ライフサイエンスコーパス: first-line

1 s to those treated with a stent retriever as first line.

2 However, first-line ablation may be more effective in maintaining

3 ic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis.

4 As stratification in intensive first-line AML treatment evolves, TDT data suggest that

5 lsant and tricyclic antidepressant drugs are first line analgesics used to treat SCI-induced neuropat

6 With targeted therapy options for first-line and relapsed CLL, it is ever more important t

7 gs have been studied and several advances in first-line and second-line treatment options should yiel

8 kpoint inhibitors (ICIs) are approved in the first-line and third-line settings for patients with ext

9 e and practical application of venetoclax in first-line and treatment of relapsed and refractory CLL.

10 p sound rationale and strategy for selecting first-line and treatment of relapsed disease and for lon

11 targeted therapy over chemoimmunotherapy in first-line and treatment of relapsed/refractory CLL.

12 and rifampicin are two of the most powerful first-line anti-TB medicines, and resistance to either o

13 preexisting isoniazid-resistant disease with first-line anti-TB therapy risks selecting for rifampici

14 d-resistant tuberculosis (TB) given standard first-line anti-TB treatment indicated an increased risk

15 tations of Mycobacterium tuberculosis to the first-line anti-tuberculosis drug isoniazid (INH).

16 stand the intrapulmonary pharmacokinetics of first-line anti-tuberculosis drugs.

17 Liver injury is a common complication of first-line anti-tuberculosis therapy.

18 bulk-lethal concentrations of rifampicin, a first-line anti-tuberculous antibiotic targeting RNA pol

19 bacteriophage detection and exposure to the first-line antibiotic azithromycin, detected in stool sa

20 um Pseudomonas aeruginosa wild-type PAO1 and first-line antibiotic gentamicin (GEN) are used in our e

21 where antibiotics were not indicated and in first-line antibiotic selection for sinusitis, otitis me

22 rt the current practice of switching empiric first-line antibiotic when resistance exceeds 5% in the

23 5% of isolates multi-drug resistant (MDR) to first-line antibiotics and 60% were extensively drug-res

24 effectiveness of beta-lactams, which remain first-line antibiotics for many infections, is an import

25 f potent biocides, the effectiveness of many first-line antibiotics has been diminished due to adapti

26 er 100,000 MSM population each year with the first-line antibiotics without worsening the burden of g

27 tensively drug-resistant (XDR), resistant to first-line antibiotics, fluoroquinolones and third gener

28 n S. Typhi are pansusceptible to traditional first-line antibiotics.

29 nin reuptake inhibitors (SSRIs) constitute a first-line antidepressant intervention, though the preci

30 d selective serotonin reuptake inhibitors as first-line antidepressants for adults with major depress

31 isinin and its derivatives (ART) are crucial first-line antimalarial drugs that rapidly clear parasit

32 st Asia, artemisinins, the core component of first-line antimalarial therapies, have experienced dela

33 Resistance to the current first-line antimalarials threatens the control of malari

34 DESIGN, SETTING, AND PARTICIPANTS: The First-line Antimetabolites as Steroid-sparing Treatment

35 InSTI)-based regimens are now recommended as first-line antiretroviral therapy (ART) for adults with

36 or (INSTI)-based regimens now recommended as first-line antiretroviral therapy (ART), the of baseline

37 tion of alternatives to efavirenz as part of first-line antiretroviral therapy for pregnant women.

38 In this work, rifampicin, a first-line antitubercular agent, was encapsulated into b

39 against M. tuberculosis compared to the two first-line antitubercular drugs rifampicin and isoniazid

40 ssay to evaluate resistance to the principal first-line antituberculosis drugs.

41 Based on 12 trials (n = 4127), first-line antiviral therapies were at least as likely a

42 s suggest that gene augmentation is a viable first-line approach for some individuals with dominant B

43 gel electrophoresis (PFGE) was applied as a first-line approach, followed by a more refined whole ge

44 In first-line aromatase inhibitor-treated patients (n=2252)

45 aboratory source data from adult patients on first-line ART at 52 South African centers between 1 Jan

46 commending the transition to dolutegravir in first-line ART for all adults, regardless of pregnancy o

47 benefits of alternative policies for initial first-line ART regimens.

48 us, evaluating clinical impact of LA-DRVs on first-line ART remains challenging.

49 re confirmed HIV-seropositive, qualified for first-line ART, planned to reside in the area for more t

50 T-naive South African children who initiated first-line ART.

51 IV received standard of care WHO-recommended first-line ART.

52 sed to standard of care received NNRTI-based first-line ART.

53 Rapid diagnostic tests are first-line assays for diagnosing infectious diseases, su

54 ) is a rare autoimmune liver disease and the first line available treatment is ursodeoxycholic acid (

55 olonged progression-free survival (PFS) with first-line avelumab + axitinib versus sunitinib in advan

56 d safety of secukinumab versus adalimumab as first-line biological monotherapy for 52 weeks in patien

57 umour-bearing mice compared to that with the first-line chemotherapeutic drug gemcitabine.

58 is extremely poor, as they are resistant to first line chemotherapy.

59 tly worse OS and PFS than patients receiving first-line chemotherapy followed by resection.

60 Addition of trastuzumab to first-line chemotherapy improves overall survival in pat

61 efore and during the first days of nivolumab first-line cHL therapy.

62 Patients were randomly assigned to first-line cladribine 0.15 mg/kg intravenously days 1-5

63 Achieving MRD-free CR of HCL after first-line cladribine is greatly enhanced by concurrent

64 IMspire150 aimed to evaluate first-line combination treatment with BRAF plus MEK inhi

65 he efficacy and safety of two antiretroviral first-line combinations (dolutegravir combined with emtr

66 asting neuropathy.SIGNIFICANCE STATEMENT The first-line cytostatic drug oxaliplatin can cause acute p

67 epithelial cells that provides an important first-line defence against viral respiratory infections

68 thways involving MyD88 or STING constitute a first-line defense against infections mainly through pro

69 of the innate immune system, contributing to first-line defenses against viral, bacterial, and fungal

70 eins with antiviral activity have evolved as first-line defenses to suppress viral replication.

71 ith lab tests, these features constitute the first-line diagnostic approach to distinguishing differe

72 rial of GS to assess the efficacy of GS as a first-line diagnostic tool for genetic white matter diso

73 nally used after unsuccessful treatment with first-line disease modifying therapies.

74 The relationships between first-line drug concentrations and clinically important

75 Methotrexate is generally the first-line drug for the treatment of RA, psoriatic arthr

76 toxic effect, anti-TB activity, synergy with first-line drugs in macrophages, pharmacokinetics and ad

77 enhanced the antitubercular activity of the first-line drugs isoniazid, rifampin, and pyrazinamide i

78 -based dosing, peak plasma concentrations of first-line drugs were below therapeutic drug monitoring

79 First-line durvalumab plus etoposide with either cisplat

80 First-line durvalumab plus platinum-etoposide showed sus

81 Treatment with mannitol, a first-line edema treatment in clinical practice, was als

82 Adrenaline is regularly used for first-line emergency management of anaphylaxis but littl

83 se findings suggest potential for RHB-105 as first-line empirical H pylori therapy, addressing an unm

84 st-line regimens, and portends high rates of first-line failure in sub Saharan Africa.

85 dence for a benefit of XTC in the context of first-line failure on this combination.

86 tter assess the depth of remission following first-line FCR treatment, we used NGS (Adaptive Biotechn

87 In first-line fulvestrant-treated patients (n=396), the med

88 ses were used to identify patients receiving first-line glaucoma therapy and to ascertain patient-lev

89 In this study, first-line GS provided earlier and greater diagnostic ef

90 ination with trastuzumab and chemotherapy in first-line HER2-positive metastatic oesophagogastric (ga

91 ination with trastuzumab and chemotherapy in first-line HER2-positive metastatic oesophagogastric can

92 These data suggest that first-line ibrutinib for unselected older adults with CL

93 he second-line in the delayed ibrutinib arm, first-line ibrutinib had an incremental cost of $478 823

94 utinib would need to be decreased by 72% for first-line ibrutinib therapy to be cost-effective at a w

95 First-line ibrutinib was associated with an improvement

96 Radiographs are the clinical first line imaging modality for evaluating hip morpholog

97 Current guidelines recommend US as the first-line imaging modality for palpable masses in pregn

98 d Duke criteria with echocardiography as the first-line imaging modality.

99 mography (CT) is considered the standard for first-line imaging of MPeM, diagnosis and risk stratific

100 X-ray suites or with portable units, are the first-line imaging test because they are widely availabl

101 Ultrasonography is the first-line imaging test to study these tumors.

102 one from fifty-six patients (3.3%) receiving first-line IMiD maintenance develop a therapy-related my

103 ns by the US Food and Drug Administration on first-line immunotherapy for advanced bladder cancer and

104 Angle surgery alone was first line in centers in the United States, United Kingd

105 Analysis included 74,196 first lines including 4,493 peripherally inserted centra

106 surfactant protein D (SP-D), a key factor in first-line innate immunity defense, removes influenza ty

107 odification to achieve weight loss remains a first-line intervention in patients with NAFLD.

108 t guidelines recommend behavior therapy as a first-line intervention, patients with TD may exhibit li

109 s superior diagnostic utility and is a valid first line investigation.

110 on vs red cell transfusion and discuss using first-line IV iron monotherapy to treat anemic patients

111 regnancy or postpartum, coexisting symptoms, first-line laboratory workup, and probability-based asse

112 However, using ibrutinib in the first-line led to significantly higher health care costs

113 Platinum segments are an ideal first-line loading implant for lagophthalmos.

114 nsidering growing evidence supporting use of first-line LT.

115 ering studying glucose-lowering therapies as first-line management of type 2 diabetes mellitus, consi

116 platinum and fluoropyrimidine doublet in the first line; median survival is less than 1 year.

117 Lithium is a first-line medication for bipolar disorder (BD), but onl

118 lizumab plus bevacizumab versus sunitinib in first-line metastatic renal cell carcinoma.

119 placebo plus platinum-based chemotherapy in first-line metastatic urothelial carcinoma.

120 phy and cardiac CT or CT angiography are the first-line modalities for clinically suspected endocardi

121 sal antihistamines or INCS may be offered as first-line monotherapy for NAR.

122 e association between neutropenia induced by first-line Nab-Gem and survival in metastatic pancreatic

123 Metastatic pancreatic patients treated with first-line Nab-Gem were included in this retrospective a

124 is urgent and still unmet need to develop a first line, non-invasive and simple method to diagnose F

125 ART; 25 studies included only individuals on first-line nonnucleoside reverse transcriptase inhibitor

126 ral endoscopic drainage are both appropriate first-line, nonsurgical approaches in managing patients

127 guidelines generally recommend NOACs as the first-line OAC, caution is required in some groups of pa

128 e major innate immune cells that provide the first line of cellular defense against infections or inj

129 al screening and optimization to develop the first line of compounds that inhibit PEX14-PEX5 PPI.

130 l DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defence leading to the production of type

131 otes cytotoxic mucosal CD4(+) T cells at the first line of defence, and cytotoxic CD4(+) and CD8(+) T

132 ithelium contributes to innate immunity as a first line of defence, understanding how the epithelium

133 The serum complement system is a first line of defense against bacterial invaders.

134 lactam susceptible bacteria by acting as the first line of defense against beta-lactam antibiotics, a

135 ulin A (sIgA) represents the immune system's first line of defense against mucosal pathogens.

136 Langerhans cells (LCs) in the skin are a first line of defense against pathogens but also play an

137 The innate immune system acts as the first line of defense against pathogens, including coron

138 n.IMPORTANCE Restriction factors provide the first line of defense against retrovirus infection by po

139 ironmental services personnel are a critical first line of defense against the spread of COVID-19.

140 The interferon system is the first line of defense against virus infection.

141 nvading microbes and therefore represent the first line of defense of the innate immune response.

142 To mimic the clinical-settings of first line of GBM-treatment, we show that tumor-resectio

143 rn recognition receptors (PRRs) triggers the first line of inducible defence against invading pathoge

144 The skin provides the first line of physical and immunological defense against

145 The epithelial barrier constitutes the first line of physical, chemical, and immunologic defens

146 by suppressing the host oxidative burst-the first line of plant defense.

147 re than 30% of patients are resistant to the first line of treatment (selective serotonin reuptake in

148 Temozolomide is the first line of treatment for glioblastoma, one of the mos

149 Metformin is the first line of treatment for type 2 diabetes, and one of

150 stillation after removal of the tumor is the first line of treatment for urothelial carcinoma in situ

151 d surgeries have been increasingly used as a first-line of treatment for patients undergoing oncologi

152 linical settings as adjuvant therapies or as first-line options for recurrent or metastatic disease.

153 KIs) are indicated with endocrine therapy as first-line or second-line treatment for hormone receptor

154 crine therapy alone might be appropriate for first-line or second-line treatment of hormone receptor-

155 Combination first-line osimertinib plus erlotinib treatment prevente

156 rst pass was non-inferior to stent retriever first line (p(non-inferiority)=0.0014).

157 status of 0 to 2 who were planned to receive first-line palliative therapy.

158 First-line pembrolizumab confers meaningful and durable

159 2 study evaluated the efficacy and safety of first-line pembrolizumab for patients with locally advan

160 First-line pembrolizumab monotherapy exhibited promising

161 Epinephrine is the first-line pharmacotherapy for uniphasic and/or biphasic

162 First-line pharmacotherapy with propranolol has reduced

163 ients achieving at least stable disease with first-line platinum-based chemotherapy and prolongs prog

164 cancer achieving at least stable disease on first-line platinum-based chemotherapy were enrolled.

165 disease recurrence more than 6 months after first-line platinum-based chemotherapy, and an Eastern C

166 isease is in complete or partial response to first-line, platinum-based chemotherapy with high-grade

167 c urothelial carcinoma who receive standard, first-line, platinum-based chemotherapy.

168 scovery efforts as this is the target of the first line pro-drug isoniazid.

169 ombined trabeculotomy-trabeculectomy was the first-line procedure for PCG in centers in India and Gha

170 ients with non-Hodgkin lymphoma who received first-line R-CHOP or CHOP.

171 n tissue on formalin-fixed paraffin-embedded first-line radical prostatectomy specimens (embedded in

172 include trastuzumab (HER2-positive patients first line), ramucirumab (anti-angiogenic second line),

173 ion of DTG in 2020 under 2 scenarios: DTG as first-line regimen for ART initiators, or DTG for all pa

174 te of disease may explain the success of the first-line regimen.

175 With INSTI-based first-line regimens in the United States, baseline genot

176 rm failure of integrase inhibitor-containing first-line regimens, and portends high rates of first-li

177 n initiating age-appropriate WHO-recommended first-line regimens.

178 Therefore, a generic strategy of first line screening was developed to detect and identif

179 als was insufficient to justify its use as a first-line screening approach.

180 Due to cross-reactivity, a positive first-line serology test requires confirmation by either

181 t continuously administered ibrutinib in the first-line setting significantly prolonged progression-f

182 s the cost-effectiveness of ibrutinib in the first-line setting, compared with a strategy of using ib

183 In the first-line setting, the addition of the anti-programmed

184 eiving atezolizumab plus chemotherapy in the first-line setting.

185 Conclusion: First-line SIRT is safe and produced promising outcomes

186 study suggest that prospective trials using first-line SIRT should be considered.

187 ted cohort included 22 patients treated with first-line SIRT.

188 , whereas microvascular decompression is the first-line surgery in medically refractory patients.

189 erent mouse models, as adjunctive therapy to first-line TB drugs.

190 Echocardiography is the recommended first-line test for the assessment of valvular heart dis

191 or the use of coronary CT angiography as the first-line test for the evaluation of CAD, the ISCHEMIA

192 xome sequencing/whole-genome sequencing as a first-line test should be considered.

193 gh lung ultrasound (LUS) is recommended as a first-line test to assess pulmonary congestion, it has n

194 When developing a first-line therapeutic for a novel pathogen, for instanc

195 Ursodeoxycholic acid (UDCA) is one of the first-line therapeutic medications used in treatment of

196 Rifampicin (Rif) is a first-line therapeutic used to treat the infectious dise

197 reatment or catheter ablation are considered first-line therapies in most patients with PVCs associat

198 cant improvements in patient outcomes for 26 first line therapy trials).

199 alone and in combination with rituximab as a first-line therapy and as a treatment of patients with r

200 Forty-two percent had isolates resistant to first-line therapy for community-acquired pneumonia.

201 Standard first-line therapy for EGFR-mutant advanced non-small-ce

202 nase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resi

203 Polyclonal anti-D is a first-line therapy for immune thrombocytopenia (ITP).

204 TEVAR has become first-line therapy for many aortic pathologies including

205 tinib to improve the survival has become the first-line therapy for metastatic RCC patients.

206 2018, osimertinib has been widely adopted as first-line therapy for patients with advanced EGFR-mutan

207 of pembrolizumab plus pemetrexed-platinum as first-line therapy for patients with metastatic non-squa

208 tion as an alternative to stent retriever as first-line therapy for stroke thrombectomy.

209 Metformin is the first-line therapy for treating type 2 diabetes and a pr

210 efficacy of cryoballoon ablation as initial first-line therapy have not been established.

211 Glucocorticoids are considered first-line therapy in a variety of eosinophilic disorder

212 We conducted a phase 2 single-group trial of first-line therapy in adults with newly diagnosed Ph-pos

213 EGFR-TKI osimertinib has been approved as a first-line therapy in NSCLC, representing the most succe

214 vestigate the safety and efficacy of SIRT as first-line therapy in patients with uveal melanoma metas

215 eoside analog gemcitabine frequently used in first-line therapy is an urgent issue in pancreatic canc

216 g, usually cladribine, has been the standard first-line therapy of hairy cell leukemia (HCL) for 30 y

217 in combination with rituximab, are preferred first-line therapy options for symptomatic patients with

218 echanism of proton pump inhibitors (PPIs) or first-line therapy remain unclear.

219 rugs (NSAIDs) with or without menthol gel as first-line therapy to reduce or relieve symptoms, includ

220 Catheter ablation is increasingly used as a first-line therapy with a high acute success rate, but r

221 Following first-line therapy with sorafenib or lenvatinib, second-

222 of 25 of 28 patients with progression during first-line therapy, 31 of 32 with progression during rei

223 sease should be offered endocrine therapy as first-line therapy, except in cases of visceral crisis o

224 onary tuberculosis received standard 6-month first-line therapy.

225 avitreal antibiotic delivery was a universal first-line therapy.

226 tients did not have access to this option as first-line therapy.

227 evidence of better IDI response when used as first-line therapy.

228 therapy, but no data exist about its use as first-line therapy.

229 all-cell lung cancer (SCLC) after failure of first-line therapy.

230 f intravitreal antibiotics was the universal first-line therapy.

231 19-2020), and 54% of patients were receiving first-line therapy.

232 Next-generation sequencing has become a first-line tool for the diagnosis of primary immunodefic

233 rapy which should therefore be regarded as a first-line tool in daily practice.

234 ole for specific indications but remains the first line treatment in most units.

235 pathways have been approved and are used as first line treatment of moderate-to-severe plaque psoria

236 te survival in castrate conditions-mimicking first line treatment resistance with hormonal therapies.

237 ely managed with intramuscular adrenaline as first line treatment.

238 ould be proposed as the standard of care for first-line treatment and rituximab-based regimens for se

239 r incidence of CMV viremia, a higher rate of first-line treatment failure and a longer time to virus

240 roup of beta-lactam antibiotics that are the first-line treatment for a range of infections.

241 or without (CHOP) rituximab is the standard first-line treatment for aggressive non-Hodgkin lymphoma

242 Epinephrine is the first-line treatment for anaphylaxis.

243 Lithium (Li) is a first-line treatment for bipolar disorder (BD).

244 r of the extracorporeal dialysis circuit) as first-line treatment for continuous kidney replacement t

245 ds the use of psychological interventions as first-line treatment for depression in low-income and mi

246 d combination therapy has been approved as a first-line treatment for head and neck squamous cell car

247 recommended by international consensus as a first-line treatment for idiopathic multicentric Castlem

248 upervised exercise therapy is recommended as first-line treatment for intermittent claudication by re

249 hout tremelimumab (a CTLA-4 inhibitor), as a first-line treatment for metastatic urothelial carcinoma

250 the stones outlet, can be considered as the first-line treatment for patients with large and multipl

251 trial investigated nivolumab monotherapy as first-line treatment for patients with previously untrea

252 Exposure-based psychotherapy is a first-line treatment for posttraumatic stress disorder (

253 ased chemotherapeutic drug, which is used as first-line treatment for some types of colorectal carcin

254 Metformin is the first-line treatment for type 2 diabetes.

255 rect oral anticoagulants (DOACs) have become first-line treatment for venous thrombotic events.

256 mab vedotin combined with pembrolizumab as a first-line treatment in February 2020 for cisplatin-inel

257 inhibitor bevacizumab (BVZ) is approved as a first-line treatment in metastatic colorectal cancer (mC

258 ibitor that blocks PD-1 and is approved as a first-line treatment in patients with advanced metastati

259 Sulfonylureas (SUs) provide an efficacious first-line treatment in patients with hepatocyte nuclear

260 L who had received Hodgkin lymphoma-directed first-line treatment in randomized GHSG trial protocols

261 ges, n = 144) who had received stage-adapted first-line treatment in the randomized GHSG HD7 to HD15

262 of patients with relapse after risk-adapted first-line treatment of early-stage, favorable, classic

263 -etoposide as a new standard of care for the first-line treatment of ES-SCLC.

264 sfer inhibitors (InSTIs) are recommended for first-line treatment of HIV-infection.

265 In first-line treatment of Hodgkin lymphoma (HL), Deauville

266 inhibitors (TKIs), such as erlotinib, as the first-line treatment of lung cancers.

267 mbrolizumab to standard chemotherapy for the first-line treatment of metastatic triple-negative breas

268 Platinum-based chemotherapy for first-line treatment of metastatic urothelial cancer is

269 delines recommend biologics as an option for first-line treatment of moderate to severe plaque psoria

270 bevacizumab (atezo + bev) may be offered as first-line treatment of most patients with advanced HCC,

271 rs sorafenib or lenvatinib may be offered as first-line treatment of patients with advanced HCC, Chil

272 First-line treatment of stage IA NLPHL usually consists

273 zopanib a putative therapeutic option in the first-line treatment of STS in patients age 60 years or

274 s platinum-based chemotherapy as a potential first-line treatment option for metastatic urothelial ca

275 ezolizumab to platinum-based chemotherapy as first-line treatment prolonged progression-free survival

276 Azathioprine is used as a first-line treatment to prevent relapses of neuromyeliti

277 im complete response rates to anti-PD1 based first-line treatment were recently reported for patients

278 Following first-line treatment with atezo + bev, and until better

279 f patients with severe acute GVHD respond to first-line treatment with corticosteroids and, for sever

280 hemotherapy-free induction and consolidation first-line treatment with dasatinib and blinatumomab tha

281 These results continue to support the first-line treatment with pembrolizumab plus axitinib as

282 phoma not otherwise specified) that received first-line treatment with R-CHOP or CHOP.

283 Data on baseline characteristics, first-line treatment, treatment response, and survival o

284 vention for mania, is no longer considered a first-line treatment.

285 to recommendations for therapy options after first-line treatment.

286 ne-kinase inhibitors had not been given as a first-line treatment.

287 (147 [74%] of 199), with 112 (57%) of 197 on first-line treatment.

288 Metronidazole is the first-line treatment; however, treatment failure and rec

289 t loss as core treatments, topical NSAIDs as first-line treatments and oral NSAIDs and intra-articula

290 Roughly 60% of patients respond poorly to first-line treatments and thus new therapeutic strategie

291 tastatic cancers that were not responding to first-line treatments met study criteria.

292 We observed a high prevalence of AMR to first-line treatments recommended by WHO, and more than

293 s of pathogens among which the resistance to first-line treatments, attributed in part to mutations i

294 esponse to chemotherapy and immunotherapy as first-line treatments.

295 lar H. pylori (aiHp) on treatment failure of first-line triple therapies.

296 es proved to be a risk factor for failure of first-line triple therapies; occurrence of aiHp should b

297 Pyrazinamide is a sterilizing first-line tuberculosis drug.

298 ulosis has developed a form of resistance to first-line tuberculosis treatments, specifically to ison

299 ence for evaluating the potential benefit of first-line tyrosine-kinase inhibitor treatment in patien

300 chemotherapy in the metastatic setting (not first-line) were excluded from our pooled analyses.