ライフサイエンスコーパス: femtomolar

1 somatostatin-28 exhibited a higher potency (femtomolar).

2 timized detection limit of this method is 20 femtomolar.

3 tease inhibitor, GRL-142, with IC(50) of 130 femtomolar.

4 nd the limit of detection calculated as 13.0 femtomolar.

5 ted ultrasensitive label-free biosensor with femtomolar (0.01 pg mL(-1)) sensitivity for the endocrin

6 copy, having higher-specificity and attained femtomolar (10 fM) sensitivity.

7 Femtomolar (10(-)(15) M) concentrations of DNA were dete

8 of trace amount of DNA/mRNA samples down to femtomolar (10(-15) M) concentrations; excellent ability

9 rating reproducible SERRS nanoparticles with femtomolar (10(-15) M) limits of detection.

10 8) M) for model assay systems and to the low femtomolar (10(-16) M) for measuring analyte in human pl

11 sterase (mAChE) complexed with syn-TZ2PA6, a femtomolar AChE inhibitor, is compared to a simulation o

12 Thus, 1 (syn-TZ2PA6), a femtomolar AChE inhibitor, which is formed in a 1:1 mixt

13 However, the mechanisms mediating femtomolar-acting compounds are poorly understood.

14 mon high-affinity site of action for several femtomolar-acting compounds, where NADPH oxidase is the

15 r, positive ionizable, hydrophobic) of these femtomolar-acting compounds.

16 One conjugate, 7h (KMR-28-39), which has femtomolar activity in the breast cancer cell line MDA-M

17 and is found to be capable of detecting sub-femtomolar AfB1 range down to 0.1 fg/ml not only in pure

18 ScsB and ScsC can bind toxic copper(I) with femtomolar affinities and transfer it to the periplasmic

19 Such a mechanism of adaptability allows femtomolar affinities for two proteases with very differ

20 We discovered Nbs with picomolar to femtomolar affinities that inhibit viral infection at co

21 n identified tozorakimab, an antibody with a femtomolar affinity for IL-33(red) and a fast associatio

22 y a heme protein sensor (SONO) that displays femtomolar affinity for NO.

23 yielded a trivalent nanobody, mNb6-tri, with femtomolar affinity for Spike and picomolar neutralizati

24 trianion binds with an exceptionally strong femtomolar affinity in the absence of Ser102, show that

25 a picomolar K(i) and binds to IleRS with low femtomolar affinity, 1600 times more tightly than mupiro

26 ctional biotin-binding site, but retains the femtomolar affinity, low off-rate and high thermostabili

27 ssing SARS-CoV-2 spike protein variants with femtomolar affinity.

28 nuclease inhibitor protein, which binds with femtomolar affinity.

29 We report the electrochemical detection of femtomolar amounts of cobalt, iridium, nickel, and iron

30 Upon addition of femtomolar amounts of hexachloroplatinic acid, which wil

31 e 32P-labeled and quantitatively detected in femtomolar amounts.

32 s (streptavidin and antibodies) at pico- and femtomolar analyte concentrations.

33 on of these species in drinking water with a femtomolar and a nanomolar LOD was achieved for the firs

34 ions with avidin and streptavidin, achieving femtomolar and picomolar affinities, respectively.

35 e linear range of the sensor was 40.0-1100.0 femtomolar and the limit of detection calculated as 13.0

36 These include a very high (femtomolar) and a high (picomolar) affinity site, with a

37 n a specific area to yield highly sensitive (femtomolar) and repeatable measurements.

38 Femtomolar assays can be achieved with this rapid and si

39 ing protein, concanavalin A (ConA), with sub-femtomolar avidity.

40 , if its metabolic clearance is compromised, femtomolar background levels of this compound in cell-cu

41 -reactive yet are highly specific, achieving femtomolar binding affinities in complexes with their co

42 , the CB[8].IsoDiam(NHMe2)2 complex displays femtomolar binding affinity, placing it firmly alongside

43 limit of the assay is further improved to 1 femtomolar by incorporating a ligation chain reaction am

44 size of isolated clusters obtained from the femtomolar Co(2+) solution through an atom-by-atom techn

45 mammalian homologues of RNase A, ANG forms a femtomolar complex with the cytosolic ribonuclease inhib

46 st and ovarian cancer cells were detected at femtomolar concentration and incorporation of negative c

47 imits were brought down to the picomolar and femtomolar concentration levels with satisfactory analyt

48 y three orders of magnitude to levels of low femtomolar concentration of target molecules.

49 us expands the limit of detection to the sub-femtomolar concentration range (LOD: 23 fg mL(-1), 800 a

50 PR), 1,N6-etheno-ADPR (epsilon-ADPR), at low femtomolar concentration range in vascular tissue superf

51 complished over the low-attomolar to the mid-femtomolar concentration range.

52 to highly selective HSA determination in the femtomolar concentration range.

53 ples by >95% when evaluated by microbubbles (femtomolar concentration) or qPCR, demonstrating both vi

54 QS was driven up to single molecule sensing (femtomolar concentration).

55 n limit was observed for the sensor, down to femtomolar concentration, outperforming the current assa

56 We find that DNAs of 5000 nucleotides, at femtomolar concentration, potently activate ATR in this

57 ed to enhance target detection limit down to femtomolar concentration.

58 l is evaluated as a measure of ultralow (sub-femtomolar) concentration of analytes in solution.

59 's high sensitivity, detecting dengue DNA at femtomolar concentrations (10-15 M) with a significant d

60 ing HGF/SF-induced uPA-plasmin activation at femtomolar concentrations (fM-GAi) in canine MDCK cells.

61 We successfully detected miRNAs at femtomolar concentrations (with limits of detection [LOD

62 nt neuroprotective protein, is protective at femtomolar concentrations against a wide array of neural

63 peptide, and naloxone are neuroprotective at femtomolar concentrations against LPS-induced dopaminerg

64 or ultrasensitive sizing of proteins down to femtomolar concentrations and enables affinity profiling

65 ivation, displaying inhibitory properties at femtomolar concentrations and nine orders of magnitude b

66 ent bacterial toxins that cause paralysis at femtomolar concentrations by blocking neurotransmitter r

67 y and selectively detect its known ligand to femtomolar concentrations by detecting a change in elect

68 ndard human plasma and urine samples, and at femtomolar concentrations from bladder cancer patient pl

69 ic transducer for the detection of avidin at femtomolar concentrations in solution.

70 of PNA vs DNA oligomers for the recovery of femtomolar concentrations of 16S rDNA targets was determ

71 e specific label-free detection of below 100 femtomolar concentrations of antibodies as well as real-

72 olar concentrations of BoNT and attomolar to femtomolar concentrations of BoNT in honey, the most com

73 Notably, the reporters can detect femtomolar concentrations of BoNT/A in 4h and BoNT/E in

74 that the neuroprotective effect elicited by femtomolar concentrations of DM is mediated through the

75 Femtomolar concentrations of hydrogen fluoride, a decomp

76 his study, we show the assay is sensitive to femtomolar concentrations of miRNA (500 fM), has a three

77 How femtomolar concentrations of NAP antagonize millimolar c

78 Femtomolar concentrations of NAP stimulated the phosphor

79 hrinking is visible to the naked eye down to femtomolar concentrations of protein.

80 This action of ethanol is antagonized by femtomolar concentrations of the neuropeptide NAPVSIPQ (

81 The detection of femtomolar concentrations of urobilin, a metabolic bypro

82 t can rapidly trap sub-10 nm biomolecules at femtomolar concentrations on demand.

83 cts: SST2 activation reduced oscillations at femtomolar concentrations reflected by high inhibiting p

84 Several compounds are neuroprotective at femtomolar concentrations through the inhibition of infl

85 cytokines like VEGF may require depletion to femtomolar concentrations using high-affinity antagonist

86 Protein markers were routinely detected at femtomolar concentrations with high selectivity, and sim

87 46 in extracellular vesicles at single-digit femtomolar concentrations with single-nucleotide specifi

88 d, direct detection of individual targets at femtomolar concentrations without the use of an amplific

89 e to their ultralow concentration (typically femtomolar concentrations) and interference by other thi

90 s directly in blood, urine and sputum at sub-femtomolar concentrations, and microorganisms in blood a

91 ), exhibits a potent angiogenic potential at femtomolar concentrations, whereas classic angiogenic fa

92 or lysis by freshly harvested CNS-IL CTLs at femtomolar concentrations.

93 alcium-mediated induction of the PT, even at femtomolar concentrations.

94 and quantitatively size Ag nanoparticles at femtomolar concentrations.

95 dopamine levels in biological assays at low femtomolar concentrations.

96 ties and kinetics with sensitivities down to femtomolar concentrations.

97 lls in a strictly Ag-dependent manner and at femtomolar concentrations.

98 producing signaling molecules active at low femtomolar concentrations.

99 In plants, CKs act at trace, often low femtomolar concentrations; therefore, sensitive and prec

100 ncreased DNA uptake 3,000-fold, allowing for femtomolar detection in samples dominated by background

101 ange from 0.1 to 200 pM and an unprecedented femtomolar detection limit are possible in undiluted blo

102 Within 20 min, the femtomolar detection limit for miRNAs was observed, 6 or

103 We report the femtomolar detection of silver (Ag) nanoparticles by dir

104 pecificity for mHTT, high sensitivity with a femtomolar detection threshold, and a broad dynamic rang

105 e a ready alternative to the more cumbersome femtomolar electrochemical assays described to date.

106 and selectivity for uranyl with a Kd of 7.4 femtomolar (fM) and >10,000-fold selectivity over other

107 croRNA (let-7a) across the nanomolar (nM) to femtomolar (fM) concentration range using the dynamic re

108 etection of NA targets in microwells down to femtomolar (fM) concentrations, without the need for any

109 This sensor allowed femtomolar (fM) detection of FAP, a detection limit well

110 etection limits of 100 attomolar (aM) and 10 femtomolar (fM) in pure samples for two ELISA assays wit

111 nsitivity with the limit of detection in the femtomolar (fM) range for synthetic targets as well as v

112 This nanofiber-based system realizes femtomolar (fM) sensitivity toward complementary target

113 non-interfering computational method for sub-femtomolar food toxin detection in complex mixture based

114 In contrast, femtomolar GABA (500 fM) directed a subset of GAD- vz ne

115 Femtomolar GABA primarily stimulated chemotaxis (migrati

116 Hence, chemotactic responses to femtomolar GABA seem to involve all three classes of GAB

117 micromolar GABA; however, only responses to femtomolar GABA were partially blocked by bicuculline, a

118 Neaumycin B is a femtomolar inhibitor of U87 human glioblastoma.

119 by transition state analysis have developed femtomolar inhibitors for MTANs, among the most powerful

120 channels were filled with buffers containing femtomolar INP concentrations from Pseudomonas syringae.

121 e lowest detection limit was observed at the femtomolar level (0.25 fM/mL) over a wide range of antig

122 ive, allowing the detection of target DNA at femtomolar level by simple spectroscopic analysis (40.7

123 The dissolved platinum was detected using a femtomolar level detection technique which involves redu

124 We show calibration curves at the femtomolar level for cobalt, nickel, and lead ions on ca

125 ckel, and lead ions were reported at 10 s of femtomolar level for the first time.

126 of DNA molecules at concentrations below the femtomolar level requires amplified detection schemes.

127 ing 868.64, detecting biomarkers down to the femtomolar level, demonstrating the platform's potential

128 lexes over 3 orders of magnitude down to the femtomolar level.

129 tect a broad range of beta-lactamases at the femtomolar level.

130 to enhance sensor sensitivities down to the femtomolar level.

131 nearly with the concentration of ions at the femtomolar level.

132 We demonstrate femtomolar-level detection of prostate-specific antigen

133 recognition specificity, ultimately enabling femtomolar levels of quantification of C-reactive protei

134 ock uPA-plasmin activation in tumor cells at femtomolar levels.

135 allows label-free detection of miRNA down to femtomolar levels.

136 ed method allows identifying LYS with a 44.6 femtomolar limit of detection, using sample volume as lo

137 a robust thresholding process and results in femtomolar limits of detection.

138 We demonstrate the feasibility of attaining femtomolar limits of quantitation in electroanalysis.

139 on (LOD) for Hg(2+) in distilled water and a femtomolar LOD in drinking water using DNA aptamer-funct

140 bringing the detection limit down to tens of femtomolar, nearly five orders of magnitude lower than t

141 RIF-1 has extraordinary potency (femtomolar, or 10(-15) M) and S. rosetta can respond to

142 ption of zinc uptake or efflux machinery are femtomolar, or six orders of magnitude less than one ato

143 IP in promoting neuronal survival, acting at femtomolar-picomolar concentration.

144 vivo clonogenic BPL xenograft cells, even at femtomolar-picomolar concentrations.

145 ogic concentration, may explain not only the femtomolar plasma levels of Abeta but the little fluctua

146 f electrocatalytic clusters of platinum from femtomolar platinate solutions.

147 Pt was plated from solutions of femtomolar PtCl6(2-), which allowed precise control of t

148 The sensing platform demonstrates a low femtomolar quantification limit and minimal cross-reacti

149 atile double emulsion sensor that can detect femtomolar quantities of aqueous hydrogen peroxide.

150 protocol with limits of detection in the low femtomolar range (3-9 fM).

151 e cell compartment, but also to quantify the femtomolar range amounts of the cell surface-associated

152 uorimetrically with a detection limit in the femtomolar range and a linear response over 3 orders of

153 y can detect specific target proteins in the femtomolar range from complex biological samples such as

154 tracking improved the extrapolated LODs from femtomolar range to [Formula: see text] 10 attomolar (le

155 pable of measuring enzymes in the low to mid femtomolar range with measurement times that range from

156 ivity, achieving a limit of detection in the femtomolar range without any target pre-amplification st

157 As the probe can detect other MMPs in the femtomolar range, it is a potentially powerful tool for

158 tion method with detection limits in the low femtomolar range, making it particularly amenable to poi

159 en free Zn(II) concentrations are in the sub-femtomolar range, making it the most sensitive Zn(II) me

160 our system enables the detection of ASFV in femtomolar range.

161 RNase A) superfamily with an affinity in the femtomolar range.

162 with dissociation constants that are in the femtomolar range.

163 I.RNase A complex having a K(d) value in the femtomolar range.

164 moting effects of dihydrotestosterone in the femtomolar range.

165 DNA site with a dissociation constant in the femtomolar range.

166 d SARS-CoV-2 with limits of detection in the femtomolar range.

167 d assay achieved detection limits in the low femtomolar range.

168 and exhibits a detection sensitivity in the femtomolar range.

169 s of detection and quantification in the low femtomolar range.

170 cation of NBD C6-glucosylceramide in the low-femtomolar range.

171 proliferation of bovine T lymphocytes in the femtomolar range.

172 eptor with the high affinity KH value in the femtomolar range.

173 ght binding with K(i) values in the nano- to femtomolar range.

174 nity with dissociation constants (Kd) in the femtomolar range.

175 equilibrium dissociation constant was in the femtomolar range.

176 a detection limit for rhodamine 6G below the femtomolar regime (10(-15) M), with high reproducibility

177 free aquacopper(I) concentration to the sub-femtomolar regime.

178 is found to be in the low-picomolar to high-femtomolar region.

179 regnant donors at a concentration of 1 and 3 femtomolar, respectively.

180 boratories reported the planar structure and femtomolar rosette-inducing activity of one rosette-indu

181 We show that this approach allows for femtomolar sensitivity and single-base mismatch selectiv

182 he assay requires a 1-microl sample, has low-femtomolar sensitivity as well as five-log linear range

183 Optimized CRISPR RNA pools enable sub-femtomolar sensitivity for target detection without any

184 engineered protein with high selectivity and femtomolar sensitivity has been examined by a combinatio

185 We also demonstrate femtomolar sensitivity in buffer and nanomolar sensitivi

186 amplification by RCA with high specificity, femtomolar sensitivity, 3 log quantitative range, and ec

187 This digital PLA method has femtomolar sensitivity, which enables the quantification

188 loid beta-protein (Abeta) oligomers with sub-femtomolar sensitivity.

189 successfully developed a 10-plex assay with femtomolar sensitivity.

190 de increase in event detection rates and sub-femtomolar sensitivity.

191 the antibiotic-resistance gene bla(TEM) with femtomolar sensitivity.

192 Aptamer-FET neuroprobes enabled femtomolar serotonin detection limits in brain tissue wi

193 racellular vesicles binding from down to 204 femtomolar solutions.

194 and with dissociation constants as low as 33 femtomolar, they are the most potent noncovalent AChE in

195 to detect at a limit of detection lower than femtomolar; they are also fast and hence innately suitab

196 coy receptor with an apparent affinity of 93 femtomolar to GAS6.

197 d over an analyte concentration range of low femtomolar to low nanomolar, with dynamic ranges for the

198 free detection of 17beta-estradiol (E2) from femtomolar to micromolar levels.

199 present at concentrations spanning from low femtomolar to mid-nanomolar levels.

200 ed cell proliferation at low concentrations (femtomolar to nanomolar), similar to E2.

201 ence or structural homology to BLIP and is a femtomolar to picomolar potency inhibitor, and the amino

202 , D, E, F, and G serotypes in real time with femtomolar to picomolar sensitivity.

203 ion of so-called "free" or "labile" pools is femtomolar to picomolar.

204 al counting of single protein molecules with femtomolar-to-attomolar limits of detection (LODs).

205 Rnl2-based RASL exhibits sub-femtomolar transcript detection sensitivity, and permits

206 e analyzed the EcMTAN mass in complex with a femtomolar transition state analogue to determine whethe

207 d target DNA at concentrations as low as 500 femtomolar with a point mutation selectivity factor of a

208 y DNA strategy enables detection down to low femtomolar (x10(-15) M) level without requiring target l