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1 d emerging microscopy techniques to quantify fibrillar collagen.
2 0/G1 arrest of human melanoma cells grown on fibrillar collagen.
3 isrupt cell proliferation in the presence of fibrillar collagen.
4 n attenuates platelet adhesion to soluble or fibrillar collagen.
5 tor was responsible for cell cycle arrest on fibrillar collagen.
6 ary evidence for the expression of a B-clade fibrillar collagen.
7 ith extracellular matrix proteins, including fibrillar collagen.
8 collagens, as well as impaired migration on fibrillar collagen.
9 been shown to be activated mainly by soluble fibrillar collagen.
10 h type IV collagen and gelatin prepared from fibrillar collagen.
11 cellular layers and a diminished content of fibrillar collagen.
12 mesenchymal tissues, the ligand of which is fibrillar collagen.
13 which appears restricted in the presence of fibrillar collagen.
14 independent platelet adhesion to immobilized fibrillar collagen.
15 t zones, enriched either in proteoglycans or fibrillar collagen.
16 anism for tension-dependent stabilization of fibrillar collagen.
17 lation may regulate cross-link maturation in fibrillar collagen.
18 r thermal stability is comparable to that of fibrillar collagen.
19 fibrosis and changes in the organization of fibrillar collagen.
20 mary epithelial cells on stiff matrices like fibrillar collagen.
21 ed to the protostome/deuterostome A clade of fibrillar collagens.
22 the -Gly-X-Y- repeating pattern found in non-fibrillar collagens.
23 t are uniquely able to cleave triple helical fibrillar collagens.
24 tients harboring mutations in genes encoding fibrillar collagens.
25 ase collagen receptors that are activated by fibrillar collagens.
26 der resulting from altered metabolism of the fibrillar collagens.
27 may be common aggregation motifs for the non-fibrillar collagens.
28 uration of extracellular matrices containing fibrillar collagens.
29 educed deposition of both elastic fibers and fibrillar collagens.
30 s different than that caused by mutations in fibrillar collagens.
31 ential for the processing of procollagens to fibrillar collagens.
32 lization of TIMP-2 with type IV collagen and fibrillar collagens.
33 s and marked depletion of elastic fibers and fibrillar collagens.
34 expression of EMT/myofibroblast markers and fibrillar collagens.
35 ed to the formation and further expansion of fibrillar collagens.
36 he cross-striated banding pattern typical of fibrillar collagens.
37 d fibroblasts and pathological deposition of fibrillar collagens.
38 capable of initiating degradation of native fibrillar collagens.
40 cells (6/14 [43%] vs 0/14 [0%]; P = .05) and fibrillar collagen (13/14 [93%] vs 2/14 [14%]; P < .0001
41 collagen, indicative of a limbal annulus of fibrillar collagen 2.2 mm in diameter, was identified in
42 diac fibrosis, and morphological evidence of fibrillar collagen accumulation at the infarcted and non
44 m Aggregatibacter actinomycetemcomitans is a fibrillar collagen adhesin belonging to the family of tr
45 oviding a physical barrier against invasion, fibrillar collagen also restricts cell proliferation.
48 accompanied by proteolytic modifications of fibrillar collagen and an influx of host proteins, the r
49 combinant human CTRP-1 specifically bound to fibrillar collagen and blocked collagen-induced platelet
51 ome a principal method for studying decidual fibrillar collagen and characterizing mouse models assoc
53 aft model and highlight the critical role of fibrillar collagen and DDRs in supporting the growth of
55 efficient induction of invadopodia on dense fibrillar collagen and for local degradation of collagen
56 primary mouse megakaryocytes in response to fibrillar collagen and in response to cross-linking of t
57 th PyMT(mgko) tumors is stiffer and has more fibrillar collagen and increased expression of the colla
58 dysfunction and immune evasion by remodeling fibrillar collagen and inhibiting T cell autophagic flux
59 cantly different, and the average content of fibrillar collagen and macrophages in the lesions was si
60 tilage and bone cells to cleave high-density fibrillar collagen and modulate their resident matrix to
62 t1 expression also leads to dysregulation of fibrillar collagen and periostin expression, as well as
64 atrix proteins have been reported to bind to fibrillar collagen and regulate the diameter of collagen
65 tially, this fibroblast response reorganized fibrillar collagen and stiffened the myocardium, albeit
66 antive reduction in cardiac fibroblasts, but fibrillar collagen and the ECM proteome were not overtly
67 al in vivo degradation of the self-assembled fibrillar collagen and the majority of implants experien
68 iple sites on the triple helical portions of fibrillar collagens and also capable of competing for su
69 d Glu40 as essential residues for binding to fibrillar collagens and collagen-related peptides (CRPs)
70 wn to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine resid
71 he catalysis of lysyl-derived cross-links in fibrillar collagens and elastin in the extracellular mat
72 s unique structural features of invertebrate fibrillar collagens and is expressed predominantly in bo
73 Cardiac extracellular matrix (ECM) contains fibrillar collagens and proteoglycans, important for mai
74 secreted by lung fibroblasts was retained on fibrillar collagen, and ACLP-deficient lung fibroblasts
75 iological stimulus for MT1-MMP expression is fibrillar collagen, and it has been shown that it up-reg
76 igitation of rete ridges, abundant organized fibrillar collagen, and plentiful arrays of elastic fibe
77 e growth regulatory signals originating from fibrillar collagen, and the proteolytic degradation of f
78 chemicals (e.g., triolein, elastin, keratin, fibrillar collagen, and type IV collagen) associated wit
79 occurrence of related motifs in other human fibrillar collagens, and located a conserved array of no
80 include MMP-1, which preferentially degrades fibrillar collagens, and MMP-3, which can initiate a loc
81 found in the triple-helix domains of all non-fibrillar collagens, and perturbations to the triple-hel
83 ephrotic syndrome and glomerular deposits of fibrillar collagen are associated with multiple exostose
86 ges reveal that the C-terminal prodomains of fibrillar collagens are partially uncleaved in PDAC ECM,
90 crosirius red-positive streaks," enriched in fibrillar collagens, are a hallmark of adipose tissue su
91 ages in cell culture, suggesting proteolyzed fibrillar collagen as a candidate ECM mediator of macrop
92 atrix (ECM) is a complex mixture composed of fibrillar collagens as well as additional protein and ca
93 ontaneous Ca(2+) oscillations in MSCs during fibrillar collagen assembly, and hypothesized that the t
94 hough sulfate and divalent phosphate bind to fibrillar collagen at physiological concentrations, our
98 s is critically dependent on the cleavage of fibrillar collagen by a previously unidentified intersti
102 xtracellular matrix components, particularly fibrillar collagens, by PRDM5 is a key molecular mechani
105 one position in the triple-helical domain of fibrillar collagen chains, and its biological significan
106 ions (PTMs) than do similar domains of other fibrillar collagen chains, PTMs consisting of hydroxylat
108 damts14, and of the genes encoding the major fibrillar collagens, Col1a1, Col2a1 and Col3a1, during m
109 to vertebrates, possess an ancestral clade A fibrillar collagen (ColA) gene that is expressed in the
110 hesis by SoxE and SoxD regulation of clade A fibrillar collagen (ColA) genes--suggesting that the cho
111 ing Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregatio
112 ined more collagen with greater alignment of fibrillar collagen compared with wild-type fibroblast-de
113 Cre tumors was enriched with stromal-derived fibrillar collagen, compared with wild-type or Hras-driv
114 Type V collagen is a quantitatively minor fibrillar collagen comprised of different chain composit
116 activity accompanied by an increase in total fibrillar collagen content and an increase in myocardial
117 changes in total MMP activity and myocardial fibrillar collagen content were related to a time- depen
118 addition, in SPARC-null mice, TAC increased fibrillar collagen content, albeit significantly less th
119 oad causes myocardial hypertrophy, increased fibrillar collagen content, and abnormal diastolic funct
120 expression, myocardial diastolic stiffness, fibrillar collagen content, and soluble and insoluble co
125 t while DDR1b clusters co-localized with non-fibrillar collagen, DDR1b/DDR2 filamentous structures as
128 s important in cell cycle arrest mediated by fibrillar collagen, demonstrate the complexity of cell c
130 ugh BMP1, as a secreted proteinase, promotes fibrillar collagen deposition from both cancer cells and
134 ding high matrix metalloproteinase activity, fibrillar collagen deposition, and release of bioactive
135 , organ atrophy was accompanied by increased fibrillar collagen deposition, suggesting a compensatory
139 tigated the role of CRT in the regulation of fibrillar collagen expression, secretion, processing, an
140 A-3D mouse immortal keratinocytes growing on fibrillar collagen failed to activate FiRE and subsequen
145 each antibody inhibited platelet adhesion to fibrillar collagen from 70 to 85%, especially during the
147 port the characterization of a further three fibrillar collagen genes (Hcol2, Hcol3, and Hcol5) and t
148 mice revealed a significant upregulation of fibrillar collagen genes at mRNA level, as well as incre
149 Phylogenetic analyses reveal that the hydra fibrillar collagen genes form a distinct clade that appe
153 p27(KIP1) in cells plated in the presence of fibrillar collagen has led to the assumption that this k
156 ge tumors that are characterized by abundant fibrillar collagen, high cyclooxygenase-2 (COX-2) expres
157 -/-) MEFs) have reduced transcript levels of fibrillar collagen I and III and less soluble collagen a
158 wn of collagen IV in the basal lamina and of fibrillar collagen I in the adjacent interstitium in the
163 roblasts are deficient in their packaging of fibrillar collagen-I and express less decorin, important
164 ure in the pathogenesis of liver fibrosis is fibrillar Collagen-I deposition; yet, mediators that cou
165 Mapping integrin-binding sites within the fibrillar collagens identified GFOGER as a high affinity
166 proteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal memb
169 The mesothelial niche was enriched with fibrillar collagen in human and murine omental metastase
173 show that it is possible to optically image fibrillar collagen in tumors growing in mice using secon
174 d-order nonlinear polarization properties of fibrillar collagen in various rat tissues (vertebrae, ti
175 increasing awareness of the critical role of fibrillar collagens in breast cancer biology, tumor-perm
176 d that OSCAR binds to specific motifs within fibrillar collagens in the ECM that become revealed on n
177 issue to resist stress is mainly imparted by fibrillar collagens in the extracellular matrix, changes
178 ation of extracellular matrix (ECM), namely, fibrillar collagens in the hepatic stellate cells (HSCs)
179 llagen fiber architecture in tissues rich in fibrillar collagen, including bone, tendon, and skin.
182 n the presence of Mg2+, platelet adhesion to fibrillar collagen induced activation of the GP IIb-IIIa
184 e I collagen and a delayed onset to low dose fibrillar collagen-induced aggregation, results consiste
185 e was an increase in intimal and medial mean fibrillar collagen intensity from 22 11 a.u. pre-LVAD to
187 mong other requirements, cross-links between fibrillar collagens, introduced by tissue transglutamina
192 o experiments.Measurements and Main Results: Fibrillar collagen is not only increased but also highly
193 y Tnap ectopic expression in cells producing fibrillar collagen is sufficient to induce pathological
195 sumed that the growth regulatory activity of fibrillar collagen is the result of an indirect restrict
201 al cultures from cKO mice expressed elevated fibrillar collagen levels, providing further evidence th
202 pattern recognition collectins that contain fibrillar collagen-like regions and globular carbohydrat
203 amily of innate immune proteins that contain fibrillar collagen-like regions and globular carbohydrat
204 le blood over a 250-mum long patch of type I fibrillar collagen/lipidated tissue factor (TF; approxim
205 s in mouse (termed SMKO) resulted in altered fibrillar collagen localization with larger, poorly orga
207 sence of a gap of transparency in scattering fibrillar collagen matrices within a narrow range of con
209 g fibroblasts generate deformation fields in fibrillar collagen matrix that provide far-reaching phys
210 asement membrane components and disorganized fibrillar collagen matrix, independently of classical in
211 oinformatic analysis provides insight on how fibrillar collagens might have arisen from the duplicati
213 gth of the heart is provided by a continuous fibrillar collagen network embracing individual myocytes
214 III, can be categorized into five subgroups: fibrillar collagens, network-forming collagens, fibril-a
215 the hypothesis that the microarchitecture of fibrillar collagen networks mechanically regulates myofi
220 e evidence for a direct inhibitory effect of fibrillar collagen on proliferation of human melanoma an
221 rombin, but not saturating concentrations of fibrillar collagen or adenosine 5'-diphosphate, uniquely
222 -Danlos syndrome gene that does not encode a fibrillar collagen or collagen-modifying enzyme, we sugg
223 ts failed to aggregate in response to type I fibrillar collagen or convulxin, a snake venom protein a
224 hese sites, together with an accumulation of fibrillar collagen, or fibrosis, as evidenced by a signi
228 l components of extracellular matrices (ECM) fibrillar collagens play a critical role, and single ami
230 differences are shown in ability to process fibrillar collagen precursors and to cleave Chordin, the
232 er SLP-76(+/-) or SLP-76(-/-) platelets, but fibrillar collagen produced a 1.9-fold increase in proco
233 ceptor tyrosine kinase in that its ligand is fibrillar collagen rather than a growth factor-like pept
235 rom mice bearing these mutations showed less fibrillar collagen, reduced axial stiffness, and lower r
236 Type XI collagen is a quantitatively minor fibrillar collagen related to type V collagen and associ
237 -1(-/-) LDLR(-/-) plaques were enriched with fibrillar collagens relative to LDLR(-/-), which also co
239 eterotypic fibrils composed of two different fibrillar collagens represents a general mechanism regul
241 OM) and texture analysis algorithms to image fibrillar collagen (second harmonic generation) and elas
242 le helices (FACITs) must differ from that of fibrillar collagens, since they lack the characteristic
243 opy of the pellet cultures revealed abundant fibrillar collagen, some of which was aligned in paralle
246 cks, powder, and HA/TCP powder-type I bovine fibrillar collagen strips, and bone was maintained for a
247 /TCP powder, the HA/TCP powder-type I bovine fibrillar collagen strips, and HA/TCP powder held togeth
250 normally in the triple helix domains of non-fibrillar collagens, such as type IV collagen in basemen
251 es P3H1 specifically to tissues that express fibrillar collagens, suggesting that other P3H family me
252 negative microvessels embedded in bundles of fibrillar collagen surrounded by F4/80-positive MC/Mph.
253 that the 5' stem-loop specifically regulates fibrillar collagen synthesis and represents a novel targ
255 exhibited higher stiffness and expression of fibrillar collagens than control fibroblasts, concomitan
257 le in amnion fibroblasts, which lay down the fibrillar collagen that gives tensile strength to the am
258 I collagen gene codes for a novel vertebrate fibrillar collagen that is highly conserved in man, mous
259 high-density breast contains more oriented, fibrillar collagen that is stiffer and correlates with h
260 triple helices (FACITs) differs from that of fibrillar collagens that have special C-propeptides.
264 Exposure of the aortic rings embedded in 3D fibrillar collagen to recombinant endorepellin for 2-4 h
266 MIF arises mainly because of alterations in fibrillar collagen turnover leading to collagen fiber ac
268 -) fibroblasts lost their ability to process fibrillar collagen type I and to activate proMMP-2.
269 entric thickening of the perivascular space (fibrillar collagen type I deposition) and affected almos
272 and an X chromosome that disrupts the minor fibrillar collagen type V gene COL5A1 in a patient with
275 Mutations in the genes encoding the major fibrillar collagen types I and III have been demonstrate
276 VWF) mediates adhesion of blood platelets to fibrillar collagen types I, II, and III, which is essent
278 rent genes, the majority of which encode the fibrillar collagen types I, III and V, modifying or proc
279 1) and alpha(2) (alpha(1)I and alpha(2)I) to fibrillar collagen types I-III and showed that each I do
280 apy, mean serum levels of antibodies binding fibrillar collagen types I-III and V were significantly
281 llagen C-proteinase that processes the major fibrillar collagen types I-III, and it may process proly
283 esion to immobilized monomeric and polymeric fibrillar collagen under static conditions in the presen
287 l area was increased with selective MMPi but fibrillar collagen volume fraction remained unchanged re
288 usceptibility to CatK-mediated hydrolysis of fibrillar collagen was observed following mineralization
290 and increased collagen content, whereas the fibrillar collagen weave in the MHCsTNF2 mice with LV di
291 independent conditions, platelets adhered to fibrillar collagen were able to secrete contents of both
293 oid potential immunogenicity associated with fibrillar collagens, were fabricated with and without ch
294 Types I, II, III, V, and XI constitute the fibrillar collagens, whereas types IV, VI to X, and XII
295 on of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of sta
296 least partly, via biosynthetic processing of fibrillar collagens, while TLD affects dorsal-ventral pa
297 h encodes the alpha chain of an atypical non-fibrillar collagen with a single transmembrane domain.
299 of A2058 human melanoma cells cocultured in fibrillar collagen with HS-68 primary human fibroblasts.
300 s to enter the cell cycle in the presence of fibrillar collagen without a requirement for spreading a