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1 2007 on various sectors of the entire valley flank.
2 lly to a maximum of 15 nucleotides into each flank.
3 in the volcano, driving magma into the lower flank.
4 nuclei from the posterior to anterior stripe flanks.
5 als drove higher sediment flux from the rift flanks.
6 y constrained Ethyl (cEt) nucleotides in the flanks.
8 tional transcription, such that the upstream flanking -1 H2A.Z-containing nucleosome is more appropri
10 e residues are located in disordered domains flanking a 12-amino acid-long amphipathic helix (residue
11 two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate i
13 m changes in tandemly repeated cis sequences flanking a transposable element (a miniature inverted re
14 n the evening) for the past 10 days and left flank abdominal pain, accompanied by sweating and fatigu
15 chuchner et al and Frohner et al report that flanking amino acids and an underappreciated posttransla
17 esis potentiates the effects of radiation in flank and orthotopic patient-derived xenograft models of
18 e angles (peaks, troughs, rising and falling flanks) and compared them to periods of low amplitude (d
20 ther than dsDNA, loop or bulge regions, with flanking bases influencing the degree of preference.
21 T3' dinucleotide target sites, and different flanking bases within diverse DNA secondary structures.
25 dsDNA methods using cheap synthesized donors flanked by 100 nt homology arms and gRNA target sites cl
27 scriptionally active or repressive intervals flanked by 6mA-enriched regions, and results from chroma
28 skeleton composed of dimethylcyclodecatriene flanked by a 7-membered and a 6-membered lactone ring ba
31 have strong preferences toward the TC target flanked by A or T, while all examined A3 proteins did no
32 that retained introns in mouse are commonly flanked by a short ( 70 nucleotide), highly base-paired
33 c structures of complex and hybrid N-glycans flanked by a terminal sulfation sequon on Gal-GlcNAc and
34 asmids for Gene Tagging), contains reporters flanked by a universal CRISPR sgRNA sequence which enabl
43 aggregations (sequestosomes), sequestosomes flanked by flat double-membraned vesicles (sequestosome:
45 igid citrate synthase homology (CSH) module, flanked by four flexible acetyl-CoA synthetase homology
47 s behave similarly, possessing a stable core flanked by highly flexible regions, some of which perfor
48 udy 20 inversions ranging from 3.1 to 742 kb flanked by inverted repeats (IRs) up to 134 kb long.
51 ered on a short loop spanning K61 to I72 and flanked by longer alpha-helices at the outer edges, and
53 e generated a virus in which the M2 gene was flanked by loxP sites (M2.loxP), enabling the use of Cre
55 Cre recombinase and deleting essential genes flanked by loxP sites, resulting in a self-limiting infe
60 ted green fluorescent protein (GFP) cassette flanked by recombination signal sequences were transduce
62 2 HSP27 dimers with a phosphorylation pocket flanked by serine residues between their N-terminal doma
67 regions characterized by single-stranded RNA flanked by structured elements and these features specif
69 anilic acid (2CPA), where the amide group is flanked by two catalytic carboxyls, reveals key mechanis
71 assuming that an E. coli cell is a cylinder flanked by two half spheres and calculating the volumes
72 A2 unit comprises an electron-deficient core flanked by two thiophene rings with branched alkyl chain
73 ants and identify that 11 million or 57% are flanked by uHs, covering 88% of protein-coding genes.
74 c expression sites (ESs) where VSG genes are flanked by upstream 70 bp repeats and downstream telomer
76 shares the alpha-crystallin domain, which is flanked by variable, disordered N- and C-terminal extens
77 e-causing hyperactive STING mutations either flank C148 and depend on disulfide formation or reside i
79 , NR2F2 directly activated enhancer elements flanking cell cycle genes to drive their expression.
80 comprised of the branchpoint and of the two flanking centers (C4-C5-C6 in aldoheptoses and higher an
83 cRNA biogenesis, including length of introns flanking circularized exons, repetitive elements such as
86 distribution and retention in a subcutaneous flank colorectal murine tumor, and therapeutic response
87 bronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required fo
88 ls containing CpX target sites in randomized flanking context and identified combined effects of CpG
90 gurations (S (p) and R (p)) at six different flanking dinucleotide sites, i.e. XT and TX (X = A, C, o
91 act weakly with both the ipso-carbons of the flanking Dipp groups and the boron centres of the diazab
94 ose to execute cleavage, open to release the flanking DNA and close again to capture and attack targe
96 mplexes, the crescent-shaped BMVC recruits a flanking DNA residue to form a BMVC-base plane stacking
97 tion unit, but rarely more than 50-100 kb of flanking DNA, even when multiple neighboring genes are a
98 and favoring bidirectional progression into flanking DNA, typically to a maximum of 15 nucleotides i
101 rone activity against amyloid formation, the flanking domains contribute additional and important cha
102 We dissect the role of N- and C-terminal flanking domains using protein with the former (htt(NT)
104 eased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA-ssDNA
108 ption factor (TF) binding regions and at the flanking eRNA initiation regions, both of which are asso
111 t AS by binding to exons at coding sequences flanking exons that are more frequently skipped in clock
112 le, we found extended haplotype homozygosity flanking FMF-associated mutations, indicating evolutiona
113 onal diphtheria toxin from engineered intein-flanked fragments upon receptor-mediated delivery of one
114 uplexes, (th)G's hypochromism was larger for flanking G/C residues but its fluorescence quantum yield
117 nascent transcript levels for several Hsp70 flanking genes also correlate with speckle association a
119 termined that one enhancer activates the two flanking genes in mammary tissue during pregnancy and la
122 lso observe long-range allosteric changes in flanking helices consistent with winding/unwinding in he
125 nct topologically associating domains (TADs) flanking HoxD, both containing a range of appropriate en
126 quence in its att sites, active 'attB' sites flanking human deleterious mutations were previously ide
128 ap in knowledge, we generated mice with loxP-flanked Il11ra1 and deleted the IL11 receptor in adult f
129 This core domain of 120 amino acids (aa) is flanked in all FGFs by highly divergent amino-terminal a
130 esent across many areas of the entire valley flank, indicating that the volumes involved may be order
131 er, gB-CD8s primed by a concurrent wild-type flank infection infiltrated the TG and were retained lon
132 tivated region more rapidly in nodes than in flanking internodes, indicating that neurofilament trans
133 ity, and the predominant circRNAs had longer flanking introns and more Alu elements than other circRN
134 usion and instead promoting the retention of flanking introns containing repeated SRSF7 binding sites
135 circulation and RNA editing in back-splicing flanking introns; (ii) a two-stage DE approach of circRN
136 mechanism for setting deletion boundaries by flanking inverted repeats in Tetrahymena thermophila.
137 dent lineage-specific segmental duplications flanking LCR16a leading to the emergence of large inters
138 tunnel of round plastic hoops or a corridor flanked left and right by rows of plastic hanging chains
141 sed under phosphate-replete conditions by 5' flanking lncRNAs prt, prt2, and nc-tgp1, respectively.
142 the 5'- and 3'-UTRs of human UTRN sequences flank luciferase, for reporter assays and the C2C12 cell
144 essing cells, and the presence of loxP sites flanking M2 did not alter viral replication or latency i
145 cific splicing regulators (ESRP1 and ESRP2), flank many AR-regulated alternatively spliced exons.
150 increase in the proportion of deletions with flanking microhomology, a signature associated with a ba
152 variant H2A.Z from the -1 and +1 nucleosomes flanking NDRs; however, Ino80C's function in transcripti
154 tations at canonical dinucleotides (73%) and flanking noncanonical positions (27%), and calculate the
158 d resolved these preferences into individual flanking nucleotides and periodic poly(A) tracts that ro
159 stematic biases, including large homopolymer flanks (odds ratio = 23.29-33.69) and the NIST high conf
160 p of the SU layers mimic the attitude of the flank of the antidune on which they were deposited.
161 ne interface binds the 5'-terminal 2'-OMe PS flank of the ASO, while the other interface binds the re
164 ngs, located on the sediment-covered western flank of the Northern Knipovich Ridge, host extensive ga
166 yhistidine peptides are introduced into both flanks of L6, has enhanced cell-penetrating ability in h
169 and earthquakes occur extensively along the flanks of the East African Rift System, including an off
170 itability with respect to rising and falling flanks of the mu-alpha cycle further reveals that voltag
171 ns a blocking motif (aspartic acid residues) flanked on either side by cleavage sequences that are re
172 f RAA is an extremely unusual cause of acute flank pain and haemodynamic instability with acute kidne
178 n of conserved core PCR primer binding sites flanking polymorphic haplotypes with high information co
181 anslocatable unit (TU) excising from an IS26-flanked pseudo-compound transposon, PTn6762, which harbo
182 a unique sequence-context specificity, i.e. flanking purines at the 5' end of the mutated nucleotide
183 Our data indicate the PRRAR sequence and the flanking QTQTN sequence are not fixed in vitro; thus, th
188 ns of SLF genes, resulting in highly similar flanking regions between different types of SLF and betw
189 he high degree of sequence similarity in the flanking regions could often be explained by the presenc
191 reening for polymorphism and ensure that the flanking regions do not have length difference that woul
193 ment of TFs and cofactors in gene bodies and flanking regions in gene lists without an a priori binar
196 V genomes were significantly enriched in the flanking regions of 84.5% the integration sites, with a
199 s revealed potential genetic exchange in the flanking regions of SLF genes, resulting in highly simil
200 ining all the introns, exons, and 5'- and 3'-flanking regions of the hCYP11B2 gene containing either
202 xamining the evolutionary properties of gene-flanking regions on the X Chromosome, we find evidence t
203 enhancer cluster or parts thereof, Nppb and flanking regions or the entire genomic block spanning Np
204 at topologically associating domain boundary-flanking regions showing high interaction frequencies wi
206 l causal variants are enriched in coding and flanking regions, as well as in regulatory elements, and
207 eously to identify genes, predicted promoter flanking regions, transcription factors and CTCF binding
210 II molecules (HLA-II), which through peptide-flanking residues (PFRs) can extend beyond the limits of
211 by forming compensatory interactions to the flanking residues including a CpG specific contact to an
214 rin-like cleavage site itself (NSPRRAR) or a flanking sequence (QTQTN), and we investigated these del
217 also observed a previously unappreciated CpG flanking sequence bias in major and minor satellite repe
218 ger than transcription factor binding sites, flanking sequence can be used to target specific sites.
219 fied combined effects of CpG recognition and flanking sequence interaction together with complex cont
221 well as DNMT3A Arg882His variant acquire CpG flanking sequence preference akin to that of DNMT3B, whi
223 tle differences suggesting a co-evolution of flanking sequence preferences and cellular DNMT targets.
227 followed by sequencing, we recovered 388 888 flanking sequence tags (FSTs) from 21 741 insertion line
229 uncover the intricate interplay between CpG-flanking sequence, DNMT1-mediated base flipping and the
230 DNA substrates revealing that DNMT1 employs flanking sequence-dependent base flipping mechanisms, wi
234 nt defects, but minor perturbations from the flanking sequences are sufficient to reduce the defects
236 o different LOV2-based switches reveals that flanking sequences can lead to relaxation times up to 11
239 In this study, we demonstrate that the 5'-flanking sequences of the C(4) type phosphoenolpyruvate
251 ons of the capsid (CA) domain of Gag and the flanking spacer peptide SP1 that stabilize VLPs, but muc
252 ds on the position and nature of nucleotides flanking splice sites, and on structural interactions be
253 controlled in major part by nucleotides that flank the 3' and 5' ends of nairoviral genes, called non
254 ped using a set of RAD-seq-derived loci that flank the supergene, and instances of recombination test
255 the high charge-density saccharide residues flanking the "canonical" antithrombin-binding hexasaccha
256 nditional Pam(cKO/cKO) mice, with loxP sites flanking the 2 exons deleted in the global Pam(KO/KO) mo
259 selective elimination of glycosylation sites flanking the CD4bs, and 2) minimize the nND immune respo
262 es while sparing well-positioned nucleosomes flanking the enhancer core, indicating that inducible TF
263 nd UV-VIS absorbance spectroscopy of samples flanking the fat, may be an important factor in cellular
264 gest that removal of the repressed chromatin flanking the GAA tract might contribute to rescue FXN to
265 novel six-amino-acid C-terminal motif (CTM) flanking the homeodomain that serves as a major determin
267 am open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequen
270 igned a series of single guide RNAs (sgRNAs) flanking the mutation and provided different single-stra
271 d, to a lesser extent, in the switch regions flanking the nucleotide binding site, can shed light on
272 cleavage, we mutagenized the eight residues flanking the prelamin A scissile bond (TRSY LLGN) to all
274 ity is strongly amplified by the DNA regions flanking the recognition site, which contain long tracts
276 eading to excitation of a tryptophan residue flanking the retinal chromophore, as a first manifestati
278 Here, we detect intrinsic instability in DNA flanking the RNA-3' side of R-loops, which Cas12a can ex
280 , we discovered ligase-activity determinants flanking the S1 site, namely LAD1 and LAD2 located aroun
284 ade the upstream and downstream RNA segments flanking the target sequence upon hybridization to speci
285 a deep mutational scan showing that residues flanking the Tn-glycan contributed significant binding e
286 The Phi31 and Bxb1 integrase attP sites flanking the transgene will also enable rapid directiona
287 nformational changes control the path of DNA flanking the transposon end and the generation of DNA-bi
288 ript origin is dictated by the sequence that flanks the 3' end of the RNA target site (called the PFS
290 t an unannotated open reading frame (Percc1) flanks the regulatory sequence, and the expression of th
291 nces, we have derived 20-amino-acid peptides flanking this region of interest in order to test the ab
295 e-depleted region (NDR), which appears to be flanked upstream and downstream by strongly positioned n
297 a HSP78 (LmxHSP78+/-) were generated using a flanking UTR-based multifragment ligation strategy and t
298 ies of recombination signal sequences (RSSs) flanking Vbeta gene segments suppress the assembly and e
299 nt NB line SK-N-BE(2)C (mutated TP53); (iii) flank xenografts of a drug-resistant NB-PDX; and (iv) xe