ライフサイエンスコーパス: filtration barrier

1 the integrity and function of the glomerular filtration barrier.

2 the selective permeability of the glomerular filtration barrier.

3 sential component of the kidney's glomerular filtration barrier.

4 grity of which is crucial for the glomerular filtration barrier.

5 involving the three layers of the glomerular filtration barrier.

6 sustaining the mechanical resistance of the filtration barrier.

7 e tetraspanin CD151 to maintain a functional filtration barrier.

8 aintaining the characteristics of the kidney filtration barrier.

9 rane (GBM) in order to maintain a functional filtration barrier.

10 podocytes, a key component of the glomerular filtration barrier.

11 ion and maintenance of the kidney glomerular filtration barrier.

12 ctural framework for a functional glomerular filtration barrier.

13 the structure and function of the glomerular filtration barrier.

14 A (VEGFA) maintains a functional glomerular filtration barrier.

15 ture of the slit diaphragm in the glomerular filtration barrier.

16 a role in the maintenance of the glomerular filtration barrier.

17 ch are critical components of the glomerular filtration barrier.

18 ria and structural changes of the glomerular filtration barrier.

19 for the establishment of a normal glomerular filtration barrier.

20 quired for proper function of the glomerular filtration barrier.

21 emove immunoglobulins that accumulate at the filtration barrier.

22 i but is critical to maintain the glomerular filtration barrier.

23 ffects on cells that comprise the glomerular filtration barrier.

24 red for proper functioning of the glomerular filtration barrier.

25 itical role in the maintenance of the kidney filtration barrier.

26 maintaining the integrity of the glomerular filtration barrier.

27 s found to cover 58 to 65% of the glomerular filtration barrier.

28 ar filtration and cleaning of the glomerular filtration barrier.

29 in in the development of a normal glomerular filtration barrier.

30 e as the central component of the glomerular filtration barrier.

31 ial for normal development of the glomerular filtration barrier.

32 cytes, cells that are a critical part of the filtration barrier.

33 novel role for kidney apoE in preserving the filtration barrier.

34 t to functional impairment of the glomerular filtration barrier.

35 ted for a gradual pressure decline along the filtration barrier.

36 nephrin, an integral component of the kidney filtration barrier.

37 ve to model joint function of the glomerular filtration barrier.

38 all essential for maintaining the glomerular filtration barrier.

39 ck the inherent complexity of the glomerular filtration barrier.

40 to their function in maintaining the kidney filtration barrier.

41 e first barrier to protein in the glomerular filtration barrier.

42 ructure of the glomerulus and the glomerular filtration barrier.

43 and TAZ in podocytes rapidly compromises the filtration barrier.

44 for the structure and function of the kidney filtration barrier.

45 zed adherens junction to ultimately form the filtration barrier.

46 e levels in the maintenance of a functioning filtration barrier.

47 pathways within all layers of the glomerular filtration barrier.

48 essential for the integrity of the kidney's filtration barrier.

49 critical component of the kidney glomerular filtration barrier.

50 he slit diaphragm are essential parts of the filtration barrier.

51 proteins that normally escape the glomerular filtration barrier.

52 rane, a critical component of the glomerular filtration barrier.

53 rane, a critical component of the glomerular filtration barrier.

54 he hydrodynamic resistance of the glomerular filtration barrier.

55 formation and maintenance of the glomerular filtration barrier.

56 podocytes, thereby restoring the glomerular filtration barrier.

57 staining efficient mechanical linkage at the filtration barrier.

58 embrane defines properties of the nephrocyte filtration barrier.

59 uses podocyte fusion and impaired glomerular filtration barrier.

60 slit diaphragm components that regulate the filtration barrier.

61 is critical to ensure integrity of the blood filtration barrier.

62 epresent a key constituent of the glomerular filtration barrier.

63 s with important function for the glomerular filtration barrier.

64 been linked to the maintenance of the kidney filtration barrier.

65 rom neighboring cells to form the glomerular filtration barrier.

66 maintaining the integrity of the glomerular filtration barrier.

67 ed macromolecules and the maintenance of the filtration barrier.

68 hat act as a key component of the glomerular filtration barrier.

69 elial cells that reside along the glomerular filtration barrier.

70 , we confirmed leakage of the size selective filtration barrier.

71 h induced severe edema and disruption of the filtration barrier.

72 evelopment and maintenance of the glomerular filtration barrier.

73 l for the maintenance of a normal glomerular filtration barrier.

74 effacement and impairment of the glomerular filtration barrier.

75 min size selectivity across their glomerular filtration barrier.

76 ural and functional roles in maintaining the filtration barrier.

77 Excess sema3a disrupts the glomerular filtration barrier.

78 he structure and integrity of the glomerular filtration barrier.

79 complex, an important part of the glomerular filtration barrier.

80 synapse formation to formation of the kidney filtration barrier.

81 helial cells that line the kidney glomerular filtration barrier.

82 ural and functional regulation of the kidney filtration barrier.

83 anosensation and the integrity of the kidney filtration barrier.

84 uptake for the maintenance of the glomerular filtration barrier.

85 subepithelial location along the glomerular filtration barrier 14 days after antibody injection, and

86 ells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filte

87 ephropathy (DN) is highlighted by glomerular filtration barrier abnormalities.

88 thereby reducing the physical stress on the filtration barrier, albuminuria, and the oxygen demand f

89 odocytes form the backbone of the glomerular filtration barrier and are exposed to various mechanical

90 nvolved in the maintenance of the glomerular filtration barrier and are key targets of injury in many

91 Podocytes form the kidney filtration barrier and continuously adjust to external s

92 are an essential component of the glomerular filtration barrier and cover the outer aspect of glomeru

93 , these mutants failed to establish a normal filtration barrier and exhibited severe proteinuria due

94 phila nephrocytes form a slit diaphragm-like filtration barrier and express the Nephrin ortholog Stic

95 y role both in maintenance of the glomerular filtration barrier and in glomerular structural integrit

96 tion it imposes added physical stress on the filtration barrier and increases the oxygen demand to dr

97 ndicates structural damage of the glomerular filtration barrier and is associated with poor kidney an

98 drome results from a breakdown of the kidney filtration barrier and is associated with proteinuria, h

99 t nanocage - is able to cross the glomerular filtration barrier and is endocytosed by the renal proxi

100 B-domain protein podocin maintains the renal filtration barrier and its mutation is an important caus

101 e slit diaphragm cell junction at the kidney filtration barrier and part of a multiprotein-lipid supe

102 essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to pro

103 hening this interaction may protect kidney's filtration barrier and preserve kidney function.

104 maintaining the integrity of the glomerular filtration barrier and preventing urinary protein leakag

105 cture, with podocytes forming the glomerular filtration barrier and progenitors being key players in

106 for maintaining their functions in the renal filtration barrier and prompting further investigations

107 maintaining the integrity of the glomerular filtration barrier and provide insight into the pathogen

108 al podocyte proteins cause disruption of the filtration barrier and rearrangement of the highly dynam

109 e effects of VEGFA to protect the glomerular filtration barrier and reduce albuminuria.

110 cal during the development of the glomerular filtration barrier and required for the proper function

111 which are capable of crossing the glomerular filtration barrier and selectively targeting FOLR1-expre

112 acids (NEFAs) across the damaged glomerular filtration barrier and subsequent reabsorption by the do

113 ion of proteins that traverse the glomerular filtration barrier and that is also involved in the exte

114 ssential for the integrity of the glomerular filtration barrier and that this protein is a key determ

115 g technology for the study of the glomerular filtration barrier and the controversy it recently gener

116 at contribute to breakdown of the glomerular filtration barrier and the development of INS.

117 rving as a crucial constituent of the kidney filtration barrier and the latter representing a support

118 the direct injurious effects of TWEAK on the filtration barrier and/or modulation of cytokine product

119 odocyte as a key component of the glomerular filtration barrier, and hence an important common pathwa

120 s are critical to maintaining the glomerular filtration barrier, and mutations in nephrotic syndrome

121 ytes are a major component of the glomerular filtration barrier, and their ability to sense insulin i

122 cytes are key components of the kidney blood filtration barrier, and their ability to withstand hemod

123 at are critical components of the glomerular filtration barrier, and their dysfunction leads to prote

124 cesses are an essential part of the kidney's filtration barrier, and their structure is regulated pri

125 ioning of the slit diaphragm and the overall filtration barrier architecture.

126 Diseases of the kidney's glomerular filtration barrier are a leading cause of end stage rena

127 Diseases of the kidney filtration barrier are a leading cause of ESRD.

128 t are critical in the formation of the renal filtration barrier are found to be regulated in associat

129 onsequently, the integrity of the glomerular filtration barrier are incompletely understood.

130 o, but its in vivo effects on the glomerular filtration barrier are not well described.

131 Podocytes, as an important component of the filtration barrier, are susceptible to lipid disorders.

132 ssential for maintaining a normal glomerular filtration barrier because of its role in modulating DNA

133 tic syndrome (NS) occurs when the glomerular filtration barrier becomes excessively permeable leading

134 the structure and function of the glomerular filtration barrier but little is known about the mechani

135 es is critical to form the normal glomerular filtration barrier, but the molecular programs driving t

136 evelopment and maintenance of the glomerular filtration barrier, but the pathogenic role of excessive

137 ne has the potential to alter the glomerular filtration barrier by compromising the integrity of podo

138 veloped a functional assay of the glomerular filtration barrier by creating transgenic zebrafish expr

139 ins play an important role in the glomerular filtration barrier by keeping the Hippo pathway inactive

140 critical role in maintaining the glomerular filtration barrier by modulating the bioavailability of

141 For example, damage to the glomerular filtration barrier can expose tubular cells to serum pro

142 s glomerular hypertrophy, impairments in the filtration barrier corresponding to microalbuminuria, an

143 s microalbuminuria resulting from glomerular filtration barrier damage.

144 ate for the loss of Lambeta2, leading to the filtration barrier defects and nephrotic syndrome.

145 Proper function of the glomerular filtration barrier depends heavily on the integrity of l

146 of Fat1 in mice induces abnormal glomerular filtration barrier development, leading to podocyte foot

147 for normal kidney patterning and glomerular filtration barrier development.

148 sal end point of podocyte injury, glomerular filtration barrier disruption, and SRNS.

149 pithelial cells that comprise the glomerular filtration barrier, drives albuminuria, proximal tubule

150 o estimate the shear stress challenge to the filtration barrier during glomerular filtration in rats.

151 aining podocytes in vivo could contribute to filtration barrier dysfunction.

152 ould play a role in aging-related glomerular filtration barrier dysfunction.

153 The filtration barrier experiences high levels of shear and

154 layer (ESL) has been postulated to act as a filtration barrier for large molecules, such as albumin.

155 We used electron microscopy to evaluate filtration barrier formation in zebrafish, and Fluo-4 to

156 tein expressed in kidney that is part of the filtration barrier formed by podocytes.

157 docyte differentiation state is critical for filtration barrier function and is regulated by WT1, a z

158 Podocytes are important for glomerular filtration barrier function and maintenance of size sele

159 in human diabetic nephropathy and may alter filtration barrier function and systolic BP through the

160 orphology of podocytes, resulting in loss of filtration barrier function and the development of scler

161 The glomerulus exercises its filtration barrier function by establishing a complex fi

162 d apoptosis, hypermotility and impairment of filtration barrier function equally in primary podocytes

163 ic cell lineage specification and glomerular filtration barrier function using a combination of CRISP

164 podocytes using Western blotting, glomerular filtration barrier function using in vitro albumin perme

165 cyte differentiation and impaired glomerular filtration barrier function, with development of pericar

166 sion of differentiation markers and improved filtration barrier function.

167 role for tmem63c in mediating the glomerular filtration barrier function.

168 calyx layer resulted in perturbed glomerular filtration barrier function.

169 wledge about podocyte biology and glomerular filtration barrier function.

170 ents of urinary albumin excretion to analyze filtration barrier function.

171 ith the glomerular capillary bed to maintain filtration barrier function.

172 for maintenance of glomerular endothelia and filtration barrier functional integrity, respectively.

173 e subepithelial space because the glomerular filtration barrier (GFB) is size selective and almost im

174 on podocyte protection within the glomerular filtration barrier (GFB).

175 characterized by breakdown of the glomerular filtration barrier (GFB).

176 rculating factors that damage the glomerular filtration barrier have been described.

177 nd nitric oxide are essential for glomerular filtration barrier homeostasis and are dysregulated in d

178 is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization

179 the structure and function of the glomerular filtration barrier; however, they also exhibit increased

180 uggest that albumin loss through the damaged filtration barrier impairs podocyte regeneration by sequ

181 a direct protective effect on the glomerular filtration barrier in FSGS.

182 xamined the effect of morphine on glomerular filtration barrier in general and podocyte integrity in

183 the structure and function of the glomerular filtration barrier in the adult kidney.

184 Podocytes help form the glomerular blood filtration barrier in the kidney and their injury or los

185 As an integral member of the filtration barrier in the kidney glomerulus, the podocyt

186 ized cells of the kidney that form the blood filtration barrier in the kidney glomerulus.

187 erminally differentiated cells that act as a filtration barrier in the kidney.

188 process effacement on long stretches of the filtration barrier in the zebrafish knockdown model and

189 The kidney glomerulus is a filtration barrier in which capillary loop architecture

190 calyx in protein leakage over the glomerular filtration barrier, in an immunogold labeling study of i

191 d in diseases that compromise the glomerular filtration barrier, including diabetic kidney disease an

192 ria accompanied by structural changes in the filtration barrier, including podocyte foot process effa

193 Morphological alterations at the kidney filtration barrier increase intrinsic capillary wall per

194 we found that the ion channel TRPC5 mediates filtration barrier injury.

195 nstitute an external layer of the glomerular filtration barrier, injury to which is a hallmark of ren

196 morphogenesis and maintenance of glomerular filtration barrier integrity is poorly understood.

197 he SHROOM3 locus on chromosome 4 (glomerular filtration barrier integrity) (odds ratio 0.95 (95% conf

198 rafish morphants caused a loss of glomerular filtration barrier integrity, podocyte foot process effa

199 controlling GBM composition, and sustaining filtration barrier integrity.

200 ng an important role of THSD7A in glomerular filtration barrier integrity.

201 define its role in maintenance of glomerular filtration barrier integrity.

202 sually caused by deterioration of glomerular filtration barrier integrity.

203 of renal disease owing to the disruption of filtration barrier integrity.

204 erular pathophysiology and disruption of the filtration barrier is associated with alternative splici

205 ases, loss of size selectivity by the kidney filtration barrier is associated with changes in the mor

206 Remarkably, when the glomerular filtration barrier is breached, the PT is able to recove

207 The kidney filtration barrier is comprised of the endothelial linin

208 ate of internalization is increased when the filtration barrier is disrupted.

209 Impairment of the glomerular filtration barrier is in part attributed to podocyte foo

210 The glomerular filtration barrier is known as a 'size cutoff' slit, whi

211 sis regulates the slit diaphragm and how the filtration barrier is maintained without either protein

212 plex cellular architecture of the glomerular filtration barrier is not recapitulated in vitro, repres

213 ship with other components of the glomerular filtration barrier is of great interest in this field.

214 the central question of whether the primary filtration barrier is the basement membrane or the epith

215 An essential part of the filtration barrier is the slit diaphragm, a multiprotein

216 Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth facto

217 gm (SD), the major constituent of glomerular filtration barrier, is still unclear.

218 terations to the structure of the glomerular filtration barrier lead to effacement of podocyte foot p

219 injures podocytes and damages the glomerular filtration barrier leading to albuminuria in mice.

220 th glomerular diseases have an injured renal filtration barrier, leading to proteinuria and reduced r

221 isruption of any component of the glomerular filtration barrier leads to glomerular dysfunction, freq

222 Ctnnb1 expression is critical for glomerular filtration barrier maintenance.

223 To study the function of Crb2 at the renal filtration barrier, mice lacking Crb2 exclusively in pod

224 Glycosaminoglycans (GAGs) contribute to the filtration barrier of aqueous outflow through the trabec

225 Podocytes are critical in maintaining the filtration barrier of the glomerulus and are dependent o

226 tes are critical components of the selective filtration barrier of the glomerulus and are susceptible

227 he delivery of therapeutic agents across the filtration barrier of the glomerulus.

228 Ultrastructurally, the glomerular filtration barrier of the Gsalpha-deficient animals feat

229 ocyte is a critical cell for maintaining the filtration barrier of the kidney and preventing albuminu

230 adherens junction that comprises the protein filtration barrier of the kidney, and interacts with a n

231 he integrity of podocytes and the glomerular filtration barrier of the kidney.

232 entiated cells and critical elements for the filtration barrier of the kidney.

233 a central role in maintaining the selective filtration barrier of the renal glomerulus.

234 changes in ultrastructure of the glomerular filtration barrier on the vascular side of the glomerula

235 he hydrodynamic forces across the glomerular filtration barrier, our data provide insight into how po

236 mpression, inflammation, fibrosis, increased filtration barrier permeability and renal nerve activity

237 ocal segmental glomerulosclerosis, increased filtration barrier permeability is restricted only to ar

238 The glomerular filtration barrier prevents large serum proteins from be

239 The mechanisms by which the glomerular filtration barrier prevents the loss of large macromolec

240 Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm

241 The health of the kidney filtration barrier requires communication among podocyte

242 Maintenance of the kidney filtration barrier requires coordinated interactions bet

243 Damage to the filtration barrier results in albumin loss in the urine,

244 The loss of integrity of the glomerular filtration barrier results in proteinuria that is often

245 terogeneous disorder of the renal glomerular filtration barrier, results in impairment of glomerular

246 A functional assay of glomerular filtration barrier revealed that absence of normal nephr

247 oteins, suggesting failure of the glomerular filtration barrier sieving properties, or different coll

248 marker EMCN in supporting normal glomerular filtration barrier structure and function by maintaining

249 y prevented albuminuria, restored glomerular filtration barrier structure, and markedly reduced glome

250 lls, particularly for cells constituting the filtration barrier, such as podocytes.

251 nephrocyte features a molecularly conserved filtration barrier, suitable for whole-animal screening

252 ialized epithelial cells of the kidney blood filtration barrier that contribute to permselectivity vi

253 ant role in maintaining the structure of the filtration barrier that prevents proteins from freely en

254 as an essential component of the glomerular filtration barrier that promotes podocyte survival by in

255 The glomerular capillaries function as the filtration barrier that retains albumin and other plasma

256 In this work we model the glomerular filtration barrier, the structure responsible for filter

257 Here, we show that a component of the renal filtration barrier--the glomerular basement membrane (GB

258 gial matrix is associated with disruption of filtration barrier, these data suggest a novel role for

259 s involved in the response of the glomerular filtration barrier to injury, we studied freshly isolate

260 of enormous volumes of plasma, exposing the filtration barrier to mechanical forces.

261 rminant required for the kidney's glomerular filtration barrier to plasma protein.

262 of dynamin in the maintenance of the kidney filtration barrier via an action on the actin cytoskelet

263 which podocytes sense the disruption of the filtration barrier via FFAs bound to albumin and respond

264 lay an integral role in the renal glomerular filtration barrier via their foot processes.

265 The ultrastructure of the glomerular filtration barrier was examined by transmission electron

266 his severe charge disruption, the glomerular filtration barrier was not compromised, even when challe

267 ient's serum on podocytes and the glomerular filtration barrier we used a podocyte cell culture model

268 se lesions and dysfunction of the glomerular filtration barrier were associated with FSGS in endothel

269 ucidated that murine cells of the glomerular filtration barrier were unresponsive to Stx2 because the

270 for particular components of the glomerular filtration barrier) were used to determine the exact loc

271 ial-podocyte crosstalk across the glomerular filtration barrier, whereby the actions of one type of c

272 a major challenge because of the glomerular filtration barrier, which effectively excludes conventio

273 calyx is a vital component of the glomerular filtration barrier, which limits the filtration of macro

274 bstacles to treatment include the glomerular filtration barrier, which restricts access of many thera

275 as an essential component of the glomerular filtration barrier, yet little is known about how they a