ライフサイエンスコーパス: fitness

1 size affects the primary components of viral fitness.

2 eumococcal competence cycle, preserving cell fitness.

3 nd paternal effect of foliage supplements on fitness.

4 eliminated by neighboring cells with greater fitness.

5 erating ageing disproportionally, decreasing fitness.

6 lations and clones show apparent declines in fitness.

7 erior inocula had a positive effect on plant fitness.

8 nology is a major component of an organism's fitness.

9 D4-binding site mutations that reduced viral fitness.

10 identifies exons underlying human cell line fitness.

11 host diet can impact both pathogen and host fitness.

12 lts in feminization and reduced reproductive fitness.

13 ion by driving mutations that increase virus fitness.

14 ate its functions and maintain physiological fitness.

15 thesise that it is associated with cognitive fitness.

16 trade-off current investment versus lifetime fitness.

17 o ensure proper development and reproductive fitness.

18 th reproductive hyperphagia and reproductive fitness.

19 lection markers complement GMOs with reduced fitness.

20 being selected against at the level of host fitness.

21 we explore how omnivory benefits lady beetle fitness.

22 d nectar and that their visits enhance plant fitness.

23 ps in the absence of individual survival and fitness.

24 th significant cellular stress and decreased fitness.

25 o 116-fold) but also on in vitro replicative fitness.

26 s and have large effects on individual plant fitness.

27 entification of genes that predict bacterial fitness.

28 nt of diseases, as well as the monitoring of fitness.

29 e of infection on reproduction and offspring fitness.

30 ironmental stress, while optimizing cellular fitness.

31 human tumors as these mutations reduce cell fitness.

32 rt phage infection, but with a cost to their fitness.

33 nvironments and in turn, affect individuals' fitness.

34 tions to offspring, which in turn can affect fitness.

35 ons these species could maintain competitive fitness.

36 target enzymes with a detrimental impact on fitness.

37 n are two essential modulators of individual fitness.

38 nal WPPC have a sizable interaction-specific fitness advantage attributable to production of and resi

39 Recoverers have a fitness advantage during a carbon source shift but are l

40 floc alone, providing snowflake yeast with a fitness advantage during competition.

41 tially and temporally heterogeneous, and the fitness advantage of cancer cells adapted to extracellul

42 Whether variants confer a fitness advantage or rise to detectable frequencies by c

43 re ceases to amplify selection if the mutant fitness advantage r is larger than r .

44 iments show that PrgA provides a significant fitness advantage to plasmid-carrying cells.

45 This fitness advantage was absent in mice that lacked epithel

46 f hematopoietic stem cells, and quantify the fitness advantages of key pathogenic variants, at single

47 Plant-associated microbiomes confer fitness advantages to the plant host, including growth p

48 gene Fitm2 is required for maintaining cell fitness after exposure to interferon-gamma (IFNgamma).

49 selection of additional traits that increase fitness along glucose-replete metastatic routes.

50 itially grow slowly, but they rapidly regain fitness and adapt, even as they retain traits from multi

51 PC) compartment aneuploid cells have reduced fitness and are efficiently purged from the bone marrow.

52 diates which may crucially affect organismal fitness and are frequently implicated in disease.

53 scientific interventions to enhance physical fitness and cognitive performance-promoting the resilien

54 rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources

55 at suboptimal anti-A3G activity shapes viral fitness and drives viral evolution in the plasma compart

56 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete

57 ication fidelity that is essential for viral fitness and evolution.

58 divergence in sexual selection, we compared fitness and extinction of monogamous versus polyandrous

59 No association was found between physical fitness and global DTI metrics (all P > 0.082).

60 virus proteins, we propose a model for viral fitness and host range which considers the full interact

61 microbiomes of juvenile oysters that reduces fitness and impedes natural and artificial repopulation

62 amide riboside enhanced T cell mitochondrial fitness and improved responsiveness to anti-PD-1 treatme

63 ritical roles for ATX in TSC2-deficient cell fitness and in TSC tumorigenesis.

64 ners directly via traits that affect partner fitness and indirectly via traits that influence interac

65 the contribution of Lon-1 to B. burgdorferi fitness and infection remains hitherto unexplored.

66 t this region significantly influences virus fitness and its biological properties.

67 f intracellular metals is essential for cell fitness and pathogenesis.

68 We tracked fitness and productivity of all generations.

69 y to catabolize L-serine increases bacterial fitness and provides Enterobacteriaceae with a growth ad

70 comprised of high-intensity interval aerobic fitness and strength training paired with a novel nutrit

71 lic acid] to high-intensity interval aerobic fitness and strength training paired with a standard of

72 modal intervention that incorporates aerobic fitness and strength training with a novel nutritional s

73 your eggs, are critical for the offspring's fitness and survival in any species.

74 nce and/or expression correlates with strain fitness and that enable early-stage colonizers to surviv

75 direct impacts of host nutrition on parasite fitness and the mechanisms underpinning these effects ar

76 ed PBAA composition plays a key role in seed fitness and therefore is rigorously maintained even unde

77 Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in

78 e forcing, causing disequilibria and reduced fitness, and abrupt responses are characterized by nonli

79 in a chronology driven in part by oncogenic fitness, and arise in an allelic configuration that refl

80 on how these effects might alter phenotypes, fitness, and community composition of microbes in the co

81 is decrease in mHR is independent of gender, fitness, and lifestyle, affecting in equal measure women

82 ied in MAGs identified as important for host fitness, and pathways for key vitamin biosynthesis and e

83 tantially affect breeding bird phenology and fitness, and underscore the need to consider sensory pol

84 Viable cells with reduced fitness are often eliminated by neighboring cells with g

85 utations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, b

86 reproductive event at the expense of future fitness as well as more investment per offspring.

87 trains of fission yeast in 59,350 individual fitness assays in 70 conditions, revealing that colony s

88 ssive cycles of material design, production, fitness assessment, selection, and mutation results in o

89 stress response to gain considerable gain-of-fitness associated with parasite transmission.

90 ent a collection of properties affecting the fitness at a given location using a color.

91 A provisioning "dad" loses fitness at the hands of nonprovisioning, mate-seeking "c

92 antitative analysis of the evidence for this fitness balance.

93 -centered or an organism-centered concept of fitness based on free-energy minimization, toward a soci

94 evant to understanding the functional (i.e., fitness-based) progression of co-evolving STM strains.

95 cise program with a signal of improvement in fitness being detected.

96 sion potentiates evolution by increasing the fitness benefit provided by DNA topoisomerase mutations

97 velop properly, thereby imparting a relative fitness benefit to symbiont-transmitting mothers.

98 ce weighted for precision, we found balanced fitness benefits across the entire dataset, but a consis

99 ffs between survivorship risk and subsequent fitness benefits and are therefore central to a species'

100 en groups are initiated by females, who gain fitness benefits from mating with extragroup males in th

101 nder which immigration can produce long-term fitness benefits in small populations without entirely s

102 isogenic symbiont-free hosts showed that the fitness benefits of symbiosis for hosts increased with i

103 function of migrants that may influence the fitness benefits of the migratory tactic at sea.

104 We suggest that such substantial fitness benefits provide the opportunity for the evoluti

105 Rescuable genes - genes with small fitness benefits that are lost from the population witho

106 ocial species, older individuals can provide fitness benefits to their groupmates through the imparti

107 requiring flight to provide some offsetting fitness benefits.

108 n total leukocyte count and not only aerobic fitness but also parts of anaerobic fitness in young mal

109 ncing, whereas low virion pp71 levels reduce fitness but promote silencing.

110 virion pp71 levels enhance viral replicative fitness but, strikingly, impede silencing, whereas low v

111 genome replication, and reduces reproductive fitness by 45%.

112 The best of our models improves fitness by 70% and 77% over the random models for a disc

113 th enough usable surface area to support GRD fitness by improving reproduction and survival.

114 Competition reduced biomass and fitness by over 98%, and plastic responses to competitio

115 how the relationships between phenotypes and fitness can be dependent upon the ecological context.

116 A significant inverse trend between fitness categories and all-cause (HR: 1.0, 0.60, and 0.5

117 part of a complex network connecting in vivo fitness, cell envelope homeostasis and resistance to ant

118 with altered regenerative capacity or tissue fitness, changes in gene expression, or more mitotic err

119 us rebound in treated patients, although the fitness characteristics of the mutant viruses were not f

120 somatic evolution, between dN/dS values and fitness coefficients is missing.

121 e analogs, and displayed reduced replicative fitness compared to the parental virus.

122 rought-competition interactions for relative fitness: competition had little effect on relative fitne

123 risk affects prey traits, which affect prey fitness components and population growth rate, which aff

124 smaller than the responses on phenotype and fitness components that are typically measured, magnifyi

125 social phenotype could experience different fitness consequences depending on the network it occupie

126 ntergroup conflicts that have very different fitness consequences for male and female group members.

127 n cause significant behavioural changes with fitness consequences for targeted whale populations.

128 eloped are widely applicable to evaluate the fitness consequences of maternal effect senescence acros

129 ronmental variables is pivotal to assess the fitness consequences of parental strategies.

130 Elucidating the fitness cost and potential reversal of metabolic resista

131 uch careful gene expression can minimize the fitness cost associated with antibiotic resistance.

132 , the TZP-resistant isolate does not incur a fitness cost compared to the TZP-susceptible ancestor.

133 Defence systems incur a fitness cost for the hosts; therefore, at least in proka

134 mediated metabolic resistance imposes a high fitness cost in malaria vectors supporting that a resist

135 The fitness costs of drive can lead to selection of unlinked

136 esistance) without incurring the significant fitness costs often associated with pathogen resistance.

137 Cardiorespiratory fitness (CRF) refers to the capacity of the circulatory

138 ive trait that has critical impacts on plant fitness, crop yield, and reproductive isolation, researc

139 Pyphe is versatile and processes fitness data from colony sizes, viability scores from ph

140 s identified genes whose disruption leads to fitness defects, a critical step in identifying candidat

141 largely disregarded in theoretical studies: fitness-dependent dispersal and strong predation in the

142 mics, spreading only when introduced above a fitness-dependent frequency.

143 We base our approach on fitness-dependent network models: as in real life, a Lig

144 lla tularensis, biotin biosynthesis is a key fitness determinant during infection(2-5), making it a h

145 We asked if lifetime fitness differed between residents and immigrants (succe

146 invoke direct fitness effects to explain the fitness difference between mismatch-repair-deficient and

147 rity (29% of the assemblage), a sign of some fitness difference.

148 The plurality of evidence indicates that fitness differences between these ecologically equivalen

149 e liberation may be finely tuned to maximize fitness during atmospheric transport.

150 ghlight the complexity of arbovirus mutation-fitness dynamics and suggest that intrahost ZIKV mutatio

151 The distribution of fitness effects (DFE) defines how new mutations spread t

152 e resolution, as well as the distribution of fitness effects (fitness landscape) within commonly muta

153 ile several genetic variants showed opposing fitness effects in different hosts, fitness effects were

154 indicating that for some proteins collateral fitness effects occur as frequently as effects on protei

155 Fitness effects of mutations depend on environmental par

156 restimated in nature due to the antagonistic fitness effects of mutations in changing environments.

157 mic strains that can be used to characterize fitness effects of mutations under different stress cond

158 rectal cancer is determined primarily by the fitness effects that they provide, rather than their mut

159 gests that there is no need to invoke direct fitness effects to explain the fitness difference betwee

160 opposing fitness effects in different hosts, fitness effects were generally positively correlated bet

161 al the importance of a mutation's collateral fitness effects, which we define as effects that do not

162 evel, with decisions representing putatively fitness-enhancing strategies.

163 that Anr and Mhr contribute to LasR- strain fitness even in biofilms grown in normoxic conditions.

164 terval: 0.83 to 0.91) per 1-MET increment in fitness for cohorts 1 and 2, respectively (p < 0.001 for

165 To demonstrate the fitness for use and robustness of this assay, we evaluat

166 ar Pesticides Method), confirming the method fitness-for-purpose of rapid compliance testing.

167 compelling evidence for fluctuations in the fitness function, causing temporal variation in the magn

168 les in various countries suggests a possible fitness gain conferred by the type VI signature SNVs.

169 nd that evolution led to diverse pleiotropic fitness gains and losses, driven by multiple types of mu

170 at has been fine-tuned to maximize inclusive fitness gains.

171 under natural conditions and epidemiological fitness generated by such events.

172 Pain-induced defensive behaviors affecting fitness have also been reported in crustaceans (Gammarus

173 nuclear allele frequencies for high- or low-fitness hybrids.

174 potential effect of host genes on rhizobial fitness (i.e. how many rhizobia are released from host n

175 To determine the fitness impact of the I38T/F/M substitutions, we generat

176 nfluence bacterial competition is clear, the fitness impacts of wielding a T6SS are not well understo

177 gthen the existing body of literature on the fitness implications of variation in infant body mass.

178 (2)O(2) Finally, DeltamumR exhibited reduced fitness in a murine model of pneumonia, indicating that

179 ese de novo emerging coding sequences impact fitness in budding yeast.

180 DynaFit revealed that cell fitness in cancer cell lines, primary cancer cells, and

181 mutations that do not compromise replicative fitness in cell culture.

182 ity, without significantly altering parasite fitness in culture.

183 GR (rTCRV/Delta39) exhibited decreased viral fitness in cultured cells, suggesting the feasibility of

184 ribution of identified metabolic pathways to fitness in different community contexts, study various e

185 loss of HepII lactose compromises gonococcal fitness in mice.

186 Sequence variants that exhibit high fitness in one strain can be deleterious in another, ind

187 shape in bacteria is a mechanism to increase fitness in planktonic and biofilm lifestyles.

188 trahost ZIKV mutations capable of augmenting fitness in pregnant vertebrates may not necessarily spre

189 temperature can allow organisms to maintain fitness in response to increasing temperatures, thereby

190 high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tra

191 -omics technologies to understand microbial fitness in the field, will enable us to better manage pl

192 tinct migratory characteristics that improve fitness in their particular ecological niches.

193 tion can result in a higher productivity and fitness in tolerant species in recurrently stressed envi

194 locus revealed gene constructs that enhanced fitness in vitro and in vivo.

195 aerobic fitness but also parts of anaerobic fitness in young males.

196 ific mutations that increase HSC competitive fitness, in conjunction with additional endogenous and e

197 influenza A virus that improve their memory fitness, indicating a novel application of IL-2 to boost

198 re detected on 5 (of 12) chromosomes in high-fitness individuals of both reciprocal crosses, whereas

199 s maternal biases were largely absent in low-fitness individuals.

200 f parental preference and to determine whose fitness interests are served by the ornamentation.

201 ution G172E probably compensates for loss of fitness introduced by S207R.

202 In such cases, microbial fitness is enhanced by the evolution of anticipatory res

203 s across a heterogeneous landscape such that fitness is equalised across the population.

204 lthough our results cannot conclude physical fitness is related to white matter microstructure in chi

205 de-off between stress tolerance and organism fitness is scarce and blurred by the interaction with di

206 d jeopardizing survival since their lifetime fitness is sensitive to this vital rate.

207 veness, a putative marker of high biological fitness, is costly to maintain throughout a lifetime and

208 ogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneu

209 well as the distribution of fitness effects (fitness landscape) within commonly mutated driver genes.

210 -breaking" epistasis creates sinkholes in SD fitness landscapes and may profoundly impact the evoluti

211 We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on

212 tual dependence on genetic network features, fitness landscapes, and developmental system drift.

213 This phenomenon shapes fitness landscapes, which have the power to reveal evolu

214 localised hypermutation (LH) compensates for fitness losses caused by bottlenecks and discuss whether

215 ompensatory effects leading to robust tumour fitness maintained throughout the tumour progression.

216 ese are the largest determined comprehensive fitness maps of point mutants.

217 cts populations towards environment-specific fitness maxima through acquisition of positively selecte

218 for strains to escape from suboptimal local fitness maxima.

219 (vp1), which successfully predicts in vitro fitness measurements.

220 Here we applied these checkpoint based fitness measures to the matched checkpoint treatment nai

221 Recently proposed tumor fitness measures, based on profiling neoepitopes for rea

222 tudy system's natural history justifying our fitness measures, while failing to account for our behav

223 Our study uncovers a flexible non-uniform fitness mechanism that enables groups of cells within a

224 To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1),

225 We find that the standardized predicted fitness of a strain, estimated by an NFDS-based model at

226 For example, mutations that increase fitness of bacteria at high antibiotic concentration oft

227 al partners caused widespread changes in the fitness of bacterial mutants compared to growth alone.

228 high-throughput measurement of the relative fitness of bacterial mutants, strains and species in mix

229 The pattern of fitness of bacterial strains observed across the differe

230 The fitness of baloxavir-resistant I38T PA mutants appears r

231 everal compounds that selectively impair the fitness of BCR-Abl-transformed cells.

232 portantly, depletion of FNDC3A increased the fitness of FAM46C-expressing cells and expression of FND

233 ss this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds t

234 ven condition by simultaneously assaying the fitness of millions of mutants, thereby relating genotyp

235 The fitness of mutants in each gene under each condition was

236 xternal and internal time is crucial for the fitness of organisms, and desynchronization has been lin

237 ance (SCAPD) to probabilistically assess the fitness of our models with empirical data.

238 nnual variability and synchrony increase the fitness of plants through economies of scale that decrea

239 he entire dataset, but a consistently higher fitness of residents over migrants in birds and herpetof

240 observe an evolutionary Stokes shift in the fitness of sequences that have undergone evolution under

241 Metabolic fitness of T cells is crucial for immune responses again

242 The fitness of the DeltadedA, DeltadsbC, DeltagntR, Deltayaa

243 e a variety of compounds that can impact the fitness of the host.

244 l division, cell separation, and impairs the fitness of the human pathogen Neisseria meningitidis dur

245 lities and disease that decrease the overall fitness of the hybrids and is therefore named as hybrid

246 te species and is positively associated with fitness of the organism, in humans we hypothesise that i

247 ened with a probability that depends on the "fitness" of the concurring nodes, which in turn depends

248 fficiently track some ultimate goal, whether fitness or another utility function, itself requires rep

249 terns of maternal expenditure and short-term fitness outcomes within seasons, using maternal daily ma

250 relationships between oxidative balance and fitness outcomes.

251 up daily mass gain to indicate within season fitness outcomes.

252 more important than others when considering fitness outcomes.

253 tages of social development predict lifetime fitness outcomes.

254 3, 1983, 347) classic performance-morphology-fitness paradigm, we tested for pre- to post-fledging ca

255 tion identifies few independently measurable fitness parameters that predict the outcome of control.

256 gnitive decline in the elderly, but physical fitness (PF) could be a better predictor of cognitive fu

257 l genome combined to elicit an epidemiologic fitness phenotype associated with the 1994 DENV2 outbrea

258 ces but may end up in winter areas with poor fitness prospects.

259 C cost of leaf growth and maintenance) as a fitness proxy.

260 proaches that seek to maintain mitochondrial fitness, rather than target downstream mitochondrial dys

261 d acute temperature stress alter fundamental fitness-related behaviors in fish, potentially shifting

262 ormance curve (TPC)-the relationship between fitness-related trait performance and temperature-is its

263 Environmental change influences fitness-related traits and demographic rates, which in h

264 We assessed morphological, behavioral, and fitness-related traits from each replicate population pe

265 tion can affect offspring lifespan and other fitness-related traits is important in our understanding

266 eding depression, measured as the decline in fitness-related traits per unit inbreeding, did not vary

267 g signals based on shifts in distribution of fitness-related traits such as body size.

268 investigated the responses to drought of key fitness-related traits such as stomatal regulation, shoo

269 dentified that hematopoietic stem cell (HSC) fitness response to stress depends on Yap1 and Taz.

270 Therefore, we analyzed correlations in fitness scores across all 492 experiments in the dataset

271 etabolic modules with poorly correlated gene fitness scores.

272 alysis pipelines associated with large-scale fitness screens, including image acquisition and quantif

273 re children with greater upper-body muscular fitness showed higher FA (P(FWE-corrected) = 0.042).

274 However, we found no fitness signatures of a change in the impact of climate-

275 ise, ratchet-like manner and reduce cellular fitness, similar to the process known as Muller's ratche

276 rs that bestow greater benefits to inclusive fitness, such as food sharing.

277 nd represent strong indicators of C. elegans fitness, there is an increasing need to replace manual a

278 ypoxia can decrease individual physiological fitness through metabolic and aerobic depression and cha

279 e interplay between genotype, phenotype, and fitness to explore a wide range of evolutionary processe

280 anism by which DNMT3A loss confers increased fitness to HSCs by analyzing a rare experiment of nature

281 isms contribute to communicate mitochondrial fitness to the rest of the cell.

282 Such fitness trade-offs include reduced virulence, resensitiz

283 id environmental changes can identify hidden fitness trade-offs that turn adaptation into maladaptati

284 t the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil

285 underlying gradients in selective agents or fitness trade-offs.

286 n organism that simultaneously maximizes all fitness traits [1].

287 In contrast to fitness traits, the amount of genotype by environment in

288 ttributes resulted in differences in overall fitness traits, where Pallid Sturgeon fecundity was grea

289 networks which are involved in survival and fitness under a given condition by simultaneously assayi

290 , whereas competition caused rank changes in fitness under drought.

291 AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced protein

292 rocess that maximizes perceptual accuracy or fitness under the often-adopted assumption that full ada

293 s: competition had little effect on relative fitness under well-watered conditions, whereas competiti

294 es may not be positively correlated with the fitness value of their habitats, and density-dependent h

295 Renal/TEC metabolic fitness was assessed by monitoring the expression of dri

296 Aerobic fitness was assessed by the time for a 3-kilometer run t

297 me for a 3-kilometer run test, and anaerobic fitness was evaluated by the numbers of sit-ups and push

298 ; for instance, the microbiome improves host fitness, whereas the host supports microbiome nutrition.

299 tance of spatial organisation for individual fitness with outcomes that are conditional on the overal

300 gs indicate that the association of muscular fitness with white matter microstructure might be more f