ライフサイエンスコーパス: finely tuned

1 lengthscales of phase separated morphologies finely tuned.

2 nt lengths or TiO(2) shell thicknesses to be finely tuned.

3 ndicate that the availability of IUPs can be finely tuned.

4 ndividuals but can become detrimental if not finely tuned.

5 regation of the triblock comicelles could be finely tuned.

6 emperature, the deformation amplitude can be finely tuned across a wide range (0%-103%).

7 Heart formation depends on the finely tuned activity of transcriptional regulators, yet

8 xponential to the stationary phase exhibit a finely tuned adaptive metabolic mechanism that enables s

9 print for engineering molecular anchors with finely tuned affinities to effectively enhance the barri

10 Multitopic supramolecular guests with finely tuned affinities toward widely explored cucurbit[

11 se results provide new insights into how the finely tuned allosteric PKA signaling network is disrupt

12 ativity, in contrast to the common view of a finely tuned allosteric residue network maintained under

13 est that intrinsic PDZ domain affinities are finely tuned and encode specific cellular responses, ena

14 data indicate that connectivity within V1 is finely tuned and precise at the level of individual neur

15 nherently provide for rationally introducing finely tuned and quantitatively predictable chemoselecti

16 onditions suggests that AREs are involved in finely tuned and stringent control of gene expression.

17 tween four radicals has been efficiently and finely tuned and the resulting allosteric complexation i

18 ulation of this second messenger needs to be finely tuned and well balanced in a context dependent ma

19 These channels are finely tuned, and either increased or decreased channel

20 se results show that active PFL synthesis is finely tuned, and feed-back inhibition and activation ar

21 quirements for inhibitory activity at P2 are finely tuned, and in agreement with the library work, th

22 rain functions and neurological diseases are finely tuned, and in certain cases fully determined, by

23 Mimicry traits often reflect complex, finely tuned, and sometimes extravagant relationships am

24 ds the prometaphase spindle and augments the finely tuned, antagonistic kinesin force balance to main

25 This has enabled a more finely tuned approach to the understanding of placode in

26 emonstration that the SSB-ssDNA complex is a finely tuned assembly in dynamic equilibrium among sever

27 Near-field coupling is finely tuned at the nanostructure edge, in which a coher

28 Thus, a finely tuned balance between (pA)p suppression and usage

29 A finely tuned balance between excitation and inhibition (

30 between humans and helminths has developed a finely tuned balance between host immunity and chronic p

31 This finely tuned balance between interdomain rigidity and fl

32 fficiency of lamellipodia is determined by a finely tuned balance between lamellipodial and cytosolic

33 Mucus biological functioning requires a finely tuned balance between solid-like and fluid-like m

34 We conclude that a finely tuned balance between the GAG-bound dimer and fre

35 Tissue homeostasis is maintained through a finely tuned balance between the immune system and the o

36 ffect variegation, providing evidence that a finely tuned balance between the levels of JIL-1 and the

37 Therefore, a finely tuned balance between the opposing forces of AC22

38 Overall, we find a finely tuned balance between thermodynamic and kinetic p

39 how that wild-type morphology results from a finely tuned balance in the expression of brlA, medA and

40 esponse to Candida infections necessitates a finely tuned balance of IFN-gamma production.

41 self-organized swarming behavior and how the finely tuned balance of neutrophil chemotaxis and arrest

42 PyV latency is actively maintained through a finely tuned balance of pro- and anti-viral signaling.

43 regulation of normal hematopoiesis through a finely tuned balance of self-renewal and differentiation

44 lized in a delocalized fashion, preserving a finely tuned balance of stabilizing interactions through

45 ount of PP1 targeted to kinetochores must be finely tuned, because recruitment of either no or one ex

46 During development, BMP activities are finely tuned by a number of modulators at the extracellu

47 Such dynamic behavior can be finely tuned by adjusting the structure and properties o

48 s is maintained to control cell death and is finely tuned by an inducible antioxidant program.

49 probability (P(o)) of the BK(Ca) channel was finely tuned by bilayer thickness, first decreasing with

50 This process is finely tuned by both cell-autonomous and non-cell-autono

51 ment and demonstrates how this phenomenon is finely tuned by CAVIN1.

52 tructure and ionizable group composition was finely tuned by changing the pH of the dipping solution.

53 the dye dipoles and surface plasmons can be finely tuned by coupling the dye molecules to specific s

54 We conclude that some mammalian CREs are finely tuned by evolution and function through complex,

55 the vagus (DMV) neurones, whose activity is finely tuned by GABAergic and glutamatergic synaptic inp

56 chiometry in virions and that infectivity is finely tuned by host cyclophilin A expression levels.

57 Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecu

58 ution, and the spectroscopic features can be finely tuned by judiciously introducing substituents of

59 ination of microtubules in cardiomyocytes is finely tuned by MARK4 to regulate cardiac inotropy, and

60 produces oscillations whose frequencies are finely tuned by methylation and by phosphorylation.

61 ated that efficacy and biased agonism can be finely tuned by minor structural modifications to the he

62 Because T cell differentiation is finely tuned by multiple positive and negative regulator

63 idence suggests that cell death pathways are finely tuned by multiple signaling events, including dir

64 ansport is an evolutionary conserved process finely tuned by posttranslational modifications.

65 rotein-protein complexes whose functions are finely tuned by rapidly changing environmental condition

66 Affinity to EGFR was finely tuned by rational engineering of aptamer sequence

67 -Teller surface area of these carbons can be finely tuned by selecting proper experimental conditions

68 n enzyme dynamin-related protein 1 (Drp1) is finely tuned by several post-translational modifications

69 These conformational states are finely tuned by substrate availability and purine balanc

70 fferentiation of TCR(hi) CD8(+) cells can be finely tuned by synthetic amino acids in the peptide, wh

71 uard cell actin filaments, a process that is finely tuned by the conserved SCAR/WAVE-Arp2/3 actin reg

72 sine phosphorylation of specific proteins is finely tuned by the dynamic balance between protein tyro

73 Corticotroph excitability can be finely tuned by the stochastic behaviour of a small numb

74 que metallocofactor, the H-cluster, which is finely tuned by the surrounding protein environment to u

75 lying that the composition of condensates is finely tuned by the thermodynamics of the underlying bio

76 outflow to visceral organs is modulated and finely tuned by vagal afferent fibres.

77 m through which the activity of VGCCs can be finely tuned by various neurotransmitters, hormones and

78 mable allosteric DNA regulations that can be finely tuned by varying the dimensions, positions, and n

79 the reactivity of these electrophiles can be finely tuned by varying the substituents on the aryl rin

80 napses called memristors, conductance can be finely tuned by voltage pulses and set to evolve accordi

81 This directional flux can be finely-tuned by the relative number of myosin V and VI m

82 sodium ions over other cations, enabling the finely tuned cascade of events associated with action po

83 Human brain development involves a finely tuned cascade of interactive events.

84 opting specific conformations in response to finely tuned changes in Ca(2+)-concentration.

85 t Mtb's stress response network depends upon finely tuned chaperone expression levels.

86 aken together, this study provides access to finely tuned chlorins for spectroscopic studies and dive

87 nism in which Tc17 cells are controlled by a finely tuned collaboration between the different types o

88 sis is a tightly regulated process requiring finely tuned complex interactions between different cell

89 ets in a strain-specific manner, implicating finely tuned, complex receptor systems in NK xenorecogni

90 Triton X-100 is employed at finely tuned concentrations to render RBCs highly permea

91 er, typical models of working memory rely on finely tuned, content-specific attractors to persistentl

92 It clarifies finely-tuned contextual PGR-chromatin interactions with

93 The finely tuned control of SCL's regulatory functions (line

94 at JUB1 constitutes a central regulator of a finely tuned control system that modulates cellular H(2)

95 e two systems that allow for the continuous, finely-tuned control of plasmid copy number between 1 an

96 opper resistance, suggesting that there is a finely tuned copper redox balance at the yeast plasma me

97 This occurs in finely tuned cortical microcircuits whose functions are

98 mple mechanical model that shows that a very finely tuned cortical tension combined with a high cell

99 tructure, hence the ferroelectricity, can be finely tuned depending on the anisotropy of the rare ear

100 its skeleton, which would provide access to finely tuned derivatives of desired properties.

101 In nature, various animals have evolved finely tuned designs and anatomical features that enable

102 phobic NaV1.7 interior intact, as well as, a finely-tuned (dictated by hydropathic interactions) dist

103 kely to be important for specificity and for finely tuned differences in cell-type-specific alternati

104 construction of nanoscale objects that have finely tuned dimensions, orientation, and structure with

105 cell by apoptosis, caspase activation, when finely tuned, directs alternative cellular functions ind

106 ophisticated plant immune system, suggesting finely tuned discrimination of mutualists and commensals

107 The authors conclude that finely tuned dopaminergic signaling within the dorsal st

108 cal stimulus can be directly translated into finely tuned, dynamic adjustments of optical transparenc

109 RNA editing is a finely tuned, dynamic mechanism for post-transcriptional

110 Taken together, we suggest that finely tuned dynamics may be a general mechanism regulat

111 selected or 'gated' by precise modulation of finely tuned EI balance, but assessing the granularity o

112 the catalytic nucleophile and illuminate the finely tuned energetics of this remarkable metalloenzyme

113 provide promising new avenues to direct the finely tuned engineering of crop yield and traits.

114 ectron transfer pathway in alpha2 suggests a finely tuned evolutionary adaptation of RNR to control t

115 amework in which control is mediated through finely tuned excitatory and inhibitory drives resonates

116 ating osteoblast and osteoclast activity and finely tuned expression of inflammatory molecules, resul

117 ve migration, but their precise role and the finely tuned expression that orchestrates this complex d

118 can limit its own generation by triggering a finely tuned "feedback" mechanism whereby A2 becomes ser

119 Here, we present a palette of 22 finely tuned fluorescent tags based on the thermostable

120 he mitochondrial network of cardiac cells is finely tuned for ATP delivery to sites of energy demand;

121 er, these findings suggest that the DMPFC is finely tuned for processing social interaction above oth

122 est that its role as a ubiquitin receptor is finely tuned for proteasome targeting.

123 mmunity trait space indicating that they are finely tuned for the available conditions.

124 es of microtubule wall-binding proteins with finely tuned force-dependent motility characteristics.

125 se but detects periodic force signals over a finely tuned frequency range.

126 chanism-known as path integration-requires a finely tuned gain factor that relates the animal's self-

127 rly the cross-frequency interactions between finely tuned gamma oscillations and the stimulation freq

128 Finely tuned gamma oscillations have been suggested to b

129 Ketamine disrupted finely tuned gamma, decreased LID and moderately increas

130 roteomic data (realised niches), we identify finely tuned gene expression governing resource usage by

131 oncept to explain how dysregulation of these finely tuned gene expression processes may drive tumorig

132 esults further suggest that mariners are not finely tuned genetic entities and that a greater amount

133 The mechanism of this finely tuned genetic switch depends on differential bind

134 scle in large mammalian hearts adopts a more finely tuned graded response to allow for their substant

135 Ibbeta3 TM heterodimer shows the hallmark of finely tuned heterodimeric interaction, while homomeric

136 ding capacity in the ER and in the ways of a finely tuned homeostat adjusts organelle abundance accor

137 ssumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve

138 has become increasingly viable, ranging from finely tuned humanisation of individual nucleotides and

139 hod and an optimal classification model with finely tuned hyperparameters.

140 relaxation (kT1-->S0) rate constants can be finely tuned in M-(PM')n-M compounds and (ii) demonstrat

141 Light utilization is finely tuned in photosynthetic organisms to prevent cell

142 suggest that the activation of TRPV4 can be finely tuned in response to different endogenous lipids,

143 HtrA regulation appears to be finely tuned in S. mutans, since strains containing mult

144 Protein synthesis must be finely tuned in the developing nervous system as the fin

145 herefore is sustained in Cx43 null mice by a finely tuned interaction between gap junction-dependent

146 cificity of the Pdr-Pdx couple may be due to finely tuned interactions at the protein-protein interfa

147 We propose that hmU preference is due to finely tuned interactions at the sites of kinking that e

148 a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradat

149 al network functioning critically depends on finely tuned interactions to afford neuronal activity pr

150 Memories are encoded by finely tuned interactions within large-scale neuronal ne

151 que structure is critically dependent on the finely tuned interplay between disulfide bonding and N-g

152 Together, these results indicate that finely tuned levels of Lamin B1 are required for NSC dif

153 A finely tuned lipid assembly machinery is required to bui

154 sed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of w

155 ar, have been elusive due to their requisite finely tuned long-ranged hoppings.

156 function of endosomes and lysosomes requires finely tuned luminal ion homeostasis and transmembrane i

157 the development of novel metamaterials with finely tuned magnetic properties, such as reconfigurable

158 ence of excitation and inhibition, each with finely tuned magnitude and duration.

159 processes to emerge and be coordinated in a finely tuned manner.

160 extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time s

161 ulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate re

162 This study highlights a finely tuned mechanism for regulating histone demethylas

163 These results unveil a new, finely tuned mechanism for TNF-alpha-induced IKK activat

164 This model suggests a finely tuned mechanism that balances transcription speed

165 an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is sy

166 are necessarily highly competitive and have finely tuned mechanisms to adjust growth and development

167 d process and is maintained by a sequence of finely tuned metabolic pathways.

168 articular, our results strongly suggest that finely tuned, moderately coupled nuclear spins are key t

169 These studies reveal the plasticity of this finely tuned molecular machine and represent a first ste

170 chanistic insights into the workings of this finely tuned molecular machine.

171 Nature provides highly evolved, finely tuned molecular machinery for solar energy conver

172 etabolic and physiological processes through finely tuned molecular mechanisms.

173 borate process that integrates a plethora of finely tuned molecular processes ranging from carefully

174 In highly polarised cells such as neurons, finely-tuned molecular regulation of these processes ser

175 ular IRP1/IRP2 ratios can provide a range of finely tuned, mRNA-specific responses to the same (iron)

176 s involves generation of new neurons through finely tuned multistep processes, such as neural stem ce

177 emically modified graphene films also yields finely-tuned negative Poisson's ratios.

178 For the trachea, where finely tuned neuromuscular activity is not an issue, tis

179 ts of Alzheimer disease is the disruption of finely tuned neuronal circuitry of discrete brain region

180 s, highly selective protein interactions and finely tuned on/off switches.

181 This finely tuned orchestra of developmental changes thus sim

182 t of a multicellular organism depends on the finely tuned orchestration of cell proliferation, differ

183 The SLC1A5 function involves finely tuned orchestration of two domain movements that

184 layed characteristics consistent with a more finely tuned oscillatory drive.

185 substituents at positions 4 and 6 and can be finely tuned over a broad range of conformation ratios.

186 dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in syste

187 ts that regulate diffusive processes through finely tuned particle-network interactions.

188 dies act as physical controllers, with their finely tuned passive mechanical responses physically "en

189 and autonomous choice; information overload, finely tuned personalization and distorted social cues,

190 In sharp contrast, complex of a finely tuned phosphino-oxazoline ligand promotes unique

191 Using finely tuned phosphoramidite ligands, it is possible to

192 Here, we introduce the hypothesis that the finely tuned poleward flux safeguards against lagging ch

193 s a novel method for developing carbons with finely tuned pores for a variety of applications, such a

194 nitrogen-fixing nodules on legume hosts is a finely tuned process involving many components of both s

195 This is a very finely tuned process regulated by an emerging number of

196 l particle assembly, and nuclear export is a finely tuned process requiring the concerted actions of

197 rturbation of sodium channel inactivation, a finely tuned process that critically regulates the flow

198 cellular polysaccharide, is synthesized in a finely tuned process that involves the activity of glyco

199 wound-induced epithelial cell migration is a finely tuned process that is dependent upon the regulate

200 Capsid assembly and maturation are finely tuned processes in which viral and host factors p

201 Y) is in fact based on a complex sequence of finely tuned processes, involving the one-electron oxida

202 cells maintain tissue homeostasis through a finely tuned program of responses to both physiological

203 isms contain biominerals and composites with finely tuned properties, reflecting a remarkable level o

204 As a result of their finely tuned properties, these scaffolds demonstrate the

205 res the design of enhanced fluorophores with finely tuned properties.

206 pool of blood cells, which require a low but finely tuned protein synthesis rate.

207 n intricately organized kinetic scheme, with finely tuned rate constants, is required to achieve high

208 We conclude that Mtb has evolved finely tuned redox and hypoxia-mediated sensing strategi

209 g redox-active MOF thin-film electrodes with finely tuned redox pendant content.

210 The results uncovered a finely tuned regulation able to shift the precursor path

211 iptional responses that maintain a balanced, finely tuned regulation of cholesterol and bile acid met

212 Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human

213 and virulence, confirming that this complex, finely tuned regulation system is crucial in the interac

214 Collectively, these data reveal a finely tuned regulatory mechanism for controlling signal

215 he signaling functions of dopamine require a finely tuned regulatory network for rapid induction and

216 A finely tuned regulatory network orchestrates the biogene

217 ironments, S. aureus relies on a complex and finely tuned regulatory network.

218 vage and polyadenylation is an important and finely tuned regulatory process during mRNA maturation.

219 and the wild-type F-MLV strain, suggesting a finely tuned relationship between the levels of mCAT1 in

220 geometric, and chemical properties have been finely tuned relative to the corresponding residues in w

221 The finely tuned response of mTOR to these stimuli results i

222 hanisms for T-cell activation and allows for finely tuned responses to extracellular cues.

223 lipids are ubiquitous in eukaryotes and have finely tuned roles in cellular signalling and membrane h

224 employs a prion mechanism to create stable, finely tuned self-perpetuating biochemical memories.

225 These cells are also finely tuned sensors of mechanical stimulation to coordi

226 A finely tuned sensory to projection neuron network secure

227 h fishes, is the result of a highly evolved, finely-tuned sensory system based on single-domain, ferr

228 set of neural oscillators for PD, but a more finely tuned set of oscillators in ET.

229 tions also exist for perioral exploration, a finely tuned skill requiring the combination of motor an

230 Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-born

231 other hormones or stress responses, and the finely tuned spatiotemporal regulation of BR signaling.

232 Human face perception is a finely tuned, specialized process.

233 nsemble coding for sucrose seeking suggest a finely tuned specificity of ensembles.

234 After process optimization, a finely tuned, stepwise click approach has emerged as a w

235 nd (2) DMSP production in low producers is a finely tuned stress response.

236 Our data paint a picture of HtrA2 as a finely tuned, stress-protective enzyme whose activity ca

237 in protein-protein interactions mediated by finely tuned structural instability and coupled with mol

238 antage conferred upon a biological system by finely tuned structural instability.

239 t the metal-binding His cluster in TraI is a finely tuned structure that achieves a sufficient affini

240 isolate rare enzyme variants that displayed finely tuned substrate specificity.

241 than previously assumed and rather involves finely tuned surface-water interactions.

242 This finely tuned switch is conferred by a naturally variable

243 This finely tuned system is responsive to developmental and p

244 re states of the organism and the world in a finely tuned system to control ingestion.

245 mucosa of the intestinal tract represents a finely tuned system where tissue structure strongly infl

246 ated labeled line from TRCs in the tongue to finely tuned taste neurons in the brain to trigger avers

247 le changing the nature of the Xaa side chain finely tuned the conformers ratio.

248 Finely tuned thermal denaturation afforded increased thr

249 perties of reactive ferryl intermediates are finely tuned through hydrogen bonding interactions betwe

250 he core histones and the linker histones are finely tuned through interactions with transcriptional r

251 In eukaryotes, this process is finely tuned through regulation at the level of transcri

252 the parameters of this leaky integrator are finely tuned through the interactions of Ng, CaM, CaMKII

253 ability to stabilize gas microbubbles can be finely tuned through variation of the surface-modificati

254 on could explain the experimentally observed finely tuned timing between parallel fiber and climbing

255 Thus, finely tuned TMS treatment has great potential to become

256 eparate classes of taste receptor cells each finely tuned to a single taste quality.

257 to ATF4 expression, allowing anabolism to be finely tuned to amino acid availability.

258 y by these specific editing reactions and is finely tuned to any perturbation of these reactions.

259 Phages tend to be predators finely tuned to attack specific hosts, even down to the

260 cells in mammalian primary visual cortex are finely tuned to binocular disparity.

261 cOA-activated ribonuclease activity that is finely tuned to cA4 levels as a second messenger of infe

262 nditions, the activity of these receptors is finely tuned to effectively mediate host defense yet con

263 all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fi

264 rstanding how HECT ubiquitin ligases must be finely tuned to ensure normal cellular behavior.

265 size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis.

266 The architecture of Kepler-223 is too finely tuned to have been formed by scattering, and our

267 otic genomes, but their mobilization must be finely tuned to maintain host organism fitness and allow

268 uggest the timing of spore liberation may be finely tuned to maximize fitness during atmospheric tran

269 rotein family that have affinity differences finely tuned to mediate their biological roles.

270 nd functional properties of mitochondria are finely tuned to meet cell-specific energetic, metabolic,

271 e physical properties of these polymers were finely tuned to optimize their photovoltaic effect.

272 However, because ILCs are finely tuned to perturbations within tissue microenviron

273 in response to inflammatory stimuli must be finely tuned to promote an effective immune response whi

274 review we illustrate how excitability can be finely tuned to provide contrasting firing templates in

275 Our data illustrate how excitability can be finely tuned to provide specific firing templates by the

276 We propose that tynA and feaB expression is finely tuned to provide the FeaB activity that is requir

277 results suggest that the locus coeruleus is finely tuned to regulate organismal arousal and that bur

278 affinity and transcription factor levels are finely tuned to regulate stochastic expression, setting

279 detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their h

280 As sessile organisms, plants are finely tuned to respond dynamically to developmental, ci

281 Sensory neurons in the airways are finely tuned to respond to reactive chemicals threatenin

282 fabrication of such particles are typically finely tuned to specific monomer or polymer species, siz

283 dox-active film whose reduction potential is finely tuned to the equilibrium potential of the H(+)/H(

284 show that stabilization of HO-1 mRNA can be finely tuned to the NO exposure, and that the effect in

285 OR effector translational repressor 4E-BP is finely tuned to the nutritional requirements of the fema

286 que transients of bar-fixation saccades were finely tuned to the speed of bar motion and were trigger

287 l black hole, but requires an accretion rate finely tuned to the thermodynamic state of the hot gas.

288 Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific rep

289 al in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathw

290 The data presented here indicate that the finely tuned transcriptional control upon salt stress is

291 Finely tuned transient Ca(+2) fluxes from the endoplasmi

292 ented herein can be readily adapted to other finely tuned triarylboranes, enabling wide applications

293 An advantage of enzymes is that they can be finely tuned using directed evolution to achieve control

294 llary bridges and resulting particles can be finely tuned using several addressable parameters: (i) t

295 mosquito vector Anopheles gambiae depends on finely tuned vector-parasite interactions.

296 d and interrupted pericyclic pathways can be finely tuned via a combination of structural and electro

297 e, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, s

298 results show that functional connectivity is finely tuned, with important implications for signal pro

299 Second, these DA events are finely tuned within and between frequency domains as bui

300 conditions (concentration, pH, etc.) can be finely tuned without cross-contamination, allowing the s