ライフサイエンスコーパス: flagella

1 surfaces by rotating long appendages called flagella.

2 orylation-related assembly of RSs and entire flagella.

3 s from IFT trains at the tip and diffuses in flagella.

4 t support transport of outer arm dynein into flagella.

5 pecies swim by rotating single polar helical flagella.

6 re at the tips of both assembling and mature flagella.

7 mutant strains of Bacillus subtilis lacking flagella.

8 ingle IFT trains and motors in Chlamydomonas flagella.

9 dle and, as basal bodies, nucleate cilia and flagella.

10 ate, where faster growing cells produce more flagella.

11 tion and maintenance of eukaryotic cilia and flagella.

12 ion negatively correlates with the length of flagella.

13 FT-B proteins, and assembles only very short flagella.

14 lar trafficking, and templating of cilia and flagella.

15 functions, including signaling in cilia and flagella.

16 with the bending waveforms of Chlamydomonas flagella.

17 FlhD4C2 levels and heterogeneous numbers of flagella.

18 esistance in these immobilized Chlamydomonas flagella.

19 er with a description of the movement of the flagella.

20 the predominant protein transport system in flagella.

21 f swimming microorganisms with front-mounted flagella.

22 r-prone Escherichia coli strain lacks mature flagella.

23 complex in unicellular organisms bearing few flagella.

24 significantly reduced or elevated in d1blic flagella.

25 e essential for normal function of cilia and flagella.

26 major structural distinctions from bacterial flagella.

27 ing sperm completely lack or have very short flagella.

28 promoted slow assembly of nearly full-length flagella.

29 ve despite many cryo-ET studies of cilia and flagella.

30 f the pellicle but only in strains that have flagella.

31 ent did not occur with G7 bacteria devoid of flagella.

32 hat is nonmotile but retains its periplasmic flagella.

33 luding mastigonemes on the modeled swimmer's flagella.

34 but is not required for, tubulin entry into flagella.

35 transport (IFT) system for assembly of their flagella.

36 onal structure of the N-DRC in Chlamydomonas flagella.

37 hly motile spirochete due to its periplasmic flagella.

38 by rotating long, helical filaments, called flagella.

39 teria exhibit heterogeneity in the number of flagella.

40 us environments by rotating multiple helical flagella.

41 messenger molecules-does not hold for sperm flagella.

42 nd injection frequencies are similar for all flagella.

43 asm and the beating of axonemes in cilia and flagella.

44 d morpholino depletion of axonemal Paralyzed Flagella 16 indicated that flagella-based forces initiat

45 understood types of motility are powered by flagella (72).

46 At the base of the bacterial flagella, a cytoplasmic rotor (the C-ring) generates tor

47 Nek8445 depletion results in short flagella, aberrant ventral disk organization, loss of th

48 Bacterial flagella, actomyosin filaments, and microtubule bundles

49 thermore, the mutants failed to resorb their flagella, an event that normally renders the zygotes imm

50 our knowledge, into the beating mechanism of flagella and a powerful tool for future studies.

51 his pathway is employed for glycosylation of flagella and autotransporters.

52 r data sets related to the cell cycle and to flagella and basal bodies and to assign isoforms of dupl

53 and processes, including cell cycle control, flagella and basal bodies, ribosome biogenesis, and ener

54 s photosynthesis and chloroplast biogenesis, flagella and basal body structure/function, cell growth

55 led to GSK3 dephosphorylation and defective flagella and cilia.

56 as the foundation for motility of eukaryotic flagella and cilia.

57 key determinant of normal orientation of the flagella and collar assembly.

58 rform micromanipulation on configurations of flagella and conclude that a mechanism, internal to the

59 is unknown how cells recognize the length of flagella and control IFT.

60 specific PRMTs and their target proteins in flagella and demonstrate that PRMTs are cargo for transl

61 imics the oscillatory behavior of biological flagella and enables propagation of microwires across a

62 assembly and function of mammalian cilia and flagella and establishes the gene-trapped allele as a ne

63 Both DeltaamiA and DeltaamiADeltapgp1 lacked flagella and formed unseparated chains of cells consiste

64 analogous to the triton model in eukaryotic flagella and gliding Mycoplasma We observed high nucleot

65 These PRMTs localize to the tip of flagella and in a punctate pattern along the length, ver

66 pYGSK3) at the base and tip of Chlamydomonas flagella and motile cilia in ependymal cells.

67 cally mediated by surface structures such as flagella and pili, followed by a permanent adhesion stag

68 or the biogenesis and stability of cilia and flagella and play important roles in metazoan developmen

69 in Chlamydomonas by myriocin led to loss of flagella and reduced tubulin acetylation, which was prev

70 nd cell membrane spanning structures such as flagella and secretion systems.

71 microtubule cytoskeleton that includes eight flagella and several unique microtubule arrays that are

72 transcriptionally modulates biosynthesis of flagella and the iron chelator ICDH-Coumarin whose produ

73 an animal model of CDI, a synergic effect of flagella and toxins in eliciting an inflammatory mucosal

74 regulated surface motility is independent of flagella and type IV pili, suggesting a novel mechanism

75 hat from flagellates (with a small number of flagella) and from ciliates (with tens or more).

76 .g., LecA and LecB lectins, type VI pili and flagella) and iron to invade host cells with the formati

77 subtilis (wild-type and a mutant with fewer flagella), and a motile Streptococcus (now Enterococcus)

78 e responsible for the formation of cilia and flagella, and for organizing the microtubule network and

79 hogen-associated molecular patterns, such as flagella, and increasing resistance to host immune molec

80 entral to the numerical control of bacterial flagella, and its deletion in polarly flagellated bacter

81 the physiological events occurring in cilia, flagella, and microvilli are of fundamental importance f

82 II (DNA binding and bending) proteins, pili, flagella, and outer membrane vesicles.

83 acterial virulence such as toxins, adhesins, flagella, and pili, among others.

84 --which define the shape of axons, cilia and flagella, and provide tracks for intracellular transport

85 are also highly enriched at the base of the flagella, and the basal localization of these PRMTs chan

86 ues are also enriched at the tip and base of flagella, and their localization also changes during fla

87 swimming and swarming motilities powered by flagella, and twitching motility powered by Type IV pili

88 Some bacterial functions (for example, flagella- and chemotaxis-associated) were systematically

89 S. Typhi strains expressing the Hj, Hd, Hz66 flagella antigens.

90 ir swimming direction is stabilised by their flagella (archaella), enhancing directional persistence

91 filaments, may appear surprising given that flagella are actuated by uncoordinated motors.

92 Polymorphic glycans on flagella are common to plant and animal pathogenic bacte

93 Flagella are complex machines embedded in the cell envel

94 Cilia and flagella are conserved eukaryotic organelles essential f

95 onas cells, the assembly dynamics of its two flagella are coupled via a shared pool of molecular comp

96 Flagella are crucial for bacterial motility and pathogen

97 Cilia and flagella are long, slender organelles found in many euka

98 Cilia and flagella are microtubule-based cellular projections with

99 Cilia and flagella are microtubule-based organelles that protrude

100 Cilia and flagella are model systems for studying how mechanical f

101 Flagella are multiprotein complexes necessary for swimmi

102 In the absence of FliD, flagella are not formed, resulting in impaired motility

103 Bacillus subtilis flagella are not only required for locomotion but also a

104 m videomicroscopy based on the fact that the flagella are of approximately constant width when viewed

105 ATEMENT How processes occurring in cilia and flagella are powered is a matter of general interest.

106 Cilia and flagella are simple organelles in which a single measure

107 Our results suggest that bacterial flagella are too straight and too far apart to form tang

108 Despite great variation across species, all flagella are ultimately constructed from a helical prope

109 Motile cilia and flagella are whiplike cellular organelles that bend acti

110 Cilia (eukaryotic flagella) are present in diverse eukaryotic lineages and

111 roduced fewer, abnormally tilted and shorter flagella, as well as diminished stators, suggesting that

112 on systems (T2SS), type 4 pili, and archaeal flagella assemble fibres from initially membrane-embedde

113 is, ATP-binding cassette (ABC) transporters, flagella assembly and bacterial chemotaxis, as well as f

114 lack of IFT74 destabilized IFT-B, leading to flagella assembly failure.

115 ium, therefore, suggested a possible role in flagella assembly in male gametes, the only flagellated

116 -glycosylation of flagellins is required for flagella assembly.

117 Here, we describe a deficiency of cilia and flagella associated protein 45 (CFAP45) in humans and mi

118 evolutionarily conserved protein, cilia- and flagella-associated protein 69 (CFAP69), in mice that re

119 We show that these bacteria eject their flagella at the base of the flagellar hook when nutrient

120 assembly of dynein arm motors into cilia and flagella axonemes.

121 The number and location of flagella, bacterial organelles of locomotion, are specie

122 xonemal Paralyzed Flagella 16 indicated that flagella-based forces initiated daughter cell separation

123 These spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; ind

124 port (LIFT) pathways are essential for cilia/flagella biogenesis, motility, and sensory functions.

125 The advantage of sheathed flagella bundles is the high rigidity, making high swimm

126 We show that magnetotactic cocci with two flagella bundles on one pole swim faster than 500 um.s(-

127 Deletion of polar flagella, but not the lateral flagella, can dramatically

128 ed IFT-B levels and enabled growth of longer flagella, but the flagella lacked outer dynein arms.

129 FlhD4C2 controls the construction of flagella by initiating the production of hook basal bodi

130 hat PRMTs are cargo for translocation within flagella by the process of IFT.

131 ction induces a conformational change in the flagella C-ring.

132 upport for 25 came from the observation that flagella can assemble and rotate when FliG is geneticall

133 effect of the active thrust generated by the flagella can be singled out.

134 the cilia in the fallopian tubes or in sperm flagella can cause female and male subfertility, respect

135 Indeed, by activating the TLR5, flagella can elicit activation of the MAPK and NF-kappaB

136 Vibrio parahaemolyticus, we found that polar flagella can reduce the phage infectivity.

137 etion of polar flagella, but not the lateral flagella, can dramatically promote the adsorption of pha

138 Bacterial flagella change their helical form in response to enviro

139 enes and class II and III (but not I) of the flagella-chemotaxis regulon.

140 Defects in flagella/cilia are often associated with infertility and

141 the axoneme central apparatus, and regulates flagella/cilia motility.

142 oaches to identify seven constituents of the flagella connector at the tip of an assembling trypanoso

143 ation and functional studies reveal that the flagella connector membrane junction is attached to the

144 establishing cell morphology, including the flagella connector, flagellum attachment zone, and bilob

145 the recently identified constituents of the flagella connector.

146 All cilia and flagella contain a microtubule-based structure called th

147 degraded in the fliD mutant but not in other flagella-deficient mutants (i.e., in the hook, rod, or M

148 ce hydrophobicity of flagellin, and enhances flagella-dependent adhesion of Salmonella to phosphatidy

149 Contrary to flagella-dependent migration modes like swarming, we sho

150 Efficient motile function of cilia and flagella depends on coordinated interactions between act

151 The assembly of cilia and flagella depends on the activity of two microtubule moto

152 l to move in a synchronized manner along the flagella, despite being correctly formed and polarized i

153 For the DeltalasR mutant, loss of flagella did not confer a selective advantage.

154 Bacterial flagella differ in their number and spatial arrangement.

155 In this model, the absence of flagella dramatically decreases the degree of mucosal in

156 s are able to efficiently pump and force the flagella-driven flow through their collar filter, thanks

157 Swarming motility is a flagella-driven multicellular behaviour that allows bact

158 We show that AeAmt1 is localized to sperm flagella during all stages of spermiogenesis and spermat

159 CD6) was enriched in ectosomes released from flagella during gamete activation.

160 Our comprehensive screens showed which flagella elements are essential for growth and which are

161 tein EB1 is present at the tips of cilia and flagella; end-binding protein 1 (EB1) remains at the tip

162 Eukaryotic cilia/flagella exhibit two characteristic ultrastructures refl

163 The flagella export AAA+ ATPase FliI was identified as a res

164 Counter-selection against flagella expression was observed during acute lung infec

165 cking the rotary motion of helical bacterial flagella for propulsion, and are often composed of monol

166 an exchange with unbleached EB1 entering the flagella from the cell body.

167 een chemosensory signaling proteins in sperm flagella from the sea urchin Arbacia punctulata.

168 Primary and motile cilia/flagella function as cellular antennae, receiving signal

169 gulatory complex (N-DRC) in motile cilia and flagella functions as a linker between neighboring doubl

170 body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, later

171 Ectosomes released from flagella have a unique protein composition, being enrich

172 Most motile flagella have an axoneme that contains nine outer microt

173 In particular, the roles of flagella have been studied in multiple solid-surface bio

174 n mutant of B. dolosa to examine the role of flagella in B. dolosa lung colonization.

175 The flagella in Chlamydomonas ndk5 mutant were paralyzed, al

176 CrSEPT was detected at the base of the flagella in Chlamydomonas, suggesting that CrSEPT is inv

177 eased research into the role of C. difficile flagella in colonisation and adherence.

178 highlight the important role of C. difficile flagella in eliciting mucosal lesions as long as the tox

179 unlike that of well-studied motile cilia and flagella in protists, such as Paramecia and Chlamydomona

180 mics of Ca(2+) elevations in the cytosol and flagella in response to salinity and osmotic stress.

181 m dynein, also fails to be imported into the flagella in the absence of the IFT46 N-terminus.

182 Here we report a role for flagella in the regulation of the K-state, which enables

183 t shear stiffness of wild-type Chlamydomonas flagella in vivo, rendered immotile by vanadate, to be E

184 ts mechanism in the numerical restriction of flagella, in which the transcriptional activity of FlrA

185 lmonella can move on 0.3% agarose media in a flagella-independent manner when experiencing the PhoP/P

186 o flat curves, and have 10 to 14 periplasmic flagella inserted at each cell end.

187 transition zone (TZ) of eukaryotic cilia and flagella is a structural intermediate between the basal

188 The long external filament of bacterial flagella is composed of several thousand copies of a sin

189 The motility of cilia and flagella is driven by thousands of dynein motors that hy

190 nonmotile flaB mutant that lacks periplasmic flagella is rod shaped and unable to infect mice by need

191 The periodic bending motion of cilia and flagella is thought to arise from mechanical feedback: d

192 tility, which is provided by its periplasmic flagella, is critical for every part of the spirochete's

193 he dynamics of physically separated pairs of flagella isolated from the multicellular alga Volvox has

194 Archaea use flagella known as archaella-distinct both in protein com

195 d enabled growth of longer flagella, but the flagella lacked outer dynein arms.

196 uno-electron microscopy reveal that ODA10 in flagella localizes strictly to a proximal region of doub

197 Obviously, avoidance of flagella-mediated activation of host immunity is advanta

198 rved in Shewanella, and histidine kinase and flagella-mediated motility are essential for taxis towar

199 In Salmonella enterica serovar Typhimurium, flagella-mediated motility is repressed by the PhoP/PhoQ

200 algae Chlamydomonas reinhardtii with its two flagella-microtubule-based structures of equal and const

201 However, flagella might remain in OMV pellets following OMV purif

202 We show that flagella motility, Rab11, and actin coordination are nec

203 Before their import into cilia and flagella, multi-subunit axonemal dynein arms are thought

204 d that the carbonic anhydrase CAH6 is in the flagella, not in the stroma that surrounds the pyrenoid

205 rly type, regardless of motor switching; the flagella of ATCC10798 did not show polymorphic transform

206 We show that flagella of Chlamydomonas mutants deficient in filamenta

207 The flagella of Chlamydomonas reinhardtii possess fibrous ul

208 PRMTs are lost from the flagella of fla10-1 cells, which carry a temperature-sen

209 With eight flagella of four different lengths, the parasitic protis

210 Motility and the number of flagella of H. pylori P12 wild-type were significantly h

211 Unlike flagella of other bacteria, spirochetes' periplasmic fla

212 Cilia and flagella often exhibit synchronized behavior; this inclu

213 adhesin RadD on Fusobacterium and removal of flagella on C difficile.

214 ouble homozygotes, with an absence of mature flagella on elongating spermatids and epididymal sperm.

215 -flight" model, which measures the length of flagella on the basis of the travel time of IFT protein

216 lower expression of the fliC gene and lacked flagella on the cell surface.

217 rm of collective bacterial motion enabled by flagella on the surface of semi-solid media.

218 cells, and this effect was dependent on the flagella only when bacteria were dead.

219 motilities that do not depend on traditional flagella or pili, but are powered by mechanisms that are

220 urfaces in the absence of appendages such as flagella or pili.

221 ive arrangement of axonemal microtubules and flagella outer dense fibers.

222 Even though DeltamotB bacteria assembled flagella, part of the mutant cell is rod shaped.

223 The conoid has been suggested to derive from flagella parts, but is thought to have been lost from so

224 ssary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within

225 AeAmt1 expression in sperm flagella persists in spermatozoa that navigate the femal

226 um Borrelia burgdorferi has 7-11 periplasmic flagella (PF) that arise from the cell poles and extend

227 -shaped ends and the presence of periplasmic flagella (PF) with pronounced spontaneous supercoiling.

228 the role played by T. denticola periplasmic flagella (PF), unique motility organelles of spirochetes

229 lated bacteria, spirochetes have periplasmic flagella (PF).

230 Further, they experience a short-flagella phenotype that may also be linked to differenti

231 cial film formation occurs in the absence of flagella, pili, or certain polysaccharides.

232 glide mysteriously on surfaces without using flagella, pili, or other external appendages.

233 These results support an emerging view that flagella play a central role in cell division among prot

234 is poorly understood, it has been shown that flagella play an important role in surface sensing by tr

235 o V. parahaemolyticus, indicating that polar flagella play an inhibitory role in the phage infection.

236 Motile cilia and flagella play critical roles in fluid clearance and cell

237 Cilia and flagella play essential roles in cell motility, sensing

238 Hypothesizing that S. Typhi flagella plays a key role during infection, we construct

239 of other bacteria, spirochetes' periplasmic flagella possess a complex structure called the collar,

240 echanism for controlling the total number of flagella produced.

241 in iron acquisition (n = 67), fimbriae/pili/flagella production (n = 117), and metal homeostasis (n

242 Flagella propel bacteria during both swimming and swarmi

243 to contribute to disease development, e.g., flagella, prophages, and salicylic acid hydroxylase.

244 and this heterogeneity and the regulation of flagella quantity, we propose a mathematical model that

245 The short flagella rarely have axonemes but assemble ectopic micro

246 lymerase (RNAP) to control the expression of flagella-related genes involving bacterial motility and

247 y; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space

248 esion and motility, mediated by fimbriae and flagella, respectively, is essential for disease progres

249 MotI-inhibited flagella rotated freely by Brownian motion, and suppress

250 These results indicated that polar flagella rotation is a previously unidentified mechanism

251 HAMP mutational phenotypes: those that cause flagella rotation that is counterclockwise (CCW) A and k

252 ructure/output to overcome higher viscosity, flagella rotation to accumulate cells and proline metabo

253 te's PF sheath, and a key determinant of the flagella's coiled structure.

254 , mastigonemes do not appear to increase the flagella's effective area while swimming, as previously

255 Contrary to a hypothesised role in flagella, SAS6L was absent during gamete flagellum forma

256 rt gate containing three proteins (FliPQR in flagella, SctRST in virulence systems).

257 fer from infertility because cilia and sperm flagella share several characteristics.

258 CFAP45-deficient cilia and flagella show normal morphology and axonemal ultrastruct

259 psilon is quadrilaterally arranged along the flagella, similar to the CatSper complex in mouse sperm.

260 pendent transcribing complexes on a complete flagella-specific promoter.

261 In bacteria, sigma(28) is the flagella-specific sigma factor that targets RNA polymera

262 in spectral counts for proteins involved in flagella structure/output to overcome higher viscosity,

263 d to abnormal cell morphologies and detached flagella, suggesting that eIF5A is important for transla

264 Flagella synthesis is a complex and energetically expens

265 ose that c-di-GMP produced by AdrA modulates flagella synthesis through SadB.

266 ation of many genes involved in sporulation, flagella synthesis, carbohydrate metabolism, and antimic

267 ODF2) is a cytoskeletal protein required for flagella (tail)-beating and stability to transport sperm

268 otation, not the physical presence, of polar flagella that inhibits the phage infection of V. parahae

269 timuli also induced Ca(2+) elevations in the flagella that occurred independently from those in the c

270 he use of rotating helical filaments, called flagella, that are powered by molecular motors.

271 In bacterial flagella, the filament and the hook have distinct functi

272 The number of flagella, their arrangement on the cell body and their s

273 ied motor-driven transport of tubulin to the flagella tips as a key component of their length control

274 EtpA interacts with the tips of ETEC flagella to promote bacterial adhesion, toxin delivery,

275 ms, it uses the breaststroke beat of its two flagella to pull itself forward [1].

276 Flagellotropic bacteriophages engage flagella to reach the bacterial surface as an effective

277 About two-thirds of bacteria use flagella to swim, but how bacteria deactivate this large

278 red the structure of Chlamydomonas wild-type flagella to that of strains with specific DRC subunit de

279 s (HBBs), protein structures that anchor the flagella to the bacterium.

280 s, supporting the functional contribution of flagella to the evolution of invasion machinery.

281 ein composition and structure from bacterial flagella-to drive cell motility, but the structural basi

282 Orientation of the flagella toward the cell body is critical for determinat

283 mechanisms, Jeffrey Orbit and shear-induced flagella unbundling, are responsible for the enhancement

284 bsequently track the movement of one or more flagella using videomicroscopy, requiring digital isolat

285 ces in the phenotypic properties of S. Typhi flagella variation and how they impact on the pathogenes

286 or merely the possession of the periplasmic flagella was crucial for cellular morphology and host pe

287 mice and the sole presence of toxins without flagella was not enough to elicit epithelial lesions.

288 ally occurring species with 4, 8, or even 16 flagella, we find diverse symmetries of basal body posit

289 lence of V. parahaemolyticus only when polar flagella were absent both in vitro and in vivo.

290 Intriguingly, ndk5's flagella were also short, resembling those of an allelic

291 reversal by fluorescent visualization of the flagella: when the bacterial body is suddenly stopped by

292 so far been mostly found on motile cilia and flagella, where it is involved in the stabilization of t

293 The pathogenesis of S. enterica depends on flagella, which are appendages that the bacteria use to

294 Male gametes also develop flagella, which assist in binding female gametes for fer

295 The C. difficile flagella, which confer motility and chemotaxis for succe

296 In motile cilia and flagella, which drive cell locomotion and fluid transpor

297 ss of spermiogenesis is the formation of the flagella, which enables sperm to reach eggs for fertiliz

298 ents of the hydrodynamic forces generated by flagella with and without mastigonemes.

299 in wild-type cells, causing paralyzed short flagella with hypophosphorylated, less abundant, but int

300 tility, these bacteria consistently regained flagella within 96 hours via a two-step evolutionary pat