ライフサイエンスコーパス: first generation

1 r nondepressed (low familiar risk) probands (first generation).

2 diet and male competitive environment in the first generation.

3 A first-generation 3D Light PAD was fabricated using the p

4 The first-generation ACM analogue dihydro-2-pyridone 1 maint

5 d describes how the lessons learned from the first-generation ADCs have led to improvements in every

6 First-generation adjuvant chemotherapy trials reported a

7 arent-offspring transmission and started the first generation affected by ALS (four children carry an

8 ular, second generation antipsychotics, like first generation agents, are associated with potentially

9 estigation focusing on several analyses of a first-generation AJICAP-ADC (Angew.

10 higher sensitivity and higher cost than the first-generation AlereLAM assay.

11 A phase I clinical trial of the first generation ALK inhibitor, crizotinib, in neuroblas

12 h carbon number group, and is not the common first generation alkyl nitrates previously reported.

13 ate between the computational models and the first-generation analytical models.

14 Here we describe the first generation and characterization of a mouse line hu

15 enic factors NF-kappaB and VEGFR2 in the 7-d first generation and second generation lungs.

16 Herein, we show that first generation and second generation progeny from gest

17 re identified in the study cohort, 578 among first-generation and 106 among second-generation immigra

18 k between 1968 and 2015, including 1 176 419 first-generation and 184 282 second-generation immigrant

19 In contrast, first-generation and 4-1BB-costimulated CAR T cells incr

20 potential to increase the efficiency of both first-generation and next-generation biofuel production.

21 lind randomised placebo-controlled trials of first-generation and second-generation antidepressants f

22 s, and the risk is further increased by both first-generation and second-generation antipsychotics.

23 ntervention with bare-metal stents (BMS) and first-generation and second-generation drug-eluting sten

24 eceptor (D3R) is a molecular target for both first-generation and several recently-developed antipsyc

25 Whereas first-generation antagonists that inhibit all modes of T

26 n sensitivity, although a high prevalence of first generation anti-gliadin antibodies of IgG class ha

27 -go potassium channel (hERG) activity of the first-generation anti-Cryptosporidium BKIs triggered fur

28 ed, except in patients receiving a standard, first-generation antiandrogen agent with a falling PSA l

29 roduced lower numbers of adverse events than first-generation antihistamines.

30 intake in patients treated with at least one first-generation antipsychotic and less progressive GM l

31 death and stroke associated with the use of first-generation antipsychotic drugs (FGAs) compared wit

32 First-line treatment with either first-generation antipsychotics (adjusted hazard ratio,

33 ed with second-generation antipsychotics and first-generation antipsychotics revealed a different and

34 um levels greater than 0.6 mEq/l, and use of first-generation antipsychotics were independently assoc

35 .32 (95% confidence interval, 2.17-2.47) for first-generation antipsychotics, and 2.74 (95% confidenc

36 dications appear to be more efficacious than first-generation antiseizure medications, highlighting t

37 Stress on first-generation aphids had cross-generational impacts o

38 The key step in the first-generation approach involves the construction of t

39 Herein we describe our first-generation approach to the formal synthesis of las

40 The limit and range of detection of this first generation assay is 10(2) and 10(2)-10(8) plaque f

41 ree BD Max assays, including the BD Max MRSA first-generation assay.

42 This first-generation barley pan-genome makes previously hidd

43 Rather it was the widespread use of first generation beta-lactams such as penicillin in the

44 the effects of nebivolol with metoprolol, a first-generation beta1-selective beta-blocker, on human

45 A series of first-generation bifunctional inhibitors was achieved th

46 First generation biofuels focused on food crops like cor

47 Here, we describe a first-generation biomimetic five-module chimeric antigen

48 A first-generation bioresorbable scaffold has been demonst

49 bodies provide many challenges compared with first-generation biosimilars, growth factors, and hormon

50 similar monoclonal antibodies in relation to first-generation biosimilars, the issues surrounding int

51 First generation bivalent and quadrivalent human papillo

52 Complete differentiation of first generation blood stages into sexual stages for sub

53 First-generation bricks used to create three-dimensional

54 ared the efficacy and safety of ibrutinib, a first-generation BTK inhibitor, with zanubrutinib, a nov

55 ned to improve on the safety and efficacy of first-generation BTK inhibitors.

56 Mouse T cells engrafted with a first-generation CAR failed to develop such autotoxicity

57 me of the current challenges associated with first-generation CARs, such as prolonged production that

58 rganic transformations and compared with the first generation catalyst.

59 can be performed efficiently with the Grubbs first-generation catalyst or [(Ph)3P]3RuCl2 in a sealed

60 However, Au/Selecfluor, our first-generation catalyst system, suffers from undesired

61 imethyl-imidazolidin-4-one (11a, MacMillan's first-generation catalyst) gives the corresponding cyclo

62 ene isomerization that was observed with our first-generation catalyst, providing vastly improved yie

63 e scaffold is structurally distinct from the first-generation CB1 inverse agonists.

64 om enriched CD8(+) TCM subsets, expressing a first-generation CD19 CAR containing only the CD3zeta en

65 tivity, thus avoiding problems observed with first generation CDK inhibitors.

66 The first-generation CDK inhibitors demonstrated broad activ

67 tissue specificity precluded clinical use of first-generation, centrally acting CB1 receptor blockers

68 ophylaxis for vascular procedures includes a first generation cephalosporin.

69 between 2016 and 2018, 6114 (40%) received a first-generation cephalosporin, 4097 (27%) received a se

70 tive antibiotics were initially collected as first-generation cephalosporin, second or third-generati

71 B-lactamase inhibitors (OR 3.65; P < .001), first-generation cephalosporins (OR 2.38; P = .03), and

72 Thus, we advance first generation chemical biology tools to aid in the id

73 nd of optogenetic inhibition; however, these first-generation chloride-conducting channels displayed

74 gh activity or reasonably long scan times, a first-generation clustered-pinhole system can provide im

75 molecular libraries is often used to develop first-generation compounds, but subsequent target identi

76 he development of viral drug resistance than first-generation compounds, the mechanisms underlying th

77 As with these first-generation consortia efforts, the GLIOGENE Consort

78 ture that addresses important limitations of first-generation consortia efforts, which comprised a po

79 n, may overcome the "therapeutic ceiling" of first-generation correctors.

80 has better cooling properties compared with first-generation cryoballon.

81 nergy value in the polymers contained within first-generation crystalline silicon (c-Si) PV modules t

82 triazene activation, a dodecaiodo-terminated first generation dendrimer, which was transformed by ano

83 nds reported here share an architecture with first-generation dendrimeric constructs, making the conv

84 cationic self-assembling multivalent (SAMul) first generation dendrons based on L or D lysine, which

85 itions where complex tooth shapes develop in first generation dentitions that lack the capacity for l

86 To study SAR of this scaffold, first-generation derivatives were synthesized and evalua

87 ibuted as follows: bare metal stent (n=388), first-generation DES (n=425), and second-generation DES

88 CI: 0.96 to 2.47]) compared with the use of first-generation DES (OR: 3.94 [95% CI: 2.20 to 7.05]; p

89 For bare metal stent, first-generation DES and second-generation DES, ACS was

90 rior clinical outcomes compared with BMS and first-generation DES and similar rates of cardiac death/

91 However, the first-generation DES had substantial drawbacks, includin

92 y syndrome) were randomly assigned to have a first-generation DES implanted.

93 eneration DES to BMS) and indirect evidence (first-generation DES with BMS and second-generation DES)

94 Of these, 38% received BMS, 15% received first-generation DES, and 47% received second-generation

95 d into 3 groups according to stent use: BMS, first-generation DES, and newer generation DES group.

96 patients receiving bare-metal stents (BMS), first-generation DES, and newer generation DES in a larg

97 interval, 0.38-0.68; P<0.001), but not with first-generation DES, compared with BMS-treated patients

98 ted with second-generation DES, but not with first-generation DES, compared with the patients treated

99 zed controlled trials comparing stent types (first-generation DES, second-generation DES or BMS) were

100 degradable polymer DES platforms compared to first-generation DES.

101 ath or MI only in patients with DM receiving first-generation DES.

102 (ST) and late adverse outcomes compared with first-generation DES.

103 These first-generation designs thicken beyond single PNTs.

104 The first generation device demonstrated great potential and

105 fabricated, and experimentally compared to a first-generation device ("Gen 1").

106 Our first-generation devices containing (PEA)2(MA)2[Pb3I10]

107 First-generation devices were pulsatile, but they had po

108 revious studies were based on less-effective first-generation devices, and analyzed only dichotomized

109 m safety and efficacy outcomes compared with first-generation devices.

110 rates than transfemoral TAVR performed using first-generation devices.

111 Two "first-generation," directly radiolabeled anti-CD20 antib

112 beta-interferons and glatiramer acetate, the first-generation DMTs, several newer therapies are imbue

113 t, mainly because of the "always-on" mode of first-generation DNAzyme sensors.

114 e- to five-times half-life compared with the first generation), dramatically enhanced inhibition of t

115 ads could drive the design of more resilient first generation drug candidates.

116 First-generation drug-eluting coronary stents (DES) were

117 second-generation drug-eluting stent to the first-generation drug-eluting stent and the noninferiori

118 Compared with bare metal stents (BMS), first-generation drug-eluting stents (DES) have signific

119 ears after PCI with bare-metal stents (BMS), first-generation drug-eluting stents (DES1) and second-g

120 First-generation drug-eluting stents were associated wit

121 olimus have been shown to be superior to the first-generation drug-eluting stents.

122 uced extrapyramidal side effects compared to first generation drugs.

123 are underway to test the efficacy of several first-generation drugs that target the alternative compl

124 First-generation Edwards SAPIEN valves and delivery syst

125 common mechanisms of acquired resistance to first generation EGFR TKIs including EMT are now being o

126 model that initially developed resistance to first-generation EGFR inhibitors via cMET activation.

127 The first generation ELFI prototype is simply assembled in a

128 Studies using a first-generation enzyme-linked immunosorbent assay test

129 creased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR)

130 Unlike first-generation epigenetic therapies, these new agents

131 The Argus I implant is the first-generation epiretinal prosthesis approved for an i

132 il practices combined with the production of first generation ethanol and electricity (scenario s2) w

133 would not perform better than the projected first generation ethanol, although the uncertainties are

134 ignaling and could be potentially useful for first-generation (F1) hybrid breeding.

135 utations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer

136 as greater dynamic range and robustness than first-generation FLARE and can be used in culture as wel

137 Altered dormancy was only observed in the first generation following herbivory, whereas defence pr

138 While generally efficacious, ACTs and the first generation fully synthetic ozonide, arterolane (OZ

139 merize BBs significantly faster than Grubbs' first generation (G1) and Hoveyda-Grubbs' second generat

140 The first generation (G1) metallo-triangles were directly ob

141 amine the association between grandparents' (first generation (G1)) life-course exposure to chronic p

142 Methods: The (18)F-labeled first-generation galactodendritic unit 4 was obtained fr

143 tility of scRNA-seq in plants and provides a first-generation gene expression map of the Arabidopsis

144 that may be exploited to improve upon these first generation GlgE inhibitors.

145 ates the biotechnology-engineered commercial first generation glyphosate-tolerant EPSPS in corn (Zea

146 gene expression in the offspring of wild and first-generation hatchery steelhead trout (Oncorhynchus

147 was reached in 2011 with the approval of the first-generation HCV NS3/4A protease inhibitors.

148 First-generation HIV protease inhibitors (PIs) alter pro

149 P = .89) and drug-eluting stent generation (first generation: HR, 0.90; 95% CI, 0.68-1.20; P = .49;

150 in regions near genes and within TEs in the first-generation hybrid, intermediate in the resynthesiz

151 ple of speciation by hybridization, in which first-generation hybrids instantly attain reproductive i

152 However, the first-generation ICG-NPs have a short shelf life (<1 mon

153 A cohort of 824 662 first-generation immigrants aged 30 to 74 as of January

154 First-generation immigrants arriving in Denmark before a

155 : Of the 4582 survey participants, most were first-generation immigrants from China (68.7%) and femal

156 ned multiple sclerosis incidence rates among first-generation immigrants in Denmark, a high-incidence

157 Multiple sclerosis risk among first-generation immigrants whose parents were born in l

158 We developed the first generation in-situ pathogen detection system (Gen1

159 are 10-fold more potent toward Cif than our first-generation inhibitors and have no detectable thyro

160 C, and D enzymes that are not susceptible to first-generation inhibitors containing a beta-lactam rin

161 First-generation insecticidal PIPs were Cry proteins exp

162 patients with virus harboring resistance to first-generation integrase inhibitors.

163 Here, we adapt the first-generation KTR for extracellular signal-regulated

164 The development of first-generation land surface models as a unifying frame

165 covery of 4 that is vastly improved from the first generation late INa inhibitor 1 (ranolazine).

166 preliminary pharmacokinetic assessment of a first-generation lead 4a (A91).

167 ivity for Ral GTPases when compared with the first-generation lead peptide.

168 An isotopologue of our first-generation lead, [(3)H]PF-367, demonstrates select

169 A series of first-generation light-driven molecular motors with rigi

170 First-generation liposomes have emerged as one of the fi

171 While first generation long acting/extended release (LA/ER) DD

172 dence for possible decomposition pathways of first-generation materials and guided synthetic modifica

173 e rapidly hydrolyzable Schiff-base moiety of first-generation members with a cyclic, unhydrolyzable p

174 First-generation memory versus non-memory comparison, an

175 We created a first-generation metastasis map (MetMap) that reveals or

176 ctive double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role

177 effects in a population comprising primarily first-generation Mexican Americans with major depression

178 Evaluation on multiple datasets-first-generation MicroArray Quality Control (MAQC) brain

179 revalent among second-generation compared to first-generation migrants.

180 A first-generation model, built from existing gene network

181 mplified model can be reduced further to the first-generation models, whereas our full model is consi

182 ers stabilized in NU-1000 provide an active, first generation MOF-based, selective methane oxidation

183 HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineff

184 Among these agents, first-generation mTOR inhibitors (rapalogs) have caused

185 al impacts have focused on relatively simple first-generation nanomaterials, including metals or meta

186 However, first generation native-like trimers expose epitopes for

187 populate the neurogenic niche containing the first-generation neuronal precursors.

188 Our first-generation nickel-based liposomes captured HIV-1 E

189 al assessments we conducted, similar to the 'first generation' non-conditional A7KO mice.

190 To obtain more detailed interactions between first generation, non-covalent inhibitors and GlgE, a va

191 Second, in an in vivo comparison with first-generation (nondegradable, molecular weight below

192 only be considered if treatments depend on a first-generation nonnucleoside analogue reverse transcri

193 Overall, our results suggest that "first generation" NP risk models have probably misrepres

194 Once specified in the niche, first generation NPs act as transit-amplifying intermedi

195 The first-generation NRTIs, including 2',3'-dideoxycytidine

196 antly improved genotype coverage relative to first-generation NS5A inhibitor daclatasvir (DCV), is de

197 19 and observe Cas9-induced mutations in the first generation of 23 % and 10 % of the lines, respecti

198 number of secondary cases was higher for the first generation of a transmission chain (mean = 1.77) c

199 and observed that it is more potent than the first generation of Ab for controlling Ab-resistant tumo

200 The first generation of Aurora kinase inhibitors did not far

201 have recently been overcome, leading to the first generation of autonomous motors and pumps on scale

202 The first generation of CB(1) positive allosteric modulators

203 However, the first generation of CB1 inverse agonists, represented by

204 The first generation of childhood cancer survivors is now ag

205 The first generation of chloride-conducting channelrhodopsin

206 ve design concepts, and it might lead to the first generation of deformable resonant devices.

207 ositions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline ta

208 The first generation of forest free-air CO2 enrichment (FACE

209 oncogene transactivation associated with the first generation of gammaretroviral vectors.

210 Here, we tested the first generation of soluble, native-like envelope trimer

211 rm are presented with the aim to achieve the first generation of specific urinary tests for the detec

212 The first generation of synthetic vaccines has been largely

213 Deletion of the mTert gene in the first generation of Tert null mice compromised tumor gro

214 on-genetic inheritance is not limited to the first generation of the progeny, but can involve the gra

215 ned with transition state analogs produced a first generation of triple-helical peptide inhibitors (T

216 panel for robust inferences of parental and first generations of admixed ancestries.

217 mediate genome merger, but occurs within the first generations of allopolyploid formation.

218 A first-generation of luminescent MCs was presented previo

219 agents for patients following the approved "first generation" of DNA methylation (e.g., Dacogen, Vid

220 o increase the density of macular pigment in first-generation offspring of parents with neovascular A

221 They were first-generation offspring of parents with neovascular A

222 Among first-generation offspring of parents with neovascular A

223 The frequency of first-generation offspring of patients affected by EoE o

224 oral rabies vaccination (ORV) campaigns: (1) first generation ORV (SAD-B19) in foxes, (2) SAD-B19 in

225 her potency than compound 1 and verapamil, a first-generation P-gp modulator.

226 -eluting stent (CoCr-EES) is superior to the first-generation paclitaxel-eluting stent (PES) and is n

227 existed in all-cause death between PCI using first-generation paclitaxel-eluting stents and CABG.

228 rcutaneous coronary intervention (PCI) using first-generation paclitaxel-eluting stents with coronary

229 First-generation pan-Jak inhibitors can be useful for a

230 The evolved octapeptides, but not first-generation peptides, discriminated one-way blinded

231 promise to improve the clinical outcomes of first-generation PES.

232 A first generation photoproximity probe, PP1, responds to

233 rate therapeutic resistance, particularly to first-generation PIs.

234 a leads to Cas9-induced mutations in 10 % of first generation plants screened.

235 PLGA-b-PEG-b-PLGA sol-gels are a first-generation platform for the localized multi-drug d

236 PEG-b-PLA micelles are a first-generation platform for the systemic multi-deliver

237 d for vastly prolonged E2 release, we report first-generation poly(pro-E2) biomaterial scaffolds that

238 nscatheter aortic valve replacement with the first generation Portico valve and delivery system or a

239 The first-generation Portico valve and delivery system did n

240 However, the first-generation precursors that produce adult-born neur

241 cterizing the reactivity and kinetics of the first-generation products of these reactions, carbonyl o

242 missense mutations revealed by sequencing in first-generation progeny of N-ethyl-N-nitrosourea-treate

243 ed TT may be a cost-effective alternative to first-generation protease inhibitors depending on pricin

244 Bortezomib is a first generation proteasome inhibitor that is the frontl

245 lowers cLogP by one log unit compared to the first-generation prototype CIQ.

246 eft ventricular assist devices have replaced first-generation pulsatile devices.

247 loline alkaloids is reported and extends our first-generation (racemic) synthesis of this alkaloid fa

248 n limited by high nonspecific binding of the first-generation radioligand, low-resolution scanners, s

249 om patients treated with RAF inhibitors, the first-generation RAF inhibitor vemurafenib stimulated in

250 Although ATP-competitive, first-generation RAF inhibitors (vemurafenib/PLX4720, RA

251 al and thyroid BRAF(V600E) cancers, in which first-generation RAF inhibitors have been ineffective.

252 First-generation RAF inhibitors paradoxically induce ERK

253 proved safety and more durable efficacy than first-generation RAF inhibitors, a concept currently und

254 The development of first-generation RAF inhibitors, including vemurafenib (

255 me several known mechanisms of resistance to first-generation RAF inhibitors.

256 p decipher this growing biology, we report a first-generation ratiometric fluorescence resonance ener

257 y up to 64-fold increase in sensitivity over first-generation reagents.

258 In at least two cases we found first-generation recombinant offspring of parents whose

259 One of these approaches is a first-generation recombinant vesicular stomatitis virus

260 rate approximately 100 times faster than the first generation ReOx-Pd/C catalyst prepared from perrhe

261 of genotoxicity caused by the integration of first-generation retroviral vectors.

262 were more effective than treatment with the first-generation reversible inhibitors in inhibiting gro

263 more than doubling the overall yield of the first generation route.

264 Median longevity of the first generation S-ICD system was 5.0 years.

265 tients who underwent imaging with a previous first-generation scanner.

266 This first-generation, selective mechanism-based inhibitor (M

267 terpyridine-based architecture that mimics a first-generation Sierpinski triangle has been synthesize

268 Many first-generation Smac-mimetics such as compound A (2) we

269 six combustion sources form 0.7 Tg y(-1) of first-generation SOA in the United States, almost 90% of

270 control despite receiving high doses of the first-generation somatostatin analogues octreotide or la

271 megaly who are inadequately controlled using first-generation somatostatin analogues.

272 Our previous study showed that some of our first-generation spiro-oxindoles undergo a reversible ri

273 These 16 amines were used to synthesize five first-generation spiroligomer-peptoids hybrids.

274 dge, this survey is the first EWAS for PD in first generation SSA migrants.

275 un, suggesting that the mass distribution of first-generation stars might extend to 100 solar masses

276 rom low-energy supernovae would have enabled first-generation stars to form over an extended period.

277 I and II clinical trials with autologous and first-generation stem cells have yielded inconsistent be

278 g L(-1), a 57,000-fold improvement over our first-generation strain.

279 a diacetoxytetraindole formed the basis of a first-generation synthetic route toward the alkaloid bis

280 o heading within families demands roguing in first generation synthetics.

281 Here, we demonstrated that first-generation TERT-null mice, unlike Terc-null mice,

282 ked to the acquired resistance against those first generation therapeutics.

283 The present study sought improvements in the first generation THPIs by enhancing thermal stability an

284 e evolution of catheter-based treatment from first-generation thrombectomy devices to the game-changi

285 homozygous TIN2(DC/DC) mice were not viable, first-generation TIN2(+/DC) mice were healthy and fertil

286 ESKM was superior to the first-generation TKI, imatinib.

287 d is a candidate resistance mechanism to the first-generation TKIs.

288 Recent insights indicate that 'first-generation' TNFRSF agonists lack efficacy as they

289 coverage, describe our efforts to develop a first-generation total-body PET/CT scanner, discuss sele

290 The first generation transgenic crops used strong constituti

291 AD) research community has historically used first-generation transgenic (Tg) mouse models that overe

292 Compared with first-generation trials, a significantly greater reducti

293 t autologous tier-2 neutralization, unlike a first-generation trimer.

294 Following on from ezutromid, the first-generation utrophin modulator, we describe the dev

295 vaccine-associated viraemia compared to the first-generation vaccine and both provided complete, sin

296 ll as the phylogenetic relationships of this first-generation vaccine.

297 ecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection.

298 hase I/II clinical trials now underway using first-generation vaccines against PfRH5, and more on the

299 First-generation vaccines used to eradicate smallpox had

300 mV) and improved photostability relative to first-generation voltage sensors.