ライフサイエンスコーパス: fibrogenic

1 cocktail, dasatinib plus quercetin (DQ), is fibrogenic.

2 tiates from circulating monocytes and is pro-fibrogenic.

3 f 2 major injury responses: inflammatory and fibrogenic.

4 ogenic potential, c-Kit(+)/PW1(+) cells were fibrogenic.

5 roblasts are major targets of TGF-beta, some fibrogenic actions may reflect activation of other cell

6 liver fibrosis and are able to modulate the fibrogenic actions of nonparenchymal liver cells.

7 s) transdifferentiate into proliferative and fibrogenic activated myofibroblastic phenotype (activate

8 attenuate HSC activation, leading to reduced fibrogenic activation in zebrafish, culture-activated HS

9 en stabilization in liver fibrosis, promotes fibrogenic activation of attenuated hepatic stellate cel

10 between HCV-infected hepatocytes and HSC in fibrogenic activation.

11 ossesses both important immunomodulatory and fibrogenic activities, and should be considered a key fo

12 n the absence of PH, associated with reduced fibrogenic activity (e.g., expression of alpha smooth mu

13 with the induction of epithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz transcr

14 , these observations indicate that increased fibrogenic activity because of dysregulated RhoA GTPase

15 of Sirtuin 1 (Sirt1)/Timp3 pathways mediate fibrogenic activity in NASH.

16 ance and consequent redox, inflammatory, and fibrogenic activity in NASH.

17 t the link between AGEs and inflammatory and fibrogenic activity in nonalcoholic steatohepatitis (NAS

18 KLF6 reduces fibrogenic activity of HSCs by way of two distinct mecha

19 y overexpressing HAI-1 or HAI-2 enhanced the fibrogenic activity of portal fibroblasts and stellate c

20 miR-200 family members can reverse the fibrogenic activity of pulmonary fibroblasts from mice w

21 In conclusion, AR induces hHSC fibrogenic activity via multiple mitogenic signaling pat

22 companied by restored MV density, attenuated fibrogenic activity, and improvements in RBF and GFR gre

23 of renal angiogenic signaling and attenuated fibrogenic activity, which ameliorates MV rarefaction an

24 and invasion of HSCs, contributing to their fibrogenic activity.

25 In response to fibrogenic agonists, such as angiotensin II (Ang II), th

26 induced in fibrotic conditions and modulate fibrogenic and angiogenic responses by regulating growth

27 left ventricular hypertrophy, plays an anti-fibrogenic and anti-hypertrophic role by blocking, among

28 Fibrogenic and contractile activities of lung fibroblast

29 nes that act on epithelial cells, as well as fibrogenic and immunosuppressive cytokines that interfer

30 xpression of SEMA7A in HSCs showed increased fibrogenic and inflammation markers expression.

31 t manner, leading to increased expression of fibrogenic and inflammation markers.

32 d oxidative stress, as well as inflammatory, fibrogenic and liver progenitor cell responses, were ass

33 Specifically, potent fibrogenic and prohypertrophic effects, as well as oxida

34 s pancreatic stellate cells (PSCs) to become fibrogenic and secrete chemokines that promote epithelia

35 ngs indicate that IPF MPCs are intrinsically fibrogenic and that S100A4 confers MPCs with fibrogenici

36 CB(1) receptors on hepatic stellate cells is fibrogenic, and CB(1) blockade slows the progression of

37 hotic septa harbor vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively

38 ings were associated with necroinflammatory, fibrogenic, and pro-oxidant activity via the NADPH oxida

39 ultiple subtypes of CAFs with diverse roles, fibrogenic, and secretory.

40 effects and local expression of angiogenic, fibrogenic, and vasoactive factors.

41 The PAI-1-miR-21 fibrogenic axis also appeared dysregulated in muscle of

42 onal medicine aimed at in vivo modulation of fibrogenic behavior.

43 essential regulator of cardiac PW1(+) cells fibrogenic behavior.

44 cular targets of miRNAs that are linked to a fibrogenic cardiac phenotype.

45 a effect on stellate cell activation and the fibrogenic cascade appears to be adiponectin-dependent;

46 l transdifferentiation is a key event in the fibrogenic cascade.

47 irectly activate hepatic stellate cells, the fibrogenic cell in the liver, and drive liver scarring.

48 of activated hepatic stellate cells, the key fibrogenic cell in the liver.

49 ated hepatic stellate cells (HSCs), the main fibrogenic cell type in the liver, undergo apoptosis aft

50 ells (HSCs) have been identified as the main fibrogenic cell type in the liver.

51 fibroblast subpopulation and the predominant fibrogenic cell type.

52 show that muscle stem cells communicate with fibrogenic cells by exosomal trafficking of microRNA-206

53 Autophagy was blocked in fibrogenic cells from liver and other tissues using smal

54 fibrosis remains unclear partly because the fibrogenic cells have not been identified with certainty

55 elective reduction of autophagic activity in fibrogenic cells in liver and other tissues might be use

56 ealed their specification from adipogenic to fibrogenic cells in the rat model of atrial cardiomyopat

57 we show that MPCs interact with interstitial fibrogenic cells to ensure proper ECM deposition and opt

58 aster regulator of collagen biosynthesis, in fibrogenic cells to prevent excessive ECM deposition.

59 angiotensin II and the relative abundance of fibrogenic cells were sexually dimorphic.

60 ssue, we demonstrate for the first time that fibrogenic cells within EFE tissue originate from endoca

61 are embedded into a dense stroma containing fibrogenic cells, lymphatics and a variety of immune cel

62 argely of collagens secreted by interstitial fibrogenic cells, which influence satellite cell activit

63 Here, we investigated the role of CTGF in fibrogenic cells.

64 hey respond to ischemic damage by generating fibrogenic cells.

65 ic chemokine CCL3 and an increase in GFAP(+) fibrogenic cells.

66 uence PF by enhancing fibrogenic factors and fibrogenic cells.

67 ivation and extended these findings to other fibrogenic cells.

68 nduced a differentiated phenotype in HCC and fibrogenic cells.

69 in human HCC cells and their crosstalk with fibrogenic cells.

70 for resolving LF by directly targeting these fibrogenic cells.

71 effects on the epithelial, inflammatory, and fibrogenic cellular subsets in pancreatic carcinoma and

72 Each of these fibrogenic changes was restored to control levels by the

73 However, LPS can also attenuate fibrogenic characteristics of aHSCs.

74 ro-inflammatory (IL-6, iNOS, ICAM-1) and pro-fibrogenic (Col1, alpha-SMA, TIMP-1) genes.

75 an epigenetic suppressive adaptation of the fibrogenic component of wound healing to the male F1 and

76 creased capacity to synthesize collagens and fibrogenic components.

77 own of integrin alpha(5) and RhoA attenuated fibrogenic, contractile, and migratory activities of IPF

78 n normal lung fibroblasts and diminishes the fibrogenic, contractile, and migratory activities of IPF

79 Fibrogenic, contractile, and migratory activities of lun

80 termine the role of miR-31 in regulating the fibrogenic, contractile, and migratory activities of lun

81 The pro-fibrogenic cytokine connective tissue growth factor (CTG

82 h control mice, accompanied by increased pro-fibrogenic cytokine expression but without a significant

83 Interleukin (IL)-17 is a proinflammatory and fibrogenic cytokine mainly produced by T-helper (Th)17 l

84 vation of HSCs and their response to the pro-fibrogenic cytokine TGF-beta was evaluated by gene expre

85 Connective tissue growth factor (CTGF) is a fibrogenic cytokine that is up-regulated by TGF-beta and

86 by subarachnoid fibrosis in which the potent fibrogenic cytokine transforming growth factor-beta has

87 These lesions overexpress a fibrogenic cytokine, TGFbeta, and an oncogene, ERBB2, ac

88 cause IL-13 is a pivotal proinflammatory and fibrogenic cytokine, we examined whether a recombinant i

89 xpression of transforming growth factor-1, a fibrogenic cytokine.

90 fibrogenesis predominantly by producing key fibrogenic cytokines and by promoting cell-to-cell commu

91 mation of ductular scars by upregulating pro-fibrogenic cytokines and positively regulating collagen-

92 tissue inhibitors of metalloproteinases, and fibrogenic cytokines but increased matrix metalloprotein

93 Stimulation of the vagus nerve increases fibrogenic cytokines in humans, therefore, activation of

94 ced HSC activation and their response to pro-fibrogenic cytokines like TGF-beta.

95 e stress, and production of inflammatory and fibrogenic cytokines were measured.

96 xidative stress, apoptosis and production of fibrogenic cytokines.

97 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the ki

98 eneficial for treating hyperproliferative or fibrogenic diseases of the skin.

99 ystemic hypertension, cancer, vasospasm, and fibrogenic diseases.

100 g growth factor (TGF)-b pathway, a canonical fibrogenic driver, suggesting that XBP1 activates a spec

101 research on whether TGF-beta has a stronger fibrogenic effect in the setting of inflammation is warr

102 Mevalonate reversed the anti-fibrogenic effect of CSA13.

103 esenchymal proteins that initiate a cycle of fibrogenic effector cell activation, leading to progress

104 L1), we hypothesize that CSA13 mediates anti-fibrogenic effects via FPRL1.

105 ta) is a potent inducer of developmental and fibrogenic EMTs(4,9,10).

106 r coordinated induction of developmental and fibrogenic EMTs.

107 ently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs

108 and increased risk for adverse vascular and fibrogenic events post-MI.

109 levels in HCV treatment outcomes and in the fibrogenic evolution of HCV-related liver disease.

110 STAT-4-T-allele is identified as fibrogenic factor and seems to have a negative impact on

111 aken together, we identify RGC-32 as a novel fibrogenic factor contributing to the pathogenesis of re

112 However, OPN acts as a fibrogenic factor independently of its phosphorylation s

113 he vagus nerve may influence PF by enhancing fibrogenic factors and fibrogenic cells.

114 n, blocked the induction of ECM proteins and fibrogenic factors and improved respiratory compliance i

115 cells in vitro but not any of the other pro-fibrogenic factors assessed.

116 We aimed to analyse the production of pro-fibrogenic factors by airway epithelium in response to A

117 RREB1 directly drive expression of SNAIL and fibrogenic factors stimulating myofibroblasts, promoting

118 the notion that both genetic and nongenetic fibrogenic factors, particularly TGF-beta1 and oxidative

119 We assessed the induction of key pro-fibrogenic factors, TGF-beta1, TGF-beta2, periostin and

120 ith increased expression of ECM proteins and fibrogenic factors.

121 several rate-limiting lipogenic enzymes and fibrogenic factors.

122 mia inhibitory factor (LIF), and IL-11, have fibrogenic features.

123 producing a secretory CAF phenotype with low fibrogenic features; and increased secretion of pro-tumo

124 es that can induce osteogenic (biglycan) and fibrogenic (fibromodulin, decorin) phenotypes, and PDL-s

125 CTA2, ELN, and COL1A1, indicating these were fibrogenic FLC cells.

126 ally dysfunctional due to its acquisition of fibrogenic functions.

127 E2F1 is a fibrogenic gene and could serve as a potential new diagn

128 rding the roles of these viral infections on fibrogenic gene expression in LX-2 cells.

129 ral infections on the phenotypic changes and fibrogenic gene expression in LX-2 cells.

130 infection in MLH co-culture had no impact on fibrogenic gene expression in LX-2 cells.

131 miR-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent HSCs and causes

132 tivated B cells signaling without increasing fibrogenic gene expression or cell proliferation.

133 id increase in proinflammatory cytokines and fibrogenic gene expression was also observed.

134 ta stimulation of rat or human PCLSs induced fibrogenic gene expression, release of extracellular mat

135 epletion of ASH1 caused broad suppression of fibrogenic gene expression.

136 Pro-fibrogenic gene expressions (COL1, TIMP-1, TGF-beta1, al

137 induced alpha-SMA protein expression and pro-fibrogenic gene expressions in HSC-T6 were suppressed in

138 malized but the lung fibrotic abnormalities, fibrogenic gene induction and pulmonary elasticity were

139 langiocytes and activates transcription of a fibrogenic gene program that supports biliary fibrosis.

140 ), whose depletion upon activation induces a fibrogenic gene program.

141 promote fibrogenesis through coregulation of fibrogenic gene targets.

142 netic machinery in cholangiocytes to support fibrogenic gene transcription.

143 6 in liver injury may allow de-repression of fibrogenic genes and decreased stellate cell clearance b

144 direct transcriptional repression of target fibrogenic genes and increased apoptosis of activated HS

145 not improve insulin resistance, but induced fibrogenic genes and inflammation in the liver.

146 ) HSCs were unable to increase expression of fibrogenic genes IL-1beta and tissue inhibitor of metall

147 Autophagy also regulated expression of fibrogenic genes in embryonic, lung, and renal fibroblas

148 y amplifying the expression of HCV-dependent fibrogenic genes in HSC.

149 mRNA expression of pro-inflammatory and pro-fibrogenic genes in livers of CDAA rats.

150 ure resulted in upregulation (>1.9x) of five fibrogenic genes including CCL2, IL1A, IL1B, IL13RA2 and

151 s, but did not demonstrate the inhibition of fibrogenic genes observed in pn.

152 he chromatin environment of inflammatory and fibrogenic genes through its atypical histone acetyltran

153 regression of liver fibrosis, down-regulate fibrogenic genes, and acquire a phenotype similar to, bu

154 H incidence and inductions of progenitor and fibrogenic genes, but rather enhances the Il-17a inducti

155 hepatic fibrosis, with reduced expression of fibrogenic genes, compared to WT mice.

156 drial DNA deletions, and renal expression of fibrogenic genes, including transforming growth factor b

157 minished fibrosis with reduced expression of fibrogenic genes.

158 a significant increase in hepatic mRNAs for fibrogenic genes.

159 on of stellate cells and expression of human fibrogenic genes.

160 yses to identify translational regulators of fibrogenic genes.

161 several proinflammatory, cancer-related, and fibrogenic genes.

162 play an important role in the production of fibrogenic growth factors and development of fibrosis.

163 e resulting offspring better adapt to future fibrogenic hepatic insults.

164 Effects of LPS on fibrogenic hepatic stellate cells (HSCs) from WT and TLR

165 Here we report that fibrogenic hepatic stellate cells (HSCs) in the liver ar

166 Thus, XBP1-mediated UPR contributes to fibrogenic HSC activation and is functionally linked to

167 HSCs were isolated 24 hours later, and fibrogenic/inflammatory parameters were analyzed.

168 GIV is expressed in the liver after fibrogenic injury and is required for HSC activation.

169 tigating hepatic steatosis and in modulating fibrogenic injury and reversal.

170 inhibited PMC migration after intratracheal fibrogenic injury.

171 cid binding protein reveal distinct roles in fibrogenic injury.

172 Our previous study showed that isolated fibrogenic lung fibroblasts have high endogenous levels

173 lved hepatic inflammation, activation of the fibrogenic machinery and early fibrosis.

174 tion, and caused substantial increase in the fibrogenic marker miR-21 expression, indicating the high

175 scle actin staining and expression levels of fibrogenic markers (eg, transforming growth factor-beta1

176 ture, paralleling the enhanced expression of fibrogenic markers alpha-smooth muscle actin (alpha-SMA)

177 AR also induced marked upregulation of hHSC fibrogenic markers and reduced hHSC death.

178 ion of Rev-erbalpha, decreased expression of fibrogenic markers and the activated phenotype in HSCs,

179 uced HSC proliferation and expression of pro-fibrogenic markers of mouse and human HSCs.

180 y, and monophosphoryl lipid A down-regulated fibrogenic markers, but elicited very weak inflammatory

181 aHSCs associated with down-regulation of key fibrogenic mechanisms and thus may have an important rol

182 ng growth factor-1 (TGF-beta1) activates pro-fibrogenic mechanisms have been extensively studied and

183 dystrophy (DMD) patients, yet the implicated fibrogenic mechanisms remain poorly understood.

184 This reflects its capacity to stimulate fibrogenic mediators and induce the expression of other

185 as betaTRCP-dependent degradation of the pro-fibrogenic mediators Sp1, TAZ and beta-catenin.

186 igate the expression of the inflammatory and fibrogenic mediators which may be involved.

187 viously discovered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serv

188 These fibrogenic mesenchymal progenitors and their progeny rep

189 ignificantly increased fibrosis and enhanced fibrogenic messenger RNA (mRNA) and protein expression.

190 ted transcriptional program leading to a pro-fibrogenic microenvironment, activation of hepatic stell

191 l cell coverage fostered the accumulation of fibrogenic molecules and the attraction of fibroblasts t

192 We have therefore been able to convert pro-fibrogenic myofibroblasts in the liver into hepatocyte-l

193 ic stellate cells or portal fibroblasts into fibrogenic myofibroblasts.

194 hese findings indicate that T-cell-regulated fibrogenic pathways are highly mechanoresponsive and sug

195 Over time, inflammation and fibrogenic pathways become dominant while in advanced di

196 y and the development of therapies targeting fibrogenic pathways hold promise for the future.

197 Fibrogenic pathways in the liver are principally regulat

198 at altered chitin clearance could exacerbate fibrogenic pathways in the setting of lung diseases char

199 s reveals intra-scar activity of several pro-fibrogenic pathways including TNFRSF12A, PDGFR and NOTCH

200 cardiac fibrosis via regulation of multiple fibrogenic pathways.

201 of genes involved in immune responses and in fibrogenic pathways.

202 ss-talk regulating cell fate-determining and fibrogenic pathways.

203 drive fibrogenesis by modulating the HSC pro-fibrogenic phenotype and Collagen-I expression.

204 aded cRGDyK-liposomes markedly inhibited the fibrogenic phenotype in bile duct ligation- or thioaceta

205 e pathogenesis of fibrosis by regulating the fibrogenic phenotype of hepatic stellate cells (HSCs).

206 he induced cellular responses that drive the fibrogenic phenotype remain to be elucidated.

207 The key mediators of the fibroblast fibrogenic phenotype were characterized using a novel as

208 om mice infected with B. abortus displayed a fibrogenic phenotype with patches of collagen deposition

209 cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.

210 ells could be turned into an inflammatory or fibrogenic phenotype.

211 promoted satellite cells to switch toward a fibrogenic phenotype.

212 y (M1 cells) as well as antiinflammatory and fibrogenic phenotypes (M2 cells); they affect transplant

213 el alternative splice form that modifies the fibrogenic potential of HSCs.

214 arker miR-21 expression, indicating the high fibrogenic potential of this specific carbon nanotube ty

215 indicating increased activation of HSCs and fibrogenic potential.

216 king poor cardiac lymphatic transport to the fibrogenic process and discussing potential avenues for

217 iscusses the role of nicotine in the general fibrogenic process that governs fibrosis and fibrosis-re

218 st activation, the key cell type driving the fibrogenic process, are essential to develop new therape

219 oblasts to myofibroblasts, a hallmark of the fibrogenic process, using pulmonary fibroblasts isolated

220 ulates HSC activation and inhibits the liver fibrogenic process.

221 rgan-resident, mesenchymal precursors in the fibrogenic processes in human adult lungs.

222 transmembrane protein Cx43 has key roles in fibrogenic processes including inflammatory signaling an

223 ay simultaneously block the inflammatory and fibrogenic processes of PF.

224 xpression is shown to impair TGF-beta-driven fibrogenic processes, including cell proliferation and p

225 ith Lonidamine decreased TGF-beta-stimulated fibrogenic processes, including profibrotic gene express

226 d with various immune, hepatoprotective, and fibrogenic processes.

227 are active participants in wound healing and fibrogenic processes.

228 protects against organ fibrosis by removing fibrogenic products of lipid peroxidation.

229 Targeting the fibrogenic progenitor response represents a promising st

230 A miR-21 as a long-term memory keeper of the fibrogenic program in MSCs.

231 perglycemia-induced epigenetic activation of fibrogenic program in the kidney.

232 HSC FA utilization and in turn regulates the fibrogenic program.

233 was sufficient to confer protection against fibrogenic progression.

234 Within days a fibrogenic, proliferative mechanism causes anatomic clos

235 differentiation trajectory IPF MPCs acquire fibrogenic properties, we analyzed the transcriptome of

236 tenuated hypoxia-induced upregulation of the fibrogenic protein connective tissue growth factor and c

237 nt autocrine signalling that is required for fibrogenic protein synthesis.

238 s well as the induction of the lipogenic and fibrogenic proteins, are completely blocked in the prese

239 vels and diminished liver expression of anti-fibrogenic receptor CB2.

240 e signaling between an immune cytokine and a fibrogenic receptor.

241 RelA-P-Ser536 may be a core fibrogenic regulator of fibroblast phenotype.

242 tension (PH) and heart failure (HF) includes fibrogenic remodeling associated with the loss of pulmon

243 taminase 2 (TG2) as a participant in adverse fibrogenic remodeling.

244 On the other hand, fibrogenic resolution after CCl(4) administration was im

245 iferation using anti-TWEAK antibody prevents fibrogenic response and augments fibrotic liver regenera

246 p-regulation of Rev-erbalpha is an intrinsic fibrogenic response characterized by cytoplasmic accumul

247 inhibited and is tightly associated with the fibrogenic response during severe liver damage.

248 ns, which could help explain the exaggerated fibrogenic response in IPF.

249 ar VEGF deprivation induces degeneration and fibrogenic response in retina.

250 The fibrogenic response in tissue-resident fibroblasts is de

251 fat overload which promotes inflammatory and fibrogenic response similar to those observed in patient

252 did not affect immune cell migration or the fibrogenic response to chronic liver injury.

253 tic sinusoidal cells are known actors in the fibrogenic response to injury.

254 lagen are targets for regulating the initial fibrogenic response to liver damage.

255 Systemic VEGF overexpression led to a fibrogenic response within the liver and was associated

256 K) activity and disrupts key features of the fibrogenic response.

257 genitor (oval) cell compartment and a severe fibrogenic response.

258 o the understanding of the TGF-beta-mediated fibrogenic response.

259 ole of pancreatic acinar cells in initiating fibrogenic responses during the early stages of alcoholi

260 yte-derived OPN and recombinant OPN promoted fibrogenic responses in HSCs (P < 0.05); neutralizing OP

261 el of AGEs, and improved proinflammatory and fibrogenic responses in mice on a high AGEs diet.

262 signaling in liver fibrosis, we compared the fibrogenic responses of wild-type (WT) and tpl2(-/-) mic

263 o RNAi-mediated silencing of CCN1 attenuates fibrogenic responses to bleomycin-induced lung injury.

264 signaling in fibroblasts and contributes to fibrogenic responses to lung injury.

265 planted mesenchymal cells, Wnt-3a stimulated fibrogenic responses while suppressing adipogenesis.

266 s off a complex sequence of inflammatory and fibrogenic responses.

267 and immunoblotting were performed to assess fibrogenic responses.

268 ardin-related transcription factor (MRTF), a fibrogenic RHOA effector, and elevated expression of con

269 To screen the fibrogenic risk factor of specific types of MWCNT, we de

270 Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by foc

271 Given the importance of TGF-beta1 as a fibrogenic signal, a microsystem with integrated biosens

272 ge CD36 is a critical regulator of oxidative fibrogenic signaling and that CD36-mediated phagocytosis

273 the SM alpha-actin cytoskeleton and classic fibrogenic signaling cascades, but also emphasize the re

274 The fibrogenic signaling events downstream of TLRs on Kupffe

275 ients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correl

276 dative stress, unfolded protein response and fibrogenic signaling.

277 lizes transactivation mechanisms to initiate fibrogenic signaling.

278 F), which serves as a central hub within the fibrogenic signalling network initiated by diverse class

279 chanism that regulates cardiomyocyte-derived fibrogenic signals and cardiac transcriptional pathways

280 hepatocytes produce hepato-inductive and pro-fibrogenic signals at the levels sufficient to shape the

281 Fibrogenic signals drive transcription of procollagen I,

282 ance activation of HSCs and induction of the fibrogenic signals in these cells.

283 Hypothesizing that early fibrogenic signals may originate in cells susceptible to

284 eam of TGFbeta that mediate transcription of fibrogenic signals.

285 e regulated by resident cardiac cells with a fibrogenic signature and identified by the expression of

286 iologic Epo-producing state and a pathologic fibrogenic state in response to microenvironmental signa

287 responsiveness of reverted HSCs to recurring fibrogenic stimulation.

288 eactivate into myofibroblasts in response to fibrogenic stimuli and strongly contribute to liver fibr

289 fully characterized, we aimed to analyze the fibrogenic stimuli in a new in vitro model of NASH.

290 egenerate hepatocytes in various contexts of fibrogenic stimuli remain elusive.

291 ions direct the cellular response of HPCs to fibrogenic stimuli, but also identify novel potential th

292 llular matrix organization and is induced by fibrogenic stimuli.

293 ate, with higher levels of responsiveness to fibrogenic stimuli.

294 kin, predominantly in the adipogenic but not fibrogenic subsets.

295 al cells toward myofibroblasts by inducing a fibrogenic transcriptional program while suppressing adi

296 TNF-alpha production as well as induction of fibrogenic transcripts.

297 or could regulate the bioavailability of the fibrogenic transforming growth factor beta in response t

298 lpha responded to both adipogenic ligand and fibrogenic transforming growth factor beta treatment.

299 During fibrogenic transition, these miRNAs are transcriptionall

300 ional repressor activity was not affected by fibrogenic treatments.