ライフサイエンスコーパス: fenestration

1 bital fracture repair and optic nerve sheath fenestration.

2 However, there are potential drawbacks to fenestration.

3 single stage and for fenestration versus no fenestration.

4 lap, and three with both stent placement and fenestration.

5 ith endovascular stent placement and balloon fenestration.

6 se of occluding a persistently patent Fontan fenestration.

7 crease in the population of endothelial cell fenestration.

8 le extending their polar tails into the IV-I fenestration.

9 pling spindle elongation to nuclear membrane fenestration.

10 tive framework for assessing view clarity of fenestration.

11 bo-peritoneal shunts) and optic nerve sheath fenestration.

12 bral artery, persistent stapedial artery and fenestration.

13 mes come in contact through one of the large fenestrations.

14 ff central cavity with occluded lateral pore fenestrations.

15 ccurs, and beta-crystallin is located in the fenestrations.

16 is required to avoid tooth or alveolar bone fenestrations.

17 d endothelial cells with loss of endothelial fenestrations.

18 rapidly induce the formation of endothelial fenestrations.

19 foot processes and disorganized endothelial fenestrations.

20 in diameter) in the plasma membrane, called fenestrations.

21 hrough openings to their membrane-accessible fenestrations.

22 cant fenestration loss and increased size of fenestrations.

23 evealed through the open activation gate and fenestrations.

24 to the channel cavity through intramembrane fenestrations.

25 of subcellular ultrastructures such as LSEC fenestrations.

26 asma membrane that supports the formation of fenestrations.

27 ian drug receptor site, and the lateral pore fenestrations.

28 ents underwent partial hepatectomy with cyst fenestration, 10 underwent cyst fenestration alone, and

29 s atrium was necessary in 33 procedures, via fenestration (16) or transbaffle puncture (17), and in 2

30 nd JPL (16 patients), PPV plus inner retinal fenestration (18 patients), and PPV plus autologous plat

31 ve remained asymptomatic with patency of the fenestration (4 to 5 mm on echocardiography) and arteria

32 This suggests that temporal fenestration, a key structural innovation with important

33 The resulting widening of the fenestrations above the TMD and opening of the transmemb

34 adjustment for Fontan type and presence of a fenestration, absolute SPC flow was significantly associ

35 nt by 46%, completely prevented formation of fenestration after engraftment as LSECs, and exacerbated

36 ayed re-vascularization and reduced vascular fenestration after engraftment, partially impairing vasc

37 A persistently patent fenestration after Fontan operation may be closed with a

38 nch pulmonary artery into the RVOT, with the fenestration aligned with the ostium of the nondominant

39 c lamina (IEL) of blood vessels are sites of fenestration allowing for passage of diffusible vasoacti

40 sociated covered stent placement through the fenestration allows TPVR for patients with dysfunctional

41 my with cyst fenestration, 10 underwent cyst fenestration alone, and 7 underwent liver transplantatio

42 ared between those with and without surgical fenestration among 536 subjects (mean age 11.9 years) en

43 lastic left heart syndrome diagnosis, patent fenestration, anatomic Fontan obstruction, clinical cyan

44 presents a case series of 9 patients with 8 fenestration and 3 dehiscence defects on implants consec

45 ral drainage occurred in 13 patients, 8 with fenestration and 5 without.

46 head-to-head trials with optic nerve sheath fenestration and cerebrospinal fluid diversion surgeries

47 cal interventions such as optic nerve sheath fenestration and cerebrospinal fluid shunting are used i

48 12 patients, enucleation in 6 patients, and fenestration and complete fulguration in 1 patient.

49 ography (CBCT) on the diagnostic accuracy of fenestration and dehiscence around dental implants.

50 ful in increasing the diagnostic accuracy of fenestration and dehiscence around dental implants.

51 d to evaluate the visibility of peri-implant fenestration and dehiscences on computed tomography (CT)

52 found few associations between a persistent fenestration and deleterious later outcomes.

53 excision of the infective focus (6 cases) or fenestration and expression of infective debris (1 case)

54 Cyst fenestration and liver transplantation, though effective

55 3,5-dichlorobenzamide groups into the II-III fenestration and place their hydrophobic tails in the ca

56 lator of liver homeostasis, controlling LSEC fenestration and protecting against perivascular hepatic

57 The status of the fenestration and the association of a currently patent f

58 findings of aortic dissection (intimal flap, fenestration and thrombosis) was assessed in the 60 pati

59 Fenestration and tubulation of the ER correlates with a

60 their structure, with increases in cisternal fenestration and tubulation.

61 ct the hepatic microenvironment as they have fenestrations and a thin morphology to allow substance e

62 imozide displaces the acyl chains within the fenestrations and binds below the selectivity filter whe

63 ore specialized endothelial cell features of fenestrations and bore size.

64 racoabdominal aneurysms with both reinforced fenestrations and directional branches.

65 neural mechanism that increases endothelial fenestrations and enhances the hypothalamic response to

66 d repair manifested with EC swelling/loss of fenestrations and expression of growth and mitogenic fac

67 Small bony defects like implant fenestrations and intact extraction sites seem not to de

68 t junctions early in development, contiguous fenestrations and mature pericytes occur much later in d

69 nt of hypertrophy, albuminuria, loss of GEnC fenestrations and protected against altered VEGF recepto

70 lipid ratio of 0.2 caused platelets to form fenestrations and pseudopodia which were longer and thin

71 Thus, imaging and quantification of fenestrations and sieve plate thickness require resoluti

72 Contiguous fenestrations and significant PV-1 were not observed unt

73 inds at a novel site at the interface of the fenestrations and the central hydrophobic cavity of the

74 aortic repair were divided into devices with fenestrations and those with formal branches.

75 several nanoscale domains such as caveolae, fenestrations and transendothelial channels, which regul

76 of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of an organized basement mem

77 barrier resistance, induces choriocapillaris fenestration, and supports the formation of Bruch's-memb

78 odynamics of false lumen thrombosis, a large fenestration, and the orbital orientation of the false l

79 blockers indeed access the pore through the fenestrations, and a mutant channel with narrower fenest

80 ion between the true and false limbs, aortic fenestrations, and pump output.

81 rated that consist of tubules, sheets, sheet fenestrations, and sheet stacks with helicoidal connecti

82 the pigmented epithelium, loss of capillary fenestrations, and thrombosis.

83 the inner margins of medial cisternae where fenestrations are abundant.

84 In addition, we provide evidence that these fenestrations are at the origin of current rectification

85 Fenestrations are frequently performed during Fontan pro

86 The fenestrations are grouped in discrete clusters, which ar

87 vessels, while micron-sized endothelial cell fenestrations are necessary for nutrient uptake.

88 Fenestrations are popular sites for various state-depend

89 Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component o

90 alysis revealed a significantly larger total fenestration area in second and first order arterioles v

91 eading us to investigate the membrane-facing fenestrations as alternative pathways for blocker access

92 l and extracardiac Fontan modifications, and fenestration, as well as technological improvements, suc

93 pulmonary venous atrial-level communication (fenestration) at the time of the Fontan procedure on lat

94 e and a hydrophobic access pathway through a fenestration between DIII and DIV.

95 ipid alkyl chains can enter the pore through fenestrations between the pore-lining helices.

96 e false-lumen outflow and/or creating distal fenestrations between the true and false lumina distal t

97 Opening the fenestration-branch loops, meant to simulate the creatio

98 Late closure of the fenestration by use of a transcatheter umbrella device h

99 increased the spatial resolution for imaging fenestrations by single molecule localization microscopy

100 Fenestration can be placed and revised easily without by

101 ', stabilizing channel opening; (3) create a fenestration capable of binding compounds specific for K

102 (WG), using antibodies against PAL-E, PV-1 (fenestrations), carbonic anhydrase IV (CA IV), eNOS, and

103 The most common procedures performed were fenestration closure and pulmonary artery intervention.

104 Fontan fenestration closure does not significantly improve peak

105 6 (median 10) years, underwent pre- and post-fenestration closure exercise testing with expiratory ga

106 Fenestration closure in Fontan patients was followed by

107 Fenestration closure increased O(2) saturation 9.4% on a

108 For these reasons fenestration closure is routinely performed post-operati

109 ate clinical status of Fontan patients after fenestration closure is unknown.

110 ively examine the effects of elective Fontan fenestration closure upon exercise capacity and ventilat

111 Among those with confirmed fenestration closure, 59% were by catheter intervention

112 Before fenestration closure, peak oxygen consumption (VO(2)) wa

113 rial saturation improved significantly after fenestration closure, there was no change in peak VO(2)

114 ways into the pore are observed: via lateral fenestrations connecting to the membrane lipid phase, as

115 octreotide (7 [21%]), sildenafil (6 [19%]), fenestration creation (15 [48%]), and relief of Fontan o

116 iculoperitoneal shunt and optic nerve sheath fenestration/decompression.

117 Fenestration defect height averaged 3.7+/-0.3 and 3.9+/-

118 ough addition of recombinant human TNAP to a fenestration defect model).

119 DBM was implanted into one randomly selected fenestration defect.

120 Contralateral fenestration defects (6 x 4 mm) were created 6 mm apical

121 ir combination on the healing of periodontal fenestration defects (PFDs) in rats.

122 BM/P-15 putty was compared in critical-sized fenestration defects in 16 mongrel dogs.

123 Local delivery of recombinant human TNAP to fenestration defects in 5-wk-old wild type (WT) and Ibsp

124 and resulted in the greater regeneration of fenestration defects in dogs at 8 weeks compared to cont

125 rate (PRP-BMA) on the healing of periodontal fenestration defects in rats.

126 ent to the dehiscence and 23 adjacent to the fenestration defects on bovine bone blocks.

127 s no adjunctive effect to GTR in periodontal fenestration defects over a four-week healing interval.

128 Fifteen days after initiation of CS, fenestration defects were created at the buccal aspect o

129 Seven days after DM induction, bilateral fenestration defects were created at the buccal aspect o

130 Fenestration defects were created at the buccal surface

131 on cementum and AB regeneration, mandibular fenestration defects were created in Ank knockout (Ank K

132 Fenestration defects were created over mandibular molar

133 Periodontal fenestration defects were surgically created in the mand

134 achieve successful GBR results of dehiscence/fenestration defects when placing implants.

135 pment and exacerbation of bony dehiscence or fenestration defects, which can manifest loss of periodo

136 ent when applied at experimental periodontal fenestration defects.

137 A thin bone contributes to risk of bone fenestration, dehiscence, and soft-tissue recession.

138 Loss of GEnC fenestration density was associated with decreased filtr

139 modal microscope provided an estimate of the fenestration diameter of 119 53 nm and average thickness

140 altering design parameters such as shunt and fenestration diameters and locations.

141 SEC porosities and fenestration diameters were measured in control livers,

142 Bimodal maximums in both porosity and fenestration diameters were observed in both zones at 5

143 fusions and multisystem organ failure before fenestration died 7 weeks after surgery secondary to low

144 on, engraftment in liver, and development of fenestration (differentiation).

145 trations, and a mutant channel with narrower fenestrations displayed no closed-state TPeA block at co

146 -tear size, branch-vessel flow distribution, fenestrations, distal reentry communication) and physiol

147 evidence that VEGF dynamically regulates SEC fenestration during liver organogenesis, a process that

148 ose-mediated signaling dysregulation impacts fenestration dynamics in glomerular endothelial cells.

149 Some groups have advocated baffle fenestration for virtually all patients to minimize post

150 ates lateral, phospholipid-lined cytoplasmic fenestrations for water and ion egress.

151 choriocapillaris (CC) and to determine when fenestrations form, the capillaries are invested with pe

152 her suggested a mechanistic role for EHD3 in fenestration formation.

153 The ability of C2-ceramide to cause platelet fenestrations, formation of irregular platelet pseudopod

154 Norfluoxetine binds within intramembrane fenestrations found in only one of these two conformatio

155 Temporal fenestration has long been considered a key character to

156 ple, in contrast to other ECs, LSECs possess fenestrations, have low detectable levels of platelet en

157 ion and sclerosis, open or laparoscopic cyst fenestration, hepatic resection, and liver transplantati

158 delivered into the nuclear envelope through fenestrations, highlighting the remarkable dynamics of t

159 -APB enter the inner cavity through distinct fenestrations, implying structural specificity to their

160 Fenestrations improve tear-mixing efficiency.

161 experience with late creation of a surgical fenestration in 9 patients (5.2 +/- 3.1 years old) exhib

162 ity; however, the role of late creation of a fenestration in aiding patients manifesting morbidity af

163 However due to larger IEL fenestration in first order arterioles, a larger spannin

164 ized trial evaluated the clinical utility of fenestration in patients with standard preoperative risk

165 a significantly better clinical outcome than fenestration in terms of tumor recurrence (p = 0.018).

166 stiffness determines the effects of a large fenestration in the descending thoracic aorta on the lum

167 d lipid-interacting residues in the membrane fenestration in the response to poking.

168 Reduced fenestrations in EHD3 knockdown b.End5 cells in vitro fu

169 However, the cellular mechanisms regulating fenestrations in glomerular endothelial cells remain poo

170 Here we show that fenestrations in LSEC contain PLVAP-diaphragms during th

171 c factor, can acutely and chronically induce fenestrations in microvascular endothelium.

172 idence that chronic VEGF exposure can induce fenestrations in nonfenestrated endothelium similar to t

173 d false limbs was more effective than aortic fenestrations in preventing true-lumen collapse.

174 study demonstrates the critical role of GEnC fenestrations in renal filtration function and suggests

175 Strikingly, within 24 hours, endothelial fenestrations in RIP-Tag2 tumors disappeared, vascular s

176 Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel p

177 Recently, it has been suggested that placing fenestrations in soft lenses increases tear mixing.

178 Individual glycocalyx tufts above fenestrations in the first three of these tissues and al

179 meant to simulate the creation of artificial fenestrations in the intimal flap, did not relieve true-

180 ixing can be achieved by selectively placing fenestrations in the pooling regions before the thinnest

181 Fenestrations in the sides of the pore module are unexpe

182 in vitro models, challenges in imaging small fenestrations in vivo, and inconsistencies between in vi

183 A covered stent was placed through the fenestration into the nondominant branch pulmonary arter

184 Surgical fenestration is associated with well-demonstrated early

185 However, it is controversial whether fenestration is beneficial for standard-risk patients.

186 An interatrial fenestration is designed to maintain cardiac output in t

187 We tested the hypothesis that IEL fenestration is greater in distal vs. proximal arteries

188 The benefit of fenestration is likely to be greatest in the early posto

189 Fenestration is not necessary in most Fontan patients wh

190 ence that a two-stage approach and/or baffle fenestration is required for a large cohort of patients

191 lar hypoplasia, microaneurysms and regressed fenestrations leading to fibrosis in subsets of glomerul

192 ycemia in diabetic mice leads to significant fenestration loss and increased size of fenestrations.

193 Key drivers of fenestration loss and size changes were identified by in

194 The choriocapillaris endothelium displayed fenestration loss.

195 ound a large variation in the performance of fenestrations made with a 25-G hypodermic needle.

196 Although some fenestrations may close spontaneously, many remain paten

197 m plasma membrane to channel through a gated fenestration ("membrane-to-channel inhibition" (MCI)).

198 odontal regeneration in a rodent periodontal fenestration model.

199 in the trabecular bone (n = 26), followed by fenestration (n = 14).

200 One is in the IV-I fenestration near the upper pore.

201 ion helped assess the hemodynamic effects of fenestration occlusion.

202 Fenestration of a Fontan connection has been proposed as

203 onducted to assess the need for, and use of, fenestration of an extracardiac conduit Fontan.

204 Simple fenestration of an off-the-shelf endograft and associate

205 by stimulating proliferation, migration, and fenestration of endocrine organ-derived endothelial cell

206 etes promotes involution of tight junctions, fenestration of endothelial cells, and pericyte regressi

207 roximately 27 mmHg and led to severe loss of fenestration of glomerular capillary endothelial cells i

208 remaining 8 (42.1 %) patients underwent only fenestration of liver cysts.

209 ved target lumen reentry by means of balloon fenestration of the aortic dissection flap.

210 Meshing or scalpel fenestration of the construct was found to stimulate ker

211 Fenestration of the Fontan circuit allows for shunting o

212 Fenestration of the Fontan circulation that results in a

213 In four patients, fenestration of the intimal flap was performed twice.

214 reated with aortic stents, four with balloon fenestration of the intimal flap, and three with both st

215 disassembly of the nuclear pores leads to a fenestration of the nuclear envelope double membrane.

216 the protein surrounded the chromosomes after fenestration of the nuclear envelope in prometaphase.

217 is activity is augmented by KLP61F after the fenestration of the nuclear envelope, a process analogou

218 Models having fenestrations of 2 to 6 mm and atrium pressures of 4 to

219 To test this hypothesis, we unplugged the fenestrations of NALCN by substituting the four aforemen

220 ype of dissection, procedure time, number of fenestrations of the intimal flap per patient, necessity

221 domain, with the wide end inserting into the fenestration on the interface between repeats II and III

222 The effect of fenestrations on improving tear mixing is explained and

223 ults demonstrate the central role of lateral fenestrations on synaptic neurotransmission.

224 urements were used to explore the effects of fenestrations on tear exchange under an SCL.

225 Both optic nerve sheath fenestration (ONSF) and lumboperitoneal shunting (LPS) m

226 fectiveness and safety of optic nerve sheath fenestration (ONSF) in pediatric PTCS cases that are res

227 e ventricle, left single ventricle [RV/LV]), fenestration open (FO) or closed (FC) at end of operatio

228 did not affect the morphology, the number of fenestrations or the overall vascular architecture in th

229 , KT (OR -0.18, p < 0.001), presence of bone fenestration (OR 0.24, p = 0.044), and cBBD (OR 0.43, p

230 tients who underwent hepatic resection, cyst fenestration, or liver transplantation for PLD from 1985

231 opulmonary anastomosis (P<0.001), and Fontan fenestration (P=0.001).

232 The fenestration-penetrating mode immediately affords an exp

233 Baffle fenestration performed at the time of Fontan surgery imp

234 Fontan in our experience, patients who had a fenestration placed had significantly higher preoperativ

235 The tooth root fenestration preclinical model is an ideal tool for hard

236 nsistent support to the hypothesis that the "fenestrations" present in the membrane-embedded region o

237 With the poor results of resective and fenestration procedures for polycystic liver disease (PC

238 Intraislet endothelial cell fenestration, proliferation, and islet angiogenic factor

239 site in the cavity, adjacent to lipid-facing fenestrations proposed to be the portals for drug entry.

240 Surgical fenestration provided complete symptomatic relief and fo

241 The introduction of a partial thickness fenestration radial to the optic disc pit was associated

242 i is composed of two membranes perforated by fenestrations ranging from tens of nanometers to several

243 edicted receptor sites for nifedipine in the fenestration region and for the 4-phenyl-pyran in the po

244 ar filtration function through aberrant GEnC fenestration regulation.

245 onal testing 8 +/- 3 years after Fontan, the fenestration remained open in 19% of subjects.

246 Thus, membrane fenestrations represent a non-canonical pathway for sele

247 Initial creation of a fenestration results in less morbidity and mortality; ho

248 Late surgical creation of fenestration results in resolution of morbidity after Fo

249 In contrast to angioplasty, a fenestration (right-to-left shunt) reduced TCPC pressure

250 The need for fenestration should be assessed after cardiopulmonary by

251 Lewis lung tumors, which lacked endothelial fenestrations, showed less regression.

252 gh nifedipine and Bay K 8644 occupy the same fenestration site at the interface of repeats III and IV

253 endothelial cells, including alterations in fenestration size and number linked to impaired glomerul

254 e in cristae connectivity and an increase in fenestration size.

255 mbosis, and growth did not differ by current fenestration status.

256 strategies to maintain the integrity of the fenestration structure, such as targeting Rho-associated

257 Compared with those without evidence of a fenestration, subjects with a current fenestration were

258 ural changes are shown to regulate access to fenestrations suggested to be pathways for lipophilic dr

259 Apo BK channels display similar fenestrations, suggesting that blockers may use them as

260 After 4-mm fenestration, TCPC baffle pressure dropped by approximat

261 highly potent gating modifiers that bind to fenestrations that become available when KCNE1 accessory

262 ous sinuses: regions of slow blood flow with fenestrations that can potentially permit blood-borne pa

263 cal residue within the intracellular lateral fenestrations that is readily accessible to thiol-reacti

264 tral ion permeation pathway, leaving lateral fenestrations that may be largely buried within the memb

265 er or exit the internal pore through lateral fenestrations that play a critical role in determining t

266 e Na(V)s and Ca(V)s, which have four lateral fenestrations that serve as routes for lipophilic compou

267 The few fenestrations that were observed were often present with

268 -VEGF), induced proliferation, migration and fenestration (the formation of membrane discontinuities)

269 st, Ca(2+) binding leads to occlusion of the fenestrations, thus preventing the lipids from entering

270 Enlargement of the fenestration to 8 mm resulted in a 3 mmHg IVC pressure d

271 closed mitosis suggests a conserved role in fenestration to enable a single microtubule organizing c

272 ngle ventricle physiology, the addition of a fenestration to the procedure mitigates perioperative mo

273 Riluzole binds within these fenestrations to stabilise the inactivated channel state

274 ic patches that may attract cations, through fenestrations, to vestibules near the ion channel.

275 Although closure of Fontan fenestrations typically results in an immediate improvem

276 Structural data suggest that occluded fenestrations underlie the pharmacological resistance of

277 staged procedure versus single stage and for fenestration versus no fenestration.

278 nt who had a residual shunt at 24 hours, the fenestration was completely closed at 1 month after coil

279 The fenestration was created in a commercially available end

280 Fenestration was performed in 361 patients (67%), and fr

281 vitrectomy with creation of an inner retinal fenestration was performed in all eyes.

282 Fenestration was performed selectively in 32 patients (3

283 In seven patients, a fenestration was placed or clipped in the early postoper

284 potentially avoided when immediate surgical fenestration was prompted by a sudden change in the EEG

285 A baseline "failing" Fontan with a 4 mm fenestration was tuned to have an elevated IVC pressure

286 s who underwent catheter closure of a Fontan fenestration were enrolled in either the Clamshell (1989

287 e of a fenestration, subjects with a current fenestration were taking more medications (p = 0.02) and

288 eceptor outer segments, and choriocapillaris fenestrations were decreased.

289 ull thickness flap reflection, 7 mm diameter fenestrations were made with a trephine in the mid-root

290 Thyroid vascular fenestrations were virtually completely blocked by VEGF

291 ets was lower, and the capillaries had fewer fenestrations, whereas the islet blood flow was threefol

292 e a reduction in both the number and size of fenestrations, which is referred to as pseudocapillariza

293 Gianturco coil was delivered to straddle the fenestration with established techniques for coil occlus

294 The utility of fenestration with extracardiac Fontan operation has not

295 on and the association of a currently patent fenestration with health status and measures of ventricu

296 Nevertheless, PLVAP in fetal LSEC (fenestrations with diaphragms) associated with LYVE-1 (l

297 se observations highlight the robust area of fenestration within intramuscular arterioles and indicat

298 Density for acyl chains is present in fenestrations within the transmembrane region that conne

299 ctor receptor 2), whereas in the adult LSEC (fenestrations without diaphragms) these complexes disapp

300 used strategies for early IOP lowering were fenestrations without wicks (70%) and with wicks (22%),