ライフサイエンスコーパス: fetal tissue

1 o compensate for the limited availability of fetal tissue.

2 own's syndrome and control post-mortem human fetal tissue.

3 uman neoplasms because they are derived from fetal tissue.

4 logy, were not found within the transplanted fetal tissue.

5 at myelin disorders is limited at present to fetal tissue.

6 ocortex in paraformaldehyde-fixed postmortem fetal tissue.

7 induced pluripotent stem cells (hiPSC) or by fetal tissue.

8 are temporarily inherited and distributed in fetal tissue.

9 t the placental barrier but do not enter the fetal tissue.

10 ygenation in specific areas of placental and fetal tissue.

11 centa into the fetal circulation and entered fetal tissue.

12 gs on chimeric maternal cells that reside in fetal tissue.

13 fection in lymphocytes, placenta, and bovine fetal tissue.

14 in response to increased invasiveness of ape fetal tissue.

15 variants of at least 500 kb in placental or fetal tissue.

16 ne expression and chromatin accessibility in fetal tissues.

17 r mechanisms of the immune response to human fetal tissues.

18 and has a tendency for higher expression in fetal tissues.

19 region that is differentially methylated in fetal tissues.

20 blood leukocytes, placenta, lung, aorta, and fetal tissues.

21 f mRNA transcripts in a variety of adult and fetal tissues.

22 tantial reactions were also found in certain fetal tissues.

23 observed in lung, pancreas and spleen and in fetal tissues.

24 ripts by northern-blot analysis of adult and fetal tissues.

25 han those seen in first and second trimester fetal tissues.

26 ceeded those observed in the placenta and in fetal tissues.

27 LCK isoform(s) in both human adult and human fetal tissues.

28 ransition from monocyte to macrophage within fetal tissues.

29 w splice variants of Bright were observed in fetal tissues.

30 is ubiquitously expressed in both adult and fetal tissues.

31 subunit, was investigated in human adult and fetal tissues.

32 and dentate gyrus in the adult brain and to fetal tissues.

33 xpression and is greatly enhanced in various fetal tissues.

34 ze all-trans-retinol and steroid alcohols in fetal tissues.

35 F. tularensis was detected in placental and fetal tissues.

36 nd mTORC2 signaling in multiple maternal and fetal tissues.

37 anoids, which was validated in primary human fetal tissues.

38 uman samples of placenta, umbilical cord and fetal tissues.

39 two bulk omics across 125 healthy adult and fetal tissues.

40 es so disproportionately in reproductive and fetal tissues.

41 els of viral RNA in maternal, placental, and fetal tissues.

42 nd increased cell death were not observed in fetal tissues.

43 ity and increases infection of placental and fetal tissues.

44 s identified in a variety of gestational and fetal tissues.

45 erived metabolites accumulated in late-stage fetal tissues.

46 and endothelial cells across human adult and fetal tissues.

47 ntion of a maternal immune attack on foreign fetal tissues.

48 ent of these cells in second trimester human fetal tissues.

49 r ACD cells, contribute to the allantois and fetal tissues.

50 the control of metabolism and maturation of fetal tissues.

51 t for BH(4) compared with maternal and other fetal tissues.

52 dinated interactions between endometrial and fetal tissues.

53 es the loss of Rb in both extraembryonic and fetal tissues.

54 romatin accessibility and gene expression in fetal tissues.

55 d more rapid uptake and clearance than other fetal tissues.

56 d on embryonic stem cells derived from human fetal tissues.

57 delicate balance of active hormone levels in fetal tissues?

58 the fetoplacental interface and in numerous fetal tissues, 2) ex vivo, the placenta released high am

59 is, VHL mRNA was reverse transcribed from 13 fetal tissues (8-10 weeks gestation).

60 It is widely expressed in fetal tissues, abundantly expressed in adult thymus, bon

61 7me3) was lower in the Zfp423 promoter of OB fetal tissue, accompanied by reduced binding of enhancer

62 was found predominant in a variety of human fetal tissue, adult tissues, and several carcinomas.

63 r 1, 2017, which offers the option to donate fetal tissue after pregnancy termination.

64 y contribute to oxidative damage observed in fetal tissues after in utero ethanol exposure.

65 A number of exploratory studies using human fetal tissue allografts have suggested that transplantat

66 f-1L have similar distributions in adult and fetal tissues, although apaf-1L transcripts are more abu

67 gnant women may result in acute infection of fetal tissue and brain tissue, causing microcephaly and

68 e perform ex vivo functional assays of human fetal tissue and find that human fetal gastrointestinal

69 sented here have been benchmarked with human fetal tissue and found to be representative of human fet

70 ion of grafted dopamine neurons derived from fetal tissue and human stem cells.

71 ry cilium in developing podocytes from human fetal tissue and in undifferentiated cultured podocytes.

72 in adult skeletal muscle but very low in the fetal tissue and in undifferentiated skeletal muscle cel

73 sment, using normal/cancer data from healthy fetal tissue and pediatric high-grade glioma patients, i

74 human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cell

75 Abundantly expressed in fetal tissues and adult muscle, the developmentally regu

76 Amounts of gadolinium chelate in the fetal tissues and amniotic fluid were minimal compared w

77 ntigen-presenting cells can be identified in fetal tissues and are related to adult populations of an

78 and KCNQ1OT1, with monoallelic expression in fetal tissues and biallelic expression in adult samples.

79 Immunohistochemistry studies of human fetal tissues and bioinformatics analysis of a microarra

80 ked enhancers previously identified in human fetal tissues and brain organoids.

81 is expressed in proliferating cells such as fetal tissues and cancers.

82 d widespread beta-gal expression in multiple fetal tissues and cell types.

83 Pediatric cancers often mimic fetal tissues and express proteins normally silenced pos

84 P-C in reproductive, placental, and selected fetal tissues and fetal fluid, PrP-Sc was detected only

85 Sc) in reproductive, placental, and selected fetal tissues and fetal fluids in sheep.

86 was present in reproductive, placental, and fetal tissues and fetal fluids.

87 ion is based upon histopathologic changes in fetal tissues and identification of tissue parasites by

88 methylation of 56 CpG sites was observed in fetal tissues and in adult blood DNA.

89 ase isozyme M2 (hPKM2) is expressed in early fetal tissues and is progressively replaced by the other

90 can penetrate the placental barrier to enter fetal tissues and is safe for use in pregnant mice.

91 ne that is highly expressed in embryonic and fetal tissues and markedly decreases after birth.

92 dditionally, using cerebral organoids, human fetal tissues and mice, we show that LGALS3BP regulates

93 endogenous CEA promoter; CEA is expressed in fetal tissues and normal gastrointestinal tissues, and C

94 ion of PCOLCE RNA in various human adult and fetal tissues and of Pcolce RNA at various stages of mou

95 Informative fetal tissues and PGL tumors demonstrate maternal alleli

96 tic domains, are expressed in neoplastic and fetal tissues and potentially have a role in embryonic d

97 The even distribution of PDE7A mRNA among fetal tissues and the relative abundance of its two mRNA

98 that appears to be primarily associated with fetal tissues and tumors.

99 decidual T cells proliferated in response to fetal tissue, and depletion of T regulatory cells led to

100 L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. m

101 Gadolinium chelate levels in the placenta, fetal tissues, and amniotic fluid were obtained by using

102 ived neural progenitors and brain organoids, fetal tissues, and animal models.

103 gans, endothelial lining of the vasculature, fetal tissues, and carcinomas.

104 n thymus, bone marrow, fetal liver and other fetal tissues, and in all proliferating cell lines teste

105 Nox3 is expressed primarily in fetal tissues, and Nox4 is expressed in not only fetal t

106 tors, diminished ZIKV burden in maternal and fetal tissues, and protected against fetal demise.

107 eptor are widely expressed in both adult and fetal tissues, and recent gene-targeting and disruption

108 as early as a few weeks post-conception, in fetal tissues, and the mechanisms underlying the phenome

109 progenitor B (pro-B), pre-B, and B cells in fetal tissues, and thus supports the idea of a multifoca

110 transcripts were detected in human adult and fetal tissues, and very high transcript levels were foun

111 Despite profound placental abnormalities, fetal tissues appeared remarkably normal, suggesting tha

112 Although embryonic and fetal tissue are frequently envisaged as providing suffi

113 Epitheliasin transcripts in fetal tissues are observed only in kidney and lung.

114 ariable, in part owing to the limitations of fetal tissue as a cell source, relating to its availabil

115 Nox5 is expressed in a variety of fetal tissues as well as in adult spleen and uterus.

116 Expression of human TBX1 in adult and fetal tissues, as determined by Northern blot analysis,

117 for the first time its distribution in human fetal tissues, as well as its expression in adult kidney

118 alyzed the Epigenomics Roadmap data for nine fetal tissues, assigning a measure of pleiotropic degree

119 sion of prolactin receptors (PRLRs) in human fetal tissues at 7.5-14 wk of gestation and in tissues o

120 nscription was detected in a wide variety of fetal tissues at both 8 and 14 weeks.

121 , we detected the presence of Tbet(+)Treg in fetal tissues at elevated levels compared to adult tissu

122 However, they are already present in fetal tissues before the onset of bone marrow hematopoie

123 c expression patterns; they are expressed in fetal tissues, breast, and prostate, and in many cancers

124 n mRNA-binding protein that is abundant in a fetal tissue but either absent from or scarce in adult t

125 l tissues, and Nox4 is expressed in not only fetal tissues, but also kidney, placenta and glioblastom

126 ts are expressed in brain and lung tumor and fetal tissues, but are generally absent from normal adul

127 It is widely expressed, including in fetal tissues, but is most highly expressed in lymphoid

128 B-1 cells are originated from fetal tissues, but, as opposed to B-2 cells, the molecul

129 ocytosed nonspecifically and then carried to fetal tissues by a pH gradient from acidic endosomes to

130 By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibro

131 Although pathogens that infect fetal tissues can induce birth defects through the local

132 Current models rely heavily on fetal tissues, can be prohibitively expensive, and are o

133 obial pathogens in the placental, blood, and fetal tissues collected.

134 l and legislative constraints restrict fresh fetal tissue collection in several countries.

135 Blood, highly perfused, and fetal tissues contained the highest levels of HPCs.

136 d CCR5 on T cells and their progenitors from fetal tissue, cord blood, SCID-hu Thy/Liv mice, and adul

137 Fetal tissue cortisone: cortisol tended to be reduced (P

138 s and trophoblastic necrosis, in addition to fetal tissue damage.

139 a pathological description of placental and fetal tissue damage.

140 roducts were observed in matching normal and fetal tissues; deleted cDNA sequence revealed canonical

141 nt mice and ICP-MS analyses of placental and fetal tissue demonstrated undetectably low transplacenta

142 However, the outcomes of fetal tissue-derived cell transplants in individuals wit

143 s higher than that previously observed using fetal-tissue-derived OPCs, and no tumors from these graf

144 story of parasite development and associated fetal tissue destruction.

145 s is developmentally lethal, indicating that fetal tissue development is tightly controlled by miRNAs

146 Although fetal tissue did not appear to rescue a significant numb

147 ero experiences, particularly in placenta, a fetal tissue discarded at birth.

148 Rates of fetal tissue donation before and after DFB introduction

149 Fetal tissue donations increased from 1.2% (8 donations

150 Fetal tissue Doppler and spectral Doppler imaging are po

151 ation of the exposure of human embryonic and fetal tissue during pregnancy to metformin and its impli

152 spite intimate juxtaposition of maternal and fetal tissues during mammalian pregnancy, reciprocal mig

153 ance of maternal tolerance to semiallogeneic fetal tissues during pregnancy, has emerged as a potenti

154 of mothers to tolerate genetically different fetal tissues during pregnancy.

155 entified thousands of MILs in multiple human fetal tissues, enlisting them as a novel category of cel

156 HsPMP20 mRNA expression was low in human fetal tissues, especially in the brain.

157 rnal clinical factors, placental evaluation, fetal tissue evaluation (from minimally invasive tissue

158 family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues.

159 ed several different Tnk1 transcripts in all fetal tissues examined.

160 In human, the gene is imprinted in most fetal tissues except the heart, and KVLQT1 is part of a

161 Fetal tissues exhibiting the highest viral tropism were

162 Although other fetal tissues express 52beta, there may be differences i

163 rthermore, using a transgenic model in which fetal tissues express the red fluorescent protein tdToma

164 ve memory immune cells have been detected in fetal tissue extremely early in gestation, where they ma

165 including novel assessments of placental and fetal tissues, facilitate more precise determination of

166 bacteriological assessments of placental and fetal tissues, facilitate more precise determination of

167 ts of three alpha-1 chains, is only found in fetal tissues, fibrosis, and cancer in humans.

168 The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collage

169 tion of individuals may be willing to donate fetal tissue for biomedical research after pregnancy ter

170 fluid (CSF) for microRNA (miRNA) studies and fetal tissue for histologic analysis.

171 However, the use of human fetal tissue for research and transplantation is controv

172 RNA-seq samples and limited availability of fetal tissue for research.

173 ed because it might be more practicable than fetal tissue for the purpose of transplantation to prima

174 neural stem cells (NSCs) as alternatives to fetal tissues for cell replacement.

175 potentially aid in the development of human fetal tissues for use in regenerative medicine.

176 Explants of fetal tissue from malaria-positive placentas also secret

177 hich implies tolerance mechanisms protecting fetal tissues from maternal immune attack.

178 of PCR in detecting N. caninum infection in fetal tissues from spontaneous bovine abortion.

179 udy, time-dependent (3 h-11 days) changes in fetal tissue gene expression in a rat model of in utero

180 ously been observed in PD patients receiving fetal tissue grafts but has not been possible to demonst

181 within the female reproductive tract and in fetal tissues harvested from CWD experimentally and natu

182 isease and the difficulty in obtaining human fetal tissue has generated interest in finding correspon

183 s, the ability of ZIKV to replicate in other fetal tissues has not been extensively characterized.

184 cultures of NPCs derived from human iPSCs or fetal tissue have similar characteristics, although they

185 Previous studies using human fetal tissue have suggested increased angiogenesis and p

186 Previously, VZV and HCMV models used fetal tissue; here, we developed an adult human skin mod

187 e in a neonatal spinal environment or within fetal tissue implants, especially because previous work

188 o the DC projection, in all groups receiving fetal tissue implants.

189 d the technical outlook for the use of human fetal tissue in clinical transplantation.

190 e highly expressed by murine gestational and fetal tissues in late pregnancy.

191 th transcriptional profiling of maternal and fetal tissues in mouse pregnancy.

192 rectly measure transcripts from a variety of fetal tissues in the maternal blood sample.

193 ross gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma a

194 the virus to specifically target developing fetal tissues in utero.

195 , and message was detected in most adult and fetal tissues including the epidermis.

196 cript of PKDL is expressed at high levels in fetal tissues, including kidney and liver, and down-regu

197 del, we found that viral transmission to the fetal tissues, including the brain, occurred at later de

198 n of survivin in several apoptosis-regulated fetal tissues, including the stem cell layer of stratifi

199 ndings were obtained in 12- to 18-week human fetal tissue, indicating a highly restricted pattern of

200 The SCID-hu mouse implanted with human fetal tissue is a novel model for investigating human vi

201 Fetal tissue is considered to be immune privileged and i

202 Human fetal tissue is essential for biomedical research, provi

203 Deriving NPCs from human fetal tissue is feasible, although problematic issues in

204 ic expression in female hybrid placental and fetal tissues is negatively correlated with the other X-

205 replicating microbial populations in healthy fetal tissues is not compatible with fundamental concept

206 NMHC II-A and II-B, the mRNA level in human fetal tissues is substantially lower than in adult tissu

207 be ubiquitously expressed in human adult and fetal tissues, is highly related to the DRPLA gene, in w

208 As the assay involves the use of fetal tissues, it is possible to follow new blood vessel

209 ough expressed in the reproductive tract and fetal tissues, its role in the pathogenesis of spontaneo

210 the most primitive hematopoietic cells from fetal tissues lack the expression of CD38.

211 Due to the limited access to fetal tissues, little is understood of human reproductiv

212 med expression in both human adult and human fetal tissues (lung, liver, brain, and kidney) and in hu

213 aternal unresponsiveness to HLA-G-expressing fetal tissues may be shaped in the thymus by a previousl

214 presents a comprehensive overview of in vivo fetal tissue metabolism and alterations due to maternal

215 While fetal tissue models provide helpful insights, it is nece

216 cell polarity (PCP) pathway is required for fetal tissue morphogenesis as well as for maintenance of

217 Analysis of human and fetal tissue mRNAs confirmed that mElf-1 is expressed in

218 In fetal tissue (n = 10), ductal plate cells, primitive bil

219 Fetal tissues, normal adult tissues, and breast carcinom

220 We report the presence in fetal tissues of 2 distinct CD19(+) B-progenitors, an ad

221 mprinting tumors was also observed in normal fetal tissues of 6 12 weeks gestation, suggesting a simi

222 al RNA copies increased in the placental and fetal tissues of DENV-immune dams but not in DENV-naive

223 infections are propagated within gestational fetal tissues of white-tailed deer populations.

224 n = 2; mid third trimester), with harvest of fetal tissues on GD 80, 100, 130, or 145.

225 olated from the placenta, amniotic fluid, or fetal tissues only from rats infected prior to breeding

226 S cell lines and restrictions on using human fetal tissue or embryos needed to generate additional li

227 n embryos (human embryonic stem cells), from fetal tissue or from adult sources (bone marrow, fat, sk

228 t occur, this has not been evident in normal fetal tissues or WTs.

229 n embryos (human embryonic stem cells), from fetal tissue, or from adult sources (bone marrow, fat, s

230 certain extrahepatic tissues (in addition to fetal tissues), our data raise the possibility that CYP3

231 on analysis revealed two active promoters in fetal tissues, P2 and P3, whereas P3 was the only promot

232 human CSF-1 concentrations were measured in fetal tissue, placenta, and fetal/maternal sera.

233 ive CSF-1 crossed the placenta and peaked in fetal tissue, placenta, and serum 10 minutes after injec

234 tal transfer of blood-derived molecules into fetal tissues, potentially activating proinflammatory pa

235 e enriched in regions of active chromatin in fetal tissues, potentially linking fetal development wit

236 Gene array techniques applied to fetal tissues present additional confounding pitfalls.

237 In fetal tissues, PTPRO expression was observed in the brai

238 ve tract and target Neu5Gc-positive sperm or fetal tissues, reducing reproductive compatibility.

239 quantitative distribution of VHL mRNA within fetal tissues reflected that seen by in situ hybridizati

240 iptional regulatory genes that might mediate fetal tissue regeneration, we surveyed homeobox gene exp

241 HOXB13 expression was decreased in wounded fetal tissue relative to unwounded fetal controls or wou

242 Use of the HDBR and other fetal tissue resources discussed here will contribute to

243 iT1 expression on a panel of mouse adult and fetal tissues revealed a concomitant increase of PiT1 an

244 Northern blotting of adult and fetal tissues revealed low and restricted expression of

245 In a small dataset of human adult and fetal tissues, RP protein levels showed development stag

246 hern hybridization analysis revealed that in fetal tissue RTVP-1 RNA was detected only in the kidney,

247 amples, 188 chorionic villus samples, and 37 fetal tissue samples were tested; the amplification fail

248 titutively in extrahepatic organs, including fetal tissue samples, and is highly inducible in various

249 eir expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells onl

250 Although present in human fetal tissues, shortly after birth telomerase activity i

251 Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in

252 Analysis of human fetal tissue showed that dysferlin was expressed at the

253 mRNA broadly distributed in normal adult and fetal tissues, structurally distinct from the 1.9-kb Sur

254 uitous expression pattern in human adult and fetal tissues suggest a critical role for TMCO1.

255 both IGF2 and H19 was observed in all other fetal tissues, suggesting a tissue-specific LOI in the c

256 on in carcinomas as well as normal adult and fetal tissues suggests an important functional role for

257 All other fetal tissues tested showed equal expression from both a

258 on of the sedlin gene in all human adult and fetal tissues tested, with the highest levels in kidney,

259 MAGE-F1, which is expressed in all adult and fetal tissues tested.

260 ot or only at very low levels in most of the fetal tissues tested.

261 4.0- and 3.0-kb transcripts in all adult and fetal tissues tested.

262 tected an approximately 6-kb mRNA in several fetal tissues tested.

263 ies of mRNA were seen in all human adult and fetal tissues tested.

264 ng LCM of epithelial cells from fresh frozen fetal tissue that enables quantitative analyses of micro

265 t-versus-host disease and the need for human fetal tissues that limit other models.

266 ressed ubiquitously in the limited number of fetal tissues that were tested, but is selectively expre

267 In fetal tissue the AR-Ser(P)-213 antigen was present in ep

268 cells are known to primarily originate from fetal tissues, the mechanisms by which they arise has be

269 t epithelial (RPE) cells isolated from human fetal tissue, three separate studies failed with various

270 rols the development and function of several fetal tissues through nutrient sensing, modulation of tr

271 its transcription persists in placental and fetal tissues, throughout embryogenesis.

272 els in the general population, children, and fetal tissue to establish background levels and the risk

273 programs remarkably similar to those of the fetal tissue to organize into cerebral cortex-like regio

274 es conducted directly in human embryonic and fetal tissue to provide an overview of what is known abo

275 he greater sensitivity of rapidly developing fetal tissues to ionizing radiation.

276 rovide evidence for the ability of different fetal tissues to support the development of gammadelta T

277 -label and double-blinded clinical trials of fetal tissue transplantation for PD(1).

278 Because of limitations associated with fetal tissue transplants, a clone (1RB3AN27) of simian v

279 genes that are unmethylated in 11 different fetal tissue types, we show that increases in DNA methyl

280 lly-infected, farmed white-tailed deer (WTD) fetal tissues using the Protein Misfolding Cyclic Amplif

281 0 days of gestation, maternal, placental and fetal tissue was frozen to determine MitoQ uptake.

282 Fetal tissue was harvested at embryonic day 14.5 (E14.5)

283 FIV sequestration in fetal tissues was common without detectable virus in blo

284 Moreover, Akt activity in various fetal tissues was unchanged compared with that observed

285 The engrafted fetal tissues were also stained positive for alpha-actin

286 In one cohort, the placenta and fetal tissues were collected at the end of gestation.

287 after the initial inoculation, and maternal/fetal tissues were collected.

288 e maternal plasma samples and homogenates of fetal tissues were determined by high-performance liquid

289 Placenta, amniotic fluid, and fetal tissues were ZIKV RNA negative in the FP isolate-i

290 opism towards reproductive and embryonic and fetal tissues where exposure to a single alpha particle

291 wed monoallelic expression in both adult and fetal tissue, whereas PHLDA2, SLC22A18, and SLC22A18AS w

292 erfamily are expressed in tumors, testis and fetal tissues, which has been described as a cancer/test

293 els of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against plac

294 have now extended these studies by replacing fetal tissue with neonatal pig thymic and hematopoietic

295 ed in a variety of human and mouse adult and fetal tissues with substantial expression levels in the

296 ely abundant 8kb transcript in all adult and fetal tissues with the exception of adult thymus.

297 hemistry and molecular techniques in several fetal tissues, with a variant analysis of the SARS-CoV-2

298 hest expression levels of FBN3 were found in fetal tissues, with only low levels in postnatal tissues

299 nces in transcript abundance among adult and fetal tissues, with predominant expression in liver, kid

300 aemia can affect the development of multiple fetal tissues, with short-term and long-term consequence