ライフサイエンスコーパス: first trimester

1 uorononanoic acid (PFNA) in maternal plasma (first trimester).

2 only in cases of a maternal infection in the first trimester.

3 n began the use of antenatal care during the first trimester.

4 d ratio, 1.26; 95% CI, 0.91-1.74) or for the first trimester.

5 r, but nonsignificant, point estimate in the first trimester.

6 and ambient temperature exposures during the first trimester.

7 increased pregnancy termination rate in the first trimester.

8 359 Chinese women with ALT measured in their first trimester.

9 es (34-191) per 10,000 women infected in the first trimester.

10 t 1 prescription for a typical AP during the first trimester.

11 s whose mothers reported symptoms during the first trimester.

12 antenatal systemic therapy and 2 during the first trimester.

13 omen were exposed to omalizumab during their first trimester.

14 Six miscarriages (8%) occurred during the first trimester.

15 with arteries only appear at the end of the first trimester.

16 4 mRNA levels in the third trimester but not first trimester.

17 o ICS monotherapy at higher doses during the first trimester.

18 re less likely to begin prenatal care in the first trimester.

19 red in the periconceptional period or in the first trimester.

20 the opportunity of serology screening in the first trimester.

21 s commenced before conception or late in the first trimester.

22 red in the periconceptional period or in the first trimester.

23 9) after a maternal primary infection in the first trimester, 0 (95% CI 0-6.49) after an infection in

24 as started early in pregnancy (when begun in first trimester, 0%-0.4%; when begun after first trimest

25 Three patients were scanned during the first trimester (1 with PET and 2 with PET/CT), 2 were s

26 ntified: 6,872 (8.8%) were vaccinated in the first trimester, 11,678 (14.9%) in the second and 12,931

27 the vaccine, 14 385 were exposed within the first trimester (14 weeks), and 7502 were exposed during

28 gns and symptoms during pregnancy, 18 in the first trimester, 4 in the second trimester, and 1 in the

29 rse outcomes after maternal infection in the first trimester, 52% after infection in the second trime

30 s (58.3%) were born to women infected in the first trimester, 8 (33.3%) in the second trimester, and

31 y pregnancy, 1.3E-02 in the late part of the first trimester, 8.5E-03 in the second trimester, and 5.

32 ernal infections and fetal infections in the first trimester, 88% (29/33) and 92% (11/12), respective

33 d with 20% (CI, 16% to 24%) of women who had first-trimester abortion and 21% (CI, 18% to 25%) who ha

34 were included in this analysis (328 who had first-trimester abortion, 383 who had second-trimester a

35 90 (9.4%) women had a record of at least one first-trimester abortion, and 10 216 (2.0%) had a suicid

36 -0.23% to 0.56%) for vaccination during the first trimester and 0.10% (CI, -0.41% to 0.62%) for vacc

37 n 65% of patients who began the study in the first trimester and in 32% who began the study in the th

38 e majority of these vaccinations were in the first trimester and in 83 (62%), no AE was reported.

39 ughout gestation whereas NPFFR2 increases in first trimester and is elevated in placenta samples from

40 on deficiency, recommending oral iron in the first trimester and IV iron later.

41 osure exclusively in the first trimester (or first trimester and periconceptional period), with no re

42 of pregnancies infected with ZIKV during the first trimester and provide estimates of microcephaly ca

43 Twelve cytokines were measured in first trimester and term maternal plasma, and in cord bl

44 hroughout pregnancy, particularly during the first trimester and the days immediately preceding deliv

45 ceptors localized to cytotrophoblasts in the first trimester and to syncytiotrophoblasts in the third

46 ers demonstrated a viral syndrome during the first trimester and who subsequently were born with micr

47 y exposed to H1N1 vaccine (13 845 during the first trimester) and 29 293 infants were unexposed.

48 (exposure during any pregnancy period or the first trimester) and cardiac malformations (exposure dur

49 or spontaneous abortion (exposure during the first trimester) and cardiac malformations (exposure dur

50 a healthy infant, 2 had miscarriages in the first trimester, and 1 had fetal death, with the macerat

51 ccinated, 349 mothers were vaccinated in the first trimester, and 5962 mothers were vaccinated in the

52 tients, the valve thrombosis occurred in the first trimester, and all 5 patients had been switched to

53 etermined by a dating ultrasound scan in the first trimester, and infant birth anthropometric measure

54 identified multiple differences between pNK, first trimester, and term pregnancy dNK, suggesting term

55 ess, to develop safe drugs to be used in the first trimester, and to consider preconceptional interve

56 on, the increase in the sex ratio during the first trimester, and total mortality during pregnancy be

57 PD status in an independent N=51 women using first trimester antenatal gene expression levels of HP1B

58 orted first-trimester antidepressant use and first-trimester antidepressant dispensations.

59 ernative hypotheses for associations between first-trimester antidepressant exposure and birth and ne

60 or pregnancy, maternal, and paternal traits, first-trimester antidepressant exposure was associated w

61 Maternal self-reported first-trimester antidepressant use and first-trimester a

62 bination therapies, it is time to reconsider first-trimester antimalarial treatment recommendations.

63 f major congenital anomalies was similar for first-trimester artemisinin (1.5% [95% CI 0.6%-3.5%]) an

64 used to evaluate the association of CAs with first-trimester ARV exposures, adjusting for demographic

65 among infants exposed to lithium during the first trimester as compared with unexposed infants and,

66 eton pregnancies were recruited during their first trimester at two major Singapore maternity hospita

67 With first-trimester atazanavir exposure, risks were highest

68 Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio

69 ce of an increase in preterm birth risk with first-trimester average temperature in the -5 degrees C

70 Chemotherapy is contraindicated during the first trimester because of a higher risk of fetal malfor

71 ight be most vulnerable to ZIKV early in the first trimester before a protective zone of mature villo

72 Higher first-trimester BPA exposure was associated with signifi

73 d cardiac malformations (exposure during the first trimester), but not for spontaneous abortion (expo

74 laparoscopic biopsy was performed during the first trimester, but complete removal of the mass was de

75 s received an influenza vaccination in their first trimester, but the association was not statistical

76 Plasma miRNAs in the first trimester can predict PTB and cervical shortening

77 tal region), and binge-level exposure in the first trimester (chin).

78 First trimester chloramphenicol exposure was associated

79 Further, in response to low oxygen, first trimester chorionic villous tissue from pregnancie

80 d late-gestation placentas and explants from first-trimester chorionic villi with the prototype Ugand

81 We hypothesize that first trimester circulating micro particle (CMP) protein

82 Vitamin K antagonist use in the first trimester compared with heparin was associated wit

83 0-19, and >=20 cigarettes per day during the first trimester compared with mothers who did not smoke

84 tion strengthened with IPT started after the first trimester compared with none (aOR, 0.71 [95% CI, .

85 ificantly increased levels of LBP during the first trimester, compared with HIV-infected women with d

86 Gestational age was estimated from first-trimester dating ultrasound.

87 Weight-averaged aggregate first-trimester DBP exposures were assigned to individua

88 reporting that they had attended ANC in the first trimester did not differ significantly between stu

89 progesterone therapy administered during the first trimester did not result in a significantly higher

90 ensations before pregnancy and with paternal first-trimester dispensations were consistent with findi

91 First trimester dNK facilitate trophoblast invasion, pro

92 arietalis tissues were compared with pNK and first trimester dNK.

93 nition of HLA-C, as was previously shown for first trimester dNK; and 3) protein and gene expression

94 and similar but weaker effect estimates for first trimester drinking.

95 ernal blood samples were obtained during the first trimester, during the third trimester, and at deli

96 First-trimester energy-adjusted maternal protein intake

97 In conclusion, elevated ALT levels in the first trimester even within normal range predicted GDM r

98 ing recommended for malaria treatment in the first trimester except in lifesaving circumstances.

99 LPS exposure in first-trimester explants decreased (P < 0.001) ABCB1 and

100 First trimester exposure to TMP-SMX was associated with

101 h none (aOR, 0.71 [95% CI, .65-.79]) or with first-trimester exposure (aOR, 0.64 [95% CI, .55-.75]).

102 n, after accounting for confounding factors, first-trimester exposure to antidepressants, compared wi

103 Preconception and first-trimester exposure to high VOC levels was associat

104 The study confirmed increased odds of first-trimester exposure to inhaled beta2-agonists for c

105 egistries to examine the association between first-trimester exposure to modafinil and risk of major

106 Of 214 live births with first-trimester exposure to second-generation antipsycho

107 At the population level, first-trimester exposure was associated with all outcome

108 In adjusted models, no association of first-trimester exposures with CAs was found for any ARV

109 (forehead), moderate to high exposure in the first trimester (eyes, midface, chin, and parietal regio

110 First-trimester falciparum and vivax malaria both increa

111 arriage increased 1.61-fold after an initial first-trimester falciparum episode (95% CI 1.32-1.97; p<

112 rimester (August to October) relative to the first trimester (February to April).

113 ebral organoids to recapitulate early stage, first trimester fetal brain development.

114 (LMWH) throughout pregnancy; 3) LMWH for the first trimester, followed by a VKA (LMWH and VKA); or 4)

115 d VKA); or 4) unfractionated heparin for the first trimester, followed by a VKA (UFH and VKA).

116 The prevalences were highest in the first trimester for both submicroscopic and microscopic

117 exposure and groups with low exposure in the first trimester (forehead), moderate to high exposure in

118 ocular findings reported symptoms during the first trimester (frequency, 0.48; 95% CI, 0.02-0.67; P =

119 fetuses, either diagnosed with a CHD in the first trimester (Group I, 127 fetuses) or only in the se

120 s evaluated by whole-genome expression in 67 first trimester human embryonic and fetal ovaries and te

121 First trimester human placental sections displayed stron

122 for miR-517a/c, a C19MC cistron microRNA, in first trimester human placentas displayed strong express

123 Despite this, the role of uterine glands in first trimester human pregnancy is little understood.

124 e characterize the first emerging B cells in first-trimester human embryos, identifying a development

125 ed in cytotrophoblast (CTB) progenitors of a first-trimester human placenta.

126 cribe a protocol to isolate trophoblast from first-trimester human placentas that can be grown long t

127 narrow 'early window' of sensitivity within first trimester, ibuprofen causes direct endocrine distu

128 ure, a recurrent case of POC detected in the first trimester in a mother whose previous pregnancy als

129 ors and ProB-progenitors appear early in the first trimester in embryonic liver, followed by a sustai

130 A testing with standard screening during the first trimester in routine prenatal populations.

131 sequelae following primary infection in the first trimester in subsequent pregnancies in a populatio

132 sequelae following primary infections in the first trimester in subsequent pregnancies.

133 reased nuchal translucency (>=4.0 mm) in the first trimester (in three [3.2%] of 93 fetuses).

134 In trimester-specific analyses, first-trimester influenza vaccination was the only perio

135 Results were similar for first-trimester intake.

136 Excessive GWG in the first trimester is a risk factor for asthma exacerbation

137 ng during pregnancy, quitting smoking in the first trimester is associated with the same risk of pret

138 The first trimester is the time window of interest for malfo

139 Increased first-trimester low-density lipoprotein (LDL-C) concentr

140 id not find evidence of any direct effect of first trimester malaria infections on birth outcomes, th

141 We aimed to assess the effect of first-trimester malaria and artemisinin treatment on mis

142 d 2013, 25 485 pregnancies were analysed for first-trimester malaria and miscarriage, in which 2558 (

143 ria and miscarriage, in which 2558 (10%) had first-trimester malaria.

144 Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal

145 We examined associations between first-trimester maternal plasma PFAS concentrations and

146 First-trimester maternal protein intake was not signific

147 First-trimester maternal total protein intake was associ

148 8%) for women receiving prenatal care in the first trimester (Maternal, Infant, and Child Health Obje

149 l processing capabilities in a subset of the first trimester MIA-exposed offspring (n = 4) and contro

150 tment does not adversely affect fertility or first trimester miscarriage, although it is associated w

151 We found an association between 25(OH)D and first-trimester miscarriages, suggesting vitamin D as a

152 Comparing first-trimester MRI (n = 1737) to no MRI (n = 1418451),

153 For first-trimester MRI exposure, the risk of stillbirth or

154 In the first trimester (n = 2), the sensors were inserted only

155 h the use of artemisinins anytime during the first trimester (n = 37/671) compared with quinine (n =

156 Although first-trimester O3 exposure was not associated with CIMT

157 k of placental growth and development in the first trimester occurs under low oxygen tension.

158 mothers who had a viral syndrome during the first trimester of gestation in an area that subsequentl

159 riods of early development, ranging from the first trimester of gestation to age 6-12 mo.

160 de spectrum of presentation on ultrasound in first trimester of gestation.

161 al: 1.09, 1.97) after famine exposure in the first trimester of gestation.

162 tages, per 10 daily cigarettes smoked in the first trimester of gestation.

163 ndymomas initiate from a cell lineage in the first trimester of human development that resides in res

164 (at a time point analogous to the end of the first trimester of human gestation) in ways relevant to

165 9.0, a developmental stage equivalent to the first trimester of human gestation.

166 th the same supplement commenced late in the first trimester of pregnancy (Arm 2) or not at all (cont

167 larger gestational weight gain (GWG) in the first trimester of pregnancy (P < .001) and increased to

168 spectively) according to exercise during the first trimester of pregnancy (vs.

169 increasing severe abdominal pain during the first trimester of pregnancy and increasing abdominal di

170 ency of the algorithm was highest during the first trimester of pregnancy and lowest during the third

171 enrollment and micronutrient use during the first trimester of pregnancy appeared to be of particula

172 ecommended for falciparum malaria during the first trimester of pregnancy because of safety concerns.

173 led 2,001 women > 18 years of age during the first trimester of pregnancy between 2008 and 2011 from

174 Exposure to MRI during the first trimester of pregnancy compared with nonexposure w

175 stricting the analysis to vaccination in the first trimester of pregnancy did not influence risk esti

176 Progesterone therapy in the first trimester of pregnancy did not result in a signifi

177 ber 30, 2014, among mothers recruited in the first trimester of pregnancy from low-risk, public mater

178 nt increase in state unemployment during the first trimester of pregnancy increased the probability o

179 The first trimester of pregnancy is a particularly high-risk

180 t animal, maternal protein intake during the first trimester of pregnancy is associated with a higher

181 ystemic therapy given for lymphoma after the first trimester of pregnancy is likely safe and results

182 or women who received IIV vaccine during the first trimester of pregnancy or received both vaccines i

183 magnetic resonance imaging (MRI) during the first trimester of pregnancy or with gadolinium enhancem

184 Use of inhaled corticosteroids during the first trimester of pregnancy seems to be safe in relatio

185 cohort of pregnant women (n = 670) in their first trimester of pregnancy was enrolled and followed u

186 , use of intranasal triamcinolone during the first trimester of pregnancy was not significantly assoc

187 febrile illness with rash at the end of the first trimester of pregnancy while she was living in Bra

188 eed for an early fetal therapy (i.e., in the first trimester of pregnancy).SIGNIFICANCE STATEMENT Ope

189 sit, completed at least one visit during the first trimester of pregnancy, attended four or more appo

190 Magnetic resonance imaging exposure in the first trimester of pregnancy, or gadolinium MRI exposure

191 However, malaria in the first trimester of pregnancy, when women are usually not

192 socioeconomic stratum) were recruited in the first trimester of pregnancy.

193 l decongestants should be avoided during the first trimester of pregnancy.

194 t of serum samples were collected during the first trimester of pregnancy.

195 as best explained by a period of risk in the first trimester of pregnancy.

196 of mothers with a viral syndrome during the first trimester of pregnancy.

197 ter exposure to antiasthma medication in the first trimester of pregnancy.

198 er patients initiated prenatal care in their first trimester of pregnancy.

199 gnancy, with a more pronounced effect in the first trimester of pregnancy.

200 re exclusively seen in those infected in the first trimester of pregnancy.

201 re 3 months before conception and during the first trimester of pregnancy.

202 planning pregnancies and for women in their first trimester of pregnancy.

203 re exclusively seen in those infected in the first trimester of pregnancy.

204 ; these small size effects were mitigated by first trimester-of-pregnancy folic acid supplementation.

205 e, we assessed the effects of malaria in the first trimester on maternal and birth outcomes using a p

206 second or third trimester) of malaria in the first trimester on maternal anemia and poor birth outcom

207 is also present if mothers smoke during the first trimester only or reduce the number of cigarettes

208 st invasion into maternal decidua during the first trimester, optimizing hemochorial placentation.

209 d with major malformations when given in the first trimester or subsequently in pregnancy.

210 high, or binge-level alcohol exposure in the first trimester or throughout pregnancy.

211 ess of whether exposure occurred only in the first trimester or throughout pregnancy.

212 255.8), and maternal trimester of infection (first trimester OR, 5.1; 95% CI, 1.9-13.2; second trimes

213 pregnancy is low, and the risk is higher for first-trimester or higher-dosage exposure.

214 conception (OR = 1.52; 95% CI: 1.22, 1.89), first trimester (OR = 1.93; 95% CI: 1.55, 2.40), second

215 rnal symptoms or exposure exclusively in the first trimester (or first trimester and periconceptional

216 n first trimester, 0%-0.4%; when begun after first trimester, or at any time if timing of ART initiat

217 atever the trimester of exposure considered (first trimester: OR, 2.09, 95% CI,1.66-2.64; second: OR,

218 We categorized first-trimester passive and active smoke exposure.

219 a set, we found a modest association between first-trimester passive smoking and oral clefts that was

220 Using human first trimester placenta, decidua, primary dNK cells, an

221 n among different trophoblast populations in first trimester placenta.

222 a major site of STC-1 protein expression in first trimester placental tissue.

223 Here, LPS (1 ug/ml) exposure of first trimester placental villous explants resulted in s

224 Incubation of first-trimester placental explants with TNF-alpha provok

225 CTB progenitors and differentiated SynTBs in first-trimester placental villi; accordingly, expression

226 e also seen in chorionic villi of one of the first trimester placentas.

227 ll lines and anchoring villous explants from first-trimester placentas infected with ZIKV ex vivo.

228 stem cells derived from human blastocysts or first-trimester placentas(7).

229 oglobin in blood plasma can, as early as the first trimester, potentially serve as a diagnostic bioma

230 This was a prospective cohort study of first trimester pregnancies.

231 congenital anomaly (primary outcomes) among first-trimester pregnancies treated with artemisinin der

232 ortantly, analysis in euploid placentas from first trimester pregnancy loss reveals that IDO1 methyla

233 nce of bacteria in the vaginal microbiome in first trimester pregnant women, 52 with their first know

234 , and glial cells missing 1 (GCM1)] genes in first trimester primary human cytotrophoblast cells.

235 at children exposed to maternal fever in the first trimester received an ADHD diagnosis more often th

236 mechanisms of deficient placentation in the first trimester remain poorly understood, although apopt

237 key model, exposure to MIA at the end of the first trimester results in abnormal gaze patterns to sal

238 f HLA-G+ EVT from term pregnancy compared to first trimester revealed their unique phenotypes, gene e

239 In a third group of first-trimester samples all progesterone sulfates were s

240 First trimester sCD14 and LBP levels and third trimester

241 independent association was observed between first trimester sCD14 levels and preterm delivery among

242 First-trimester screening had a significant impact on th

243 The study analyzed the impact of first-trimester screening on the spectrum of congenital

244 n the second-trimester groups differed after first-trimester screening was implemented.

245 imester from 1996 to 2001, the period before first-trimester screening was introduced).

246 6 and 2015 from women with available data on first-trimester screening.

247 48.6% female; 1.4% [n = 22544] with maternal first-trimester self-reported antidepressant use) born t

248 iously shown that these women have increased first trimester serum HBD2.

249 ression models to estimate associations with first-trimester serum levels of triglycerides, total cho

250 Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adv

251 following maternal primary infection in the first trimester suffer long-term sequelae.

252 sociated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE),

253 e mother had an onset of ZVD symptoms in the first trimester than in those with an onset during the s

254 54% of pregnancies that progressed past the first trimester, the dose or the frequency of use of ecu

255 Use of APs during the first trimester, the etiologically relevant period for o

256 For children exposed twice or more in the first trimester, the OR was 2.64 (CI = 1.36-5.14).

257 While no excess risk was observed during the first trimester, the second (adjusted-HR 1.67, 95% CI 1.

258 ed oxidative stress in the transformed human first trimester trophoblast cell line (HTR-8/SVneo).

259 s well as its ligand (CSF-1) in immortalised first trimester trophoblast cells.

260 A profiling of sorted populations of primary first-trimester trophoblasts, we evaluated the first sta

261 f around 12 weeks was referred for a routine first trimester ultrasound scan.

262 Each 1-percentage-point increase in the first-trimester unemployment rate was associated with a

263 During the Great Recession, however, first-trimester unemployment was associated with a 16% i

264 men received CSB Plus (treatment) during the first trimester until delivery or continued their normal

265 ollowing a maternal primary infection in the first trimester, up to 30% of infected neonates suffer l

266 easured 11 phthalate metabolites in maternal first trimester urine samples and assessed folic acid su

267 First trimester urine samples were tested for 12 phthala

268 We analyzed associations between first-trimester urine concentrations of 8 phenols and 11

269 BPA was assayed in first-trimester urine samples from 385 participants who

270 dicaid data to estimate associations between first-trimester use of intravenous ondansetron and risk

271 etrium during the implantation window and in first-trimester uterine decidua.

272 and the adjusted hazard ratio when comparing first-trimester vaccination to no vaccination was 1.06 (

273 genes are significantly decreased, in human first trimester versus term decidual cells.

274 d in self-rated health or chronic pain after first-trimester versus second-trimester abortion.

275 The prevalence of malaria infections in the first trimester was 21.8%.

276 Maternal use of lithium during the first trimester was associated with an increased risk of

277 Lithium exposure during the first trimester was associated with higher odds of spont

278 l exposure to multiple air pollutants in the first trimester was associated with lower DNA methylatio

279 years, 1 mug/m(3) higher exposure during the first trimester was associated with lower FEV(1)% predic

280 red to quinine, artemisinin treatment in the first trimester was not associated with an increased ris

281 2 888 children included, ZDV exposure in the first trimester was significantly associated with CHD (1

282 Malaria in the first trimester was significantly associated with matern

283 Maternal weight gain from 0 to 13 wk (first trimester) was not associated with fetal size at 1

284 More than 5 kg first-trimester weight gain was associated with an incre

285 Malaria infections in the first trimester were highly prevalent and have deleterio

286 Children exposed in the first trimester were not more likely to be hospitalized

287 her trimesters, but models that excluded the first trimester were not supported by the data.

288 ng loss) following maternal infection in the first trimester were respectively 24 and 6-fold higher (

289 ydrocarbons before conception and during the first trimester were significantly associated with 8%-20

290 oid-exposed, and nonexposed women during the first trimester were studied for major congenital malfor

291 microcephaly given maternal infection in the first trimester were the primary drivers of both magnitu

292 loss) following a maternal infection in the first trimester were, respectively, 24- and 6-fold highe

293 ongenital malformations, particularly in the first trimester when most organogenesis occurs.

294 Screening and treatment in the first trimester, when IPTp-SP is contraindicated, could

295 ic pregnant women exposed to ICSs during the first trimester who delivered between January 1990 and M

296 ergy-adjusted SCB intake was assessed in the first trimester with a food-frequency questionnaire.

297 presented to antenatal clinics during their first trimester with a viable fetus.

298 ronger association beginning as early as the first trimester with post-delivery maternal serum leptin

299 70.2%) of GBCA exposures occurred during the first trimester, with a 4.3-fold greater prevalence comp

300 s and microcephaly, whereas among women with first-trimester Zika infection, 11% of fetuses or infant