ライフサイエンスコーパス: flatworm

1 nates the outer surface of a human parasitic flatworm.

2 in Schistosoma mansoni, a derived, dioecious flatworm.

3 of amidated neuropeptides in these parasitic flatworms.

4 and it was initially linked to turbellarian flatworms.

5 e properties of TRPM(PZQ) in other parasitic flatworms.

6 yla such as sponges, jellyfish, rotifers and flatworms.

7 ian-like planula larva and simple acoel-like flatworms.

8 lopment are scarce, especially for parasitic flatworms.

9 sis and other infections caused by parasitic flatworms.

10 itting important groups of animals including flatworms.

11 Planarians are a group of flatworms.

12 ls, has an important role in regeneration in flatworms.

13 o defend the germline integrity of parasitic flatworms.

14 ution of the complex life cycle of parasitic flatworms.

15 logical features, including Platyhelminthes (flatworms)(2), Priapulida (penis worms)(3) and Rotifera

16 ogeneous cell mixture of a whole dissociated flatworm (5-25 mum in diameter) within highly monodisper

17 atures that makes the fascinating biology of flatworms accessible to the wider research community.

18 Previous experimental data on planarian flatworms' adaptation to a barium-containing environment

19 essential function of these two proteins in flatworm adhesion.

20 As a flatworm amenable to transgenesis, it complements the hi

21 ted regenerative capabilities make planarian flatworms an ideal system with which to investigate thes

22 iability in nucleotide binding sites between flatworm and human RIOK proteins.

23 ms, we have sequenced transcriptomes from 18 flatworms and 5 other metazoan groups.

24 diffusivity previously observed in planarian flatworms and housefly larvae.

25 c paralog that is conserved across parasitic flatworms and is required for the normal response to gen

26 d transcriptomes from a broad range of other flatworms and provide a phylogeny-aware interface that m

27 Planarians are flatworms and regenerate from tiny body fragments, a pro

28 by gastropod-borne helminths, predominantly flatworms and roundworms, whose life cycles are characte

29 implications for the evolution of parasitic flatworms and suggest a potential role for nonribosomal

30 xity.(1-3) Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea urchi

31 species (e.g. prickly pear cactus, hydra and flatworms) and is indicative of their negligible or even

32 la: chordates (fish, frog), platyhelminthes (flatworm), and arthropods (crustacean).

33 As the first sequenced flatworm, and a representative of the Lophotrochozoa, it

34 TRPM(PZQ) is present in all parasitic flatworms, and the consensus PZQ binding site was well c

35 ll-known regenerative abilities of planarian flatworms are attributed to a population of adult stem c

36 Freshwater planarian flatworms are capable of regenerating complete organisms

37 The remarkable regenerative abilities of flatworms are closely linked to neoblasts - adult plurip

38 Regeneration-capable flatworms are informative research models to study the m

39 Flatworms are not just everyone's favorite experimental

40 Snails, earthworms and flatworms are remarkably different animals, but they all

41 stem where the adult stem cells of planarian flatworms are required to migrate to a distal wound site

42 Here, we use the planarian flatworm as a simple chemical-genetic screening model fo

43 an, should serve to reignite interest in the flatworm as an experimental model for studying the probl

44 erview with Carrie Adler, who uses planarian flatworms as a model system to study the molecular and c

45 Here, using planarian flatworms as a model system, we demonstrate that imaging

46 ed sugars in the surrounding water inhibited flatworm attachment, while positively charged molecules

47 This set of unique properties makes many flatworms attractive organisms for studying the evolutio

48 and epidermal ultrastructure, to acoelomorph flatworms based on body plan and ciliary ultrastructure

49 e model for regeneration, with the planarian flatworm being one of the most important model species.

50 ed tropical diseases worldwide, is caused by flatworms (blood flukes or schistosomes) that live in th

51 cki homologs are ubiquitous in parasitic flatworms but are absent from their free-living ancestor

52 pioneer programmed gene-editing in parasitic flatworms, but also the striking, clinically-relevant pa

53 Planarian flatworms can regenerate heads at anterior-facing wounds

54 Planarians are free-living flatworms capable of rapidly regenerating from small bod

55 Planarians are flatworms capable of regenerating all body parts using a

56 Planarians are flatworms capable of regenerating all body parts.

57 Planarians are flatworms capable of regenerating any missing body regio

58 Using planarian flatworms capable of whole-body regeneration, we report

59 Parasitic flatworms cause various clinical and veterinary infectio

60 Schistosomes are parasitic flatworms causing one of the most prevalent infectious d

61 Planarian flatworms completely regenerate their nervous systems af

62 Riegeria symbionts in mouthless Paracatenula flatworms comprise up to half of the biomass of the cons

63 The nervous system of temnocephalid flatworms consists of the brain and three pairs of longi

64 Planarian flatworms contain a population of adult stem cells (neob

65 rst reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these

66 richuris sp., the roundworm Ascaris sp., the flatworm Dicrocoelium sp. and the fish tapeworm Diphyllo

67 molluscs, annelids, nemerteans, and polyclad flatworms) display a well-conserved early developmental

68 in other eukaryotes, the loss of RIOK-3 from flatworms does not result in an evolutionary disadvantag

69 previously reported as absent in free-living flatworms, e.g., planarians.

70 The ability to genetically manipulate these flatworms enables deeper investigation of their (patho)b

71 s intermediate hosts (vectors) for parasitic flatworms (flukes) that cause neglected tropical disease

72 tissue maintenance in long-lived free-living flatworms (for example, planarians), and neoblast-like c

73 Freshwater planarians, flatworms from order Tricladida, are experimental models

74 ents, we show that TTXs do not protect these flatworms from some predators but instead are used to ca

75 Parasitic flatworms from the group Digenea (flukes) have free-livi

76 nized from all currently available parasitic flatworm genomes.

77 ides evidence supporting the hypothesis that flatworm germ cells and yolk cells share a common evolut

78 hts the importance of the nervous system for flatworm gonad differentiation.

79 that the globally invasive, human-infectious flatworm, Haplorchis pumilio, possesses the most physica

80 Planarian flatworms have an extensive stem cell population respons

81 nd the regeneration of the protonephridia of flatworms have been reported,(6)(,)(7) the molecular und

82 Flatworms have organs called protonephridia that could b

83 Platyhelminthes (flatworms) have captivated the imagination of biologists

84 roup may be closely related to the ancestral flatworm; however, polyclad embryos have been the subjec

85 tumor suppressor-like function in parasitic flatworms implies that the ability to respond to genotox

86 Infections caused by parasitic flatworms impose a considerable worldwide health burden.

87 sly unknown prey item (soft-bodied planarian flatworms in the genus Dugesia) made up the majority of

88 he abundance of larval trematodes (parasitic flatworms) in the declining northern leopard frog Rana p

89 Parasitic flatworms, including Fasciola hepatica, are active secre

90 an essential medicine for treating parasitic flatworm infections such as schistosomiasis, which affli

91 m for the sHsp-related pathogenicity of some flatworm infections.

92 The planarian flatworm is an emerging model that is useful for studyin

93 asis, a tropical disease caused by parasitic flatworms known as schistosomes.

94 we show that planarians, and possibly other flatworms, lack centrosomes.

95 olytic secretions from schistosome parasitic flatworm larvae and a pancreatic cancer cell line were d

96 aryngium, a member of the earliest-branching flatworm lineage, lacks conventional neoblasts despite b

97 case study, we used 35 transcriptomes of 29 flatworm lineages to recover 3427 putative hidden orthol

98 e evolutionary relationships among the major flatworm lineages, suggesting new roots and conflicting

99 The flatworm Macrostomum lignano features a duo-gland adhesi

100 The regeneration-capable flatworm Macrostomum lignano is a powerful model organis

101 The free-living flatworm, Macrostomum lignano has an impressive regenera

102 We characterized xenopsin in a flatworm, Maritigrella crozieri, and found it expressed

103 to respond to genotoxic stress in parasitic flatworms may have arisen from convergent evolution.

104 phylogenies have suggested that acoelomorph flatworms might provide insights into the nature of the

105 complements the historically used planarian flatworm models, such as Schmidtea mediterranea.

106 At the phylum level, flatworms, nematodes and tardigrades show the largest re

107 the first cell-lineage fate map for an acoel flatworm, Neochildia fusca, using modern intracellular l

108 Flatworms number among the most diverse invertebrate phy

109 Asian tapeworms, respectively) are parasitic flatworms of major public health and food safety importa

110 tating neglected tropical disease, caused by flatworms of Schistosoma genus.

111 s is a neglected disease caused by parasitic flatworms of the genus Schistosoma and affects more than

112 transcriptomes representing all free-living flatworm orders, we provide resolution of platyhelminth

113 atworm Schmidtea mediterranea suggested that flatworm P53 plays an important role in stem cell mainte

114 ed to the dissemination of data from flukes, flatworm parasites of the class Trematoda, phylum Platyh

115 deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, imm

116 tive agents, schistosomes, are intravascular flatworm parasites that feed on blood and lay eggs, resu

117 opment of anthelmintics against nematode and flatworm parasites.

118 yses robustly support a modern hypothesis of flatworm phylogeny, one which emphasizes the primacy of

119 The interrelationships of the flatworms (phylum Platyhelminthes) are poorly resolved d

120 In planarian flatworms, PIWI proteins are essential for regeneration,

121 ific island of Guam, we found an undescribed flatworm (planocerid sp. 1) that contains high levels of

122 Flatworms (Platyhelminthes) are a basally branching phyl

123 Monogeneans are flatworms (Platyhelminthes) that are primarily found on

124 x-linked, by analyses of multiple species of flatworms (Platyhelminthes; among which schistosomes rec

125 ysis of the riok gene family in 25 parasitic flatworms (platyhelminths) for which extensive genomic a

126 larity observed in the vertebrate kidney and flatworm protonephridia(6)(,)(7) is also seen in the dev

127 between free-living and vertebrate-parasitic flatworms, providing new opportunities to shed light on

128 ificant proportion of the gene repertoire in flatworms, qualifying the impact of gene losses and gain

129 Planarian flatworms readily restore missing tissue due to injury-i

130 Planarian flatworms regenerate every organ after amputation.

131 n that canonical neoblasts are necessary for flatworm regeneration and open up the possibility that n

132 n pluripotent stem cells and drive planarian flatworm regeneration from diverse injuries.

133 system.IMPORTANCE Planarians are freshwater flatworms, related more distantly to tapeworms and fluke

134 f regenerative abilities with age, planarian flatworms remain highly regenerative throughout adulthoo

135 Despite the importance of vitellaria for flatworm reproduction (and parasite transmission), littl

136 te-producing gonads, planarian and parasitic flatworm reproduction relies on yolk cell-generating acc

137 ther, these results elucidate key aspects of flatworm reproductive biology and will be relevant for b

138 Adult planarian flatworms respond to nearly any injury with a robust, wh

139 Schistosomes, parasitic flatworms responsible for the neglected tropical disease

140 ef Gelei proposed that chromosome pairing in flatworms resulted from the formation of a telomere bouq

141 nalis, the hard tick Ixodes ricinus, and the flatworm Schistosoma mansoni.

142 two different P53 homologs in the parasitic flatworm Schistosoma mansoni.

143 y a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni.

144 logical agents of this disease are trematode flatworms (Schistosoma) that live and lay eggs within th

145 ng an ommochrome body pigment, the planarian flatworm Schmidtea mediterranea generates porphyrins in

146 The flatworm Schmidtea mediterranea is an emerging model spe

147 Previous studies in the freshwater planarian flatworm Schmidtea mediterranea suggested that flatworm

148 atial expression of SL RNAs in the planarian flatworm Schmidtea mediterranea, with the goal of identi

149 ying asexual reproduction in adult planarian flatworms, Schmidtea mediterranea.

150 Tsp36, like other flatworm sHsps, possesses two divergent sHsp repeats per

151 ral schistosome stages demonstrated that the flatworm SL AUG can serve as a translation initiator met

152 In other flatworm species, such as the typhloplanoid Mesostoma an

153 hese phenotypes in Dugesia japonica, another flatworm species.

154 e provided evidence that another function of flatworm spliced leader trans-splicing is to provide som

155 nssplicing metazoan groups (e.g. nematodes), flatworm spliced leaders are variable in both sequence a

156 solutely conserved and unique feature of all flatworm spliced leaders is the presence of a 3'-termina

157 elop a concept for an in vivo test, based on flatworm stem cell dynamics, to detect and classify carc

158 a P53(Smed-p53) and human TP53 and regulates flatworm stem cell maintenance and skin production.

159 We found that none of the flatworms studied have a riok-3 gene, which is unprecede

160 tion structure of an sHsp from the parasitic flatworm Taenia saginata Tsp36, the first metazoan cryst

161 No flatworm target has been identified that readily explain

162 cids with less than 28% missing data from 27 flatworm taxa in 11 orders covering all major clades.

163 fferences from the pattern observed in other flatworm taxa in regard to the number of neurons that ex

164 ble in both sequence and length in different flatworm taxa.

165 Further, this model of flatworm temporary adhesion may serve as the starting po

166 ptome of Schmidtea mediterranea, a planarian flatworm that can regenerate all organs, including the g

167 f mice with Schistosoma mansoni, a parasitic flatworm that causes schistosomiasis.

168 Schistosoma mansoni is a parasitic flatworm that causes the major neglected tropical diseas

169 Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, most

170 Planarians are regenerative flatworms that bidirectionally scale their adult body si

171 Schistosomes are intravascular, parasitic flatworms that cause debilitating disease afflicting >20

172 Schistosomes are parasitic flatworms that cause schistosomiasis, a major tropical d

173 Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropic

174 Schistosomes are parasitic flatworms that cause schistosomiasis, which affects hund

175 Schistosomes are human parasitic flatworms that constitute an important public health pro

176 Planarians are flatworms that constitutively maintain adult tissues thr

177 be better understood by studying planarians, flatworms that continuously change their body size accor

178 Human schistosomes, parasitic flatworms that cycle between freshwater snails and human

179 odes are a large, complex group of parasitic flatworms that infect an incredible diversity of organis

180 Schistosomes are parasitic flatworms that infect more than 200 million people globa

181 Schistosomes are parasitic flatworms that infect over 200 million people, causing t

182 criptomes of major cell types of planarians--flatworms that regenerate from nearly any injury--and id

183 o define a clade within the Platyhelminthes (flatworms), the Rhabditophora.

184 ontrast, three other classes of turbellarian flatworm, the Acoela, Nemertodermatida, and Catenulida,

185 iropters, marsupials), one amphibian and one flatworm, the planarian Schmidtea mediterranea.

186 Within flatworms, the vast majority of parasitism is innate to

187 an important role in the ability of certain flatworms to identify wounds that require the production

188 the varied sensitivities of these different flatworms to PZQ.

189 Comparisons with hermaphroditic flatworm transcriptomes show masculinisation and some de

190 is a small protein secreted by the parasitic flatworm (trematode) Fasciola hepatica that belongs to a

191 ces for parasitic roundworms (nematodes) and flatworms (trematodes), collectively known as helminths.

192 n PZQ, which is finally unmasked as a potent flatworm TRP channel activator.

193 ing of trematode, cestode, and a free-living flatworm TRPM(PZQ) ortholog revealed differing sensitive

194 variation were defined across the parasitic flatworm TRPM(PZQ) pocketome with the identity of an aci

195 due found in other parasitic and free-living flatworm TRPM(PZQ) was associated with lower sensitivity

196 Planarians, highly regenerative flatworms, use pluripotent stem cells called neoblasts t

197 dants to ensure regenerative capacity of the flatworm via transposon silencing.

198 suggests that the evolution of parasitism in flatworms was aided by an unusual means of metazoan gene

199 the function of P53 homologs across diverse flatworms, we examined the function of two different P53

200 Indeed, planarian flatworms were used as experimental models decades befor

201 lecular phylogenies however, place the acoel flatworms, which have only one opening to their digestiv

202 esis method for Macrostomum lignano, a basal flatworm with excellent regeneration capacity.

203 o reverse-engineer systems such as planaria: flatworms with a complex bodyplan and nervous system tha

204 e we study the telomere biology of planarian flatworms with apparently limitless regenerative capacit

205 Planarians are flatworms with robust regenerative capacities and utiliz

206 the question: how does the germline of these flatworms withstand mobilization of TEs?

207 from single-celled bacteria to multicellular flatworms-yet share many common features in their life h