ライフサイエンスコーパス: first-degree relative

1 incomplete data and/or availability of only first-degree relatives).

2 and a family history of PCOS in at least one first degree relative.

3 syndrome (51%) reported a CRC diagnosis in a first-degree relative.

4 were enrolled, 69% of whom had 1 AD-affected first-degree relative.

5 ily history of sudden unexplained death in a first-degree relative.

6 Thirty-seven (70%) of the donors were first-degree relative.

7 orted a positive family history of FEVR in a first-degree relative.

8 en 1994 and 2017 after diagnosis of HCM in a first-degree relative.

9 static location depending on cancer in their first degree relatives.

10 y improve risk assessment among their female first-degree relatives.

11 individuals with bipolar disorder and their first-degree relatives.

12 bility to schizophrenia by including healthy first-degree relatives.

13 re independent of a family history of VTE in first-degree relatives.

14 ychiatric symptom information for additional first-degree relatives.

15 incomplete data and/or availability of only first-degree relatives.

16 er I with psychosis probands (BDP) and their first-degree relatives.

17 sychotic disorder probands, and 300 of their first-degree relatives.

18 DD), 110 orthopedic controls, and 1734 adult first-degree relatives.

19 d between ADHD probands and their unaffected first-degree relatives.

20 ing and their 2082 adult living and deceased first-degree relatives.

21 e ratios (SIRs) for different cancers in the first-degree relatives.

22 nancy-related factors and deaths of mothers' first-degree relatives.

23 no history of neurodegenerative disorder in first-degree relatives.

24 be comparable to phenotypic correlations in first-degree relatives.

25 showing a ~ 8-fold increased risk of CLL in first-degree relatives.

26 is associated with its increased risk among first-degree relatives.

27 = 201 healthy controls and n = 20 unaffected first-degree relatives.

28 , and 72 controls without NAFLD and their 72 first-degree relatives.

29 be without evidence of NAFLD and 69 of their first-degree relatives.

30 t of 26 probands with NAFLD-cirrhosis and 39 first-degree relatives.

31 for CRC in both groups, as well as in their first-degree relatives.

32 entive screening and surveillance in at-risk first-degree relatives.

33 There had been 123 VTEs in 2617 first-degree relatives (0.12 per 100 person-years).

34 tients with ALS were reported, including 924 first-degree relatives, 1128 second-degree relatives, an

35 L was found for those with multiple affected first-degree relatives (13-fold; 95% CI, 2.8- to 39-fold

36 psychotic bipolar I disorder), 369 of their first-degree relatives (134 were relatives of individual

37 4 probands with NAFLD-cirrhosis and their 72 first-degree relatives, 24 probands with NAFLD without a

38 ed beyond first-degree relatives versus only first-degree relatives (3.65 versus 0.80), used active s

39 In the per-protocol analysis, 28 first-degree relatives (3.9%) in the FIT group and 43 (5

40 earest affected relative was almost always a first-degree relative (37 of 39, 95%).

41 M) by vitiligo recurrence among a total 8034 first-degree relatives (3776 siblings, 4258 parents or o

42 l testing would be considered for those with first-degree relatives (42 [72%] of 58; 95% CI, 59.8%-82

43 m buccal smears from 63 patients with BD, 74 first-degree relatives (49 relatives had no lifetime psy

44 io (LMR) at recruitment in 1420 asymptomatic first-degree relatives (6-35 years old) of patients with

45 Of all eligible asymptomatic first-degree relatives, 782 were included in the colonos

46 site testing the POCT was positive in 12/148 first-degree relatives (8%) and all these subjects were

47 In first-degree relatives, ACPA reactivity was assessed, an

48 of patients having newly diagnosed AF with a first-degree relative affected by AF between 2000 and 20

49 Patients having AF with a first-degree relative affected by AF did not have more M

50 Individuals with a first-degree relative affected by AF had a relative risk

51 9 [9.2] years) had newly diagnosed AF with a first-degree relative affected by AF.

52 highest among young women (< 45 years) with first-degree relatives affected at young ages (< 45 year

53 of CRC or a documented advanced adenoma in a first-degree relative age <60 years or 2 first-degree re

54 ) had a family history of breast cancer in a first-degree relative age 50 years or younger, and 363 (

55 -1.43), and were related to their recipient (first-degree relative: aIRR, 1.28; 95% CI, 1.08-1.52; sp

56 gated with disease in all available affected first-degree relatives, although four asymptomatic paren

57 ar disorder (BD)), 315 of their nonpsychotic first-degree relatives and 202 healthy controls.

58 Fifty-seven percent of anti-CCP-2-positive first-degree relatives and 8% of anti-CCP-2- negative fi

59 absent from the anergic compartment of some first-degree relatives and all prediabetic and new-onset

60 efficiently incorporating information beyond first-degree relatives and allows for the inclusion of c

61 who had SRCC reported no diagnoses of DGC in first-degree relatives and did not meet established crit

62 es is significant and higher when focused on first-degree relatives and on conditions usually express

63 Patients' first-degree relatives and pairwise age- and sex-matched

64 ily histories of single or multiple affected first-degree relatives and their diagnostic ages.

65 olar spectrum, particularly among unaffected first-degree relatives and those with milder expressions

66 8 patients with schizophrenia, 37 unaffected first-degree relatives, and 139 healthy controls, we det

67 omprising 20 adults with ADHD, 20 unaffected first-degree relatives, and 20 typically developing cont

68 st-episode psychosis, 25 of their unaffected first-degree relatives, and 26 healthy control subjects

69 psychotic bipolar I disorder, 1,055 of their first-degree relatives, and 459 healthy comparison subje

70 wed documented presence or absence of CFH in first-degree relatives, and 61.5% of medical records doc

71 NAFLD without advanced fibrosis and their 24 first-degree relatives, and 72 controls without NAFLD an

72 (HP), schizophrenia probands (SZ) and their first-degree relatives, and bipolar disorder I with psyc

73 patients with NLPHL, identified their 4,280 first-degree relatives, and calculated the registry-base

74 bands with psychotic bipolar disorder, their first-degree relatives, and healthy comparison subjects.

75 First-degree relatives, and second-degree relatives of a

76 young age and unprovoked VTE predict VTE in first-degree relatives, and that the influence of these

77 group of adults with ADHD, their unaffected first-degree relatives, and typically developing control

78 r (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects.

79 hat relatives of celiac patients, especially first degree relatives are at high risk of developing ce

80 ion in psychotic disorder patients and their first-degree relatives as a possible endophenotype.

81 he entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-re

82 First-degree relatives at similar genetic distances (eg,

83 The highest familial risk was observed among first-degree relatives (attempted suicide: OR = 2.42 [95

84 Despite high heritability in first-degree relatives, AV genetic determinants remain i

85 cancer history (FCH) is often collected for first-degree relatives, but more extensive FCH informati

86 In patients lacking CD first-degree relatives, carriage of HLA-DQ2.5 with doubl

87 tisol-producing hyperplasias, 5 (including 2 first-degree relatives) carried a germline copy-number g

88 suspected antibiotic exposure, personal and first-degree relatives' comorbidities, and history of at

89 al activation or connectivity alterations in first-degree relatives compared with healthy controls, s

90 Persons with a single first-degree relative diagnosed at >/=60 years with CRC

91 so refines the risk assessment of women with first-degree relatives diagnosed with breast cancer, par

92 ancer in families with increasing numbers of first-degree relatives diagnosed with melanoma, includin

93 If the first-degree relative died aged <35 years, the rate of c

94 perly in the group of patients with affected first-degree relatives due to the small sample size.

95 c mutation carriers) or were healthy at-risk first-degree relatives (either presymptomatic mutation c

96 ertained cohorts, replacing cases with their first-degree relatives enables studies of diseases that

97 orrelation coefficient, 0.73 in NF1-affected first-degree relatives) exceeded that observed in the ge

98 Subjects with 1 first degree relative (FDR) with CRC (n = 238; HR, 1.23;

99 e quantified the risk of CRC and adenomas in first-degree relatives (FDRs) and second-degree relative

100 differentiate autoantibody-positive at-risk first-degree relatives (FDRs) from autoantibody-negative

101 cts differed from those of autoantibody-free first-degree relatives (FDRs) in the abundance of four t

102 atients combined with including or excluding first-degree relatives (FDRs) or different conditional l

103 ividuals based on age and number of affected first-degree relatives (FDRs) using data from publicatio

104 ing number of melanomas in either 1 or >/= 2 first-degree relatives (FDRs).

105 c counseling was observed more frequently in first-degree relatives, female relatives, primary arrhyt

106 The 205 previously negative first degree relatives from Group II that underwent new

107 It has recruited 2,632 first-degree relatives from across the USA.

108 WES was performed in 2 affected first-degree relatives from each family.

109 dent AF patients with vs without an affected first-degree relative had similar MACE-free survival.

110 egree relatives or healthy control subjects; first-degree relatives had intermediate enlargement comp

111 Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabe

112 The POCT was found to be positive in 8/9 first-degree relatives having coeliac-type mucosal lesio

113 tients with hypoplastic left heart and their first-degree relatives identified 5 individuals with rig

114 Cascade genetic testing in first-degree relatives identified 6 additional individua

115 time period of migration and not having any first-degree relatives in Sweden at the time of immigrat

116 asia was detected in 33 (4.2%) and 44 (5.6%) first-degree relatives in the FIT and colonoscopy groups

117 direct contact of relatives, testing beyond first-degree relatives, in-home-based sample collection,

118 774 individuals (the exposed cohort) with a first-degree relative (index case patient) previously ho

119 action was observed regarding the sex of the first-degree relative (interaction P for parents = 0.85;

120 ng as preadolescents; a diagnosis in a child first-degree relative is made in 8% of families screened

121 creening for CRC among surgeons and/or their first-degree relatives is currently not performed at the

122 in our study were sporadic, and the risk to first-degree relatives is lower than previously reported

123 Cognitive dysfunction in first-degree relatives is more closely related to psycho

124 riteria for serrated polyposis, and in their first-degree relatives, is similar to that of patients d

125 Ninety-nine first-degree relatives living within a 100-mile radius o

126 en and families with sudden cardiac death in first-degree relatives <40 years.

127 , and higher rate of sudden cardiac death in first degree relatives<age 30 (4.5% versus 0%, P=0.026).

128 Three hundred four first-degree relatives (median age, 47 years; age range,

129 y history of pancreatic cancer affecting two first-degree relatives meet criteria for familial pancre

130 of AF was defined as the presence of AF in a first-degree relative: mother, father, sibling, or child

131 0001) and family history of breast cancer in first-degree relatives (n = 7,472; ptrend = 0.0003).

132 itions: bipolar disorder (n = 9), unaffected first-degree relatives (n = 8), and clinical high risk (

133 order (manic, N=110; depressed, N=55), their first-degree relatives (N=316, N=259, N=133, and N=64, r

134 polar disorder with psychosis (N=711), their first-degree relatives (N=883), and demographically comp

135 The risks for first-degree relatives (odds ratio [OR], 18.69; 95% CI,

136 ks of EoE were significantly increased among first-degree relatives (odds ratio [OR], 7.19; 95% CI, 5

137 From a total of 634 first degree relatives of 186 biopsy-proven celiac disea

138 Although it is known that first degree relatives of celiac patients have an increa

139 ly increased risk of breast cancer, untested first-degree relative of a gene mutation carrier, family

140 A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed b

141 % mutation carriers [92% plakophilin-2]; 28% first-degree relatives of a mutation-negative proband).

142 erall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, wh

143 sed cohort revealed that the rate of EoE, in first-degree relatives of a proband, was 1.8% (unadjuste

144 First-degree relatives of ADHD probands were at elevated

145 First-degree relatives of adults with psychotic experien

146 First-degree relatives of affected individuals have a mo

147 icosteroid-induced ocular hypertension among first-degree relatives of affected individuals support a

148 dentified through cascade genetic testing of first-degree relatives of affected mutation carriers.

149 uals were enrolled in a prospective study of first-degree relatives of ALS and FTD patients carrying

150 on screening should be extended to more than first-degree relatives of an index carrier patient.

151 Among first-degree relatives of an index case with factor V Le

152 9 patients with inactive CD and 35 controls (first-degree relatives of and in the same age bracket as

153 on, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying

154 (95% confidence interval [CI] 13.1-22.0) in first-degree relatives of BDI patients, higher than that

155 ORs of BDII were 13.6 (95% CI 10.2-18.2) in first-degree relatives of BDII patients and 9.8 (95% CI

156 ves of schizophrenia probands (n = 264), and first-degree relatives of bipolar disorder I with psycho

157 The prevalence of keratoconus in pediatric first-degree relatives of diagnosed keratoconus patients

158 [OR], 7.19; 95% CI, 5.65-9.14), particularly first-degree relatives of EoE cases diagnosed <18 years

159 Seventy-five asymptomatic first-degree relatives of FIP patients (mean age, 50.8 y

160 A genetic effect was assessed in first-degree relatives of HS-TLE subjects who did not ha

161 pective, multicentre, observational study of first-degree relatives of individuals carrying the C9orf

162 We analyzed 12-lead ECGs of 401 first-degree relatives of individuals who had died from

163 risk for developing the disorder (unaffected first-degree relatives of individuals with bipolar disor

164 First-degree relatives of individuals with T1DM were rec

165 nced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.

166 First-degree relatives of NHL, HL, and CLL patients have

167 s in age-matched islet autoantibody-negative first-degree relatives of patients (n = 392; P = 0.00001

168 During an average follow-up of 7 years, first-degree relatives of patients with aortic aneurysm

169 First-degree relatives of patients with AVNRT presented

170 by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 perso

171 The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder

172 First-degree relatives of patients with both familial an

173 y is the recommended screening procedure for first-degree relatives of patients with colorectal cance

174 In a prospective study, 1918 first-degree relatives of patients with CRC were randoml

175 nography is an effective screening method in first-degree relatives of patients with CRC.

176 lonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC.

177 gitudinal cohort of self-reported unaffected first-degree relatives of patients with familial interst

178 Pediatric first-degree relatives of patients with keratoconus.

179 While first-degree relatives of patients with MM show an incre

180 The risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fat

181 nts determined to be at high risk, including first-degree relatives of patients with pancreas cancer

182 may be present in greater than 1 in 6 older first-degree relatives of patients with PF.

183 We assessed the risk for VTE in 915 first-degree relatives of patients with provoked VTE, co

184 th FPF and sporadic IPF.Methods: Undiagnosed first-degree relatives of patients with pulmonary fibros

185 relative-control sample, 58 were unaffected first-degree relatives of patients with schizophrenia (m

186 We examined 58 unaffected first-degree relatives of patients with schizophrenia an

187 renia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia, a

188 In this study, first-degree relatives of patients with SCZ and their re

189 evious studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate

190 First-degree relatives of patients with SCZ showed signi

191 ted by the presence of cognitive deficits in first-degree relatives of patients with SCZ; however, un

192 ked VTE, compared this with the risk in 1752 first-degree relatives of patients with unprovoked VTE,

193 When counseling first-degree relatives of patients with venous thromboem

194 ired from 25 patients with schizophrenia, 25 first-degree relatives of patients, and 29 healthy volun

195 s of SZ probands (SZREL), and 206 unaffected first-degree relatives of PBP probands to identify DMNs

196 MS) project is a prospective cohort study of first-degree relatives of people with MS.

197 ols, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis

198 The prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis

199 otyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis

200 vely assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.

201 Z (n = 229) and BDP (n = 188), HP (n = 284), first-degree relatives of schizophrenia probands (n = 26

202 A total of 54 healthy first-degree relatives of schizophrenic patients and 80

203 Healthy first-degree relatives of schizophrenic patients show al

204 No differences were demonstrated between first-degree relatives of SCZ patients and healthy subje

205 Five percent of our patients were first-degree relatives of subjects with CD, with HLA-DQ

206 Z probands, 300 PBP probands, 179 unaffected first-degree relatives of SZ probands (SZREL), and 206 u

207 In our model, first-degree relatives of the patients with detected PTE

208 an American and 76.3% were white; 76.1% were first-degree relatives of their recipient.

209 RC also did not differ significantly between first-degree relatives of these groups (serrated polypos

210 lsive disorder (OCD) patients, 18 unaffected first-degree relatives of these OCD patients and 49 heal

211 Z or schizoaffective disorder, 30 unaffected first-degree relatives of these SCZ patients, 13 obsessi

212 veloping aortic aneurysm or dissection among first-degree relatives of those with aortic aneurysm or

213 Finally, first-degree relatives of those with DS shared volume ab

214 We examined IA-2var AAb in first-degree relatives of type 1 diabetes (T1D) probands

215 c screening revealed abnormalities in 30% of first-degree relatives of UCA or sudden unexplained deat

216 ion Fraction Registry prospectively assessed first-degree relatives of UCA or sudden unexplained deat

217 f B-cell lymphoproliferative disorders among first-degree relatives of WM patients, has been reported

218 gnificantly larger in probands compared with first-degree relatives or healthy control subjects; firs

219 icantly with breast cancer in the proband or first-degree relative (P < .01), and with colorectal can

220 and with colorectal cancer in the proband or first-degree relative (P < .01), but not family history

221 from recent-onset patients and GADA-positive first-degree relatives participating in the Bart's-Oxfor

222 234 psychotic bipolar (PBP) probands and 231 first-degree relatives (PBPR), and 200 healthy control s

223 r whether these abnormalities are present in first-degree relatives, possibly representing genetic pr

224 %, 87.4%, and 91.0% for third-, second-, and first-degree relatives, respectively).

225 ata revealed no difference in mean number of first-degree relatives screened between nonfamilial and

226 ore cost-effective given that the decedent's first-degree relatives should only need minimal cardiolo

227 Compared with controls, healthy first-degree relatives showed a highly significant decre

228 S aureus bacteremia was observed among these first-degree relatives (SIR, 2.49 [95% CI, 1.95 to 3.19]

229 eosinophilic esophagitis (EoE) mostly among first-degree relatives, suggesting a genetic contributio

230 bsessive-compulsive disorder (OCD) and their first-degree relatives, suggesting involvement of the fr

231 of results between SDIs and their unaffected first-degree relatives, suggesting that the proposed end

232 of other common cardiovascular conditions in first-degree relatives, supporting the use of systematic

233 s, and second-degree relatives of a deceased first-degree relative suspected of having an inherited c

234 esting state EEGs of 225 SZ probands and 201 first-degree relatives (SZR), 234 psychotic bipolar (PBP

235 individual ADs was consistently higher among first-degree relatives than among second- and third-degr

236 o do not have Parkinson's disease but have a first degree relative that does), and 1.4 million contro

237 ounders, infants of mothers who had lost any first-degree relative the year before or during pregnanc

238 sed 100-fold; given >/=2 premature deaths in first-degree relatives, the rate increased more than 400

239 complete ANGPTL3 deficiency and 3 wild-type first-degree relatives using computed tomography angiogr

240 rates approached 1 per 1000 person-years for first-degree relatives versus 11 to 13 (aortic aneurysm)

241 ct contact (2.06 versus 0.86), tested beyond first-degree relatives versus only first-degree relative

242 ere at risk of carrying a mutation because a first-degree relative was a known symptomatic carrier.

243 A family history of AD in first-degree relatives was associated with an RR of 6.82

244 The risk for VTE in first-degree relatives was higher if the index cases had

245 Using prospectively registered data on their first-degree relatives, we evaluated the impact of paren

246 ives (5.4%), increasing to 7% (6/85) if only first-degree relatives were assessed.

247 % male) who had received a diagnosis of CUP, first-degree relatives were at an elevated risk of CUP t

248 The lifetime risk of HL was higher when first-degree relatives were diagnosed at early ages (bef

249 A total of 10 of 99 (10.10%) first-degree relatives were diagnosed with PDS (1 with P

250 Available first-degree relatives were invited to undergo noncathar

251 s aged below 50 years, high-volume surgeons' first-degree relatives were more likely to be up-to-date

252 All remaining 135 healthy first-degree relatives were negative for both POCT and E

253 ree relatives and 8% of anti-CCP-2- negative first-degree relatives were positive for >/=9 ACPAs.

254 First-degree relatives were submitted to cardiac screeni

255 Their first-degree relatives were unaffected.

256 years reported that 56.1% (n = 210) of their first-degree relatives were up-to-date with CRC screenin

257 ree relative with PCa (FH); and those with a first-degree relative who had died of PCa (FHD).

258 ontrol subjects with tetramer(+) cells was a first-degree relative who had insulin-specific cells wit

259 undergoing radical prostatectomy, those with first-degree relatives who died of PCa did not have an i

260 lepsy from 1935-94 (probands) and their 2439 first-degree relatives who resided in Olmsted County.

261 uated, and those who agreed to contact their first-degree relatives who were at least 40 years old we

262 sotypes), and sera from 99 antibody-negative first-degree relatives who were never autoantibody posit

263 mutation that results in AD and 115 (38.5%) first-degree relatives who were noncarrier controls.

264 ate ACPAs in sera from 111 antibody-positive first-degree relatives who were positive on at least 1 v

265 ion and of new cases of celiac disease among first degree relatives with negative results at a first

266 Eight patients had first degree relatives with visual snow.

267 controlled trial in infants with at least 1 first-degree relative with allergic disease.

268 .82 x 10(-7)) and were more likely to have a first-degree relative with AMD (P = 5.38 x 10(-6)).

269 8 939 individuals (mean age, 42 years) had a first-degree relative with aortic aneurysm and 7209 pers

270 and 7209 persons (mean age, 39 years) had a first-degree relative with aortic dissection.

271 rticipants, 71 individuals with at least one first-degree relative with BD (at-risk), and 80 control

272 iduals aged 18 to 30 years with at least one first-degree relative with bipolar disorder were compare

273 tion task: 24 with BP, 29 at risk based on a first-degree relative with BP, and 53 healthy, low-risk

274 was 1.3-fold higher for HL survivors with a first-degree relative with cancer ( P < .001), with 3.3-

275 We randomly assigned 832 newborns who had a first-degree relative with celiac disease to the introdu

276 for HLA-DQ2 or HLA-DQ8 and had at least one first-degree relative with celiac disease.

277 iduals between ages 45 and 65 years with one first-degree relative with CRC age < 50 years or two fir

278 ers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to

279 r monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of

280 Of 430 young CRC cases, 111 (26%) had a first-degree relative with CRC.

281 nors with (n = 1245) vs. without (n = 757) a first-degree relative with ESRD.

282 implantations), individuals with at least 1 first-degree relative with history of pacemaker insertio

283 men), and 94 were healthy controls without a first-degree relative with mental illness (mean [SD] age

284 risk of developing eczema (ie, at least one first-degree relative with parent-reported eczema, aller

285 o men with no family history of PCa (NFH); a first-degree relative with PCa (FH); and those with a fi

286 om the general population and those having a first-degree relative with T1D were enrolled if they had

287 ctively), adjusting for the HLA-DR genotype, first-degree relative with T1DM, maternal education, and

288 h HLA-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited fro

289 ilial adenomatous polyposis), or one or more first-degree relatives with a history of thyroid cancer.

290 n 1 year of age at high risk of atopy (>/= 2 first-degree relatives with allergic disease) but with n

291 tratified by recruiting centre and number of first-degree relatives with atopic disease) and particip

292 ts from our institution, of whom 20 had >/=1 first-degree relatives with AVNRT.

293 ; RR, 2.5; 95% CI, 1.1 to 5.3) or women with first-degree relatives with bilateral disease (RR, 3.6;

294 95% CI, 50 to 66) for those with two or more first-degree relatives with breast cancer at 50 years of

295 a of any size, or an adenoma of any size and first-degree relatives with colorectal cancer.

296 gree relative with CRC age < 50 years or two first-degree relatives with CRC were selected.

297 athogenic mutations of the RET gene, or were first-degree relatives with histologically proven medull

298 A gene mutation, and patients with 1 or more first-degree relatives with pancreas cancer with Lynch s

299 n a first-degree relative age <60 years or 2 first-degree relatives with these findings at any age ar

300 Serum samples were obtained from first-degree relatives without RA according to the 1987