ライフサイエンスコーパス: fiber cell

1 bilization of the myelin sheath and the lens fiber cell.

2 mily of proteins that are also unique to the fiber cell.

3 ructure that has been found only in the lens fiber cell.

4 nt for induction of Spry1 and -2 in the lens fiber cells.

5 , packing, and membrane organization of lens fiber cells.

6 e organization of highly elongated hexagonal fiber cells.

7 sposal of unfolded/misfolded proteins in the fiber cells.

8 espectively, in both the lens epithelium and fiber cells.

9 etely at the tricellular junctions in mature fiber cells.

10 ting morphology that characterized wild-type fiber cells.

11 dnNCOA6 in postmitotic transgenic mouse lens fiber cells.

12 zed along the lateral and basal membranes of fiber cells.

13 emichannels in the nonjunctional membrane of fiber cells.

14 l permeable dyes should be measurable in the fiber cells.

15 fluorogenic calpain substrates into cortical fiber cells.

16 induced cell death in a group of transgenic fiber cells.

17 alpain 1, 2, 3, and 7 were expressed in lens fiber cells.

18 uclear Golgi streaks in differentiating lens fiber cells.

19 post-organelle degradation maturation stage fiber cells.

20 cell genesis, particularly that of secondary fiber cells.

21 or lens mass and differentiated into primary fiber cells.

22 cell division and thus a decreased number of fiber cells.

23 in terminally differentiating secondary lens fiber cells.

24 taracts associated with disrupted inner lens fiber cells.

25 -localize at the plasma membrane in maturing fiber cells.

26 iate the formation of thin junctions between fiber cells.

27 hment of the unique cytoarchitecture of lens fiber cells.

28 fferent lens IF into the biology of the lens fiber cells.

29 icantly reduced secondary wall thickening in fiber cells.

30 increase in apoptosis of lens epithelial and fiber cells.

31 s system and by both E2f3a and E2f3b in lens fiber cells.

32 ed proteins characteristic of differentiated fiber cells.

33 ially as epithelial cells differentiate into fiber cells.

34 srupt the denucleation process of inner lens fiber cells.

35 oreductase was inhibited in the central lens fiber cells.

36 eposition of crystallin proteins in the lens fiber cells.

37 f the acid nuclease activity in the cortical fiber cells.

38 egions: anterior epithelial, equatorial, and fiber cells.

39 ng into myofibroblasts or maturing into lens fiber cells.

40 eased connexins were observed in mutant lens fiber cells.

41 assembly pattern of ferritin chains in lens fiber cells.

42 veolin-1 and clathrin in lens epithelial and fiber cells.

43 increased intercellular spaces between lens fiber cells.

44 ity and solubility of the crystallins in the fiber cells.

45 ent of ethylene in the development of cotton fiber cells.

46 pulsion of the lens nucleus and degenerating fiber cells.

47 ing differentiation of epithelial cells into fiber cells.

48 uniformly shaped and precisely aligned lens fiber cells.

49 dditionally greatly reduced carbon flux into fiber cells.

50 flux into vascular bundles versus that into fiber cells.

51 ibit several features characteristic of lens fiber cells.

52 lso a component of adhaerens plaques in lens fiber cells.

53 The H-chain identified in cataractous fiber cells (29 kDa) differed from the 21-kDa standard c

54 hese hexagonally shaped differentiating lens fiber cells, a region devoid of actin; while beta-cateni

55 ong longitudinal actin cables, the short Li1 fiber cells accumulated disoriented transverse cables.

56 is a water-permeable channel, has a role in fiber cell adhesion, and is essential for fiber cell str

57 around embryonic day 16.5, primarily in the fiber cells adjacent to the organelle free zone.

58 bundance changes, which correlated with lens fiber cell age.

59 ns that undergo proteolytic degradation with fiber cell age; however, the specific sites of modificat

60 The abnormal Snf2h(-/-) fiber cells also retain their nuclei.

61 oteome and phosphoproteome of the human lens fiber cell and provide a valuable reference for future r

62 structural specialization in the mouse lens fiber cell and to delineate its emergence relative to le

63 led irregular secondary cell wall margins in fiber cells and a lower xylan degree of polymerization.

64 long lateral borders of differentiating lens fiber cells and blocked their elongation.

65 ed oxygen led to the production of more lens fiber cells and larger lenses.

66 f the long-range stacking that characterizes fiber cells and that has been considered essential for c

67 fiber cells, swelling and disorganization of fiber cells, and defective fiber cell migration and elon

68 Differentiation of fiber cells, and thus proper vision, is dependent on cro

69 Lens fiber cell architecture was examined by scanning electro

70 Moreover, the walls of fiber cells are composed of thousands of fibers (or macr

71 The lenticular fiber cells are comprised of extremely long-lived protei

72 Cotton fiber cells are developmentally synchronous, highly elon

73 thelial cells to differentiated primary lens fiber cells are poorly characterized.

74 t, and early differentiation of primary lens fiber cells are regulated by counterbalancing BMP and FG

75 Regular interlocking membrane protrusions on fiber cells are replaced by irregularly spaced and missh

76 m1 was present in epithelial and superficial fiber cells as a heavily glycosylated protein with an ap

77 ctivation of the SCW biosynthetic pathway in fiber cells, as revealed by transcriptome and promoter a

78 also resulted in an increased proportion of fiber cells, as was found in Rbpj and Jag1 conditional m

79 We compared RNA and DNA from cotton fiber cells at five developmental time points from early

80 etected in the lens epithelium and secondary fiber cells at postnatal day 1.

81 nd elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium.

82 nd equatorial samples were uncontaminated by fiber cells because they showed high expression of alpha

83 and are diminished in newly differentiating fiber cells, become widely distributed in the apical, la

84 n results in nuclear cataracts in which lens fiber cells begin to show variable degrees of degenerati

85 ers and a near total loss of F-actin in lens fiber cells but not epithelial cells.

86 erritin chains were not identified in canine fiber cells, but a small amount of fully assembled ferri

87 signaling regulates differentiation of lens fiber cells by maintaining a proliferating precursor poo

88 extracellular spaces between outer cortical fiber cells, (c) attenuated denucleation during confocal

89 However, in contrast to wild-type lens fiber cells, Cadm1-null fiber cells had an irregular, hi

90 of terminally differentiated, amitotic lens fiber cells capped on the anterior surface by a layer of

91 ed membrane-cytoskeleton structures of inner fiber cells, causing increased calcium influxes.

92 Expression of CBP in primary lens fiber cells coincides with alphaA-crystallin.

93 as E11.5, and aberrant DNA synthesis in the fiber cell compartment by E14.5.

94 nged though incomplete apoptosis in the lens fiber cell compartment that preserved nuclei in its cell

95 titioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation

96 generate elastic fibers and increase elastic fiber-cell connections in vivo.

97 Lens epithelial cells and early lens fiber cells contain the typical complement of intracellu

98 as AtLAC4, AtPRX64, and AtPRX71 localized to fiber cell corners.

99 found uniquely localized to the younger lens fiber cell cortex region.

100 ysiological levels causes lens opacities and fiber cell defects, confirming the pathogenicity of this

101 on in cell wall lignification of extraxylary fiber cells demonstrates that extraxylary fibers undergo

102 Failure of lens fiber cell denucleation (LFCD) is associated with congen

103 gest novel insights into the process of lens fiber cell denucleation and apoptosis.

104 In the absence of Epha2, fiber cells deviated from their normal course and termin

105 r example protein redistribution during lens fiber cell differentiation and aging.

106 ion of the hsf4 gene exhibit defects in lens fiber cell differentiation and early cataract formation.

107 lls constrict to form an anchor point before fiber cell differentiation and elongation at the equator

108 f the transgenes had adverse effects on lens fiber cell differentiation and eventually induced cell d

109 o processes essential for lens transparency--fiber cell differentiation and gap junction-mediated int

110 tch signaling controls the timing of primary fiber cell differentiation and is essential for secondar

111 r Notch signaling in progenitor cell growth, fiber cell differentiation and maintenance of the transi

112 ies have shown that Brg1 regulates both lens fiber cell differentiation and organized degradation of

113 rate a cell-autonomous role of Ncoa6 in lens fiber cell differentiation and suggest novel insights in

114 say system to identify pathways critical for fiber cell differentiation and to test therapies for the

115 o spatially and temporally distinct waves of fiber cell differentiation are crucial steps for normal

116 fect, linking MTOR signaling to induction of fiber cell differentiation by TGFbeta.

117 the vertebrate lens, FGF signaling regulates fiber cell differentiation characterized by high express

118 owed reduced growth; a wide spectrum of lens fiber cell differentiation defects, including reduced ex

119 thelial cell survival but is dispensable for fiber cell differentiation during lens development.

120 However, only Fgfr stimulation leads to lens fiber cell differentiation in the developing mammalian e

121 Lens fiber cell differentiation is marked by the onset of bet

122 aling is further required after the onset of fiber cell differentiation is not clear.

123 Defects identified in fiber cell differentiation may explain the formation of

124 rganelles, suggesting that this component of fiber cell differentiation may not require ongoing trans

125 ial lens development and the early phases of fiber cell differentiation proceed in a manner largely i

126 riate activation of some aspects of the lens fiber cell differentiation program.

127 le of Notch2 and Jagged1 (Jag1) in secondary fiber cell differentiation using rat lens epithelial exp

128 Primary fiber cell differentiation was apparent at approximately

129 Fiber cell differentiation was disrupted in the PDGF-A a

130 epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear

131 ens indicated that Cadm1 was degraded during fiber cell differentiation, at approximately the same ti

132 te that spectrin is cleaved in vivo, late in fiber cell differentiation, at or about the time that le

133 n of several proteins characteristic of lens fiber cell differentiation, including Prox1, p57(KIP2),

134 ructural specialization that emerges late in fiber cell differentiation, largely after the cell has l

135 ctions of the cellular actin cytoskeleton in fiber cell differentiation, the interaction of AQP0 and

136 ptosis, cell cycle withdrawal, and secondary fiber cell differentiation.

137 d Nf2 from the lens to determine its role in fiber cell differentiation.

138 ion of Ncoa6 also resulted in disrupted lens fiber cell differentiation.

139 direct role for Notch signaling in secondary fiber cell differentiation.

140 (E-cad), a cadherin switch characteristic of fiber cell differentiation.

141 an essential component of FGF-dependent lens fiber cell differentiation.

142 e lens epithelium and cell cycle exit during fiber cell differentiation.

143 ition and cell migration but did not prevent fiber cell differentiation.

144 fferentiation and is essential for secondary fiber cell differentiation.

145 s emergence relative to lens development and fiber cell differentiation.

146 removal of organelle components during lens fiber cell differentiation.

147 proliferation and survival, as well as lens fiber cell differentiation.

148 sis are adapted for removal of nuclei during fiber cell differentiation.

149 s placode invagination to E12.5 lens primary fiber cell differentiation.

150 on analysis was undertaken in epithelial and fiber cells dissected from clear human donor lenses.

151 n ocular lens, there is no lipid turnover in fiber cells during the entire human lifespan.

152 y, eventual loss of the anterior epithelium, fiber cell dysgenesis, denucleation defects, and catarac

153 Fiber cells elongate, undergo organelle elimination, and

154 plays an important role in balancing cotton fiber cell elongation and wall synthesis.

155 These included lack of fiber cell elongation, abnormal proliferation in prospec

156 re/Rac1 cKO lenses displayed delayed primary fiber cell elongation, lenses from both Rac1 cKO strains

157 tion with actin cytoskeletal assembly during fiber cell elongation.

158 Those lens fiber cells entered an alternate proapoptotic pathway, a

159 riched in basolateral membranes, whereas, in fiber cells, expression was restricted to the lateral me

160 ial cell elongation and differentiation into fiber cells, followed by the symmetric and compact organ

161 ripts increased 200-fold in abundance during fiber cell formation, and DNase IIbeta activity accounte

162 We find that fiber cells from spatially and developmentally discrete

163 ithelium and promoted the withdrawal of lens fiber cells from the cell cycle.

164 DS-PAGE analysis the composition of cortical fiber cells from wild-type and Lim2-null lenses appeared

165 rom mice and rats showed that the density of fiber cell gap junction channels was approximately the s

166 ](i) in HeLa cells transfected with the lens fiber cell gap junction protein sheep Cx44 also results

167 g, we show that Jagged1 is required for lens fiber cell genesis, particularly that of secondary fiber

168 st to wild-type lens fiber cells, Cadm1-null fiber cells had an irregular, highly undulating morpholo

169 Wild-type fiber cells had hexagonal cross-sectional profiles with

170 rphologic differentiation into epithelium or fiber cells had occurred at approximately 28 hpf.

171 At higher magnification, the walls of fiber cells have an interesting morphology-a distinctly

172 network, which functions to maintain regular fiber cell hexagonal morphology and packing geometry.

173 than normal lenses, revealing disruptions in fiber cell hexagonal packing, membrane skeleton and memb

174 tial fiber cell morphogenesis is normal, but fiber cell hexagonal shapes and packing geometry are not

175 Canine and human lens fiber cell homogenate proteins were separated by one-dim

176 P49 were enriched by urea extraction of lens fiber cell homogenates after the water-soluble fraction

177 Lens fiber cell homogenates were analyzed by SDS-PAGE, and fe

178 ated from myoclonic epilepsy with ragged-red fiber cells if provided with sufficient ATP (2 mM).

179 many important genes, which may have led to fiber cell improvement in (AD)(1).

180 NA binding protein that is expressed in lens fiber cells in distinct TDRD7-RGs that interact with STA

181 thelial cells and persist in differentiating fiber cells in Epha2(-/-) lenses.

182 ere detected primarily in the outer cortical fiber cells in lenses up to 29 years of age.

183 Lens fiber cells in mice lacking ephrin-A5 function appear ro

184 tributed in both the epithelium and cortical fiber cells in mouse lens.

185 rom the nascent to terminally differentiated fiber cells in the developing mouse lens.

186 ates with a transition zone in maturing lens fiber cells in which cytoskeleton is reorganized.

187 The human lens fiber cell insoluble membrane fraction contains importan

188 Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain t

189 Extensive elongation of lens fiber cells is a central feature of lens morphogenesis.

190 In freshly dissociated fiber cells isolated from knockout Cx50 (KOCx50) mouse l

191 ue to Cx46 hemichannels, the authors studied fiber cells isolated from the lenses of double knockout

192 elated polymorphism of human and canine lens fiber cell L-chains and human H-chains.

193 analysis revealed that cortical Lim2(Gt/Gt) fiber cells lacked the undulating morphology that charac

194 Fiber cells lacking Nf2 did not fully exit the cell cycl

195 r interactions of the crystallin proteins in fiber cells lacking organelles.

196 degradation and degeneration of inner mature fiber cells led to the dense nuclear cataract.

197 ate and Pi uptake predominantly occurred via fiber cells located above leaf veins, with pathways to t

198 Many fiber cells lost their elongated morphology.

199 Human lens epithelial cell lysates and lens fiber cell lysates also catalyzed ubiquitination but onl

200 d was most likely contained initially within fiber cell lysosomes before release into the cytoplasm.

201 st-mitotic cells lack CDK1 and cyclins, lens fiber cells maintain these proteins.

202 About 500 single fiber cells, manually isolated from a 2-day-old transgen

203 FoxE3 and E-cadherin, despite expressing the fiber cell marker Prox1.

204 es disorganized and begins to upregulate the fiber cell markers beta- and gamma-crystallins, the tran

205 c three-dimensional architecture of the lens fiber cell mass.

206 f the membrane cytoskeleton that occurs with fiber cell maturation.

207 However, as lens fiber cells mature they must destroy their organelles, i

208 s and packing geometry are not maintained as fiber cells mature.

209 Fiber cell membrane conductance was a factor of 2.7 time

210 e of this study was to characterize the lens fiber cell membrane proteome and phosphoproteome from hu

211 entified Cadm1 as a major constituent of the fiber cell membrane proteome.

212 Cadm1 is an abundant component of the lens fiber cell membrane.

213 d gammaTM regulation of F-actin stability on fiber cell membranes is critical for the long-range conn

214 udy the proteome and phosphoproteome of lens fiber cell membranes, respectively.

215 econd most abundant integral protein of lens fiber cell membranes.

216 srupted distribution of beta2-spectrin along fiber cell membranes.

217 ilitating the transport of water across lens fiber cell membranes.

218 es a potential role for this protein in lens fiber cell migration and adhesion.

219 isorganization of fiber cells, and defective fiber cell migration and elongation.

220 ture formation and capsule integrity, and in fiber cell migration, adhesion and survival, via regulat

221 hways in processes underlying morphogenesis, fiber cell migration, elongation and survival in the dev

222 erized by abnormal shape, impaired secondary fiber cell migration, sutural defects and thinning of th

223 tastatic UMUC-3 cells decreases actin stress fibers, cell migration, and metastasis, while Cav-1 over

224 n of an actin cytoskeleton that governs lens fiber cell morphogenesis in vivo.

225 In mouse lenses lacking Tmod1, initial fiber cell morphogenesis is normal, but fiber cell hexag

226 electron microscopy (SEM) revealed abnormal fiber cell morphology in Tdrd7-/- lenses.

227 d ERM proteins may play an important role in fiber cell morphology, elongation, and organization.

228 almia, reduced pupillary openings, disrupted fiber cell morphology, eventual loss of the anterior epi

229 Lens fiber cell N-cadherin/beta-catenin/Rap1/Nectin-based cel

230 It is well established that vertebrate lens fiber cells normally express a modified intermediate fil

231 Lens fiber cells normally undergo nuclear degradation for tra

232 abundant membrane protein in mammalian lens fiber cells, not only serves as the primary water channe

233 s, lens fiber cell differentiation, and lens fiber cell nuclear degradation.

234 Sustained fiber cell nuclei and nuclear remnants scatter light, wh

235 essed at sites where differentiation of lens fiber cells occurs.

236 Lens fiber cells of alphaA-R49C homozygous mice displayed an

237 Ferritin H- and L-chains in canine and human fiber cells of healthy lenses were extensively modified.

238 e the density of open Na(+)-leak channels in fiber cells of larger lenses.

239 The structures are not found in fiber cells of lenses younger than two weeks of age, nor

240 from the 12-kDa modified H-chain present in fiber cells of noncataractous lenses.

241 Here, we used fiber cells of the vertebrate eye lens as a model system

242 BiP expression was upregulated in the fiber cells of transgenic mouse lenses expressing platel

243 r and transcript abundance in the elongating fiber cells of Upland cotton (Gossypium hirsutum L.).

244 to undergo differentiation into either lens fiber cells or myofibroblasts.

245 icroscopic examination, (d) disrupted normal fiber cell organization and structure during scanning el

246 The human eye lens is composed of fiber cells packed with crystallins up to 450 mg/ml.

247 Therefore, lens fiber cells, particularly from older lenses, may have li

248 t germ agglutinin (WGA) staining of Tdrd7-/- fiber cells, particularly those exhibiting nuclear degra

249 maintenance in post-nuclear degradation lens fiber cells, perturbation of which causes early-onset ca

250 ber cells undergo loss of the differentiated fiber cell phenotype and loss of the long-range stacking

251 red for the generation of the differentiated fiber cell phenotype but is required to maintain that di

252 ost abundant integral protein (Lim2) of lens fiber cell plasma membranes.

253 fully, with only a handful of differentiated fiber cells present at birth.

254 , abnormal proliferation in prospective lens fiber cells, reduced expression of the cell cycle inhibi

255 ithelial cells to highly organized hexagonal fiber cells remains unknown.

256 Why the lens fiber cell requires two unique IF proteins and why and h

257 Nuclear degradation in lens fiber cells requires the nuclease DNase IIbeta (DLAD) bu

258 ive disorganization and swelling of cortical fiber cells resembling the phenotype reported for altere

259 lens can induce ER or overall cell stress in fiber cells, resulting in the activation of UPR signalin

260 n filaments to the plasma membrane of muscle fiber cells (sarcolemma).

261 r tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell interactions.

262 raction through which AQP0 may maintain lens fiber cell shape and organization.

263 a change that presumably adapts the IF to a fiber cell-specific function.

264 Phakosin and filensin are lens fiber cell-specific intermediate filament (IF) proteins.

265 dated alphaA-crystallin caused disruption of fiber cell structural integrity, protein aggregation, in

266 ens and is essential for establishing proper fiber cell structure and organization.

267 in fiber cell adhesion, and is essential for fiber cell structure and organization.

268 th cytoplasmic Hspb1 mRNA in differentiating fiber cells, suggesting that TDRD7-ribonucleoprotein com

269 erity, comprising large vacuoles in cortical fiber cells, swelling and disorganization of fiber cells

270 Nf2 is required for complete fiber cell terminal differentiation, maintenance of cell

271 paced, complex, lateral projections from the fiber cell that align themselves with similar structures

272 Fiber cells that arise later than 2 weeks of age undergo

273 ally characterize a small subpopulation of C-fiber cells that express high levels of TRPV1 (HE TRPV1

274 es younger than two weeks of age, nor in the fiber cells that initially differentiate before that tim

275 antly, the molecular variability of cortical fiber cells, the hallmark of the WT lens, is absent in t

276 rystallin is concentrated in the oldest lens fiber cells, the lens nucleus, whereas gammaS-crystallin

277 l of GSH diffusion from outer cells to inner fiber cells through gap junctions.

278 ally, the opacities remain confined to a few fiber cells, thus presenting an opportunity to investiga

279 ibute to the organizational structure of the fiber cell tissue and microcirculation within it, as req

280 lular voltages varied from -45 mV in central fiber cells to -60 mV in surface cells.

281 ssure varied from 335 +/- 6 mm Hg in central fiber cells to 0 mm Hg in surface cells.

282 goes from approximately 340 mmHg in central fiber cells to 0 mmHg in surface cells.

283 concentrations varied from 17 mM in central fiber cells to 7 mM in surface cells, and intracellular

284 cate that glutathione diffuses from cortical fiber cells to the nucleus via gap junction channels for

285 In spite of the failure of all Acvr1(CKO) fiber cells to withdraw from the cell cycle, they expres

286 In the absence of external calcium, fiber cells took up both dyes.

287 t, we compared the mouse lens epithelial and fiber cell transcriptomes with hESC- and iPSC-derived le

288 on, thereby establishing temporal control of fiber cell transition to the SCW stage.

289 In the lens fiber cell, two members of the IF family have evolved to

290 Subsequent to those stages, however, fiber cells undergo loss of the differentiated fiber cel

291 These results support a model in which lens fiber cells use integrin alpha5 to migrate along a Fn-co

292 f elastic moduli of lignocellulosic (bamboo) fiber cell walls with moisture content (MC).

293 The water-insoluble fraction of lens fiber cells was chemically cross-linked, and cross-linke

294 lulose deposition during secondary growth in fiber cells, was examined by live-cell imaging in cells

295 the PDGF-A and DN-Spry2 lenses, whereas the fiber cells were degenerating in the DN-FGFR lens.

296 roteins that were abundant in wild-type core fiber cells were diminished in the cores of Lim2(Gt/Gt)

297 Differentiating fiber cells were isolated from mouse lenses using collag

298 PRV immunoreactive fibers/cells were not altered by neonatal MSG treatment

299 sed from 3 to 8-DPA in the developing cotton fiber cells while transcript levels remained low.

300 , where they alternate with regularly spaced fiber cells whose branches contact all other cell types,

301 by the symmetric and compact organization of fiber cells within an enclosed extracellular matrix-enri