ライフサイエンスコーパス: first step

1 th step was larger than that effected in the first step.

2 ave greatly alleviated the constraint of the first step.

3 In the first step, a simple W(1)/O emulsion was prepared with d

4 We too find that some first-step adaptive mutations can improve all traits to

5 essing across societies, we argue that, as a first step, all epidemiological and intervention researc

6 In the first step, already before ZGA, Pou5f3 and Nanog destabi

7 y downregulation of pluripotent genes in the first step and upregulation of the 2-cell-embryo-specifi

8 ome-directed catalyst prodrug therapy, whose first steps are presented herein with the cell-specific

9 e Institute of Laser Engineering, Osaka, the first steps are taken towards the development of a table

10 water mass exchange was reduced by ~90% in a first step at ca. 20 Ma.

11 We present a first step, based on a regional analysis, towards a long

12 We report here the first step by step anchoring of a W(=C(t)Bu)(CH(2)(t)Bu)

13 Restriction achieved at the first step can be further refined in a second step, if n

14 The first step consists of an "antigen scanning" phase in wh

15 Hype and hypocrisy are but first steps down a slippery slope towards falsification

16 covery rely on a '2-Step' approach where the first step encompasses building transcripts from individ

17 This PSC technology offers a first step for creating an artificial limb bud in cultur

18 helial cells as a necessary but insufficient first step for development of blinatumomab-associated ne

19 nism to retain the injected substrate in the first step for subsequent labeling.

20 m a mass of heterogeneous cells is a crucial first step for the analysis of single-cell RNA-seq (scRN

21 Read assembly is usually an essential first step for the follow-up studies in metagenomic rese

22 ction by sensory hair cells represents a key first step for the sound sensing ability in vertebrates.

23 A high quality genome assembly is a vital first step for the study of an organism.

24 ORTANCE Virus entry into target cells is the first step for virus infection.

25 ily accessible data sources and suggest some first steps for aspiring computational data analysts.

26 The uptake by plants from soil is one of the first steps for hexachlorocyclohexane (HCH) isomers to e

27 As a first step, how do we systematically trace the provenanc

28 rt prechlorination periods because it is the first step in a complex system of reactions that leads t

29 Here, we show that the very first step in a latent HCMV infection, entry of the viru

30 A first step in accumulation was identified between two an

31 Lifestyle changes are the first step in addressing TBWL, but uncommonly result in

32 As a first step in addressing the last problem, we developed

33 led, structural gene annotation is often the first step in analysis.

34 e preferential colonization of seafloor as a first step in animal evolution is also unusual.

35 As a first step in assessing the feasibility of viral genome

36 The present study takes a first step in better understanding the acceptance of the

37 ied the initial deposition of anaerobes, the first step in biofilm formation, with a consortium isola

38 The first step in both of these processes is catalyzed by me

39 e of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of

40 ism, and its reverse reaction represents the first step in carbon assimilation in the acetogenic and

41 ock-controlled genes mediating the essential first step in circadian output, a group encoding both tr

42 gmented, habitat quantification is often the first step in conservation.

43 and vitamin D supplementation should be the first step in correcting bone mineralization impairment

44 Resolving an fCNA's structure is a first step in deciphering the mechanisms of its genesis

45 Closing this gap is an essential first step in decreasing mortality from HIV-associated h

46 screening in this disease and represent the first step in defining the genetic architecture of RBM20

47 ore of these compartments can therefore be a first step in determining its function.

48 t is important to note that this is only the first step in determining their influence on image-formi

49 This is the first step in developing a biobank of reproductive tissu

50 t to pursue is a challenging and error-prone first step in developing a therapeutic treatment for a d

51 isogenic control isolates, consistent with a first step in developing beta-lactam resistance.

52 These results are a first step in developing methods to utilize user-generat

53 A first step in developing miRNAs as biomarkers for inner

54 Dimensionality reduction is an essential first step in downstream analysis of the scRNA-seq data.

55 Ventral furrow formation, the first step in Drosophila gastrulation, is a well-studied

56 As a first step in drug discovery, we conducted an unbiased c

57 This work is the first step in elucidation of the function of this enigma

58 y ETEC fimbriae is believed to be a critical first step in ETEC pathogenesis.

59 targeted signaling pathways is the essential first step in evaluating their therapeutic potential.

60 The first step in exogenous fatty acid assimilation is phosp

61 two conditions would serve as a significant first step in filling this void.

62 of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the

63 ) of the fungal UDP-glycosyltransferase, the first step in GPI biosynthesis, with good selectivity ov

64 minolevulinate synthase (ALAS) catalyzes the first step in heme biosynthesis, generating 5'-aminolevu

65 This work presents the first step in incorporating a precomputed subpath networ

66 As the first step in investigating the role oxidants plays in t

67 Automated phase identification is the first step in making EBSD into a high-throughput techniq

68 The extraction of bioanalytes is the first step in many diagnostic and analytical assays.

69 separation of plasma from whole blood is the first step in many diagnostic tests.

70 This spatially sensitive technique is the first step in mapping host-influenced de novo lipid A mo

71 ansition from radial to vertical growth, the first step in melanoma invasion, we developed a zebrafis

72 ances of microbes in a sample, is a critical first step in microbiome analysis.

73 Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key

74 -level abundances for each cell is a crucial first step in most dscRNA-seq analyses.

75 a widespread T4F, mediating DNA uptake (the first step in natural transformation) in bacteria with o

76 This paper represents an important first step in opening new avenues of research by leverag

77 The data represent an important first step in our efforts to provide genetically improve

78 ase 1 (Acox1), the enzyme that catalyzes the first step in peroxisomal beta-oxidation, is enriched in

79 Our approach is a first step in providing metrics aimed at unifying the ps

80 The mechanistic reaction of the clot is the first step in providing scaffolding for the formation of

81 specific basic reproductive ratio is a vital first step in public-health planning.

82 Here, we take a first step in recapitulating the depth and scale of natu

83 This work represents a first step in reconciling the advantages of high status

84 indings of this study represent an important first step in repurposing class I PI3K inhibitors to mod

85 The first step in SARS-CoV-2 infection is binding of the vir

86 leading to CTC homing to the endothelium, a first step in secondary tumor formation.

87 The first step in several catalytic cycles is P-H oxidative

88 The first step in sour taste transduction is believed to be

89 quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H(2)S oxidatio

90 As a first step in testing this hypothesis, we set out to dem

91 hane by methanogenic archaea, as well as the first step in the anaerobic oxidation of methane to meth

92 se from Ajuga reptans, catalyzing the likely first step in the biosynthesis of a variety of insect-an

93 agnesium-dependent enzyme that catalyses the first step in the biosynthesis of branched-chain amino a

94 on of glutaminase (GLS), which catalyzes the first step in the conversion of glutamine to glutamate.

95 This work represents a first step in the design of bacteria with non-canonical

96 and electrocardiography (ECG) variables as a first step in the detection of LV diastolic dysfunction.

97 The content outline represents a first step in the development of a national undergraduat

98 The first step in the development of an MS-based method is t

99 Development of a half-strip LFA is a useful first step in the development of any LFA format.

100 The first step in the diagnostic algorithm is to rule out sp

101 for asymmetric gamete signaling could be the first step in the evolution of non-recombinant mating-ty

102 Bacterial deposition is the first step in the formation of microbial biofilms in env

103 Here, we measure the first step in the in vitro pathway, the folding of DNA i

104 ntothenate kinase Cab1p, which catalyzes the first step in the metabolism of pantothenic acid for CoA

105 stent with transcriptional regulation of the first step in the pathway.

106 They carry out the first step in the production of prostaglandins, importan

107 i of cells in microscopy images is often the first step in the quantitative analysis of imaging data

108 The first step in the S-acylation process is the recognition

109 lycerate dehydrogenase (PHGDH) catalyzes the first step in the synthesis of the amino acid serine, im

110 riendly format requiring simple steps is the first step in the translation of plasmonic enhancement s

111 ubilization from the membrane is usually the first step in the workflow.

112 her using DNA-mediated charge transport as a first step in their search for lesions.

113 ir gene expression profiles is a fundamental first step in this endeavour.

114 Together these data provide a critical first step in understanding how mycobacteria recycle the

115 This study is a key first step in understanding how RQ is made in parasitic

116 This study represents a first step in understanding how side-stream cannabis vap

117 yses of healthy, nonpregnant cervixes is the first step in understanding other SWE changes related to

118 It is a first step in understanding the distinctions of origin f

119 ata from a limited cohort provide a critical first step in understanding the earliest immune response

120 As a first step in understanding the effect of long-term appl

121 This study represents an important first step in understanding the functional urinary glyco

122 This work represents a first step in using computational methods to guide and t

123 the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding

124 ivated, platelets induce blood clotting (the first step in wound healing) in part by the release of p

125 development of molecules that can module the first steps in alphaS aggregation towards novel treatmen

126 The first steps in dereplication and characterization of PNP

127 etised large animal model, and represent the first steps in driving KHFAC modulation towards clinical

128 segmenting objects from images are often the first steps in quantitative measurement of these biomark

129 anges and associated berry softening are the first steps in ripening and that delaying cell expansion

130 icate that these are likely to represent the first steps in the proton translocation mechanism.

131 isogenic control isolates, consistent with a first-step in developing beta-lactam resistance.

132 The first step involves the elucidation of all intracellular

133 ding and the rate constants suggest that the first step is copper complex binding within the channel,

134 The first step is the binding of DndCDE-FeS to DNA and searc

135 A critical first step is the de novo identification and accurate co

136 tide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second s

137 In the proposed technique, the first step is to detect anatomical components within a m

138 the regulation of body weight, an important first step is to establish the normal range of metabolic

139 f interest (ROIs) from original dataset, the first step is to train our proposed deep fusion models o

140 The first step is to use incoming and outgoing truncated Kor

141 In the first step, it phases and imputes parental genotypes bas

142 sordered nitrobenzene guests released in the first step (lower temperatures) because of the absence o

143 aco-ECPL, a minimally invasive procedure, as first-step management in PAC disease, for which combined

144 oncentrations of pyruvate and lactate in the first step medium and EAA and Glu in the second step med

145 For the first step, methylmercury was extracted into 1-undecanol

146 sions, the contingency of lineage outcome on first-step mutations and the ability for strains to esca

147 DMAPP) dependent UbiX enzymes, we reveal the first step, N5-C1' bond formation, is contingent on the

148 y approaches and strategies, and defines the first steps needed to deliver them.

149 The first step, occurring over several years of (*)OH exposu

150 e mRNA decapping complex, that catalyzes the first step of 5'mRNA decay.

151 nt enzyme-adenylate intermediate is a common first step of all DNA ligases.

152 Scaling by sequencing depth is usually the first step of analysis of bulk or single-cell RNA-seq da

153 These results shed light on the first step of biofilm formation on the membranes in AnMB

154 udy aimed to provide understanding about the first step of bread digestion by exploring release of co

155 late physiological processes is an important first step of drug discovery.

156 ed on how the MCMV genome is translated, the first step of gene expression by all positive-strand RNA

157 E Virus entry into a susceptible cell is the first step of infection and a significant point at which

158 ceptor, thiamine transporter feTHTR1, is the first step of infection.

159 th respect to the cell membrane - a probable first step of its translocation into cytoplasmic targets

160 GlcNAc) acyltransferase (LpxA) catalyzes the first step of lipid A biosynthesis, the transfer of an R

161 Reverse transcription is the first step of most analyses of gene expression, yet the

162 y system of flies.SIGNIFICANCE STATEMENT The first step of olfactory processing is receptor binding,

163 This constitutes the first step of photochemical and photophysical processes

164 failure by restoring oxygenated blood as the first step of preconditioning.

165 ield of genomic data analysis: (i) takes the first step of proactive data analysis by utilizing avail

166 ids to cognate tRNA molecules, the essential first step of protein translation.

167 these steps, nucleic acid extraction is the first step of sample preparation, which remains one of t

168 tion and active site dynamics induced by the first step of splicing facilitate the progression to the

169 anch-site adenosine, the nucleophile for the first step of splicing(1).

170 ture intermediate, CRK9 is essential for the first step of splicing.

171 e given to the drug combination treatment as first step of the antihypertensive therapeutic intervent

172 19 000 mol(-1) L s(-1) by simulation of the first step of the cathodic reduction of 4-nitrophenylace

173 The first step of the cycloaddition is rate-determining, and

174 ructose to fructose-1-phosphate (F1P) in the first step of the metabolic cascade.

175 ylalanine ammonia-lyase, which catalyzes the first step of the phenylpropanoid biosynthesis pathway.

176 neutral triradicals (and DMDS) influence the first step of the reaction while the vertical electron a

177 ls by flavin-dependent monooxygenases is the first step of their biotransformation in various microor

178 events occurring downstream of Org-1 in this first step of transdifferentiation and show that alary m

179 wers tRNA binding affinity, representing the first step of tRNA release.

180 Receptor recognition and binding is the first step of viral infection and a key determinant of h

181 y controlled self-association represents the first step of VLP assembly and, in concert with scaffold

182 ed resistance by genetically hard-wiring the first steps of an induced immune response to become cons

183 erefore, our findings shed some light on the first steps of APN-mediated MMP activation and open the

184 racellular matrix remodeling represented the first steps of glomerulosclerosis, paving the way for fu

185 further provide a detailed mechanism of the first steps of hydrolysis.

186 Here, we investigated the first steps of MC formation in zebrafish using transgeni

187 herapeutic target for its involvement in the first steps of neurodegeneration as well as in cancer on

188 Our evidence illuminates the first steps of the assembly of the pterosaur body plan,

189 s hindered by a lack of understanding of the first steps of the photochemical gas-to-particle convers

190 the atomistic nature of these sites and the first steps of transformation is therefore critical to m

191 tem at low forces that likely constitute the first steps of VWF's mechano-activation.

192 In a first step, Raman spectra of aqueous solutions are evalu

193 e residues of enzymes with DAP permits their first-step reaction with native substrates, allowing the

194 We found that cell segregation is the first step required for basal extrusion of luminal cells

195 tion of ingested spores is often a necessary first step required for enabling bacterial outgrowth and

196 ischemic burden, suggests its potential as a first-step screening tool in intermediate-risk patients

197 During the strongly temperature-dependent first step, sensitization, the channel pore remains clos

198 ps in horseradish and watercress represent a first stepping stone for future whole-genome sequencing

199 These results represent a first stepping stone into integrated chemical networks r

200 In the first step the amine is formylated via an in situ formed

201 In a first step, the activities of the enzymes are quantified

202 In the first step, the ambiphilic M(2)[DBA] activate H(2) in a

203 The first step, the conversion of GTP to cyclic pyranopterin

204 In the first step, the VOC observations were used to optimize t

205 As a first step, this article briefly describes the start-to-

206 consensus recommendations were an important first step to address opioid prescribing, our data sugge

207 nderstanding late recurrence is an essential first step to address this issue.

208 Clustering is often the first step to be performed in sequence analysis.

209 Our review is a critical first step to building the evidence-base for healthcare

210 mic changes inflicted by both pathogens as a first step to characterize specific infection strategies

211 A first step to combating antimicrobial resistance in ente

212 This study is a first step to disentangle the interaction between psycho

213 This study is a first step to evaluate the risk associated with submarin

214 the query cavity space, thereby proposing a first step to fragment-based design approaches targeting

215 dability of EAT-Lancet benchmark diets, as a first step to guiding interventions to improve diets aro

216 r mixture toxicity testing at least within a first step to identify and prioritize relevant mixtures

217 sed mood and anhedonia) and can be used as a first step to identify patients for evaluation with the

218 na across a range of ecosystems represents a first step to study future changes that may result from

219 lying landscape of variation is an essential first step to understanding the drivers of this variatio

220 As a first step to understanding the recombination landscape

221 The results provide the first step to untangle the role played by water dynamics

222 Herein, we report the first steps to create long-lasting (for tens of minutes)

223 ual patients to enteritis and have taken the first steps to develop such an assay.See related article

224 The conditions identified (first step: toluene/AcOH = 1:1, 1 h, 50 degrees C; secon

225 ific glycosylation features and is a crucial first step toward a better understanding of the mechanis

226 w of chemicals on the market as an essential first step toward a global understanding of chemical pol

227 iquitination pathway, making these PROTACs a first step toward a new class of antiapoptotic B-cell ly

228 proach presented here provides an innovative first step toward a portable OP quantification method th

229 This treatment constitutes a first step toward a unification of VB theory and concept

230 Nevertheless, the first step toward advancing from laboratory-scale to ind

231 aling laws are shown to provide an important first step toward an accurate local closure to predict t

232 This work is a first step toward assessing quantitatively how cellular

233 eRPA represents a first step toward at-home SARS-CoV-2 detection and can b

234 This preliminary study is a first step toward automated PET/CT assessment for lympho

235 olved transcriptomic studies is an important first step toward characterizing the spatial transcripto

236 hese findings show that iDEP can represent a first step toward designing a high-throughput, fast, and

237 The proof of concept reported here is the first step toward designing stretchable inertial microfl

238 The proposed framework is a first step toward developing asthma remission as a treat

239 The development of this method is a first step toward direct observation of the traveling wa

240 erceptions of why this occurs is a necessary first step toward equitable application of this potentia

241 Our finding is the first step toward establishing a standardized RT-qPCR an

242 This is our first step toward establishing OFCD study models by gene

243 wich lanthanide SMMs, which is the necessary first step toward rationally achieving higher magnetic b

244 ption and production patterns is a necessary first step toward reducing the health and climate impact

245 Since intraspecific divergence is often the first step toward speciation, the same factors can be im

246 ng of S. aureus colonization is an important first step toward the development of novel, ecological t

247 As a first step toward the elucidation of the structural basi

248 Our work represents a first step toward the mechanistic understanding of the p

249 aB constituents to infection is an essential first step toward the possibility of targeting this path

250 Our results may provide a first step toward the rational design of electrochromic

251 This serves as a first step toward translating predicted response in the

252 Such categorization is a first step toward understanding how diversification rela

253 As a first step toward understanding practical benefits of th

254 the already complex stomatopod eye and is a first step toward understanding the functional significa

255 This work represents an important first step toward understanding the mechanisms that unde

256 s for P. putida, which can be leveraged as a first step toward understanding the pan metabolic capabi

257 network science have allowed us to take the first steps toward a comprehensive assessment of the exp

258 Building first steps toward a future monitoring system, we levera

259 during heart development, which are crucial first steps toward deciphering oligogenic underpinnings

260 This study represents the first steps toward the evaluation of rationally formulat

261 This demonstration is a first step towards a full cryogenic memory architecture

262 This panel represents the first step towards a quantitative genotypic model of ins

263 suring the vulnerability of each island is a first step towards a risk analysis to identify where the

264 xtend this methodology to other systems as a first step towards characterizing complex interfaces and

265 with dissipative Kerr solitons, providing a first step towards connecting semiconductor ring lasers

266 As a first step towards determining whether motion perception

267 Our work marks the first step towards electron-to-photon (spin-to-polarisat

268 gnition of this role of public health is the first step towards encouraging a joined-up approach to d

269 abiotic stress responses in the plant, as a first step towards establishing a comprehensive picture

270 specific role compared to H2A.2 and may be a first step towards evolution of a repair-specific functi

271 eptual progress from these various models, a first step towards harnessing quiescent NSCs for therape

272 Together, this information may provide the first step towards lead compound development for therape

273 tion of MM and VD(3) loading is an essential first step towards manipulating food structures for impr

274 n long-generation trees, and constitutes the first step towards marker-assisted disease resistance br

275 se materials reported herein demonstrate the first step towards next-generation implantable biomateri

276 As a first step towards testing the hypothesis that chemical

277 This work demonstrates that NeuralXC is a first step towards the design of a universal, highly acc

278 We view this work as a first step towards the large scale hardware implementati

279 In eukaryotes, a first step towards the nuclear DNA compaction process is

280 This work represents a first step towards the simultaneous multicomponent enant

281 maps and newborn estimates are an important first step towards this aim.

282 ition of a population, our study serves as a first step towards understanding the generation and main

283 This question is the first step towards understanding the potential influence

284 These results provide first step towards understanding what microstructural an

285 within linkage region 1 which may provide a first step towards unravelling more complex genetic patt

286 Our study is the first step towards using purified insect odorant recepto

287 Our results represent first steps towards a model that can make predictions on

288 These high-resolution models provide the first steps towards representing soil ecological process

289 ntegration of activated macrophages offers a first-step towards a multi-factorial amenable IBD platfo

290 (chloroplast, leaf and whole plant) and is a first-step towards representing mechanistically leaf ont

291 In the first step, untargeted metabolomics was used, which empl

292 future of scalable analogical innovation and first steps using crowds and artificial intelligence (AI

293 curs in at least three steps, where only the first step was affected by the membrane density of ATRAM

294 As a first step, we examined the effects of single very low d

295 As a first step, we sought to identify potential 14-3-3-bindi

296 As a first step, we used Tg(Pcp2-L10a-Egfp) TRAP mice to prof

297 Patients who tested positive in the first step were randomly allocated to a training or a te

298 Droplet growth is the first step, which accelerates with decreasing temperatur

299 s downregulation of pluripotent genes in the first step, while Dnmt1 impedes 2-cell-embryo-specific g

300 lines of 21%-32% on average, gains from this first step would be significant if quality was improved