ライフサイエンスコーパス: fission

1 SCRT pathway constricts membranes to promote fission.

2 some of which were in the process of binary fission.

3 Klf5 overexpression suppresses mitochondrial fission.

4 acity, consistent with reduced mitochondrial fission.

5 the nuclear envelope and sites of ER tubule fission.

6 of sublineage restriction and limited islet fission.

7 1 (DRP1), is a key mediator of mitochondrial fission.

8 1 depletion impairs SNX17-mediated endosomal fission.

9 TPase Vps4, induces membrane deformation and fission.

10 er membranes is sufficient for mitochondrial fission.

11 ng bilayer, lowering the barrier to membrane fission.

12 contribute to the actin-dependent aspect of fission.

13 ia, resulting in inhibition of mitochondrial fission.

14 e in regulating mitochondrial morphology and fission.

15 le network dynamics, including mitochondrial fission.

16 rtant regulatory mechanism for mitochondrial fission.

17 uring high-yield T(1) formation from singlet fission.

18 mbrane potential, and promoted mitochondrial fission.

19 membrane undergoes extreme remodeling during fission.

20 ailor new potential chromophores for singlet fission.

21 osphorylation of Drp1 S637 and mitochondrial fission.

22 activation and the consequent mitochondrial fission.

23 lecules and provide a platform for organelle fission.

24 ation of AMPK and promotion of mitochondrial fission.

25 ng and ESCRT-III in membrane deformation and fission.

26 alga Chlamydomonas proliferates by "multiple fission": a long G1 with >10-fold cell growth followed b

27 ed that PIM inhibitors promote mitochondrial fission and apoptosis in vivo.

28 at hypoxia-induced ROS trigger mitochondrial fission and CDDP resistance through downregulation of p-

29 tional insight into the process of endosomal fission and connecting the sorting and fission machineri

30 tures of DN along with reduced mitochondrial fission and diminished mitochondrial ROS in vivo.

31 Klf5 down-regulation leads to mitochondrial fission and excessive ROS production.

32 network through a simultaneous disruption of fission and fusion abrogates the lifespan increase induc

33 How the processes of fission and fusion are balanced by the cell is unclear.

34 Mitochondrial fission and fusion are highly regulated by energy demand

35 Here we show that mitochondrial fission and fusion are spatially coordinated at ER membr

36 elles adapting their morphology by cycles of fission and fusion events to control cellular homeostasi

37 Mitochondria undergo fission and fusion events, but the dynamics and regulati

38 Furthermore, fission and fusion machineries colocalize to form hotspo

39 rial ROS production via selective control of fission and fusion proteins (mitofusins, OPA1 and DRP1)

40 k is maintained by a balance of constitutive fission and fusion reactions.

41 Because these hotspots can undergo fission and fusion, they have the potential to quickly r

42 his lipid acts as a molecular switch between fission and fusion.

43 cell through the processes of mitochondrial fission and fusion.

44 fibroblasts) displayed excess mitochondrial fission and had increased expression of PDK isoforms 1 a

45 e oligomers that undergo endothermic singlet fission and have endothermicities in the range 5-10 k(B)

46 SCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose upta

47 While both mitochondrial fission and mitochondrial fusion mutants showed increase

48 Mitochondrial fission and mitophagy are quality control mechanisms tha

49 nt for multiexcitonic processes like singlet fission and photon upconversion.

50 tion site in Drp1 can regulate mitochondrial fission and progression of DN in vivo, and highlight the

51 , Eps15 homology domain protein 1, catalyzes fission and releases endosome-derived vesicles for recyc

52 nations are thought to be crucial in fusion, fission and remodeling of cells and present in many huma

53 f PIM kinases caused excessive mitochondrial fission and significant upregulation of mitochondrial su

54 , utilize host proteins to catalyze membrane fission and to free progeny virions.

55 tate acts as an intermediate in both singlet fission and triplet-triplet annihilation and that this i

56 Singlet fission and triplet-triplet annihilation represent two h

57 proteins at sites of nuclear envelope and ER fission and, by genetic analysis of cdc42 mutant yeast,

58 goblet-like cell maturation, increased crypt fission, and accelerated the development of tumors in th

59 turation of goblet-like cells, reduced crypt fission, and developed fewer tumors.

60 ased symmetric stem cell division, glandular fission, and more rapid stem cell lineage tracing, a pro

61 itochondrial calcium transfer, mitochondrial fission, and vesicle transport.

62 n regulator of membrane remodeling, membrane fission, and vesicular trafficking.

63 agy (mitophagy) and mitochondrial fusion and fission are protective quality control mechanisms that c

64 of membranes, particularly their fusion and fission, are critical for the transmission of chemical i

65 the Saltatorellus clade to divide by binary fission as well as budding, we identified previously unk

66 nflux and Drp1-mediated, rapid mitochondrial fission at the injury site help polarize the repair resp

67 Best known for their role in fission at the late stages of CME, many studies have sug

68 Mitochondria undergo dynamic fusion/fission, biogenesis and mitophagy in response to stimuli

69 intaining dendritic spines and mitochondrial fission biology, two subcellular niches affected early i

70 s is a key driver of membrane remodeling and fission by BAR domain-containing proteins.

71 that CDKA1 and Rb/E2F/Dp1 regulate multiple fission by distinct mechanisms.

72 the cristae during mitochondrial fusion and fission can be clearly observed.

73 power production through the use of nuclear fission can be enabled by recycling long-lived actinide

74 ed and immobilized in an inert host, singlet fission can be strongly state-selective.

75 of tunability and several thousand potential fission-capable candidates, while clearly demonstrating

76 Mitochondrial fission catalyzed by dynamin-related protein 1 (Drp1) is

77 blish a link between defective mitochondrial fission, cellular senescence and age-dependent oxidative

78 criteria on the state ordering for a singlet fission chromophore.

79 tric model for the identification of singlet fission chromophores, and we explore what factors limit

80 disrupted by mutations in the mitochondrial fission component dynamin DRP-1.

81 Molecules that undergo singlet fission, converting singlet excitons into pairs of tripl

82 we propose a mechanistic model for multiple-fission cycles and cell-size control in Chlamydomonas.

83 experimentally observed features of multiple-fission cycles and the response of Chlamydomonas cells t

84 ased uncoupled oxygen consumption, increased fission, decreased membrane potential, and increased exp

85 Inhibition of mitochondrial fission decreases ROS production and VSMC senescence.

86 ionine synthase suppressed the mitochondrial fission defect of a dynamin mutation.

87 ethionine synthase also suppresses the drp-1 fission defect, suggesting that vitamin B12 regulates mi

88 2 also strongly suppressed the mitochondrial fission defect.

89 nized mitochondria caused by a mitochondrial fission-defective dynamin mutation is strongly suppresse

90 hondria show signs of damage, such as fusion/fission defects and vacuolation, but axons do not show i

91 CAV1 protein abundance as well as endosomal fission defects resulting from pathogenic SPG8 mutations

92 We found that disrupting mitochondrial fission (DRP1/drp-1) or fusion (OPA1/eat-3, MFN/fzo-1) g

93 been characterized as a regulator of vacuole fission during hyperosmotic shock, where it interacts wi

94 Suppression of mitochondrial fission enhanced the CDDP sensitivity of hypoxic ovarian

95 e possible advantages of endothermic singlet fission (enhanced use of photon energy and larger triple

96 itochondria contacts, increased mitochondria fission, enhanced receptor-mediated mitophagy, and incre

97 as a positive regulator of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1).

98 The mitochondrial network undergoes fission events after HCMV infection.

99 rphology is regulated by constant fusion and fission events to maintain a functional mitochondrial ne

100 During ionomycin-induced mitochondrial fission, F-actin clouds colocalize with mitochondrial co

101 We found that the receptors mitochondrial fission factor (Mff) and mitochondrial elongation factor

102 he translational inhibition of mitochondrial fission factor (MFF) regulates cellular homeostasis and

103 gmentation is dependent on the mitochondrial fission factor DRP-1 (dynamin-related protein 1) and its

104 and the phosphorylation of the mitochondrial fission factor Drp1 at Ser(616) The lack of the MCU was

105 terials, exemplified here by singlet exciton fission followed by separation into weakly bound, locali

106 n sorted receptors bud and undergo vesicular fission from the sorting endosomes remain elusive.

107 transport-III (ESCRT-III) catalyzes membrane fission from within membrane necks, a process that is es

108 ium possess some life-like behaviors such as fission, fusion, movement and chemotaxis.

109 More broadly, our study reveals how fission-fusion dynamics and ecological factors can simul

110 face of ecological change suggests that the fission-fusion nature of lion prides might be essential

111 ing carriers, membrane homeostasis proteins, fission-fusion proteins, cristae-shape controlling and M

112 g-lasting social associations can persist in fission-fusion social systems such as those observed in

113 Finally, within this larger fission-fusion system, individuals tended to maintain sp

114 , the presence of such ties can be masked in fission-fusion systems like that exhibited by most parro

115 ridinium (MPP(+)) dysregulates mitochondrial fission-fusion, mitophagy, and mitochondrial biogenesis.

116 of mitochondria with the SSC, mitochondrial fission/fusion imbalance, a remarkable reduction in mito

117 reases mitochondrial size, and alters fusion/fission gene expression.

118 th, our findings identify that mitochondrial fission generates localized signaling required for cell

119 ncode 0, 1 or 2 alleles of the mitochondrial fission GTPase Drp1 and demonstrate that these mitochond

120 ion dynamics of the GFP-tagged mitochondrial fission GTPase dynamin-related protein 1 (Drp1) both in

121 However, excessive fission has been associated with multiple neurodegenerat

122 ular machineries involved in membrane fusion/fission have been dissected, regulation of membrane dyna

123 08-atom molecular movie of ultrafast singlet fission in a pentacene dimer, explicitly treating 252 vi

124 They were used to induce fission in foil targets made of natural uranium.

125 synaptic activity and reduced mitochondrial fission in ligand 1-treated mutant APP cells.

126 axis linking PIM1 to Drp1 and mitochondrial fission in lung cancer.

127 following cohabitation, with a shift toward fission in males.

128 ally regulates mitochondrial and peroxisomal fission in multicellular organisms.

129 hly regulated equilibrium between fusion and fission in order to sustain biological function.

130 t the cost of one photon via singlet exciton fission in organic semiconductors can potentially enhanc

131 and fused states that shifts heavily toward fission in response to cellular damage.

132 ted protein 1 (Drp1)-dependent mitochondrial fission in response to oxidative stress.

133 Both macrocycles undergo singlet fission in solution with rates that differ by an order o

134 itochondria because of reduced mitochondrial fission in the former and elevated fission in the latter

135 chondrial fission in the former and elevated fission in the latter.

136 how that progeny number and the frequency of fission initiation are correlated with parent size.

137 g pathways as regulators of the frequency of fission initiation rather than the position of fission p

138 analyze correlated-triplet-pair (TT) singlet-fission intermediates toward two-triplet separation (T..

139 lear envelope to deform it, which results in fission into two daughter nuclei.

140 Membrane fusion/fission is a highly dynamic and conserved process that r

141 Singlet fission is a photoconversion process that generates a do

142 nd electron tomography, we show that nuclear fission is achieved via local disassembly of nuclear por

143 Although mitochondrial fission is considered to be an indicator of cell damage

144 phores needed to undergo endothermic singlet fission is three, which provides sufficient statistical

145 ing efficient intramolecular singlet exciton fission (iSEF) in pai-bridged pentacene dimers.

146 athway, an unexpected intramolecular singlet fission (iSF) process is responsible for excited state d

147 RIPK3 promotes mitochondrial fission leading to elevated oxidative stress via DRP1.

148 cell stress, mitochondrial dynamics shift to fission, leading to mitochondrial fragmentation, membran

149 somal fission and connecting the sorting and fission machineries.

150 These organelles share fission machinery components, oxidative metabolism pathw

151 zed that SNX17 couples receptors to the EHD1 fission machinery in mammalian cells.

152 The ESCRT-III membrane fission machinery maintains the integrity of the nuclear

153 Not only do we access novel singlet fission materials, they also exhibit excellent ambient s

154 esirable for the design of efficient singlet fission materials.

155 s true for both endo- and exothermic singlet fission materials.

156 Mek-Erk controls the activity of the fission mediator Drp1 GTPase, while PI3K may contribute

157 ned the position where PB and stress granule fission occurs.

158 Fission of injury-proximal mitochondria allows for great

159 LZTR1 affects the dynamics of fusion and fission of recycling endosomes by controlling ubiquitina

160 r 1 (mdivi-1), an inhibitor of mitochondrial fission, on the structure and function of both mitochond

161 itochondrial network homeostasis by blocking fission or fusion synergizes with reduced mitochondrial

162 ised in organic chromophores through singlet fission or via charge recombination.

163 Singlet exciton fission photovoltaic technology requires chromophores wi

164 w chromophores with potential use in singlet fission photovoltaics.

165 ssion initiation rather than the position of fission planes.

166 tube and reducing its diameter nearly to the fission point.

167 il to undergo injury-triggered mitochondrial fission, preventing polarized mitochondrial calcium incr

168 ost promising methods to harness the singlet fission process is via the efficient extraction of the d

169 nergetics can play outsized roles in singlet fission processes.

170 omise has not been fulfilled because singlet fission produces two low-energy triplet excitons that ha

171 Technetium-99 (Tc), a high yield fission product generated in nuclear reactors, is one of

172 arily due to interactions between lanthanide fission products and cladding constituents.

173 mitigated by utilizing fast transport of the fission products by a gas flow to a carbon filter, where

174 Singlet fission promises to surpass the Shockley-Queisser limit

175 sion of a dominant negative (DN) form of the fission protein [dynamin-related protein 1 (DRP1)] marke

176 bules physically impedes the assembly of the fission protein Dnm1 around mitochondria, resulting in i

177 Embryos mutant for the mitochondrial fission protein, Drp1 (dynamin-related protein 1), die i

178 Here, by generating an optimized planarian fission protocol in Schmidtea mediterranea, we show that

179 We also establish that Env7 vacuole fusion/fission regulation and vacuolar localization are mediate

180 use of loss of activity of the mitochondrial fission regulator Drp1 onto mitochondria.

181 rying a knockout of the mitochondrial fusion-fission-related gene solute carrier family 25 member 46

182 herefore, unlike with tetracenes, carotenoid fission requires above-gap excitations.

183 excellent stability of this class of singlet fission scaffold.

184 Singlet fission (SF) holds the potential to boost the maximum po

185 ns and, in turn, on the key steps in singlet fission (SF), that is, the (1)(S(1)S(0))-to-(1)(T(1)T(1)

186 effects of exciton delocalization on singlet fission (SF).

187 hus provide a strategic advantage to singlet fission solar cells by suppressing singlet dissociation

188 obstacle to the design of efficient singlet fission solar cells.

189 been found previously to be required for the fission stage of COPI vesicle formation.

190 Singlet fission-that is, the generation of two triplets from a l

191 In organic semiconductors exhibiting singlet fission, the geometric relationship between molecules pl

192 the properties of modern materials, nuclear fission, the merging of neutron stars, and the expansion

193 Singlet fission, the process of splitting a singlet exciton into

194 roteins are recognized as the key drivers of fission, there is a growing body of evidence that strong

195 del for regulation of Chlamydomonas multiple fission, these results suggest that CDKA1 may promote a

196 tically, PGAM5 is required for mitochondrial fission through dephosphorylating DRP1.

197 Here, we demonstrate that mitochondrial fission, together with the lack of mtDNA replication, se

198 While the effect of temperature on fission track annealing has been studied extensively to

199 Fission track thermochronology is routinely used to inve

200 To simulate fission tracks in a controlled environment, ion tracks w

201 olecules cannot probe the defects created by fission tracks.

202 rticle assemblies to undergo both fusion and fission transitions.

203 nsights: (a) the canonical tetracene singlet-fission unit cell supports precisely three low-lying TT

204 al biogenesis and then affects mitochondrial fission via chromatin pathways.

205 MPK) activation by 991 promote mitochondrial fission via phosphorylation of MFF and induce mitophagy

206 romotes mitophagy by enhancing mitochondrial fission (via MFF phosphorylation) and autophagosomal eng

207 polymer that we show is competent to promote fission when bound on the inside of membrane necks.

208 domain is sufficient to induce mitochondrial fission when expressed in mouse embryonic fibroblasts in

209 Here, motivated by work in fission yeast (Schizosaccharomyces pombe), we generated

210 inc-requiring Pho8 alkaline phosphatase from fission yeast (Schizosaccharomyces pombe).

211 on in both mammalian and yeast cells, and in fission yeast a single mitotic cyclin can drive the cell

212 eviously discovered that competition between fission yeast actin binding proteins (ABPs) for binding

213 By using mutants of the fission yeast actin severing protein Adf1, we observed t

214 We have tested Pomegranate on fission yeast and demonstrate its ability to 3D segment

215 In radially symmetric cells, such as fission yeast and many bacteria, this 2D segmentation ca

216 omoter choices for potential applications in fission yeast and other organisms.

217 age analysis portfolio already available for fission yeast and other radially symmetric cell types.

218 he RNA-binding characteristics we observe in fission yeast are likely to apply to related proteins in

219 anches formed from purified muscle actin and fission yeast Arp2/3 complex and observed debranching ev

220 Here, we show that fission yeast Aurora B localizes at telomeres during mei

221 ess, we have carried out a genetic screen in fission yeast by random mutation of the genome, looking

222 ing of mRNA quantities is apparent in single fission yeast cells during a normal cell cycle.

223 phatases, promotes the symmetric division of fission yeast cells through spatial control of cytokines

224 roscopy, and mathematical modeling in single fission yeast cells to uncover the precise molecular mec

225 of the popular green-to-red PCFP mEos3.2 in fission yeast cells under a wide range of imaging condit

226 chromatin, we affinity-selected solubilized fission yeast CENP-A(Cnp1) chromatin.

227 hizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus.

228 onary divergence of this response within the fission yeast clade.

229 e, we use efficient conditional depletion of fission yeast condensin to determine its contribution to

230 The developmental asymmetry of fission yeast daughter cells derives from inheriting 'ol

231 A large region of fission yeast DNA inserted into a mouse chromosome was p

232 oscopy indicate that the heterochromatinised fission yeast DNA is organised into smaller chromatin lo

233 ntragenic antisense transcription of ~10% of fission yeast genes, with each perturbation affecting la

234 ve heterochromatin are maintained within the fission yeast genome through self-reinforcing mechanisms

235 matin at endogenous and ectopic sites in the fission yeast genome.

236 complex are more sensitive to debranching by fission yeast GMF (glia maturation factor) than branches

237 nt epimutants resistant to caffeine arise in fission yeast grown with threshold levels of caffeine.

238 In the last few decades, experiments on fission yeast have revealed different molecular players

239 We find that the fission yeast homologues of Tristetraprolin/TTP and Pumi

240 We phenotype gene-deletion strains of fission yeast in 59,350 individual fitness assays in 70

241 Here we investigate the role of fission yeast inner nuclear membrane proteins in determi

242 ivity of human Aurora A but also for that of fission yeast MAPK-activated kinase (Srk1) and PKA (Pka1

243 heterochromatin invasion by manipulating the fission yeast mating type locus boundary using a single-

244 ocking region, the hydrophobic patch, on the fission yeast mitotic cyclin Cdc13 as a potential mechan

245 Here, we show that fission yeast Mso1 is also a Sec1-binding protein and Ms

246 Fission yeast Mso1 shares homology with budding yeast Ms

247 Here we address this issue via analysis of fission yeast peptidyl-prolyl isomerase Pin1.

248 The fission yeast phosphate homeostasis (PHO) regulon compri

249 Fission yeast phosphate homeostasis genes are repressed

250 Moreover, the LIM domain region from the fission yeast protein paxillin like 1 (Pxl1) also locali

251 emonstrate the importance of uncharacterized fission yeast proteins Mso1 and Sec1 in membrane traffic

252 n-containing region from mammalian zyxin and fission yeast Pxl1 binds to mechanically stressed F-acti

253 Fission yeast Rai1 also has HDH activity although it doe

254 res of mammalian DXO with 3'-FADP or CoA and fission yeast Rai1 with 3'-FADP provide elegant insight

255 g was highlighted by experiments on isolated fission yeast rings, where sections of ring became unanc

256 probed these fundamental questions using the fission yeast Schizosaccharomyces japonicus, which break

257 Here, using the fission yeast Schizosaccharomyces pombe (a classical mod

258 plored cytokinetic calcium transients in the fission yeast Schizosaccharomyces pombe by adopting GCaM

259 Here, we utilize the fission yeast Schizosaccharomyces pombe to investigate h

260 In the fission yeast Schizosaccharomyces pombe, H3K9me heteroch

261 In the rod-shaped fission yeast Schizosaccharomyces pombe, symmetric divis

262 In the fission yeast Schizosaccharomyces pombe, the formin For3

263 Here, in fission yeast Schizosaccharomyces pombe, we successfully

264 sterol flow between PM and endosomes in the fission yeast Schizosaccharomyces pombe.

265 A translation during histidine starvation in fission yeast Schizosaccharomyces pombe.

266 started a program of searches for mutants in fission yeast that revealed a range of phenotypes inform

267 assembly in Schizosaccharomyces japonicus, a fission yeast that undergoes partial mitotic NE breakdow

268 ied single-molecule speckle tracking in live fission yeast to directly measure molecular turnover wit

269 thyltransferase PRMT3 that is conserved from fission yeast to humans.

270 onclude that like the larger animal embryos, fission yeast triggers calcium transients that may play

271 Here, we show that fission yeast whole-cell poly(A)(+) RNA-protein crosslin

272 MP as a highly sensitive calcium reporter in fission yeast, allowing us to capture calcium transients

273 i-mediated post-transcriptional silencing in fission yeast, and unveil an important role for post-tra

274 In fission yeast, Exo1 is the primary resection nuclease, w

275 During closed mitosis in fission yeast, growing microtubules push onto the nuclea

276 where a putative histone demethylase Epe1 in fission yeast, has a non-enzymatic function that opposes

277 omyosin ring is essential for cytokinesis in fission yeast, proper furrow formation also requires sep

278 haracterized example of sizer behavior is in fission yeast, Schizosaccharomyces pombe, which enters m

279 he cleavage furrow during cytokinesis of the fission yeast, Schizosaccharomyces pombe.

280 In fission yeast, the correct ordering of CDK substrate pho

281 In fission yeast, the inverted repeats IR-L and IR-R functi

282 In fission yeast, the septation initiation network (SIN) en

283 In fission yeast, the two HP1 proteins Chp2 and Swi6 assume

284 ere, using a non-essential minichromosome in fission yeast, we identify roles for the HR factors Rqh1

285 Using replication fork barriers in fission yeast, we report that relocation of arrested for

286 ent of heterochromatin at pericentromeres in fission yeast.

287 ed CDC mutants in the very distantly related fission yeast.

288 is catalyzed by the cohesin loader, Mis4 in fission yeast.

289 activity against Gram-positive bacteria and fission yeast.

290 rapid genomic gene editing and regulation in fission yeast.

291 e II (RNAPII), and are mutually dependent in fission yeast.

292 p coordinate cytokinetic furrow formation in fission yeast.

293 mitochondrial and nuclear DNA of budding and fission yeast.

294 tion speed and depth are two-fold greater in fission yeast.

295 RdDM, reflecting an analogous interaction in fission yeast.

296 dels in matched GI datasets from baker's and fission yeast.

297 epigenetic inheritance of heterochromatin in fission yeast.

298 indle, we developed a computational model of fission-yeast mitosis.

299 Cell cycle mutants in the budding and fission yeasts have played critical roles in working out

300 ress this fundamental question using related fission yeasts Schizosaccharomyces pombe and Schizosacch