ライフサイエンスコーパス: ferret

1 nd marmoset), a rodent (mouse) and a weasel (ferret).

2 ng process, this being even more frequent in ferret.

3 ayers, which is not observed in the domestic ferret.

4 nimal models, including mouse, pig, rat, and ferret.

5 licate in ferrets and transmit from swine to ferret.

6 sted for their virulence or organ tropism in ferrets.

7 antly higher viral load was observed in aged ferrets.

8 the primary auditory cortex of anaesthetized ferrets.

9 l SFTSV-specific T cell response in mice and ferrets.

10 t transmission from infected pigs to contact ferrets.

11 e markedly upregulated and persisted in aged ferrets.

12 trograde tracer to label CG neurons in adult ferrets.

13 vaccines with wild-type HA VLPs in preimmune ferrets.

14 properties of 20 H10 viruses in vitro and in ferrets.

15 IV-H3N2 was selected for characterization in ferrets.

16 5N1 strains, and improved viral clearance in ferrets.

17 ing a heterologous lethal virus challenge in ferrets.

18 elds in the auditory cortex of freely moving ferrets.

19 lesions were induced in 24 canine teeth of 6 ferrets.

20 nogenic and exhibited protective efficacy in ferrets.

21 y and are transmissible by direct contact in ferrets.

22 transmission of avian viruses in humans and ferrets.

23 Adjuvanticity was then validated in ferrets.

24 by the airborne route and was pathogenic in ferrets.

25 genic ebolaviruses in mice, guinea pigs, and ferrets.

26 olecularly homologous counterpart in mice or ferrets.

27 accine candidates were assessed in preimmune ferrets.

28 was inefficiently transmitted among cohoused ferrets.

29 lication efficiency, and transmissibility in ferrets.

30 cted and influenza virus-infected humans and ferrets.

31 ain the elevated firing rates in experienced ferrets.

32 th an H3.2010.1 H3N2 IAV and aerosol contact ferrets.

33 ed increased replication and transmission in ferrets.

34 mans, macaques and marmosets but not mice or ferrets.

35 he H18N11 viruses caused symptoms in mice or ferrets.

36 V-2 was detected in all naive direct contact ferrets.

37 urse of infection in experimentally infected ferrets.

38 or respiratory droplet transmissible between ferrets.

39 and pathogenicity on H9N2 virus in mice and ferrets.

40 collection during necropsy of virus-infected ferrets.

41 cterized the morphology of CG neurons in the ferret, a visual carnivore with distinct feedforward par

42 In ferrets, a model for human adaptation, a relatively stab

43 rus had limited capacity to transmit between ferrets, a property considered consistent with a higher

44 rue for scheduled necropsy of virus-infected ferrets, a standard component in evaluation of influenza

45 , MEDI8852 blocked influenza transmission in ferrets, a unique finding among influenza-specific mAbs.

46 A direct comparison with ferret A1 shows many similar forms, and the spectral and

47 Ferrets accurately generalized pitch discriminations to

48 n by recording local field potentials in two ferrets after administration of isoflurane in concentrat

49 1 was evaluated in vivo by administration in ferrets after NiV and HeV virus challenge.

50 MBP134(AF) could fully protect ferrets against lethal EBOV, SUDV, and BDBV infection, a

51 Compared to naive ferrets, all vaccinated ferrets showed improved cellular

52 ancestry of the banded mongoose and domestic ferret allows us to generate observations relevant to un

53 mbling the parcellation observed in cats and ferrets, although not all of the auditory areas known fr

54 hemagglutination inhibition (HI) titer with ferret and chicken antisera, respectively.

55 f similarity between serological patterns in ferret and human data.

56 nsmissible via the air preferentially infect ferret and human nasal respiratory epithelium.

57 ctral and temporal modulation tuning of both ferret and model STRFs show similar ranges over the popu

58 n extended tropism for brain tissues in both ferret and mouse models.

59 We have compared ferret and mouse to identify differences between cortice

60 primordium (NP), the NP was the same size in ferret and mouse, which would allow morphogen patterning

61 nd group II (H7N9) pandemic IAVs in mice and ferrets and could be used to block transmission of influ

62 was associated with mild illness in mice and ferrets and did not spread well between ferrets, it none

63 perimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibil

64 and protein contacts indicates that macaque, ferrets and hamster are the most suitable models for the

65 We show that antibodies elicited in ferrets and humans exposed to the egg-adapted 2016-2017

66 the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans.

67 is functionally parallel stream-specific in ferrets and macaques.

68 Y/108), caused mild and transient illness in ferrets and mice but did not transmit to naive cohoused

69 ce in frequency preferences is equivalent in ferrets and mice.

70 Here we show that experimentally infected ferrets and naturally infected humans establish strong "

71 c treatment of both NiV and HeV infection in ferrets and non-human primates with a cross-reactive, ne

72 transmission in the ferret model, given that ferrets and related members of the weasel genus transmit

73 ld-type H18N11 replicates poorly in mice and ferrets and that N11 is a determinant for viral transmis

74 e agricultural fair outbreak to replicate in ferrets and transmit from swine to ferret.

75 are present in carnivores (such as cats and ferrets) and primates but are absent in rodents.

76 ct sprouting endothelial tip cells in mouse, ferret, and human neonatal white matter.

77 s well as the noncanonical epitopes in mice, ferrets, and humans.

78 trated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between

79 te disease was observed in infected mice and ferrets, and the virus was inefficiently transmitted amo

80 H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathoge

81 e constructed and probed for reactivity with ferret antisera against MN/10 and BJ/92 in hemagglutinat

82 Ferret antisera detected no or little cross-reactivity b

83 Ferret antisera detected no or little cross-reactivity b

84 n/26221/2014 (H5N6) virus was developed, and ferret antisera generated against this virus were demons

85 Human vaccine sera and ferret antisera were analyzed by hemagglutination inhibi

86 Human vaccine sera and ferret antisera were analyzed by hemagglutination inhibi

87 Human and ferret antisera were tested in HI assays against 1 repre

88 fluenza A(H3N2) (sH3N2), using postinfection ferret antisera.

89 970s-1990s were observed using postinfection ferret antisera.

90 i/1/2013 virus in the presence of homologous ferret antiserum resulted in immune escape viruses conta

91 ed the viruses in the presence of homologous ferret antiserum.

92 ivisions of posterior parietal cortex of the ferret are strongly interconnected, however area PPc sho

93 Ferrets are a major developmental animal model due to th

94 pitulate fatal clinical symptoms, vaccinated ferrets are completely protected from lethal SFTSV chall

95 we observe that the viruses in the recipient ferrets are of the same genotype as the viruses inoculat

96 pensity of swine IAV to transmit from pig to ferret as a measure of risk to the human population.

97 Our findings establish the ferret as a strong animal model for development of highe

98 t observed in primates, which highlights the ferret as a useful animal model to understand visual sen

99 We mapped DCX+ cells in the brains of ferrets at P20 (analogous to human term gestation), P40,

100 s, their emergence in an ascending series of ferret auditory and frontal cortical fields, and the dyn

101 auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning i

102 Collectively, these findings suggest that ferret B cells expressing an Igkappa or Iglambda BCR pos

103 the visual cortex of freely-moving juvenile ferrets before and after eye-opening.

104 We show that Sox9 is expressed in human and ferret BPs and is required for BP proliferation in embry

105 ribute to a macro connectome database of the ferret brain, providing essential data for connectomics

106 viruses were able to transmit among cohoused ferrets but exhibited a limited capacity to transmit by

107 All viruses replicated in inoculated ferrets, but no airborne transmission was detected, and

108 pH1N1-1 transmitted to aerosol contact ferrets, but pH1N1low-1 did not.

109 tro, all 38T/M viruses disseminated to naive ferrets by contact and airborne transmission, while 38F-

110 MEDI8852 was administered to mice and ferrets by intraperitoneal injection at varying doses, 2

111 s; they also transmitted efficiently between ferrets by respiratory droplets.

112 ions had previously been performed in swine, ferrets, calves, and guinea pigs in order to study IDV p

113 stimuli that are presented to visually naive ferrets can influence the parameters of speed tuning and

114 H10 virus infection of ferrets caused variable weight loss, and all 20 viruses

115 sing streams, and compared the morphology of ferret CG neurons with CG neuronal morphology previously

116 TAT1-binding motif or the Y116E mutation for ferret challenge studies (rNiV(M)-STAT1(blind)).

117 Despite the reduced IFN inhibitory function, ferrets challenged with these rNiV(M)-STAT1(blind) mutan

118 osterior and pulvinar nuclei in the domestic ferret compared to the banded mongoose and other carnivo

119 ctive treatment for lethal H5N1 infection in ferrets compared to oseltamivir and R347, and MEDI8852 p

120 5N6 viruses possessed increased virulence in ferrets compared to the H5N2 virus; however, pathogenici

121 block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control mAb R347 and

122 e, we investigated whether the gyrencephalic ferret cortex possesses human-equivalent postnatal strea

123 In the most immature ferrets, cortical neurons developed selectivity to these

124 Here we show for the first time that ferrets could be used to study development of higher-lev

125 hereas antisera from dk/Hok/69 ca-vaccinated ferrets cross-reacted with clade 2.3.4.4 and 2.2.1 virus

126 HI data was similar to the map created using ferret data.

127 Transmission studies in ferrets demonstrated that the gull-origin IAV could infe

128 ith 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydroge

129 nd that viruses which replicated well in the ferret did not replicate to the same extent in the human

130 han adult ferrets, whereas most newly weaned ferrets did not lose weight but had a lack of weight gai

131 broad range of hosts including humans, pigs, ferrets, dogs, cats, hamsters, and at least 2 genera of

132 cterise the cell-mediated immune response in ferrets during heterosubtypic protection induced by low-

133 corded from primary auditory cortex of awake ferrets during presentation of noise with natural tempor

134 SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus rep

135 In contrast, infected patients and ferrets exhibit large changes in bacterial community com

136 Aged ferrets exhibited greater weight loss and higher rates o

137 Newly weaned ferrets exhibited minimal pneumonia, whereas adult and a

138 broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses.

139 Results from a ferret experiment demonstrated that a gull-origin H10N7

140 es from the primary auditory cortex in awake ferrets exposed passively to stimuli with two correlated

141 mice but did not transmit to naive cohoused ferrets following traditional or aerosol-based inoculati

142 e overall airborne transmission frequency in ferrets for four isolates tested was 42%, and isolate G1

143 COBRA HA proteins were screened in mice and ferrets for the elicitation of antibodies with HA inhibi

144 MEDI8852 was able to protect naive ferrets from airborne transmission of H1N1pdm09.

145 inhibition assay, and effectively protected ferrets from lethal challenge with the highly pathogenic

146 multiple formulations protects both mice and ferrets from lethal H5N1 homologous virus challenge.

147 th the WT and the G218E CVVs fully protected ferrets from parental HPAI virus challenge.

148 Using ferret-generated antiserum, we determined that CIV-H3N2

149 symptoms and mortality, SFTSV-infected aged ferrets (>=4 years of age) demonstrated severe thrombocy

150 nonpermissive small-animal species, namely, ferret, guinea pig, and hamster.

151 To date, mouse, hamster, ferret, guinea pig, and non-human primates have been inv

152 ed minimal pneumonia, whereas adult and aged ferrets had a spectrum of pneumonia severity.

153 Adult and aged ferrets had alveolar infection, but aged ferrets were un

154 aked earliest in adult ferrets, whereas aged ferrets had delayed presentation.

155 Newly weaned ferrets had little alveolar cell infection.

156 These COBRA preimmune ferrets had superior breadth of HAI activity after vacci

157 on, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig DPP4, do not.

158 so acts as a determinant of permissivity for ferret, hamster, and guinea pig DPP4.

159 However, biomedical research in ferrets has been hindered by the lack of rapid and cost-

160 In contrast to our previous study in the ferret IC, task engagement had little effect on sound-ev

161 (Igkappa) and lambda (Iglambda) L chains of ferret Ig.

162 Ferrets immunized twice with a mix of recombinant rabies

163 throughout the respiratory tract of mice and ferrets.IMPORTANCE Bats are reservoirs for several sever

164 alizing mAbs, HENV-26 and HENV-32, protected ferrets in lethal models of infection with NiV Banglades

165 experienced milder disease compared to other ferrets in the group.

166 d the activity of CG neurons in anesthetized ferrets in vivo using a combined viral-infection and opt

167 s in fruit flies, zebrafish larvae, mice and ferrets in vivo.

168 However, in ferrets in which learning was initially disrupted by per

169 A competitive transmission study in ferrets indicated that 195K provides a replicative advan

170 vaccines were attenuated and immunogenic in ferrets, inducing antibodies that neutralized homologous

171 ceived MEDI8852 or R347 prior to exposure to ferrets infected with an H1N1pdm09 virus.

172 Specifically, ferrets infected with the 1986 virus and vaccinated with

173 Importantly, antibodies elicited in ferrets infected with the current circulating H3N2 viral

174 resence of polyclonal antiserum derived from ferrets infected with the same strain of virus (homologo

175 This observation indicates that the ferret is a potentially valuable experimental model anim

176 These findings indicate that ferret is a suitable animal model to study the human-rel

177 and ferrets and did not spread well between ferrets, it nonetheless possessed several markers of vir

178 Whereas young adult ferrets (<=2 years of age) did not show any clinical sym

179 g risk assessment models for H9N2 viruses in ferrets may not always have a strong correlation with th

180 As the smallest gyrencephalic mammal, ferrets may provide an important animal model to study t

181 varied in abundance and RNA expression among ferrets, mice and primates, but varied less among primat

182 on as a function of disease severity using a ferret model and our lectin microarray technology.

183 V P, V, and W in NiV-mediated disease in the ferret model are likely to be in the inhibition of viral

184 The ferret model is a valuable resource for evaluating influ

185 We report a ferret model of SARS-CoV-2 infection and transmission th

186 Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fu

187 Thus, this immunocompetent age-dependent ferret model should be useful for anti-SFTSV therapy and

188 Here, we used the ferret model to address this for an avian influenza H5N1

189 of which were airborne-transmissible in the ferret model without prior adaptation.

190 In a ferret model, control viruses outcompeted those carrying

191 oV-2 infection and block transmission in the ferret model, given that ferrets and related members of

192 uenza virus infection and vaccination in the ferret model.

193 ls, and to cause disease and transmit in the ferret model.

194 broadly reactive H3N3 vaccine in a preimmune ferret model.IMPORTANCE After exposure to influenza viru

195 r universal influenza vaccine in a preimmune ferret model.IMPORTANCE Currently, many groups are testi

196 influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of t

197 on of stem cell therapy, and transgenesis in ferret models of human disease.

198 els, i.e. guinea pig, dog, cat, rat, rabbit, ferret, mouse, hamster and macaque.

199 The domestic ferret (Mustela putorius furo) has proven to be a useful

200 The domestic ferret (Mustela putorius furo) is a commonly used animal

201 banded mongoose (Mungos mungo) and domestic ferret (Mustela putorius furo).

202 banded mongoose (Mungos mungo) and domestic ferret (Mustela putorius furo).

203 model, we developed a differentiated primary ferret nasal epithelial cell (FNEC) culture model for in

204 opment of differentiated primary cultures of ferret nasal epithelial cells is an important step towar

205 Subsequently, the size of ferret neocortex shot past that of the mouse.

206 s required for BP proliferation in embryonic ferret neocortex.

207 hich would allow morphogen patterning of the ferret NP.

208 ar perceptual ability in animals by training ferrets of both sexes to detect a stream of repeating no

209 We trained mice, rats and ferrets on a range of tasks to examine how testing conte

210 n mice, it was not observed in cell culture, ferrets or human challenge participants.

211 ctral localisation cues had little impact on ferrets' performance, or on neural spatial tuning.

212 eurons in primary auditory cortex (A1) while ferrets performed a relative localisation task.

213 ) titers of cell-cultured virus isolates and ferret postinfection sera displayed a directional evolut

214 between the posterior parietal cortex of the ferret (PPc and PPr) and the cat (area 7 and 5), indicat

215 In this study, ferrets, preimmune to historical H3N2 viruses, were vacc

216 The domestic ferret presented with an overall lower myelin density th

217 ction of interferon-gamma-secreting cells in ferrets previously infected with H1N1 virus, but not in

218 of single-unit neural responses recorded in ferret primary auditory cortex.

219 nputs contacting single pyramidal neurons in ferret primary visual cortex (V1) by combining in vivo t

220 Different species, including mice, rats, ferrets, rabbits, pigs, sheep, zebrafish, and fruit flie

221 expelled from the upper respiratory tract of ferrets rather than from trachea or the lower airways.

222 ransmission study, naive respiratory contact ferrets received MEDI8852 or R347 prior to exposure to f

223 Ferret reference antisera were raised using clinical spe

224 Thus, ferrets represent an infection and transmission animal m

225 Ferrets represent an invaluable animal model to study in

226 nasal turbinates of one or several infected ferrets, respectively.

227 /OH/2017 displayed robust replication in the ferret respiratory tract, causing slight fever and moder

228 anscriptome analysis of SFTSV-infected young ferrets revealed strong interferon-mediated anti-viral s

229 In ferrets, rP11 antigen and RNA were detected at low level

230 e vaccine was changed because human, but not ferret, sera distinguish A(H1N1)pdm09 viruses isolated a

231 tial stages of infection.IMPORTANCE Although ferrets serve as an important model of influenza virus i

232 ities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and f

233 Compared to naive ferrets, all vaccinated ferrets showed improved cellular immunity in the lungs a

234 neurons in the auditory cortex of the awake ferret, showing adaptive efficient neural coding of two

235 ormation in the banded mongoose and domestic ferret, species belonging to the two carnivoran superfam

236 juvenile-like behavior in the adult domestic ferret, such as a muted fear response.

237 y infected with H1N1 virus, but not in naive ferrets, suggests induction of memory T-cells.

238 oth signaling centers were identified in the ferret telencephalon, as were expression gradients of th

239 ing and tract tracing methods to examine the ferret temporal region: the lateral rostral suprasylvian

240 imates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exc

241 ala transition zone observed in the domestic ferret that is absent in the banded mongoose.

242 viral escape mutations is not present among ferrets that have been infected just once with a defined

243 enza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of he

244 the vaccine efficacy is investigated in aged-ferrets that recapitulate fatal clinical symptoms, vacci

245 rk, we studied Purkinje cells in decerebrate ferrets that were conditioned using electrical stimulati

246 virus-like particle vaccines were tested in ferrets that were previously exposed to historical H3N2

247 of the perireticular nucleus in the domestic ferret, that was not observed in the banded mongoose.

248 d wild species, such as otters, dolphins and ferrets, that form calcium oxalate, struvite, uric acid,

249 e the range of influenza viruses assessed in ferrets, the measures of experimental disease severity i

250 that the virus could be transmitted between ferrets through direct contact and aerosol droplets.

251 rigin H10N7 virus can be transmitted between ferrets through the direct contact and aerosol routes, w

252 gether with previous reports in macaques and ferrets) thus provide no scientific basis for the use of

253 in vivo properties and antibody response in ferrets to 20 diverse H10 viruses.

254 s infection in newly weaned, adult, and aged ferrets to better understand age-dependent susceptibilit

255 cortex is required for the normal ability of ferrets to detect a mistuned harmonic within a complex s

256 We tested the ability of adult female ferrets to detect the presence of a mistuned harmonic in

257 To evaluate the prospect of using ferrets to study Zika virus infection, we injected seven

258 n-seq) library of a pneumococcal strain in a ferret transmission model.

259 Uninfected human patients and ferret URT microbiomes have stable healthy ecostate comm

260 ng spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticog

261 pital visual areas 17, 18, 19, and 21 in the ferret using standard anatomical tract-tracing methods.

262 the temporal visual areas 20a and 20b in the ferret using standard anatomical tract-tracing methods.

263 parietal rostral cortical area (PPr), in the ferret using standard anatomical tract-tracing methods.

264 ar transformations in motion signals between ferret V1 and higher-level visual area PSS, located in t

265 h COBRA HA VLP vaccines than COBRA preimmune ferrets vaccinated with VLP vaccines expressing wild-typ

266 All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-

267 ible via the air are used to co-infect donor ferrets via the intranasal and intratracheal routes to c

268 on to demonstrate that inhibitory neurons in ferret visual cortex respond robustly and selectively to

269 tuning of layer 2/3 inhibitory inputs in the ferret visual cortex using a combination of in vivo axon

270 In this study of ferret visual cortex using in vivo calcium imaging, we f

271 development of direction selectivity in the ferret visual cortex, which occurs rapidly over a few da

272 A subset of ferrets was infected with influenza viruses expressing t

273 Limited transmission between co-housed ferrets was observed with the H5N6 viruses but not with

274 inant H9 viruses previously evaluated in the ferret, we found that viruses which replicated well in t

275 ing electrophysiological recordings in young ferrets, we show that auditory cortex neurons respond to

276 lencing of ArchT-expressing neurons in adult ferrets, we show that within-trial activity in primary a

277 When vaccinated ferrets were challenged with homologous and heterologous

278 culpt the emergent responses, visually naive ferrets were exposed to several hours of experience with

279 For example, recent experiments where ferrets were exposed to two influenza strains within a s

280 Although the ferrets were not protected against the infection by H3N2

281 Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne

282 Ferrets were then challenged with the wild-type virus an

283 Ferrets were trained on two auditory Go-NoGo categorizat

284 ged ferrets had alveolar infection, but aged ferrets were unable to clear infection.

285 s-induced pneumonia peaked earliest in adult ferrets, whereas aged ferrets had delayed presentation.

286 oss and higher rates of mortality than adult ferrets, whereas most newly weaned ferrets did not lose

287 tion inhibition (HI) titres from 5 groups of ferrets which were exposed to different combinations of

288 was equally effective for H7N9 infection in ferrets while the combination yielded similar protection

289 A vaccinated ferret with no detectable HAI-antibodies but high flu-sp

290 trast, secondary infection of H1N1 preimmune ferrets with an antigenically distinct H1N1 virus elicit

291 Immunization of ferrets with beta-propiolactone-inactivated recombinant

292 y, our group demonstrated that priming naive ferrets with broadly reactive H1 COBRA HA-based vaccines

293 Overall, priming naive ferrets with COBRA HA based viruses or using COBRA HA ba

294 sequentially infected mice, guinea pigs and ferrets with divergent H1N1 or H3N2 subtypes of influenz

295 Moreover, sequential infection of ferrets with H1N1 influenza viruses elicited an Igkappa-

296 l-in-water adjuvants, we generated groups of ferrets with undetectable (geometric mean titer [GMT] <

297 fluenza A infection of immunologically naive ferrets with various H1N1 or H3N2 strains, the acute Ab

298 Furthermore, sequential infection of ferrets with viral vectors expressing chimeric HA, aimed

299 Vaccinating ferrets with virus-like particle (VLP) vaccines expressi

300 sertion at the ROSA26 "safe harbor" locus in ferret zygotes and created transgenic animals expressing