ライフサイエンスコーパス: finely

1 y, and therefore ROS levels must be balanced finely.

2 tor, which capture the mediator process more finely.

3 Our data demonstrate that Tregs can finely adapt, or even subvert, their classical inhibitor

4 ns, volume, and duration of incubations were finely adapted with respect to the surface probe density

5 f strategies for molecular biosensing over a finely adjustable dynamic range is essential for underst

6 rphology of the bee proboscis is shown to be finely adjusted to the floral morphology and nectar prod

7 lts indicate the presence of mechanisms that finely align the cytoskeleton of the axon with the one o

8 anocrystals, we use gentle chemical means to finely and reversibly tune the nanocrystal band gap over

9 etry of the substrate-NAD(+) interactions is finely arranged to promote hydride transfer.

10 Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic en

11 Plants need to finely balance resources allocated to growth and immunit

12 ted using a numerical model, demonstrating a finely balanced expression range that is essential to su

13 These findings define a finely balanced homeostatic mechanism involving PTH and

14 The mechanisms by which these finely balanced mechanotransduction events occur, howeve

15 Immune regulation is a finely balanced process of positive and negative signals

16 ledge potential pitfalls-hyperstimulation of finely balanced receptor-ligand interactions could also

17 Signalling by Wnt proteins is finely balanced to ensure normal development and tissue

18 rdered enhanceosome assembly to maintain the finely balanced transcription program underlying naive p

19 ynamically forms aggregates and disrupts the finely-balanced gene control mechanisms in neuronal cell

20 ole of the miR858-MYB83 regulatory system in finely balancing gene expression patterns during H. scha

21 Our results show that Notch signaling is finely calibrated in the cochlea to produce precisely tu

22 s linear and nonlinear features were able to finely characterize the affective haptic perception, wit

23 Four bentonites were adopted and finely characterized together with the potential release

24 Here we show how liquids can be used to finely control disorder in porous 3D photonic crystals,

25 and favorable electrostatic interactions to finely control nucleotide signaling.

26 We demonstrate a strategy to trigger and finely control the assembly of supramolecular DNA nanost

27 en relies on molecular-scale nucleators that finely control the kinetics and structural features.

28 beam lithography offers us the capability to finely control the structure of silk proteins in two and

29 n frequency detuning, with frequency spacing finely controllable over seven orders of magnitude (10 h

30 The reported dealkylation reactions are finely controlled by the annealing parameters, which gov

31 ll as their electrocatalytic properties were finely controlled by varying the weight percentages of t

32 my, either by iterative treatment or through finely controlled expression of mtZFN, which limits off-

33 acid (AA) in the final block copolymer were finely controlled from 0.25 to 0.94, and the molecular w

34 gineers is the extracellular matrix (ECM); a finely controlled in vivo niche which supports hepatocyt

35 oper brain development and function requires finely controlled mechanisms for protein turnover, and d

36 (BTO)/poly(dimethylsiloxane) membranes with finely controlled parallel, zigzag, and mosaic patterns

37 astating diseases, replication is robust and finely controlled to maintain genome stability and funct

38 , mixing and mass and heat transport are all finely controlled, and are easily modulated.

39 em cells to proliferate and differentiate is finely controlled.

40 lopment, the degree of pigmentation could be finely controlled.

41 ace areas of nanomaterials to yield massive, finely-controlled, and stable changes in the Seebeck coe

42 This study suggests a paradigm for finely controlling the activity of DEAD-box proteins to

43 capable of processing biochemical inputs and finely controlling the assembly of DNA-based nanostructu

44 temperature of 120 K are in-situ obtained by finely controlling the oxidation reaction.

45 regulation of MT stability by p27(kip1) and finely controlling the spatiotemporal activation of the

46 nipulations on the performance of a complex, finely coordinated dexterous skill, we optogenetically s

47 This thus defines a feed-forward cycle that finely coordinates plant growth and nutrition.

48 ics, especially flexible RF electronics with finely defined patterns, thereby significantly broadenin

49 and dissolution of many RNP condensates are finely dependent on the RNA-to-RNP ratio, giving rise to

50 teen interactions in stabilizing the system, finely depicting the time-dependent disruption of the hy

51 By finely designing the curvature and torsion, double-stran

52 indings from these studies we have secured a finely detailed picture of the molecular structure of cr

53 of an Excel-based static cohort model with a finely disaggregated age structure.

54 Here we describe the growth of a finely dispersed array of anchored metal nanoparticles o

55 apping mechanism may be the incorporation of finely dispersed V-Mo-Nb carbides in a ferrite matrix.

56 g of a white-gold metallic glass matrix with finely dispersed yellow-gold microdendrites are explored

57 techniques have provided the opportunity to finely dissect cellular heterogeneity within populations

58 arly floral development in Aquilegia at four finely dissected developmental stages, with eight biolog

59 Using finely disseminated carbonates precipitated in paleosols

60 vasive tumor cells were typically round with finely divided, granular, or smudgy chromatin without pr

61 onal catalysts, synergistic interactions are finely engineered through modulating the degree of freed

62 luorescently labeled cells rapidly transit a finely focused, frequency-modulated laser beam.

63 e capacities and behaviors allowed T. rex to finely fragment bones and more fully exploit large dinos

64 on reporting guidelines and facilitates more finely grained data exploration and querying of datasets

65 ted by others, with the goal of developing a finely grained portrait of postdoctoral career outcomes

66 Electron microscopy revealed finely granular electron-dense deposits coating the surf

67 In this work, finely ground and heat-treated serpentinite [Mg3Si2O5(OH

68 d standardized skin prick tests (SPTs) using finely ground tree-nut solution and basophil activation

69 ics and the genomic sciences may become more finely integrated for empowering new measurement paradig

70 Finely-laminated sediments were deposited from ca. 5000

71 The ability to organize and finely manipulate the hierarchy and timing of dynamic pr

72 vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells du

73 To finely map transcriptionally active regions of the prote

74 We finely mapped the Rj4 locus within a small genomic regio

75 DENV4 were isolated, and their epitopes were finely mapped using recombinant viruses and alanine scan

76 oscopy (SEM) imaging showed a non-porous and finely meshed microstructure for the crosslinked gels co

77 development of further derivatives, able to finely modulate multiple pathways of cancer or parasite

78 luminescent color of the Tb/Eu(TATB) can be finely modulated by changing the Tb(3+)/Eu(3+) ratio in

79 s have previously shown that p53 activity is finely modulated by different multilevel mechanisms duri

80 tional modifications play essential roles in finely modulating eukaryotic circadian clock systems.

81 may provide a platform for the discovery of finely optimized catalysts.

82 of these dynamic pathways must therefore be finely orchestrated in order to ensure that the DNA meth

83 An immune response consists of a finely orchestrated interplay between initial recognitio

84 DC development and activation is finely orchestrated through transcriptional programs.

85 ze, it also facilitated diversification into finely partitioned niches.

86 ntrast, a series of subtle but iterative and finely patterned asymmetric divisions controls the shape

87 a continuum of cis-interaction profiles that finely position individual cells along the cell cycle.

88 Finely preserved details also reveal similarities in pro

89 s Toll-like receptors (TLRs), play a role in finely programming the final outcome of virus infection.

90 nces and collaborations grow, our ability to finely quantify and explore morphological variation in 3

91 HSP70 machinery with powerful, flexible, and finely regulatable disaggregase activity and a further l

92 f additional coactivator proteins, which can finely regulate HBV transcription.

93 Achieving strategies to finely regulate with biological inputs the formation and

94 acement strategies that can be triggered and finely regulated at either basic or acidic pHs.

95 s of Notch signaling are highly variable and finely regulated at multiple levels, but also depend on

96 These dynamics are finely regulated by a second magnesium dication, thus co

97 kbone, nucleobase, and ribose conformations, finely regulated by the combination of hydrogen bonds an

98 se that the activity of the ATG4 protease is finely regulated by the intracellular redox state, and i

99 otein expression and ubiquitin signaling are finely regulated during the sensing, repair and resoluti

100 efore, our data underscore the importance of finely regulated endosomal traffic in TCR signal transdu

101 mechanism by which mTORC1 activation may be finely regulated in a tissue-specific manner in response

102 f great importance to understand how YBX1 is finely regulated in cancer.

103 Blood coagulation is a finely regulated physiological process culminating with

104 accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiologic

105 Currently, how CRISPR-Cas systems are finely regulated remains to be defined.

106 Transcription initiation is finely regulated to ensure proper expression and functio

107 haliana), stamen filament elongation must be finely regulated to ensure that anthers reach the pistil

108 ormation, maturation, and turnover require a finely regulated transport system that delivers selected

109 Therefore, it is critical to have a finely regulated transport system to deliver selected sy

110 Production of SIgA is finely regulated, and distinct T-independent and T-depen

111 f photosynthesis, requiring that its rate be finely regulated.

112 d amplitude of autophagy activity have to be finely regulated.

113 Ca(2+) influx into the mitochondrial matrix, finely regulates metabolic energy production.

114 s, we propose that Gcn5-mediated acetylation finely regulates Rph1 protein level and that autophagic

115 Our work highlights the importance of finely regulating flavivirus polyprotein processing.

116 of RRM1 provides an alternative mechanism to finely regulating RNR and therapeutic opportunities for

117 HB1 is deleterious for the plant and, hence, finely repressed by a translational mechanism.

118 uitable habitat and environment simulated by finely resolved biogeochemical models, under three IPCC

119 We leveraged finely resolved congestion data to investigate short-ter

120 traditional societies of eastern Indonesia, finely resolved cophylogenies of languages and genes rev

121 Here we use finely resolved spatial and temporal influenza disease d

122 doryssus, a Miocene stickleback fish from a finely resolved stratigraphic sequence that spans nearly

123 We present a finely sampled diffuse scattering map from triclinic lys

124 Point-based approaches implemented with finely sampled telemetry data overestimate the presence

125 Finely-set small-scale experiments are not only very exp

126 an alternative method to prepare uniform and finely size-controlled colloidal lead halide perovskite

127 action was carried out at 100 degrees C from finely sized particles (249 mum) in a 1:12 solute:solven

128 More finely stratifying the sample according to clinical judg

129 Finely tailored pulse-shaping operations, including spli

130 We found that HSV-1 utilizes a robust and finely targeted mechanism of local immune evasion.

131 A new method of finely temperature-tuning osmotic pressure allows one to

132 The formation of water-stable aggregates in finely textured and polymineral magnetite Fe ore tailing

133 Whisking rodents can discriminate finely textured objects using their vibrissae.

134 nematic elasticity could offer ways to tune finely the spatial organization of complex colloidal sys

135 in the auditory neural system are optimized finely to process and discriminate behaviorally relevant

136 We sought to finely trace the temporal evolution of spatial biases by

137 uctures with highly uniform morphologies and finely tunable dimensions.

138 and 360(+/-15) nm wide, and their period is finely tunable in situ from 500 nm to 7 mum.

139 sponses operating on different timescales to finely tune behavior and metabolism according to metabol

140 dentify a class of regulatory molecules that finely tune cell homeostasis and are deregulated in dise

141 dered actin network may allow a cell to more finely tune control of molecular release enabling a more

142 der inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sit

143 ure could modulate stability in GASright and finely tune dimerization to support biological function.

144 vides neuromodulators with an opportunity to finely tune energy consumption and temporal delays acros

145 A variety of signals finely tune insulin secretion by pancreatic beta cells t

146 like all other persistent pathogens, has to finely tune its interplay with the host cellular machine

147 codon optimization exists as a mechanism to finely tune levels of mRNAs and, ultimately, proteins.

148 ting and vasoconstricting systems that could finely tune local blood flow depending on neuronal activ

149 The capability to finely tune multimetallic nanoparticle morphology stems

150 on of kinases and counteracting phosphatases finely tune the activity of cytokinesis proteins.

151 minated by multiple inhibitory pathways that finely tune the activity of mitral and tufted cells, the

152 n layers on AlOx supported nano-Cu which can finely tune the catalytic performance of the supported c

153 range of different halide precursors, we can finely tune the chemical composition and the optical pro

154 our results support the view that cells can finely tune the expression of different integrin types t

155 Cells finely tune the generation and amplification of [Ca(2+)

156 an epitaxial perovskite film can be used to finely tune the lattice symmetry by modifying the local

157 were investigated and optimized in order to finely tune the performance of the MIP-based sensor.

158 network organizes these protein complexes to finely tune the photosynthetic reactions.

159 in which a neighbouring functional group can finely tune the reactivity of the isocyano group or can

160 The possibility to finely tune the stiffness, size and shape of this simple

161 ysiological functions and various mechanisms finely tune their activity, including the Ca(2+) ion its

162 These findings show that humans finely tune their fixational eye movements so that they

163 BAA receptors, which provides a novel way to finely tune their function in physiological and pathophy

164 processed and integrated, and their numerous finely tuneable bandgaps that cover a broad spectral ran

165 xponential to the stationary phase exhibit a finely tuned adaptive metabolic mechanism that enables s

166 print for engineering molecular anchors with finely tuned affinities to effectively enhance the barri

167 se results provide new insights into how the finely tuned allosteric PKA signaling network is disrupt

168 ativity, in contrast to the common view of a finely tuned allosteric residue network maintained under

169 est that intrinsic PDZ domain affinities are finely tuned and encode specific cellular responses, ena

170 data indicate that connectivity within V1 is finely tuned and precise at the level of individual neur

171 nherently provide for rationally introducing finely tuned and quantitatively predictable chemoselecti

172 Thus, a finely tuned balance between (pA)p suppression and usage

173 fficiency of lamellipodia is determined by a finely tuned balance between lamellipodial and cytosolic

174 We conclude that a finely tuned balance between the GAG-bound dimer and fre

175 Tissue homeostasis is maintained through a finely tuned balance between the immune system and the o

176 Overall, we find a finely tuned balance between thermodynamic and kinetic p

177 Such dynamic behavior can be finely tuned by adjusting the structure and properties o

178 the dye dipoles and surface plasmons can be finely tuned by coupling the dye molecules to specific s

179 the vagus (DMV) neurones, whose activity is finely tuned by GABAergic and glutamatergic synaptic inp

180 Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecu

181 ution, and the spectroscopic features can be finely tuned by judiciously introducing substituents of

182 Because T cell differentiation is finely tuned by multiple positive and negative regulator

183 rotein-protein complexes whose functions are finely tuned by rapidly changing environmental condition

184 Affinity to EGFR was finely tuned by rational engineering of aptamer sequence

185 These conformational states are finely tuned by substrate availability and purine balanc

186 uard cell actin filaments, a process that is finely tuned by the conserved SCAR/WAVE-Arp2/3 actin reg

187 lying that the composition of condensates is finely tuned by the thermodynamics of the underlying bio

188 the reactivity of these electrophiles can be finely tuned by varying the substituents on the aryl rin

189 napses called memristors, conductance can be finely tuned by voltage pulses and set to evolve accordi

190 sodium ions over other cations, enabling the finely tuned cascade of events associated with action po

191 Human brain development involves a finely tuned cascade of interactive events.

192 t Mtb's stress response network depends upon finely tuned chaperone expression levels.

193 sis is a tightly regulated process requiring finely tuned complex interactions between different cell

194 Triton X-100 is employed at finely tuned concentrations to render RBCs highly permea

195 The finely tuned control of SCL's regulatory functions (line

196 This occurs in finely tuned cortical microcircuits whose functions are

197 mple mechanical model that shows that a very finely tuned cortical tension combined with a high cell

198 tructure, hence the ferroelectricity, can be finely tuned depending on the anisotropy of the rare ear

199 its skeleton, which would provide access to finely tuned derivatives of desired properties.

200 Taken together, we suggest that finely tuned dynamics may be a general mechanism regulat

201 selected or 'gated' by precise modulation of finely tuned EI balance, but assessing the granularity o

202 amework in which control is mediated through finely tuned excitatory and inhibitory drives resonates

203 ating osteoblast and osteoclast activity and finely tuned expression of inflammatory molecules, resul

204 ve migration, but their precise role and the finely tuned expression that orchestrates this complex d

205 he mitochondrial network of cardiac cells is finely tuned for ATP delivery to sites of energy demand;

206 er, these findings suggest that the DMPFC is finely tuned for processing social interaction above oth

207 mmunity trait space indicating that they are finely tuned for the available conditions.

208 es of microtubule wall-binding proteins with finely tuned force-dependent motility characteristics.

209 se but detects periodic force signals over a finely tuned frequency range.

210 chanism-known as path integration-requires a finely tuned gain factor that relates the animal's self-

211 rly the cross-frequency interactions between finely tuned gamma oscillations and the stimulation freq

212 Finely tuned gamma oscillations have been suggested to b

213 roteomic data (realised niches), we identify finely tuned gene expression governing resource usage by

214 has become increasingly viable, ranging from finely tuned humanisation of individual nucleotides and

215 hod and an optimal classification model with finely tuned hyperparameters.

216 relaxation (kT1-->S0) rate constants can be finely tuned in M-(PM')n-M compounds and (ii) demonstrat

217 Light utilization is finely tuned in photosynthetic organisms to prevent cell

218 Protein synthesis must be finely tuned in the developing nervous system as the fin

219 a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradat

220 al network functioning critically depends on finely tuned interactions to afford neuronal activity pr

221 Memories are encoded by finely tuned interactions within large-scale neuronal ne

222 que structure is critically dependent on the finely tuned interplay between disulfide bonding and N-g

223 Together, these results indicate that finely tuned levels of Lamin B1 are required for NSC dif

224 A finely tuned lipid assembly machinery is required to bui

225 ar, have been elusive due to their requisite finely tuned long-ranged hoppings.

226 function of endosomes and lysosomes requires finely tuned luminal ion homeostasis and transmembrane i

227 the development of novel metamaterials with finely tuned magnetic properties, such as reconfigurable

228 This model suggests a finely tuned mechanism that balances transcription speed

229 etabolic and physiological processes through finely tuned molecular mechanisms.

230 borate process that integrates a plethora of finely tuned molecular processes ranging from carefully

231 s involves generation of new neurons through finely tuned multistep processes, such as neural stem ce

232 The SLC1A5 function involves finely tuned orchestration of two domain movements that

233 layed characteristics consistent with a more finely tuned oscillatory drive.

234 dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in syste

235 ts that regulate diffusive processes through finely tuned particle-network interactions.

236 and autonomous choice; information overload, finely tuned personalization and distorted social cues,

237 s a novel method for developing carbons with finely tuned pores for a variety of applications, such a

238 nitrogen-fixing nodules on legume hosts is a finely tuned process involving many components of both s

239 This is a very finely tuned process regulated by an emerging number of

240 As a result of their finely tuned properties, these scaffolds demonstrate the

241 res the design of enhanced fluorophores with finely tuned properties.

242 g redox-active MOF thin-film electrodes with finely tuned redox pendant content.

243 Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human

244 Collectively, these data reveal a finely tuned regulatory mechanism for controlling signal

245 A finely tuned regulatory network orchestrates the biogene

246 ironments, S. aureus relies on a complex and finely tuned regulatory network.

247 and the wild-type F-MLV strain, suggesting a finely tuned relationship between the levels of mCAT1 in

248 These cells are also finely tuned sensors of mechanical stimulation to coordi

249 set of neural oscillators for PD, but a more finely tuned set of oscillators in ET.

250 other hormones or stress responses, and the finely tuned spatiotemporal regulation of BR signaling.

251 nsemble coding for sucrose seeking suggest a finely tuned specificity of ensembles.

252 nd (2) DMSP production in low producers is a finely tuned stress response.

253 This finely tuned system is responsive to developmental and p

254 ated labeled line from TRCs in the tongue to finely tuned taste neurons in the brain to trigger avers

255 le changing the nature of the Xaa side chain finely tuned the conformers ratio.

256 perties of reactive ferryl intermediates are finely tuned through hydrogen bonding interactions betwe

257 the parameters of this leaky integrator are finely tuned through the interactions of Ng, CaM, CaMKII

258 ability to stabilize gas microbubbles can be finely tuned through variation of the surface-modificati

259 Thus, finely tuned TMS treatment has great potential to become

260 Phages tend to be predators finely tuned to attack specific hosts, even down to the

261 cOA-activated ribonuclease activity that is finely tuned to cA4 levels as a second messenger of infe

262 nditions, the activity of these receptors is finely tuned to effectively mediate host defense yet con

263 rstanding how HECT ubiquitin ligases must be finely tuned to ensure normal cellular behavior.

264 The architecture of Kepler-223 is too finely tuned to have been formed by scattering, and our

265 otic genomes, but their mobilization must be finely tuned to maintain host organism fitness and allow

266 uggest the timing of spore liberation may be finely tuned to maximize fitness during atmospheric tran

267 However, because ILCs are finely tuned to perturbations within tissue microenviron

268 affinity and transcription factor levels are finely tuned to regulate stochastic expression, setting

269 que transients of bar-fixation saccades were finely tuned to the speed of bar motion and were trigger

270 l black hole, but requires an accretion rate finely tuned to the thermodynamic state of the hot gas.

271 al in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathw

272 The data presented here indicate that the finely tuned transcriptional control upon salt stress is

273 ented herein can be readily adapted to other finely tuned triarylboranes, enabling wide applications

274 llary bridges and resulting particles can be finely tuned using several addressable parameters: (i) t

275 d and interrupted pericyclic pathways can be finely tuned via a combination of structural and electro

276 e, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, s

277 Second, these DA events are finely tuned within and between frequency domains as bui

278 conditions (concentration, pH, etc.) can be finely tuned without cross-contamination, allowing the s

279 se results show that active PFL synthesis is finely tuned, and feed-back inhibition and activation ar

280 er, typical models of working memory rely on finely tuned, content-specific attractors to persistentl

281 RNA editing is a finely tuned, dynamic mechanism for post-transcriptional

282 ssumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve

283 articular, our results strongly suggest that finely tuned, moderately coupled nuclear spins are key t

284 After process optimization, a finely tuned, stepwise click approach has emerged as a w

285 ndividuals but can become detrimental if not finely tuned.

286 regation of the triblock comicelles could be finely tuned.

287 This directional flux can be finely-tuned by the relative number of myosin V and VI m

288 It clarifies finely-tuned contextual PGR-chromatin interactions with

289 emically modified graphene films also yields finely-tuned negative Poisson's ratios.

290 n of MERCs, controls autophagy that, in turn finely tunes lipid degradation to fuel OxPHOS supporting

291 It is also found that hydration finely tunes the electric field distribution between AuN

292 These applications illustrate the benefit of finely tuning nanoscale conduit geometries, which can be

293 These are constructed for finely tuning the delivery of chemical or biochemical sp

294 The possibility of finely tuning the macrocycle properties by synthetic mod

295 highlight the key role of lactate fluxes in finely tuning the metabolic activity of beige adipocytes

296 in controlling the mobilization of HSPCs by finely tuning their bone marrow niche.

297 design of efficient electrocatalysts through finely tuning their electrical conductivities.

298 dvantage of having rich chemistry capable of finely tuning their microscopic parameters.

299 sfer between host CdS QDs and dopants can be finely turned in a wide range by dopant migration toward

300 terior half of the stroma displayed thin and finely vacuolated lamellae, and keratocytes throughout t