ライフサイエンスコーパス: first-degree relative of

1 assessed through family informants in 6,660 first-degree relatives of 1,049 nondemented probands age

2 The study population comprised 9,705 first-degree relatives of 1,951 adults with epilepsy asc

3 ee relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls.

4 A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed b

5 ee relatives of 162 patients with PD and 850 first-degree relatives of 147 controls.

6 A family study of 838 adult first-degree relatives of 152 probands in 3 diagnostic g

7 Of 37 first-degree relatives of 16 sensitive patients, 23 (62%

8 d, historical cohort study, we included 1000 first-degree relatives of 162 patients with PD and 850 f

9 conducted a historical cohort study of 1,001 first-degree relatives of 162 probands with PD and of 85

10 odifying the risk of rheumatoid arthritis in first degree relatives of 165 cases ascertained from Jan

11 From a total of 634 first degree relatives of 186 biopsy-proven celiac disea

12 imated the degree of increased risk of PD in first-degree relatives of 221 PD probands with age of on

13 sonality disorder by direct interview of 106 first-degree relatives of 23 patients with generalized s

14 tients with generalized social phobia and 74 first-degree relatives of 24 comparison subjects without

15 ability was assessed by Southern blotting on first-degree relatives of 27 probands.

16 The authors interviewed 888 first-degree relatives of 300 overweight or obese proban

17 Of 147 first-degree relatives of 32 people who died of SADS, 10

18 Eighty-three nonpsychotic first-degree relatives of 38 patients with schizophrenia

19 onset older than 50 years compared with the first-degree relatives of 409 control probands.

20 In addition, we studied 2,713 first-degree relatives of 411 probands with PD referred

21 A total of 124 of 213 (58%) available first-degree relatives of 47 patients with AS in Iceland

22 es from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 f

23 ML, MDS, and other malignancies among 24,573 first-degree relatives of 6,962 patients with AML and 1,

24 ly increased risk of breast cancer, untested first-degree relative of a gene mutation carrier, family

25 % mutation carriers [92% plakophilin-2]; 28% first-degree relatives of a mutation-negative proband).

26 Among first-degree relatives of a nationwide MGUS cohort, we f

27 erall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, wh

28 sed cohort revealed that the rate of EoE, in first-degree relatives of a proband, was 1.8% (unadjuste

29 AD dementia as well as healthy controls and first-degree relatives of AD dementia patients (AD-rel)

30 First-degree relatives of ADHD probands were at elevated

31 First-degree relatives of adults with psychotic experien

32 monozygotic twins (30-50%) and high risks to first-degree relatives of affected individuals (risk rat

33 First-degree relatives of affected individuals have a mo

34 icosteroid-induced ocular hypertension among first-degree relatives of affected individuals support a

35 146 probands, known affected relatives, and first-degree relatives of affected individuals.

36 dentified through cascade genetic testing of first-degree relatives of affected mutation carriers.

37 lifetime morbid risk was estimated in adult first-degree relatives of affected probands and control

38 First-degree relatives of African Americans with AD have

39 abstinence duration 957.66 days), 62 healthy first-degree relatives of alcohol-dependent individuals,

40 uals were enrolled in a prospective study of first-degree relatives of ALS and FTD patients carrying

41 on screening should be extended to more than first-degree relatives of an index carrier patient.

42 Among first-degree relatives of an index case with factor V Le

43 9 patients with inactive CD and 35 controls (first-degree relatives of and in the same age bracket as

44 Deficits were also found in unaffected first-degree relatives of attention deficit hyperactivit

45 in social behaviors have also been noted in first-degree relatives of autistic individuals and may e

46 on, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying

47 (95% confidence interval [CI] 13.1-22.0) in first-degree relatives of BDI patients, higher than that

48 ORs of BDII were 13.6 (95% CI 10.2-18.2) in first-degree relatives of BDII patients and 9.8 (95% CI

49 ves of schizophrenia probands (n = 264), and first-degree relatives of bipolar disorder I with psycho

50 in euthymic bipolar patients and unaffected first-degree relatives of bipolar patients to define the

51 rostate cancer, and all other cancers in the first-degree relatives of carriers and non-carriers.

52 ncreatic, and prostate cancer occurred among first-degree relatives of carriers of BRCA2 mutations on

53 ts diagnosed in Sweden, 43 550 controls, and first-degree relatives of cases (n = 24 577) and control

54 ve-, six- and threefold, respectively, among first-degree relatives of cases carrying BRCA1 mutations

55 ET was present in 25 (22.5%) of the 111 first-degree relatives of cases compared to 6 (5.6%) of

56 erformed a kin-cohort analysis on the 14 704 first-degree relatives of cases for each SNP associated

57 In first-degree relatives of cases with </=17, 18-21, and >

58 isk for JIA was significantly elevated among first-degree relatives of cases with JIA (OR 30.4).

59 nd calendar-specific CRC rates in the 50,924 first-degree relatives of cases.

60 Although it is known that first degree relatives of celiac patients have an increa

61 irtually all the excess risk of cancer among first-degree relatives of children with cancer can be ac

62 ds with generalized social phobia than among first-degree relatives of comparison probands.

63 First-degree relatives of compulsive buyers were more li

64 relatives of patients with PD compared with first-degree relatives of controls (hazard ratio [HR], 1

65 latives of cases compared to 6 (5.6%) of 107 first-degree relatives of controls [relative risk (RR) =

66 4.4; p = 0.0002) when each was compared with first-degree relatives of controls.

67 gnosed adenomas compared with the risk among first-degree relatives of controls.

68 -onset schizophrenia (AOS) by determining if first-degree relatives of COS probands have an increased

69 (DCM) PM study (Precision Medicine), living first-degree relatives of DCM probands were invited to u

70 The prevalence of keratoconus in pediatric first-degree relatives of diagnosed keratoconus patients

71 rvosa and bulimia nervosa were determined in first-degree relatives of diagnostically pure proband gr

72 First- degree relatives of early-onset COPD probands had

73 Reduced spirometric values in first-degree relatives of early-onset COPD probands were

74 Among the entire group of first-degree relatives of early-onset COPD probands, uni

75 approximately three in current or ex-smoking first-degree relatives of early-onset COPD probands.

76 3.4% predicted for both control subjects and first-degree relatives of early-onset COPD probands.

77 chronic bronchitis in current or ex-smoking first-degree relatives of early-onset COPD probands.

78 Risk of PD was similar among first-degree relatives of early-onset PD probands (risk

79 [OR], 7.19; 95% CI, 5.65-9.14), particularly first-degree relatives of EoE cases diagnosed <18 years

80 PrePF and its relationship to survival among first-degree relatives of families with FIP.

81 Seventy-five asymptomatic first-degree relatives of FIP patients (mean age, 50.8 y

82 selves sensitive, compared with 1 (7%) of 15 first-degree relatives of four patients with normal resp

83 ve family members and every 3 to 5 years for first-degree relatives of gene-elusive cases, as long as

84 006) to measure excess cases of cancer among first-degree relatives of glioma probands.

85 A genetic effect was assessed in first-degree relatives of HS-TLE subjects who did not ha

86 First-degree relatives of IBD patients have a 10-fold in

87 are significantly increased in frequency in first-degree relatives of IIM patients, affect more wome

88 pective, multicentre, observational study of first-degree relatives of individuals carrying the C9orf

89 We analyzed 12-lead ECGs of 401 first-degree relatives of individuals who had died from

90 mined gene expression profiles in unaffected first-degree relatives of individuals with autoimmune di

91 First-degree relatives of individuals with biopsy-proven

92 risk for developing the disorder (unaffected first-degree relatives of individuals with bipolar disor

93 ggest that the yield of cascade screening of first-degree relatives of individuals with high Lp(a) le

94 raphic and electrocardiographic screening of first-degree relatives of individuals with IDC and FDC i

95 First-degree relatives of individuals with PSC had highe

96 Evidence is beginning to show that screening first-degree relatives of individuals with several famil

97 First-degree relatives of individuals with T1DM were rec

98 Then, we identified the first-degree relatives of individuals with TRD (n = 34 4

99 First-degree relatives of individuals with TRD had lower

100 of data from 2,164 (1,329 women and 835 men) first-degree relatives of individuals with type 2 diabet

101 First-degree relatives of individuals with type 2 diabet

102 A 1:4 comparison group (n = 137 868) of first-degree relatives of individuals without TRD was ar

103 ing case-control study, we evaluated whether first-degree relatives of lung cancer cases are at incre

104 y tract cancers, occurred more frequently in first-degree relatives of lung cancer patients than in c

105 ,388 patients with MDS compared with 106,224 first-degree relatives of matched controls.

106 Among first-degree relatives of melanoma cases diagnosed befor

107 ed risks for five additional cancer types in first-degree relatives of melanoma cases suggest that in

108 The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies sh

109 S and lymphoproliferative malignancies among first-degree relatives of MGUS patients.

110 of 5- to 7-fold elevated risk of MPNs among first-degree relatives of MPN patients support the hypot

111 I 0.86-1.23, chi(2)=0.47, p=0.49), or in the first-degree relatives of MS probands compared with cont

112 termined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS

113 By considering the cancer risk in first-degree relatives of mutation-positive and -negativ

114 nced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.

115 First-degree relatives of NHL, HL, and CLL patients have

116 and von Willebrand factor (vWF) occur (1) in first-degree relatives of NIDDM patients and (2) in asso

117 Fasting blood samples were taken from 132 first-degree relatives of NIDDM patients and 151 age mat

118 First-degree relatives of NIDDM patients have an approxi

119 The DCM hazard was higher in first-degree relatives of non-Hispanic Black probands th

120 Compared with adult first-degree relatives of normal controls, the risks of

121 s inhibitory control processes in unaffected first-degree relatives of OCD patients for the first tim

122 nts, including patients with OCD, unaffected first-degree relatives of OCD patients, and healthy cont

123 ly screening for CRC might be considered for first degree relatives of patients with polyps.

124 authors assert that the affection status of first degree relatives of patients with rheumatoid arthr

125 the risk of amyotrophic lateral sclerosis to first degree relatives of patients with sporadic amyotro

126 tients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and contr

127 atives, 16,658 matched control subjects, and first-degree relatives of patients (n = 17,991) and cont

128 s in age-matched islet autoantibody-negative first-degree relatives of patients (n = 392; P = 0.00001

129 es to evaluate the relative cancer risks for first-degree relatives of patients diagnosed between age

130 Although first-degree relatives of patients exhibit a two-fold in

131 Dissection risk was highest in first-degree relatives of patients who carried a diagnos

132 Among first-degree relatives of patients who were 50 years of

133 RR, 4.36 [CI, 2.24 to 8.51]) than that among first-degree relatives of patients who were older than 6

134 First-degree relatives of patients with adenomas did not

135 During an average follow-up of 7 years, first-degree relatives of patients with aortic aneurysm

136 Many first-degree relatives of patients with AS appear to hav

137 rn of subclinical intestinal inflammation in first-degree relatives of patients with AS.

138 First-degree relatives of patients with AVNRT presented

139 ollowing populations compared with controls: first-degree relatives of patients with BAV (hazard rati

140 the risk of aortic dissection was higher in first-degree relatives of patients with BAV (HR, 3.63 [9

141 First-degree relatives of patients with BAV, thoracic an

142 lly abnormal and dilation is common (32%) in first-degree relatives of patients with BAV.

143 by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 perso

144 eir control groups, BD1 patients and healthy first-degree relatives of patients with BD1 showed signi

145 The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder

146 First-degree relatives of patients with both familial an

147 y is the recommended screening procedure for first-degree relatives of patients with colorectal cance

148 ce of neoplastic colorectal polyps among the first-degree relatives of patients with colorectal lesio

149 e the frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesio

150 In a prospective study, 1918 first-degree relatives of patients with CRC were randoml

151 nography is an effective screening method in first-degree relatives of patients with CRC.

152 lonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC.

153 gut barrier function in a cohort of healthy first-degree relatives of patients with Crohn's disease.

154 mental Microbial (CCC-GEM) cohort of healthy first-degree relatives of patients with Crohn's disease.

155 gitudinal cohort of self-reported unaffected first-degree relatives of patients with familial interst

156 ng adults with connective tissue disease and first-degree relatives of patients with familial pulmona

157 A total of 493 asymptomatic first-degree relatives of patients with FIP were evaluat

158 Pediatric first-degree relatives of patients with keratoconus.

159 ) patients at risk of VHL disease, including first-degree relatives of patients with known VHL diseas

160 While first-degree relatives of patients with MM show an incre

161 de that autoimmune disease is more common in first-degree relatives of patients with multiple scleros

162 ated (RR, 1.74 [95% CI, 1.24 to 2.45]) among first-degree relatives of patients with newly diagnosed

163 First-degree relatives of patients with newly diagnosed

164 First-degree relatives of patients with non-insulin-depe

165 The risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fat

166 nts determined to be at high risk, including first-degree relatives of patients with pancreas cancer

167 sed risk of several psychiatric disorders in first-degree relatives of patients with PD compared with

168 may be present in greater than 1 in 6 older first-degree relatives of patients with PF.

169 We assessed the risk for VTE in 915 first-degree relatives of patients with provoked VTE, co

170 th FPF and sporadic IPF.Methods: Undiagnosed first-degree relatives of patients with pulmonary fibros

171 relative-control sample, 58 were unaffected first-degree relatives of patients with schizophrenia (m

172 We examined 58 unaffected first-degree relatives of patients with schizophrenia an

173 First-degree relatives of patients with schizophrenia ap

174 Studies of first-degree relatives of patients with schizophrenia ov

175 renia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia, a

176 In this study, first-degree relatives of patients with SCZ and their re

177 evious studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate

178 First-degree relatives of patients with SCZ showed signi

179 ted by the presence of cognitive deficits in first-degree relatives of patients with SCZ; however, un

180 FWE) > .05, SVC) symptoms; and 3) reduced in first-degree relatives of patients with SZ (p(FWE) = .01

181 of developing Alzheimer's disease among the first-degree relatives of patients with this disorder.

182 th BAV (HR, 3.63 [95% CI, 2.68-4.91]) and in first-degree relatives of patients with thoracic aneurys

183 azard ratio [HR], 6.88 [95% CI, 5.62-8.43]); first-degree relatives of patients with thoracic aortic

184 aneurysm (HR, 5.09 [95% CI, 3.80-6.82]); and first-degree relatives of patients with thoracic aortic

185 4 (IL-4) in anti-islet autoantibody-positive first-degree relatives of patients with type 1A diabetes

186 ) by radioassay, in addition to ICAs, in 882 first-degree relatives of patients with type I diabetes,

187 isease (AD), and it is also increased in the first-degree relatives of patients with typical late-ons

188 ked VTE, compared this with the risk in 1752 first-degree relatives of patients with unprovoked VTE,

189 When counseling first-degree relatives of patients with venous thromboem

190 ired from 25 patients with schizophrenia, 25 first-degree relatives of patients, and 29 healthy volun

191 whether such abnormalities occur in healthy first-degree relatives of patients, indicating they may

192 s of SZ probands (SZREL), and 206 unaffected first-degree relatives of PBP probands to identify DMNs

193 Targeting the first-degree relatives of people with a particular compl

194 MS) project is a prospective cohort study of first-degree relatives of people with MS.

195 de patients with MEN1 or its phenocopies and first-degree relatives of persons with MEN1.

196 he early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia.

197 related to risk of islet autoimmunity among first-degree relatives of persons with type 1 diabetes (

198 Of all first degree relatives of probands, 9.3% were diagnosed

199 Managing disease risk among first-degree relatives of probands diagnosed with a heri

200 ries of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples-populati

201 First-degree relatives of probands with (vs without) IC

202 tudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's dise

203 tudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's dise

204 Chronicity was assessed in 37.8% of affected first-degree relatives of probands with chronic depressi

205 First-degree relatives of probands with comorbid alcohol

206 arkedly higher (approximately 10-fold) among first-degree relatives of probands with generalized soci

207 ated the prevalence of autoimmune disease in first-degree relatives of probands with multiple scleros

208 otyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis

209 ols, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis

210 The prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis

211 vely assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.

212 ntrols, the risks of panic disorder in adult first-degree relatives of probands with panic disorder o

213 Among 227 female first-degree relatives of probands, 4.8% (11) had FMD, r

214 s a 30-50-fold increased incidence of VUR in first-degree relatives of probands, compared with the ge

215 udies have found an increased rate of SAH in first degree relatives of SAH patients (relative risk 3.

216 1256 psychosis-related conditions, including first-degree relatives of schizophrenia (SCZ) and schizo

217 Lower cancer rates in first-degree relatives of schizophrenia patients suggest

218 althy comparison subjects, and 19 unaffected first-degree relatives of schizophrenia patients were st

219 have evaluated verbal working memory in the first-degree relatives of schizophrenia patients, who li

220 Z (n = 229) and BDP (n = 188), HP (n = 284), first-degree relatives of schizophrenia probands (n = 26

221 Thirty-two first-degree relatives of schizophrenic patients (13 wit

222 A total of 54 healthy first-degree relatives of schizophrenic patients and 80

223 Healthy first-degree relatives of schizophrenic patients show al

224 Some unaffected first-degree relatives of schizophrenics also manifest c

225 No differences were demonstrated between first-degree relatives of SCZ patients and healthy subje

226 FNC changes, we compared age-related FNC in first-degree relatives of SCZ patients mostly including

227 lta SaO2) were significantly lower among the first-degree relatives of SDB families than among contro

228 Five percent of our patients were first-degree relatives of subjects with CD, with HLA-DQ

229 theses, mood disorder was not more common in first-degree relatives of subjects with depressive perso

230 us, abnormal glucose metabolism is common in first-degree relatives of subjects with type 2 diabetes.

231 ate of suicide attempts was increased in the first-degree relatives of suicide probands compared with

232 Z probands, 300 PBP probands, 179 unaffected first-degree relatives of SZ probands (SZREL), and 206 u

233 y increased in prevalence (21.9%) in the 151 first-degree relatives of the 21 IIM probands compared w

234 family history data were available for 6430 first-degree relatives of the cases and 4936 first-degre

235 Genotyping first-degree relatives of the cases identified potential

236 first-degree relatives of the cases and 4936 first-degree relatives of the controls.

237 tibody- and/or insulin autoantibody-negative first-degree relatives of the IDDM subjects, and in 28 a

238 In our model, first-degree relatives of the patients with detected PTE

239 hen including sex and the number of affected first-degree relatives of the proband (N(aff)) as covari

240 ng the clinical severity of LQTS in affected first-degree relatives of the proband.

241 93 to 1997 for 685 family members, including first-degree relatives of the probands and spouse contro

242 f 133 probands and 273 directly interviewed, first-degree relatives of the probands were included in

243 Among the first-degree relatives of the probands with acute schizo

244 c treatment as well as clinically unaffected first-degree relatives of the schizophrenia patients.

245 an American and 76.3% were white; 76.1% were first-degree relatives of their recipient.

246 RC also did not differ significantly between first-degree relatives of these groups (serrated polypos

247 lsive disorder (OCD) patients, 18 unaffected first-degree relatives of these OCD patients and 49 heal

248 sing cardiovascular clinical screening among first-degree relatives of these patients.

249 Z or schizoaffective disorder, 30 unaffected first-degree relatives of these SCZ patients, 13 obsessi

250 veloping aortic aneurysm or dissection among first-degree relatives of those with aortic aneurysm or

251 Finally, first-degree relatives of those with DS shared volume ab

252 nce of ADHD and learning disabilities in 679 first-degree relatives of three groups of index children

253 are rates of familial psychopathology in the first-degree relatives of three proband groups: 1) patie

254 We assessed uptake of screening by first-degree relatives of two groups of index cases: peo

255 We examined IA-2var AAb in first-degree relatives of type 1 diabetes (T1D) probands

256 , 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients.

257 First-degree relatives of type 1 DM individuals were rec

258 muscle from 10 insulin-resistant nondiabetic first-degree relatives of type 2 diabetic families and 6

259 Nondiabetic first-degree relatives of type 2 diabetic patients have

260 c screening revealed abnormalities in 30% of first-degree relatives of UCA or sudden unexplained deat

261 ion Fraction Registry prospectively assessed first-degree relatives of UCA or sudden unexplained deat

262 f B-cell lymphoproliferative disorders among first-degree relatives of WM patients, has been reported

263 mily studies have suggested that some female first-degree relatives of women with polycystic ovary sy