ライフサイエンスコーパス: filament protein

1 e filament protein vimentin, an intermediate filament protein.

2 hat encodes the major astrocyte intermediate filament protein.

3 on of nestin, an embryonic cell intermediate filament protein.

4 lens proteins and the ancestral intermediate filament protein.

5 3 different proteins with a single flagellar filament protein.

6 to the orientation of other known transverse filament proteins.

7 times, containing predominantly intermediate filament proteins.

8 d diverse interactions with neighboring thin filament proteins.

9 l modifications (PTMs) in bovine lens beaded filament proteins.

10 lowed by multiple structural changes of thin filament proteins.

11 ared by K6, other keratins, and intermediate filament proteins.

12 nization, such as lamin nuclear intermediate filament proteins.

13 ssion of genes encoding thick, but not thin, filament proteins.

14 of structural changes in cTnC and other thin filament proteins.

15 ovel nonmechanical function for intermediate filament proteins.

16 mechanisms involving phosphorylation of thin filament proteins.

17 Cia export requires at least one of the two filament proteins.

18 I (K9-K20) and type II (K1-K8) intermediate filament proteins.

19 epeat domains characteristic of intermediate filament proteins.

20 , all common features of type 6 intermediate filament proteins.

21 K8) and 18 (K18) as their major intermediate filament proteins.

22 eton belonging to the family of intermediate filament proteins.

23 y the most abundant of neuronal intermediate filament proteins.

24 to promote differentiation by citrullinating filament proteins.

25 (K18), two epithelial-specific intermediate filament proteins.

26 auxiliary beta subunit through intermediate filament proteins.

27 simple epithelial cell-specific intermediate filament proteins.

28 s prevented the loss of both desmin and thin filament proteins.

29 the FlaA major flagellin and other flagellar filament proteins.

30 Beaded filament protein accumulation lags significantly behind

31 is review describes the isoforms of the thin filament proteins actin and tropomyosin and the three tr

32 The results suggest that an intermediate filament protein acts in a novel pathway to direct the t

33 rotein as the neuronal specific intermediate filament protein, alpha-internexin.

34 function of internexin neuronal intermediate filament protein-alpha a (inaa), the encoding gene of wh

35 Gelsolin-dependent removal of thin filament proteins also reduced myofilament-bound PKA-typ

36 e roles of vimentin, a type III intermediate filament protein and a marker of epithelial-mesenchymal

37 t role for a polymorphic helix of the needle filament protein and the residues that line the lumen of

38 tion is modified by specific changes in thin filament proteins and by agents that promote the actin-m

39 ing insights into the basic biology of thick filament proteins and reinforce the idea that myosin bin

40 unsuspected association between intermediate filament proteins and the adaptor complex AP-3.

41 with pan-specific antibodies to intermediate filament proteins and to cytokeratins suggest that contr

42 to LNDS in vimentin, a Type III intermediate filament protein, and have examined the impact of this c

43 wth factors, membrane proteins, intermediate filament proteins, and chaperones.

44 myosin messenger RNAs, reexpression of thick-filament proteins, and increased specific tension were o

45 NH2-terminal region does not bind other thin filament proteins, and its sequence is hypervariable bet

46 epeat domains characteristic of intermediate filament proteins, and several of the mutations in Bic-D

47 within the SC is similar to other transverse-filament proteins, and that the N terminus of C(2)M is l

48 ctions with 14-3-3 and vimentin intermediate filament proteins, and vimentin depletion increased auto

49 Mutations in genes encoding thin filament proteins are less prevalent in HCM than previou

50 ells, suggesting that these two intermediate filament proteins are necessary for fulvestrant-induced

51 VI nestin and type III vimentin intermediate filament proteins are replaced by a series of type IV pr

52 Lamins, the type V nuclear intermediate filament proteins, are reported to function in both inte

53 PC1 proteins included keratin intermediate filaments; proteins associated with inflammatory respons

54 oes not contain binding sites for other thin filament proteins, but alteration of its structure affec

55 eukaryotic actin, tubulin, and intermediate filament proteins, but they also have cytoskeletal eleme

56 s with sequences from the smooth muscle thin filament protein caldesmon (CaD) by using small-angle X-

57 The thin filament protein cardiac troponin T (cTnT) is an importa

58 ha-tropomyosin (alpha-TM), an essential thin filament protein, cause both dilated cardiomyopathy (DCM

59 Lengsin and lens intermediate filament proteins co-localize at the plasma membrane in

60 arked reduction in detectable FlaB flagellar filament protein compared to that of wild type; however,

61 Myosin-binding protein C (MyBP-C) is a thick filament protein consisting of 1274 amino acid residues

62 AP-3 and intermediate filament proteins cosedimented and coimmunoprecipitated

63 Importantly, dL5 fusions to an intermediate filament protein CreS are significantly less perturbativ

64 manner similar to deleting the intermediate filament protein crescentin, but it does not disrupt cre

65 Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and m

66 In particular, lamin A/C, an intermediate filament protein critical for the interphase nuclear arc

67 el association of AIRE with the intermediate filament protein cytokeratin 17 (K17) in the THP-1 monoc

68 tions of cells that express the intermediate filament protein cytokeratin 5 (CK5).

69 The cytoplasmic filament protein-deficient mutant exhibited pleiotropic

70 1 induced the expression of the intermediate filament protein desmin and interstitial matrix componen

71 we describe the muscle-specific intermediate filament protein desmin as a novel caspase substrate.

72 Mice lacking the intermediate filament protein desmin demonstrate abnormal mitochondri

73 The intermediate filament protein desmin is encoded by the gene DES and c

74 how that S-nitrosylation of the intermediate filament protein desmin is significantly increased (5.7-

75 in the DES gene coding for the intermediate filament protein desmin may cause skeletal and cardiac m

76 loss of immunostaining for the intermediate filament protein, desmin.

77 To evaluate the effects of two thick filament protein domains on passive sarcomeric stiffness

78 erone for the reorganization of intermediate filament proteins during terminal differentiation in the

79 lternative, antigenic forms of its flagellin filament protein, either type B or C.

80 The A-type lamins, nuclear intermediate filament proteins encoded by the LMNA gene, are basic co

81 aracterized as an intracellular intermediate filament protein expressed broadly in mesenchymal cells.

82 also positive for vimentin, an intermediate filament protein expressed by mesenchymal cells.

83 The basis for the lack of filament protein expression is unknown.

84 This interdependence of thin-filament protein expression led us to postulate that som

85 s in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss

86 Vimentin, a member of the intermediate filament protein family, is regulated both developmental

87 The lens fiber cell-specific intermediate filament protein filensin is essential for beaded filame

88 t induced increased expression of the beaded filament protein filensin when compared with control cel

89 The lens beaded filament proteins filensin and CP49 are phosphorylated p

90 eins revealed the lens-specific intermediate filament proteins filensin and CP49.

91 d markedly decreased levels of the flagellar filament proteins FlaA and FlaB.

92 c flagella consist of a polymer of the major filament protein FlaB and a minor protein, FlaA.

93 ene encoding the major periplasmic flagellar filament protein FlaB.

94 E), the hook-capping protein (FlgD), and the filament protein flagellin (FliC).

95 ired to activate expression of the flagellar filament protein, flagellin.

96 t repression of translation of the flagellar filament protein, flagellin.

97 The flagellar filament protein FliC is a natural antigen recognized by

98 ecific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacit

99 sed in number with aging, and the two beaded filament proteins form covalent complexes with crystalli

100 trin regulates the placement of intermediate filament proteins forming a terminal web around the lume

101 purified flagellin (FliC or FljB), the major filament protein from Salmonella enterica serovar Enteri

102 the gene that encodes a lens-specific beaded filament protein gene, BFSP2.

103 Mutations in intermediate filament protein genes are responsible for a number of i

104 in astrocytes that contain the intermediate filament protein GFAP in association with small heat-sho

105 e was loss of expression of the intermediate filament proteins GFAP and vimentin, the expression of b

106 from missense mutations of the intermediate filament protein, GFAP.

107 tions in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP).

108 The accumulation of the intermediate filament protein, glial fibrillary acidic protein (GFAP)

109 ich encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP)

110 myopathy and indicate that this intermediate filament protein has an important role in cardiac conduc

111 Several hair-specific keratin intermediate filament proteins have been characterized, and all have

112 Mutations in thin-filament proteins have been linked to hypertrophic cardi

113 GNIFICANCE STATEMENT Nestin, an intermediate filament protein highly expressed in neural progenitors,

114 n gene (ACTA1) is one of five genes for thin filament proteins identified so far as responsible for d

115 rofilaments, but its effects on intermediate filament proteins (IFs) are unknown.

116 In addition, an increase in intermediate filament protein immunoreactivity (vimentin and glial fi

117 Alpha-internexin, a neuronal intermediate filament protein implicated in neurodegenerative disease

118 Peripherin, a neuronal intermediate filament protein implicated in neurodegenerative disease

119 le-type epithelial keratins are intermediate filament proteins important for mechanical stability and

120 ontribute to its function as an intermediate filament protein in radial glia.

121 Desmin is an intermediate filament protein in skeletal muscle that forms a meshlik

122 g the role of Akt signaling and intermediate filament proteins in autophagy and cancer.

123 s of neurofilament and vimentin intermediate filament proteins in cultured cells using cell fusion, p

124 ions in lamins A and C, nuclear intermediate-filament proteins in nearly all somatic cells, cause a v

125 ges in the expression levels of intermediate filament proteins in response to these treatments were a

126 inal ends of the rod domains of intermediate filament proteins in reverse transcriptase-PCR experimen

127 The evidence for proteolysis of thin filament proteins in situ during ischemia and stunning i

128 keratin-18 (K18) are the major intermediate filament proteins in the intestinal epithelia.

129 In contrast, the roles of intermediate filament proteins in this process are poorly understood,

130 ression of vimentin, a type III intermediate filament protein, in alveolar epithelial cells (AECs) ar

131 f phosphorylated 14-3-3 binding intermediate filament proteins, including keratins, coupled with redu

132 Co-sedimentation of thin filament proteins indicated that no significant changes

133 Thus, both thin and thick filament proteins influence the ability of cardiac tropo

134 h border, and redistribution of intermediate filament proteins into the brush border.

135 on, expression levels of alpha-actin, a thin filament protein involved in contraction, remained relat

136 Myosin binding protein C (MyBP-C) is a thick filament protein involved in the regulation of muscle co

137 Loss of sarcomere thin filament proteins is a frequent cause of NM; therefore,

138 Although no binding site for the other thin filament proteins is found at the COOH terminus of TnI,

139 Although the decreased content of thick-filament proteins is important for prolonged muscle weak

140 yperphosphorylation of neuronal intermediate filament proteins is involved in AD.

141 Vimentin, an intermediate filament protein, is an M phase substrate for both Auror

142 uman, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithel

143 Nestin, an intermediate filament protein, is widely used as stem cell marker.

144 fter birth; however, during adult life, thin filament protein isoform composition seems to be stable

145 of the sarcomere and changes in contractile filament protein isoforms.

146 L), interacts specifically with intermediate filament proteins K8, K18, and vimentin via its C-termin

147 The intermediate filament protein keratin 14 (K14) provides vital structu

148 Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulate

149 The intermediate filament protein keratin 17 (Krt17) shows highly dynamic

150 The intermediate filament protein keratin 8 (K8) and its cross-linking by

151 The intermediate filament protein keratin 8 (K8) is critical for the deve

152 nd the breast-cancer marker and intermediate filament protein keratin-19.

153 Mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is a

154 nucleus comes from meshworks of intermediate filament proteins known as lamins forming the inner laye

155 The filament protein lacks detectable homology to structural

156 r membrane is enriched with the intermediate filament protein lamin A.

157 d, there is evidence that the nuclear lamina filament protein Lamin A/C protects RB from proteasomal

158 We report that the intermediate filament protein lamin B, a component of the interphase

159 The intermediate filament protein lamin B2 (LB2), normally associated wit

160 gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural

161 ar lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear

162 implicated in NM, as well as a putative thin filament protein, leiomodin 3 (LMOD3).

163 Its filament protein-like structure makes it a likely candid

164 Tomato MFP1 has a predicted filament-protein-like structure and is associated with t

165 llary acidic protein (GFAP), an intermediate filament protein located within their cytoplasm.

166 of Tax and a neuronal specific intermediate filament protein may provide a clue to the pathogenesis

167 atins, members of the family of intermediate filament proteins, may represent a new class of receptor

168 onally engineered TnC constructs, three thin filament protein modifications representing different pr

169 mong these is expression of the intermediate filament protein nestin and the brain fatty acid binding

170 e also have determined that the intermediate filament protein nestin correlates with tumorigenic and

171 The intermediate filament protein Nestin identifies stem/progenitor cells

172 The intermediate filament protein Nestin labels populations of stem/proge

173 We found that the intermediate filament protein nestin physically interacts with Cdk5 a

174 The intermediate filament protein Nestin serves as a biomarker for stem c

175 ese cells expressed the type VI intermediate filament protein nestin whose expression was upregulated

176 s known to bind the cytoplasmic intermediate filament protein nestin with high affinity.

177 d astrocytes, and expressed the intermediate filament protein nestin, a marker for progenitor cells.

178 The intermediate filament protein, nestin, marks progenitor cells of the

179 Vimentin is an intermediate filament protein normally expressed in cells of mesenchy

180 e identified critical residues of the needle filament protein of a Salmonella Typhimurium type III se

181 dic protein (GFAP) is the major intermediate filament protein of astrocytes in the vertebrate central

182 hat is specific for a cytosolic intermediate filament protein of astrocytes.

183 e the role of desmin, the major intermediate filament protein of muscle in organizing costameres.

184 ociation with nebulin, a major actin-binding filament protein of striated muscle.

185 Myosin binding protein C is a thick filament protein of vertebrate striated muscle.

186 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several

187 teracts with the characteristic intermediate filament proteins of postsynaptic densities, and that th

188 8 and 18 (K8/18) are the major intermediate filament proteins of simple-type epithelia.

189 w alterations in A-type lamins, intermediate filament proteins of the nuclear envelope expressed in m

190 atins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive epithelia an

191 Understanding the effects of thin and thick filament proteins on the kinetics of Ca(2+) exchange wit

192 mutations in desmin, a type III intermediate filament protein, or alphaB-crystallin, a chaperone for

193 show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits

194 induction of expression of the intermediate filament protein peripherin, which is associated with CN

195 d against the neuronal type III intermediate filament protein peripherin.

196 rtin and of the neuron-specific intermediate filament protein, peripherin, and by RA-stimulated exten

197 -crystallins, the lens-specific intermediate filament proteins phakinin (CP49) and filensin (CP115),

198 stallins (possibly fragments) and two beaded filament proteins (phakinin and filensin).

199 se in myofibrillar Ca2+ sensitivity and thin filament protein phosphorylation is noted.

200 No changes in thin filament protein phosphorylation were evident.

201 en troponin C (TnC) and other thin and thick filament proteins play a key role in the regulation of c

202 nt experiments show that the conformation of filament proteins play a role in the motility and morpho

203 Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle con

204 Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and serves an an

205 Vimentin, an abundant intermediate filament protein, presumably has an important role in st

206 Keratins are cytoplasmic intermediate filament proteins providing crucial structural support i

207 ere we show that keratin 17, an intermediate filament protein rapidly induced in wounded stratified e

208 ed proteins; c) very low thick-filament/thin-filament protein ratios; d) absence of myosin messenger

209 associated with a specific decrease in thick-filament proteins related to an altered transcription ra

210 tion might extend to nonkeratin intermediate filament protein-related diseases.

211 The functions of these filament proteins remain unknown.

212 deleted the genes encoding two intermediate filament proteins required for astrocyte activation-glia

213 ly is desmin, a muscle-specific intermediate-filament protein responsible for the structural integrit

214 We found that mutations in the needle filament protein result in various specific phenotypes a

215 Neither beaded filament protein showed focal basal accumulations.

216 ular distribution of vimentin and the beaded filament proteins showed marked differences within the c

217 The gene for the sarcomeric thin-filament protein, slow skeletal muscle troponin T (TNNT1

218 association, dependent on the SC transverse-filament protein Sme4/Zip1, before moving to bridges and

219 49 (BFSP2; phakinin), a related intermediate filament protein specific to the lens.

220 astoma, including expression of intermediate filament proteins specific for neurons and glia.

221 del in which a mutation in a sarcomeric thin filament protein, specifically TM, leads to DCM.

222 ing a mechanism for the regulation of beaded filament protein stoichiometry.

223 These results show that alterations in thin filament protein structure and function can lead to sign

224 To understand how mutations in thick filament proteins such as cardiac myosin binding protein

225 In addition, several intermediate filament proteins such as vimentin and annexin, as well

226 Phosphorylation of thin filament proteins, such as troponin I and T, dramaticall

227 in, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin

228 The intermediate filament protein synemin is present in astrocyte progeni

229 gether, Nes-S is a new neuronal intermediate filament protein that exerts a cytoprotective function i

230 Flightin is a thick filament protein that in Drosophila melanogaster is uniq

231 n-A (LaA), a well-characterized intermediate filament protein that is a constituent of the nuclear la

232 Keratin 17 (K17) is a type I intermediate filament protein that is constitutively expressed in ect

233 olypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and sim

234 GFAP is an intermediate filament protein that is expressed predominately within

235 muscle tropomyosin (TM) is an essential thin filament protein that is sterically and allosterically i

236 yosin-binding protein-C (cMyBP-C) is a thick filament protein that modulates cross-bridge cycling rat

237 the expression of vimentin, an intermediate filament protein that polymerizes into networks extendin

238 Cardiac MYBPC is a thick filament protein that regulates sarcomere organization a

239 sed mainly of lamins, which are intermediate filament proteins that assemble into a filamentous meshw

240 Lamins are intermediate filament proteins that assemble into a meshwork undernea

241 e of the interactions between the transverse filament proteins that create this structure has emerged

242 Lamins are intermediate filament proteins that form a scaffold, termed nuclear l

243 A-type lamins are intermediate filament proteins that provide a scaffold for protein co

244 ith that of peripherin, another intermediate filament protein, the RNA for which does not bind hnRNP

245 d function depend on the type V intermediate filament proteins, the lamins, which are major structura

246 it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not

247 hagfishes contains thousands of intermediate filament protein threads that are manufactured within sp

248 he gene for CP49 (phakinin), an intermediate filament protein thus far demonstrated only in the lens

249 nary interactions between TnT and other thin filament proteins, TnI, TnC and Tm.

250 e nucleoporin Nup153 and the pore-associated filament protein Tpr, previously shown to reside at dist

251 Nestin is an intermediate filament protein, transiently and abundantly expressed e

252 e expression of two radial glia intermediate filament proteins, transitin and vimentin, in the develo

253 nd structural changes in cTnC and other thin filament proteins triggered by Ca(2+) movement.

254 tal proteins, including several intermediate filament proteins, triggers the dramatic disassembly of

255 Thin filament proteins tropomyosin (Tm), troponin T (TnT), an

256 eraction is sterically regulated by the thin filament proteins tropomyosin and troponin (Tn), with th

257 Selective proteolysis of the thin filament protein troponin I has been correlated with stu

258 resulting from the hdp2 mutation in the thin filament protein troponin I.

259 Missense mutations in the cardiac thin filament protein troponin T (TnT) are a cause of familia

260 The thin filament protein troponin T (TnT) is a regulator of sarc

261 ration conditions due to actions of the thin filament protein troponin.

262 htly regulated by Ca(2+) binding to the thin filament protein troponin.

263 muscles are regulated by Ca(2+) via the thin filament proteins troponin (Tn) and tropomyosin (Tm).

264 that differences among other thick and thin filament proteins underlie these XBr alterations.

265 , we find that the rapid destruction of thin filament proteins upon fasting was accompanied by increa

266 tified by mass spectrometry the intermediate filament protein vimentin and the microtubule protein al

267 1 as bait, we have isolated the intermediate filament protein vimentin as a Raf-1-associated protein.

268 artemisinin, we identified the intermediate filament protein vimentin as an artemisinin target, vali

269 ed by the redistribution of the intermediate filament protein vimentin as well as by the recruitment

270 superresolution imaging of the intermediate filament protein vimentin by stimulated emission depleti

271 The intermediate filament protein vimentin is involved in the regulation

272 ated C kinase 1 (RACK1) and the intermediate filament protein vimentin that correlated with increased

273 All cells expressed the intermediate filament protein vimentin, an intermediate filament prot

274 pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and co

275 The intermediate filament protein vimentin, which has been previously sho

276 Focusing on the intermediate filament protein vimentin, which is frequently citrullin

277 ior of in vitro networks of the intermediate filament protein vimentin.

278 domain and rod domain 1A of the intermediate filament protein vimentin.

279 in and the structurally related intermediate filament protein vimentin.

280 -kDa protein, identified as the intermediate filament protein vimentin.

281 ize Rac1 but rather detects the intermediate filament protein vimentin.

282 e proteins H2A, H3, and H4; the intermediate filament protein vimentin; the major HSV-1 capsid protei

283 antly differed from that of the intermediate filament proteins vimentin and desmin as well as that of

284 AEEEKKVEGAGEEQAAAK) and another intermediate filament protein, vimentin (FADLSEAANR).

285 by directly phosphorylating an intermediate filament protein, vimentin, thereby inhibiting assembly

286 The intermediate filament protein, vimentin, was upregulated approximatel

287 between SspC and an eukaryotic intermediate filament protein was identified.

288 were identified that encoded an intermediate filament protein we subsequently named desmuslin (DMN).

289 ubulin associates strongly with intermediate filament proteins, we examined the contribution of cytok

290 (MYH7, MYBPC3) and thin (TNNT2, TNNI3, TPM1) filament proteins were compared with sarcomere mutation-

291 The sequences of lens beaded filament proteins were systematically mapped, and putati

292 Vimentin is an intermediate filament protein whose expression correlates with increa

293 Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the sup

294 Myosin binding protein-C (MyBP-C) is a thick-filament protein whose precise function within the sarco

295 yosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by p

296 8) and keratin 18 (K18) are the intermediate filament proteins whose phosphorylation/transamidation a

297 Nestin, an intermediate filament protein widely used as a marker of neural proge

298 atin polypeptide 20 (K20) is an intermediate filament protein with preferential expression in epithel

299 intervening at the level of regulatory thin filament proteins would have potential therapeutic benef

300 se set of proteins, including the transverse filament protein, Zip1.