ライフサイエンスコーパス: fine-tuning of

1 how that ABHD6 inhibition in vivo allows for fine-tuning of 2-AG levels in mice, therefore reducing l

2 Fine tuning of a previously reported imino-acid directin

3 ng from bacteria to humans; this facilitates fine-tuning of activities from signaling to catalysis.

4 linkers of the framework allow for chemical fine-tuning of activity and stability and, perhaps most

5 mics vary between neuronal classes to enable fine-tuning of adaptive circuit responses.

6 genera also contribute to microevolutionary fine-tuning of adaptive traits within some species.

7 DCs, the action of which contributes to the fine-tuning of Ag cross-presentation.

8 , Crem loss-of-function mutation resulted in fine-tuning of all measured adrenal clock genes (Per1/2/

9 sent select examples of functional molecular fine-tuning of allosterism and discuss consequences rele

10 ernatively spliced, but the significance and fine-tuning of alternative splicing in different biologi

11 We report that this fine tuning of ATP and O2(.-) levels by cooling controls

12 t-dark regulation, mothra retained wild-type fine-tuning of ATP synthase activity in response to chan

13 e multiple levels of regulation that grant a fine tuning of BCL6 expression and activity in physiolog

14 e for mounting novel responses and decreased fine-tuning of BCR specificities by somatic hypermutatio

15 Our results show that fine-tuning of BCR-ligand recognition can lead to B cell

16 ur data suggest that PIST contributes to the fine-tuning of beta1AR sorting both during biosynthetic

17 We show a strict fine-tuning of binding and sequence-dependent alteration

18 eature double covalent dynamics allowing for fine-tuning of both exchange and incorporation processes

19 to damaged chromatin, ZMYM3 facilitates the fine-tuning of BRCA1 interactions with DNA damage sites

20 rial function that negatively impacts on the fine tuning of Ca(2+) dynamics.

21 Thus, the fine tuning of Ca(2+) signals plays a key role in shapin

22 M is influenced by calcium, allowing further fine-tuning of Ca(V)1.3 channel activity for particular

23 nabled model provides insights into thermal "fine-tuning" of carbohydrate metabolism and a warning th

24 te complex with actin and myosin that allows fine tuning of cardiac muscle contraction.

25 This vital function is based on the fine-tuning of cardiac performance by the Frank-Starling

26 es of novel UAS-Cas9 transgenes, which allow fine tuning of Cas9 expression to achieve high gene edit

27 whether it leads to cell death or LTD, thus fine-tuning of caspase-3 activation is critical in disti

28 Such location sensitivity may reflect fine-tuning of category-specific visual processing to re

29 city of the CBC:HapX:DNA interaction permits fine tuning of CBC:HapX binding specificities that could

30 lar body and repair of adult tissues require fine--tuning of cell adhesion, cell mechanics, and inter

31 are water channel proteins that mediate the fine-tuning of cell membrane water permeability during d

32 different plexins and co-receptors to allow fine-tuning of cell signalling.

33 material properties of the cell wall and the fine-tuning of cellular biophysical parameters in the mu

34 of KSRP destabilizes CX3CL1 mRNA, providing fine-tuning of cellular inflammatory reactions in respon

35 TIP isoforms allow the spatial and temporal fine-tuning of cellular water transport, which is critic

36 eful properties that can be tailored through fine-tuning of certain parameters, such as size, shape a

37 the Weyl semimetal state does not depend on fine-tuning of chemical composition or magnetic order, w

38 This provides a mechanism for acute fine-tuning of cholesterol transporter activity in respo

39 ation dynamics play an intricate role in the fine-tuning of chromatin states during periodontal devel

40 ase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditi

41 dium influence on fluorescence, allowing the fine tuning of color.

42 Sensing membrane curvature allows fine-tuning of complex reactions that occur at the surfa

43 Fine-tuning of compound properties was achieved by small

44 Fine tuning of conditions will be needed for other amino

45 Finally, we propose that precise fine-tuning of conduction along already-myelinated axons

46 and Arp2/3 and suggest a mechanism for rapid fine-tuning of cortex structure and mechanics by adjusti

47 Besides physiological fine-tuning of cytokine signals, altering the nature or

48 Fine-tuning of cytokine-inducing pathways is essential f

49 Subsequently, fine-tuning of cytokinin metabolism by root-specific exp

50 calization and activity, suggesting that the fine-tuning of DA homeostasis involves multiple mechanis

51 ating that m(6)t(6)A plays a general role in fine-tuning of decoding in organisms from bacteria to ma

52 btle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites.

53 ge remains to identify guidelines that allow fine-tuning of detergents for individual applications in

54 al stresses that require the involvement and fine-tuning of different stress signaling pathways.

55 ebbian-type learning rules and contribute to fine-tuning of distinct aspects of inhibitory function m

56 ebbian-type learning rules and contribute to fine-tuning of diverse aspects of inhibitory function me

57 recognition and metabolizing activities for fine tuning of DNA repair processes.

58 e of the nucleocytosolic compartment and the fine-tuning of dNTP levels for chloroplast translation a

59 Fine-tuning of electron-poor aromatic rings in position

60 n which structural changes are necessary for fine-tuning of electronic properties.

61 indings point at resource partitioning and a fine-tuning of enzyme levels in E. coli to respect the c

62 suggesting that neoGATA3 interferes with the fine tuning of ER-dependent gene expression.

63 We conclude that a fine tuning of ERK1/2 signaling strength is critically i

64 based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis pa

65 and increase efficiency of neural function, fine-tuning of excitatory and inhibitory neurotransmitte

66 nominal M n+1AX n compounds enables not only fine tuning of existing properties but also entirely new

67 This may contribute to the fine tuning of expression of the denitrification respiro

68 These adjustments involve fine-tuning of expression levels and mutual interactions

69 bacterial optogenetic control, allowing the fine-tuning of expression levels, programming of tempora

70 our results demonstrate for the first time a fine-tuning of FACT by a ubiquitin proteasome system in

71 vation, "envelope docking" of ACCase permits fine-tuning of fatty acid supply during the plant life c

72 This may enable fine-tuning of filament switching in the cell.

73 LC-SOC1 signaling network contributes to the fine-tuning of flowering during changing seasons.

74 ent advances in the design, preparation, and fine-tuning of fluorophores by means of multicomponent r

75 ferentiation during embryogenesis and in the fine-tuning of fundamental biological processes, such as

76 MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human

77 Fine-tuning of G(K1) is an important step in DC experime

78 This fine tuning of GAL1/glycan interactions may be a strateg

79 , in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide ran

80 Instead, they control the fine-tuning of gene expression and ensure regulatory pre

81 regulation is an important mechanism for the fine-tuning of gene expression via 3'-untranslated regio

82 mRNA decay mechanisms suggests selection for fine-tuning of gene expression.

83 uf3p plays a broad, but nuanced, role in the fine-tuning of gene expression.

84 criptional regulation of RNA facilitates the fine-tuning of gene expression.

85 ors of circadian regulation that mediate the fine-tuning of gene expression.

86 in function of m(6)A is post-transcriptional fine-tuning of gene expression.

87 A-mediated feedback and feedforward loops in fine-tuning of gene expression; (ii) the miRNA-target in

88 o protein is fundamentally important for the fine-tuning of gene expression; additionally, precise tr

89 ese data highlight a global coordination and fine-tuning of gene regulation during stress that mostly

90 , REST is essential for experience-dependent fine-tuning of genes involved in synaptic plasticity.

91 nt of two independent H3.3 genes facilitates fine-tuning of H3.3 expression across cellular programs.

92 This process plays a fundamental role in the fine-tuning of HCN channel activity and is critical for

93 The results show that conformational fine-tuning of helical pore-forming peptides is a powerf

94 nd AtPMEI7 could be partners involved in the fine tuning of HG methylesterification during plant deve

95 tions as a mucosal protective factor through fine tuning of HIF activity.

96 Thus, we have discovered that fine-tuning of HlyA expression by the CpxRA system is cr

97 ty while minimizing P-gp mediated efflux was fine-tuning of hydrogen bond acceptor basicity.

98 that IL-15 has a negative regulatory role in fine-tuning of IL-17A production and Th17-mediated infla

99 Therefore, precise fine-tuning of IL-2 expression is crucial for adjusting

100 , cell trafficking to sites of inflammation, fine-tuning of immune responses leading to activation or

101 appear during the catalytic cycle may allow fine-tuning of inhibitor discovery efforts.

102 ral circuits, which often requires exquisite fine-tuning of inhibitory connections.

103 Thus, fine-tuning of innate immunity depends on optimization o

104 advances, in particular how pharmacological fine-tuning of innate/adaptive immunity and its combinat

105 Fine-tuning of insulin release from pancreatic beta-cell

106 topes on the same target molecule may enable fine-tuning of intracellular delivery based on the hemod

107 rol of thickness thus enables generation and fine-tuning of intrinsic strain to optimize catalytic re

108 oped by cytochrome c for the solvent driven, fine-tuning of its redox functionality.

109 that this expansion of the JAZ family allows fine-tuning of JA-mediated transcriptional responses.

110 to regulation at multiple levels that allow fine-tuning of key biological responses.

111 ively stimulate abortive termination without fine-tuning of kinetic rate parameters at ribosome stall

112 Fine-tuning of Kv1.1 surface expression by RNA editing m

113 Thus, the fine-tuning of Kv1.3 function is crucial for the immune

114 NHCs and provides a guide to the structural fine-tuning of ligand requirements and stereochemical mo

115 -red- and blue/UV-sensing pathways, enabling fine-tuning of light responses to different spectral inp

116 The results suggest that efficient fine-tuning of light-induced quantum behavior mediated v

117 HY5, downregulating BBX22 expression for the fine-tuning of light-mediated seedling development.

118 ntiation and offer a potential mechanism for fine tuning of lineage-restricted transcription factors

119 Both organs rely on fine tuning of local blood flow to match metabolic deman

120 findings provide a framework for structural fine-tuning of LOV scaffold proteins to maximize their p

121 ate the method's accuracy and to demonstrate fine-tuning of marker density as needed.

122 Tissue modulation is dependent on the fine-tuning of mechanical forces that are transmitted in

123 he body of work on the synthesis and optical fine-tuning of meso-aryl-substituted bacteriochlorins.

124 ation by promoting Tnfaip3 transcription and fine-tuning of metabolic reprogramming in macrophages.

125 The fine tuning of metabolism and hERG followed by different

126 icate that RASSF1A is a key regulator in the fine tuning of microtubule dynamics in interphase cells

127 n underscores the importance of SLC25A46 and fine tuning of mitochondrial fission and fusion in ponto

128 the tissue-specific regulation of OXPHOS and fine tuning of mitochondrial translation accuracy.

129 miRNAs are crucial for fine-tuning of molecular mechanisms.

130 tween its various metastable states, through fine-tuning of molecular packing in a reproducible manne

131 lopments in materials, thin-film processing, fine-tuning of morphology, and optimization of device fa

132 ubiquitinase interactions and imply that the fine tuning of motion has played a key role in the evolu

133 for a variety of processes, ranging from the fine-tuning of motor skill learning to important social

134 tive valorisation of lignin requires careful fine-tuning of multiple "upstream" (i.e., lignin bioengi

135 s that MYB182 plays an important role in the fine-tuning of MYB134-mediated flavonoid metabolism.

136 ct with other G(i)-coupled receptors for the fine tuning of neuronal activity.SIGNIFICANCE STATEMENT

137 8.0, a property likely to participate in the fine tuning of neuronal membrane potential and to neuron

138 s without requiring any form of learning, or fine-tuning of neuronal parameters to replicate these re

139 he involvement of the receptor mGluR5 in the fine-tuning of NMDA receptors, specifically in the conte

140 d suggests that the Paf1C contributes to the fine tuning of nuanced levels of regulation that exist a

141 These data demonstrate miR-644a mediated fine-tuning of oncogenesis, stimulating pathways and res

142 in this compound correlates closely with the fine-tuning of one of the band-edge singularities to wit

143 ensures site-specific NCP ubiquitination and fine-tuning of opposing enzymatic activities.

144 The fine-tuning of optical and switching properties relies o

145 ranscription factors and coregulators in the fine tuning of organismal metabolism.HDAC3 is a critical

146 en ITAM and RANK/TNFR signaling and allowing fine tuning of osteoclastogenesis during bone homeostasi

147 echanism refined by evolution to allow for a fine tuning of p38alpha kinase activity.

148 signaling downstream of p53 and allowed the fine tuning of p53-induced senescence by N-WASP.

149 unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a gener

150 lead to scale-invariant dynamics without any fine tuning of parameters or other model-specific constr

151 nd alternative platforms that do not require fine-tuning of parameters and can be easily scaled to la

152 s to realize MF, however, generally requires fine-tuning of parameters.

153 ith remarkable precision, without fitting or fine-tuning of parameters.

154 ial counterregulatory role of EBV miR in the fine-tuning of PD-L1/L2 expression remains to be establi

155 nctional conformations, this enzyme exerts a fine-tuning of phosphorylation signals.

156 These results give fresh insight into fine tuning of photophysical and chiroptical properties

157 icity and anisotropy, can further permit the fine-tuning of plasmon behaviors in borophene, potential

158 osine modulation may provide a mechanism for fine-tuning of plasticity and learning according to brai

159 Fine-tuning of pore size, shape, and chemistry afforded

160 s protein recoding by RNA editing allows for fine tuning of protein function.

161 criptome diversification is required for the fine-tuning of protein expression in monocytes, suggesti

162 tudy was to demonstrate the optimization and fine-tuning of quantitative and nonselective analysis of

163 crutinity of polymerization outcomes and the fine-tuning of reaction conditions.

164 eceptor-interacting proteins also facilitate fine-tuning of receptor activity and tissue specificity.

165 m memory, which is robust to noise and where fine-tuning of recurrent excitation or inclusion of sub-

166 ivation in multidomain proteins allowing for fine tuning of regulatory mechanisms.

167 ortant role in accelerating the evolutionary fine-tuning of regulatory networks.

168 rved physiological role for Oma1 protease in fine-tuning of respiratory function.

169 trograde signaling pathways is essential for fine-tuning of responses to the prevailing environmental

170 e, to our knowledge, for the first time that fine-tuning of ROS production by RhoA, through a delicat

171 frequency of specific T cells depends on the fine-tuning of several parameters, the structural determ

172 roles in RNA processing, contributing to the fine-tuning of specific signaling pathways.

173 ays between pump and probe pulses allows for fine tuning of spectral resolution, bandwidth and imagin

174 The fine-tuning of stoichiometry and organization is realize

175 y of the mPFC and its projections are key to fine-tuning of stress responses and adaptation.

176 l pathways have been suggested to accomplish fine-tuning of stress responses at the expense of growth

177 natural environment requires cross-talk and fine-tuning of stress signalling pathways.

178 Fine-tuning of such balance requires synaptic plasticity

179 Fine-tuning of such nucleic acid-free protein machines f

180 However, rational fine-tuning of such responsive properties is very desira

181 n many interacting components that allow for fine-tuning of switching and memory properties.

182 central role of AMPARs in neurobiology, the fine-tuning of synaptic AMPA responses by endogenous mod

183 privation, 2-AG signaling may play a role in fine-tuning of synaptic strengths via presynaptically-ex

184 going autoimmune responses through the local fine tuning of T-cell-receptor-proximal activation event

185 epresent molecular tools for transcriptional fine tuning of target genes.

186 unctional characteristics now allows for the fine-tuning of targeting strategies.

187 The dynamic fine-tuning of tendon ECM composition and assembly thus

188 al search efficiency but enables rapid local fine-tuning of TF search parameters.

189 roteolysis thus provide mechanisms for rapid fine-tuning of TFAM function and abundance in mitochondr

190 e novel mechanism proposes the DDB2-mediated fine-tuning of TGF-beta signaling and its downstream eff

191 Thus, the fine tuning of TGFbeta signalling derives from positive

192 e grooves on an amyloid fibril, resulting in fine tuning of the binding affinities for a specific amy

193 bond-breaking elementary steps and thus the fine tuning of the biological repair function for optima

194 unctional group of the dipolarophile and the fine tuning of the catalyst plays an important role in p

195 While allowing for a fine tuning of the catalytic properties through ligand d

196 3+2] side pathway could be suppressed though fine tuning of the conditions.

197 ls whose synthesis critically depends on the fine tuning of the crystal growth and error correction r

198 Fine tuning of the emission characteristics through stru

199 ed regions of imprinted genes, an additional fine tuning of the expressed allele is achieved by a mod

200 r level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and li

201 nd TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular sy

202 ence suggests that galectin-3 is involved in fine tuning of the inflammatory responses at the periphe

203 y determined new patterns can be achieved by fine tuning of the initial microstructure.

204 This structure was obtained through fine tuning of the linker lengths between the core and t

205 of a Nedd8-moiety to Cullin proteins) in the fine tuning of the NF-kappaB response (via Cullin-1).

206 Fine tuning of the protein folding environment in subcel

207 The fine tuning of the regulation of CCD represents a novel

208 (usually life history) time frames, offering fine tuning of the response to environmental context.

209 a series of lanthanide-based MOFs that allow fine tuning of the sheet stacking.

210 dings illustrate that Sox4 mediates critical fine-tuning of the 2 opposing forces in early B-cell dev

211 screening platform promises to enable rapid fine-tuning of the ABA sensors and engineering of plant

212 sites) indicate that AtNBR1 is essential for fine-tuning of the ABA signalling pathway.

213 ds for RGD-recognizing integrin subtypes; 5) fine-tuning of the affinity and selectivity by additiona

214 the folding of the aptamer, allows rational fine-tuning of the affinity of our model aptamer across

215 Following fine-tuning of the anesthetic regime, stimulation elicit

216 in that it enables the flexible control and fine-tuning of the aspect ratio and the plasmonic resona

217 The results showed a fine-tuning of the binding properties of [8]CPP 1 toward

218 By capitalizing on a more precise genetic fine-tuning of the biotin-binding vestibule, unrivaled l

219 potential mechanism for the maintenance and fine-tuning of the BMP signaling pathway in various syst

220 Fine-tuning of the bone morphogenetic protein (BMP) path

221 bolites biliverdin IXbeta and IXdelta, allow fine-tuning of the cell-surface signaling system in resp

222 n receptor trafficking and signaling for the fine-tuning of the cellular response.

223 ffinity to the substrate-binding pocket, and fine-tuning of the chemical composition of the polymer t

224 Breaking this symmetry allows fine-tuning of the circumference, providing better contr

225 ication and amplification may be followed by fine-tuning of the cis-regulatory element supplied by th

226 In addition, fine-tuning of the crystal structure by changing the cry

227 The fine-tuning of the degree of methylesterification of cel

228 n or peptide-based imaging probes and allows fine-tuning of the desired blood half-life, because long

229 In this unconventional approach, a fine-tuning of the dihedral angle between the C4 phenyl

230 Fine-tuning of the EBX reagents allows optimization of t

231 The fine-tuning of the electronic properties and redox poten

232 An easy synthetic approach has enabled the fine-tuning of the electronic structure of the organobor

233 ion of excitation and inhibition and enables fine-tuning of the excitation-inhibition balance.

234 (reg) depended on PD-1 expression and that a fine-tuning of the expression of this molecule directly

235 rent solvent systems, as key factors for the fine-tuning of the extraction properties, are discussed.

236 propose a general mechanism that enables the fine-tuning of the Fermi velocity in Dirac materials in

237 This work provides new insight into the fine-tuning of the flavin cofactor in offsetting the inn

238 es at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination.

239 tigen insertion site and vector dose allowed fine-tuning of the in vivo growth and immunogenicity of

240 tential therapeutic target that could enable fine-tuning of the integrated stress response for benefi

241 r, human LCN2-R-NTD could be involved in the fine-tuning of the interaction between NGAL and its cell

242 l bursting individually allows combinatorial fine-tuning of the level of MHC class I gene expression

243 In conclusion, fine-tuning of the levels of EBOV GP expressed at the su

244 ata suggest that it might be involved in the fine-tuning of the life span and function of activated D

245 bis(diphenylphosphino)amine (DPPA) allows a fine-tuning of the ligand properties and offers a consid

246 ystematic study, we show that the structural fine-tuning of the linkers allows access to variations i

247 Fine-tuning of the maintenance of lysogeny is facilitate

248 ocked a versatile toolbox for the design and fine-tuning of the material properties of these hydrogel

249 y acquisition, possibly allowing more subtle fine-tuning of the maturation process.

250 hes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjus

251 rinciples of mu-EME transfer enabled further fine-tuning of the mu-EME process.

252 ial for improving the material properties by fine-tuning of the nanoscale architecture.

253 hylenediamine kappa pharmacophore allows the fine-tuning of the pharmacodynamic and pharmacokinetic p

254 These modifications allowed for fine-tuning of the photoluminescence (PL) and ECL emissi

255 Fine-tuning of the pluripotency program is executed by a

256 uch polyplex formulation and determined that fine-tuning of the polyplex structure is essential for e

257 antly, the ligands on the boronate allow for fine-tuning of the properties and reactivity of acylboro

258 This allows a fine-tuning of the properties of these macrocycles throu

259 gory, essential design parameters that allow fine-tuning of the properties of these magnetic responsi

260 lish successfully this challenging coupling, fine-tuning of the reaction conditions were required.

261 arylpalladium insertion was controlled by a fine-tuning of the reaction system, which provided regio

262 this deacetylase proteome could lead to the fine-tuning of the regulation of microtubule dynamics an

263 on of RNA/codon-optimized gene sequences and fine-tuning of the relative expression levels of the two

264 noncovalent attractive interactions through fine-tuning of the remote substituents of the D(2)-symme

265 ty of GAIT elements may provide hierarchical fine-tuning of the resolution of inflammation.

266 nd aryl boronate coupling partners, allowing fine-tuning of the resultant macrocycle conformation.

267 trolled reactivity and achieved quantitative fine-tuning of the self-assembled structures.

268 This enabled fine-tuning of the separation conditions for each indivi

269 sition 7 of quinolinone ring combined with a fine-tuning of the substituents on the benzyl group in p

270 be integrated into one single 2.5 nm AuNP by fine-tuning of the surface coverage; a ratiometric pH re

271 s within the IleRS.tRNA complex, whereas the fine-tuning of the synthetic site is attained via confor

272 Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal

273 This striking cooperativity switch enables fine-tuning of the thermodynamic accessibility of the te

274 This fine-tuning of the transcriptome between different neuro

275 teroaromatic moiety provided a means for the fine-tuning of the UV/vis absorption and emission spectr

276 lin head domain, as well as protein-specific fine-tuning of the VBS sequence, including sequence inve

277 Golgi trafficking and thus contribute to the fine-tuning of the water permeability of the plasma memb

278 the cell membrane, their activation and the fine tuning of their biophysical properties are all dram

279 This allows for the fine tuning of their optical and electrochemical propert

280 rsity of their building blocks, which allows fine-tuning of their chemical and physical properties by

281 plication in molecular electronics is in the fine-tuning of their electronic properties through struc

282 ir detailed atomic structures, which enables fine-tuning of their functionalities for desired applica

283 Our results demonstrate that fine-tuning of their photophysical properties can be obt

284 ar design of these detergents, we anticipate fine-tuning of their properties for specific application

285 , plays an important role in the control and fine-tuning of these stress responses.

286 Fine-tuning of this network becomes crucial during infec

287 ampal circuits throughout adulthood, and the fine-tuning of this process is likely important for effi

288 Here we explore how the fine-tuning of this unique replication system and the me

289 is landscape that allows for both gross- and fine-tuning of tissue oxygen unloading to meet the disti

290 This mechanism likely participates in fine-tuning of transcript levels in response to differen

291 s of tissue-specific genes and to facilitate fine-tuning of transcription in the human genome.

292 Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morp

293 ssor activity and might be important for the fine-tuning of transcription regulation within this regi

294 interactions at these loci contribute to the fine-tuning of transcription.

295 Such a mechanism would permit the fine-tuning of transcriptional networks during different

296 offer untapped opportunities for therapeutic fine-tuning of Tregs and their all-important restraint o

297 he aortic microenvironment landscape and the fine-tuning of various factors interacting to control he

298 n knowledge from the literature and requires fine-tuning of very few parameters.

299 litate host adaptation through sRNA-mediated fine-tuning of virulence gene expression.

300 tegy to maintain vascular quality control by fine-tuning of VSMC phenotypic switching.