1 g is not channeled to the subsequent enzyme,
flap endonuclease 1.
2 or recombination that may overlap with human
flap endonuclease-1.
3 Addition of
Flap endonuclease-1,
a nuclease known to remove 5' overh
4 The role of human FEN1 (
flap endonuclease-1),
an RTH1 (RAD two homolog-1) class
5 e with a 5'- and 3'-flap that was cleaved by
flap endonuclease 1 and a 3'-5' endonuclease Mus81/Eme1,
6 o profoundly altered PCNA's interaction with
Flap endonuclease 1 and DNA Ligase 1, DNA metabolism enz
7 tion factor C complex, DNA polymerase delta,
flap endonuclease 1 and DNA ligase 1.
8 these processes, acting in conjunction with
flap endonuclease 1 and replication protein A in DNA lag
9 ses, apurinic/aprymidinic endonuclease 1 and
flap endonuclease 1 and several other factors involved i
10 ion of Okazaki fragments escapes cleavage by
flap endonuclease-1 and anneals to a complementary ectop
11 of the related RAD2 family nucleases, FEN1 (
Flap endonuclease 1)
and EXO1 (exonuclease 1), on substr
12 provide strand displacement synthesis, human
flap endonuclease 1,
and human DNA ligase I.
13 Finally, a combination of HIV-1 RT,
Flap endonuclease-1,
and DNA ligase is capable of quanti
14 Treatment of extracts with
flap endonuclease 1 antiserum significantly reduced MHEJ
15 Finally, we found that aprataxin and
flap endonuclease 1,
as compensatory DNA-end processing
16 ivity of HEX1-N2 is similar to that of human
flap endonuclease-1,
both in terms of turnover efficienc
17 sion repair proteins DNA polymerase beta and
flap endonuclease-1 by 4-6-fold.
18 protein complex (LIG1, pol B, aprataxin, and
flap endonuclease 1)
can coordinate to prevent the forma
19 pt annealing at the ectopic site and promote
flap endonuclease-1 cleavage.
20 This resembles the mechanism of
flap endonuclease 1,
consistent with cooperation of thes
21 lymerase-1 (PARP-1) and the BER participants
flap endonuclease-1,
DNA polymerase beta, and apurinic/a
22 substrate recognition and specificity of the
flap endonuclease-1 enzymes.
23 Bacteriophage T4 RNase H, a
flap endonuclease-1 family nuclease, removes RNA primers
24 This is the first structure of a
flap endonuclease-1 family protein with its complete bra
25 acts with DNA polymerase beta (Pol-beta) and
flap endonuclease 1 (
Fen-1) and blocks Pol-beta-directed
26 replication proteins, including the enzymes
flap endonuclease 1 (
FEN-1) and DNA ligase I that comple
27 ociation of condensin I with the BER factors
flap endonuclease 1 (
FEN-1) and DNA polymerase delta/eps
28 The interaction between
flap endonuclease 1 (
FEN-1) and proliferation cell nucle
29 approach has been demonstrated that utilizes
flap endonuclease 1 (
FEN-1) fused to the Fok1 endonuclea
30 helicase-endonuclease that participates with
flap endonuclease 1 (
FEN-1) in Okazaki fragment processi
31 Human
flap endonuclease 1 (
FEN-1) is a member of the structure
32 PCNA binds to
flap endonuclease 1 (
FEN-1), a structure-specific endonu
33 ases is with the structure-specific nuclease
Flap Endonuclease 1 (
FEN-1), an enzyme that is implicate
34 Here we show that NEIL1 interacts with
flap endonuclease 1 (
FEN-1), an essential component of t
35 (RFC) complex, DNA polymerase delta (POLd),
flap endonuclease 1 (
FEN-1), and DNA ligase 1 (LIG1).
36 lly bound DNA polymerase beta (Pol beta) and
flap endonuclease 1 (
FEN-1).
37 a protein domain of WRN which interacts with
flap endonuclease 1 (
FEN-1).
38 A and provides binding sites for polymerase,
flap endonuclease-1 (
FEN-1) and ligase during DNA replic
39 Flap EndoNuclease-1 (
FEN-1) and the processivity factor
40 replication protein A (RPA), which inhibits
flap endonuclease-1 (
FEN-1) but stimulates Dna2 nuclease
41 y transfer (FRET) analyses show that WRN and
Flap Endonuclease-1 (
FEN-1) form a complex in vivo that
42 Flap endonuclease-1 (
FEN-1) is a critical enzyme for DNA
43 Human
flap endonuclease-1 (
FEN-1) is a member of the structure
44 Human
flap endonuclease-1 (
FEN-1) is a member of the structure
45 Flap endonuclease-1 (
FEN-1) is a multifunctional and str
46 Human
flap endonuclease-1 (
FEN-1) is a structure-specific endo
47 Mammalian
flap endonuclease-1 (
FEN-1) is a structure-specific meta
48 Flap endonuclease-1 (
FEN-1) is a structure-specific nucl
49 termediates in DNA replication and repair by
flap endonuclease-1 (
FEN-1) is essential for mammalian g
50 a Caenorhabditis elegans homologue of human
flap endonuclease-1 (
FEN-1) that is normally involved in
51 Human
flap endonuclease-1 (
Fen-1) was examined for its ability
52 Flap endonuclease-1 (
FEN-1), a 43-kDa protein, is a stru
53 rimidinic endonuclease, DNA polymerase beta,
flap endonuclease-1 (
FEN-1), and PARP-1.
54 olog-1 (RTH-1) class nuclease, also known as
flap endonuclease-1 (
FEN-1).
55 stically, we showed that MLH1 interacts with
Flap endonuclease 1 (
FEN1) and competes to process the R
56 ivities of DNA polymerase delta (Pol delta),
flap endonuclease 1 (
FEN1) and DNA ligase I (Lig1).
57 he enzymes DNA polymerase delta (Pol delta),
flap endonuclease 1 (
FEN1) and DNA ligase I (LigI) that
58 Flap endonuclease 1 (
FEN1) and Dna2 are responsible for
59 Flap endonuclease 1 (
FEN1) and Dna2 endonuclease/helicas
60 Flap endonuclease 1 (
Fen1) and exonuclease 1 (Exo1) have
61 Human
flap endonuclease 1 (
FEN1) and related structure-specifi
62 This flap structure was cleaved by
flap endonuclease 1 (
Fen1) and the resultant nick was li
63 onuclease 1 (APE1) physically interacts with
flap endonuclease 1 (
FEN1) and with proliferating cell n
64 DNA polymerase beta (pol beta) and
flap endonuclease 1 (
FEN1) are key players in pol beta-m
65 The Dna2 helicase/nuclease and then
flap endonuclease 1 (
FEN1) are proposed to act sequentia
66 Dna2 nuclease/helicase and
flap endonuclease 1 (
FEN1) are proposed to cleave the fl
67 This stimulated
flap endonuclease 1 (
FEN1) cleavage of TNRs engaged in a
68 Flap endonuclease 1 (
FEN1) cleaved the displaced downstr
69 uted with purified enzymes demonstrated that
Flap endonuclease 1 (
FEN1) efficiently excises a displac
70 AMP-dRP group through its lyase activity and
flap endonuclease 1 (
FEN1) excises the 5'-AMP-dRP group
71 The structure-specific endonuclease
flap endonuclease 1 (
FEN1) has also been suggested to be
72 Flap endonuclease 1 (
FEN1) is a central component of Oka
73 Flap endonuclease 1 (
Fen1) is a highly conserved structu
74 Flap endonuclease 1 (
FEN1) is a long-standing target of
75 Flap endonuclease 1 (
FEN1) is a protein that plays a rol
76 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
77 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
78 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
79 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
80 5'-
Flap endonuclease 1 (
Fen1) is an important enzyme involv
81 We identify that the
flap endonuclease 1 (
FEN1) is one of the interacting pro
82 that the DNA replication and repair protein
Flap endonuclease 1 (
FEN1) is required for replication o
83 DNA replication and repair enzyme
Flap Endonuclease 1 (
FEN1) is vital for genome integrity
84 Flap endonuclease 1 (
FEN1) participates in removal of RN
85 Flap endonuclease 1 (
FEN1) phosphorylation is proposed t
86 Flap endonuclease 1 (
FEN1) plays a crucial role in both
87 Flap Endonuclease 1 (
FEN1) plays important roles both in
88 Here, we characterized a
flap endonuclease 1 (
FEN1) plus hairpin DNA probe (hpDNA
89 nuclease 1 (FAN1), exonuclease 1 (EXO1), and
flap endonuclease 1 (
FEN1) process a substrate reminisce
90 Flap endonuclease 1 (
FEN1) processes Okazaki fragments i
91 Flap endonuclease 1 (
FEN1) proteins, which are present i
92 nent in the maturation of Okazaki fragments,
flap endonuclease 1 (
FEN1) removes the 5'-flap and maint
93 In one model for this process, the
flap endonuclease 1 (
FEN1) removes the iRNA.
94 e proteome of FA-induced DPCs and found that
flap endonuclease 1 (
FEN1) resolves FA-induced DPCs.
95 s in concert with alternate flap cleavage by
flap endonuclease 1 (
FEN1) to mediate CAG repeat expansi
96 cates the lagging strand and cooperates with
flap endonuclease 1 (
FEN1) to process the Okazaki fragme
97 s derived from Xenopus laevis, we found that
flap endonuclease 1 (
FEN1) was a factor responsible for
98 Recently,
Flap endonuclease 1 (
FEN1) was shown to contribute to te
99 Most flaps are cleaved by
flap endonuclease 1 (
FEN1) while short, and the remainin
100 Here, we demonstrate that
flap endonuclease 1 (
FEN1), a canonical lagging strand D
101 Here we show RAD27/FEN1, which encodes
flap endonuclease 1 (
FEN1), a structure-specific nucleas
102 Human
flap endonuclease 1 (
FEN1), an essential DNA replication
103 Polymorphisms and somatic mutations in
Flap Endonuclease 1 (
FEN1), an essential enzyme involved
104 se 1 (APE1), DNA polymerase beta (pol beta),
flap endonuclease 1 (
FEN1), and DNA ligase I (LigI).
105 n genes involved in DNA replication, such as
flap endonuclease 1 (
FEN1), can cause single-stranded DN
106 p21 disrupts PCNA-directed stimulation of
flap endonuclease 1 (
FEN1), DNA ligase I, and DNA polyme
107 AP endonuclease, replication factor C, PCNA,
flap endonuclease 1 (
FEN1), DNA polymerase delta, and DN
108 Flap endonuclease 1 (
Fen1), has an endonuclease activity
109 In most cases, the flap was removed by
flap endonuclease 1 (
FEN1), in a reaction required to re
110 Flap endonuclease 1 (
FEN1), involved in the joining of O
111 d cancer avoidance of the structure-specific
flap endonuclease 1 (
FEN1), its cellular compartmentaliz
112 , which is removed by the structure-specific
flap endonuclease 1 (
FEN1), leaving a nick for ligation.
113 is via long-patch BER (LP-BER) dependent on
flap endonuclease 1 (
FEN1), not previously known to be p
114 and handoff of DNA-editing enzymes, such as
flap endonuclease 1 (
FEN1), with sliding clamps are key
115 Flap endonuclease 1 (
FEN1)-dependent long-patch repair h
116 Okazaki fragments generated by Pol delta and
Flap endonuclease 1 (
FEN1).
117 brogated two of three nuclease activities of
flap endonuclease 1 (
FEN1).
118 age of the flap by Dna2 nuclease followed by
flap endonuclease 1 (
FEN1).
119 he primer into a flap that is cleaved off by
flap endonuclease 1 (
FEN1).
120 Flap endonuclease-1 (
FEN1) belongs to the Rad2 family of
121 Flap endonuclease-1 (
FEN1) is a multifunctional, structu
122 Flap endonuclease-1 (
FEN1) is proposed to participate in
123 The prototypical 5'-nuclease,
flap endonuclease-1 (
FEN1), catalyzes the essential remo
124 cture- and strand-specific phosphodiesterase
flap endonuclease-1 (
FEN1), the prototypical 5'-nuclease
125 isomer of RECQL5, RECQL5beta, with the human
flap endonuclease 1,
FEN1, which plays a critical role i
126 Human
flap endonuclease 1 (
h-FEN1) mutations have dramatic eff
127 ase/endonuclease, called RAD2 homologue 1 or
flap endonuclease 1,
has a unique cleavage activity, dep
128 Interaction between human
flap endonuclease-1 (
hFEN-1) and proliferating cell nucl
129 Human
flap endonuclease-1 (
hFEN-1) is highly homologous to hum
130 Human
flap endonuclease-1 (
hFEN1) catalyzes the essential remo
131 cates a back-up function of exonuclease 1 to
flap endonuclease-1 in RNA primer removal during lagging
132 In most cases, FEN1 (
flap endonuclease 1)
is able to efficiently cleave short
133 long flap (20 nucleotides) by M. acetivorans
flap endonuclease 1 (
MacFEN1).
134 Instead,
flap endonuclease 1 must recognize and bind to the inter
135 Flap endonuclease-1 or FEN-1 is a structure-specific and
136 es lacking genes encoding the orthologues of
flap endonuclease-1,
PCNA, and MutS.
137 Until cleaved by FEN1 (
flap endonuclease 1),
such flaps can initiate homologous
138 We further demonstrate that hDNA2 and
flap endonuclease 1 synergistically process intermediate
139 Coordinating with
flap endonuclease 1,
the APE1 3'-5' exonuclease activity
140 a long flap that was efficiently cleaved by
flap endonuclease 1,
thereby leading to repeat deletion.
141 evolution methodology that uses the nuclease
flap endonuclease 1 to achieve the efficient discovery o
142 Flap endonuclease 1,
which preferentially cleaves unanne
143 ssed by DNA polymerase beta and processed by
flap endonuclease 1 with different efficiency.
144 beled the eukaryotic DNA replication protein
flap endonuclease 1 with mKikGR and added it to replicat