

39 biopsies were obtained endoscopically, oral felodipine kinetics were determined, and liver CYP3A4 ac

40 The smaller neutral felodipine molecule is sequestered with its dichlorophen

41 molar (clevidipine, delavirdine, etravirine, felodipine, nicardipine, nilotinib, and sorafenib) or lo

42 Clevidipine, felodipine, nicardipine, nilvadipine, and nimodipine hav

43 aking a calcium-channel blocker (amlodipine, felodipine, nifedipine, diltiazem, or verapamil).

44 -penetrant dihydropyridines (eg, nifedipine, felodipine) on parkinsonism milestones as measured by ti

45 Inhibition of LTCCs with felodipine or nifedipine induces progressive cortical ca

46 tion and atrial peptide did not persist, but felodipine prevented worsening exercise tolerance and qu

47 Furthermore, felodipine protected SH-SY5Y cells against vincristine-i

48 Felodipine retards the rate of tumor progression in a xe

49 Felodipine significantly reduced blood pressure and, at

50 l edema was the only apparent side effect of felodipine therapy.

51 binding of the common antihypertension drug felodipine to the oncogenic Aurora A kinase protein via

52 oth soluble and membrane rich fractions from felodipine treated lenses by SDS-PAGE in conjunction wit

53 Histological analyses of felodipine treated lenses revealed extensive disorganiza

54 Significantly, loss of transparency in the felodipine treated lenses was preceded by an increase in

55 Felodipine treatment led to a significant increase in ge

56 on correlated with the increase in Cmax when felodipine was taken with either the 1st or the 16th gla

57 Felodipine was withdrawn and the diabetes was controlled

58 sodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rab

59 r the curve and the maximum concentration of felodipine were significantly (P < 0.001) greater with c

60 diabetes was managed at the same time as the felodipine withdrawal, it remains difficult to speculate