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1 ices, separated by a well-defined turn and a flexible region.
2 ic and constitute synaptobrevin-2 C-terminal flexible region.
3  are consistent with a more conformationally flexible region.
4  not the antitoxin but the toxin possesses a flexible region.
5 Trp(195), indicating the former is in a more flexible region.
6 mains of different sizes loosely linked by a flexible region.
7 ombin-2 showed a similar distribution of the flexible regions.
8 tended helical bundles that are connected by flexible regions.
9 s of single-structure approaches in modeling flexible regions.
10 its complex architecture and multiple highly flexible regions.
11 tructural changes due to crowding except for flexible regions.
12 er large protein complexes with unstructured flexible regions.
13 ting a compact globular core with peripheral flexible regions.
14 ic characteristics compared to disordered or flexible regions.
15 tely disordered or possess long structurally flexible regions.
16  collagen molecule to the stretching of less flexible regions.
17 thorhombic crystal (0.97 A) revealed several flexible regions.
18 that is followed by a 30-residue disordered, flexible region (609-638).
19    NC preferentially initiates compaction at flexible regions along the dsDNA, such as AT-rich region
20                                        These flexible regions also coincide with those regions of Sem
21 aled altered charge density surrounding this flexible region although its position was unaffected.
22 at a three-helix junction constitutes both a flexible region and part of a rigid RNA superhelix.
23                           The results reveal flexible regions and concerted global motions of the sub
24                         The results identify flexible regions and potential conformational changes in
25  residue refinements, as well as to identify flexible regions and potentially functional sites in lar
26     In such cases, the removal of inherently flexible regions and the addition of stabilizing ligands
27 significant differences are observed in the "flexible" region and to a lesser extent in the G-bulged
28 fibrinogen alpha-chain (excluding two highly flexible regions) and the N termini of the beta-chain, c
29                                        These flexible regions are located on the outside of the spher
30                The results indicate that the flexible regions are not critical for SspA function, whe
31                                   When these flexible regions are unresolvable structurally, computat
32 c surfaces of PrPC and PrPSc identifies this flexible region as a component of the conformational rea
33 king interfaces as well as information about flexible regions as the N- and C-termini and the functio
34 ein unfolding, and identify the emergence of flexible regions as unfolding proceeds.
35  similar to that afforded by an interspersed flexible region associated with a (TT).(TT) mispair.
36                                          The flexible region at the middle of the central helix (Gly9
37 nt spanning its entire sequence except for a flexible region between the C(2)A and CaMb domains.
38 n studies reveal a fifth binding site in the flexible region between the octarepeats and the PrP glob
39 example, when a hydrogen bond forms within a flexible region, both energy and conformational entropy
40 es have been located on a solvent-accessible flexible region by computational analysis of the structu
41 folic acid [1], and why mutations within the flexible region can either abolish or change the species
42  cis autoubiquitination could occur if these flexible regions come in proximity to the E2.
43                        Loops in proteins are flexible regions connecting regular secondary structures
44 mere-specific interaction domain linked to a flexible region containing determinants that promiscuous
45            Adjacent to each active site is a flexible region containing three arginines positioned ap
46 nhinging of the N-terminal bundle around two flexible regions containing G39 and G65 to elongate the
47                              The presence of flexible regions could allow C-RING1B to bind a variety
48                                   Two large, flexible regions deduced from the DeltaTm map aligned wi
49 tagenesis of residues exclusively located at flexible regions distal to the active site of Homo sapie
50 nes are 13 angstrom apart and connected by a flexible region exclusive to photosynthetic eukaryotes-t
51 h is fast for use with proteins that contain flexible regions for structure-based drug design.
52                         Substituting charged flexible regions from two other proteins for M created v
53 omain of Atg7 (Atg7(NTD)) recruits a unique "flexible region" from Atg3 (Atg3(FR)).
54 mited proteolysis to identify an exposed and flexible region in IAPP monomer.
55  the nucleotide-free form where a conserved, flexible region in the N-terminus masks the [4Fe-4S] clu
56  the myosin VI structure has an unfolded and flexible region in the proximal tail which makes such a
57 ation, when combined with the existence of a flexible region in the structure, which takes part in st
58         GraTA represents a TA module where a flexible region in the toxin rather than in the antitoxi
59 that internal conformational fluctuations of flexible regions in KRAS result in three distinct membra
60 drolase domains, whilst revealing additional flexible regions in the catalytic site.
61  states of the peripheral stalk and assigned flexible regions in the enzyme.
62 gesting a common distribution of compact and flexible regions in their folding intermediates.
63                 Natural proteins can contain flexible regions in their polypeptide chain.
64  76 amino acid residues are disordered; this flexible region is required for optimal activity.
65 xibility of dipeptide sequences found in the flexible regions is about a factor of five higher than t
66                                            A flexible region, known to interact with cpn60, extends f
67 hannel from Magnetococcus marinus includes a flexible region linking the TM domains to a four-helix c
68                              We used an AF-2 flexible region mutant and an AF-2 static region mutant.
69                        This conformationally flexible region of gp41 assumes mostly helical conformat
70 ication of the ATG12 binding sequence in the flexible region of human ATG3 and the crystal structure
71 ly that the double mutation L55S/L56S in the flexible region of RhoGDI drastically decreases its affi
72 e occurs within a serine-rich, intrinsically flexible region of TbSP1, does not involve the phospholi
73 ing to backbone 1H-15N NOE results, the most flexible region of the apoprotein, except for the termin
74 correlated with residues located in the most flexible region of the G-loop, the major cytosolic gate
75 e amino terminus is an extended and possibly flexible region of the protein, allowing it to efficient
76         The kinks coincide with a relatively flexible region of the sequence, and this is probably a
77 on the conditions, are separated by a highly flexible region of undefined conformation.
78 al modeling supports the hypothesis that two flexible regions of ALAS2 interact with heme, locking th
79 significant conformational rearrangements in flexible regions of alpha-bungarotoxin, mainly loops I,
80 RelB-p105 complex formation, all domains and flexible regions of each protein are engaged in the RelB
81 s that de-repressed the UPR in cells, encode flexible regions of IRE1(LD) that mediated BiP-induced m
82                  Our results identify highly flexible regions of MdfA, which may play an important ro
83   These structures revealed new insights for flexible regions of p53 along with biologically relevant
84    By repeatedly reconstructing the core and flexible regions of phage genomes from different metagen
85 active site cleft where it may interact with flexible regions of Pol II and the general factor TFIIB
86 ECD fragmentation is not limited only to the flexible regions of protein complexes and that regions l
87 ooperative binding interactions in specific, flexible regions of protein structure.
88 ese ILMs might play a functional role in the flexible regions of proteins and in proteins in a non-na
89 are a possible indication of the role of the flexible regions of proteins for the biological function
90 ation about the dynamic behavior of the most flexible regions of proteins.
91 n for structure-based drug design, elucidate flexible regions of the AR LBD, and provide insight as t
92    We consider a method that treats multiple flexible regions of the binding site independently, reco
93 e are due to a change from the stretching of flexible regions of the collagen molecule to the stretch
94 tions, we present the first NMR study on the flexible regions of the E1 component from Escherichia co
95 r gD-gH/gL-blocking MAbs were located within flexible regions of the gH N terminus and the gL C termi
96 rameters, indicating that these are the most flexible regions of the molecule.
97 n the trigger loop and bridge helix, the two flexible regions of the Pol II subunit Rpb1 that partici
98 and gamma(t) time-series] were found only in flexible regions of the protein for a few residues which
99 ament, focusing on conformational changes in flexible regions of the troponin I subunit.
100 uggest a critical role for the structurally 'flexible' region of PrP in agent replication and targeti
101 5-Lys404), indicating that this represents a flexible region on the protein surface.
102 in responsible for RNA binding activity by a flexible region on which lie two functionally critical s
103 with hypotheses that envision the linkers as flexible regions, or as looping away from one another, a
104 impossible to identify independent subunits, flexible regions, or hinges simply by visual inspection
105 tures of multidomain proteins, proteins with flexible regions, or protein complexes obtained by X-ray
106                            Many structurally flexible regions play important roles in biological proc
107 We conclude that the cytoplasmic domain is a flexible region poised for stabilization by small change
108  that ~57% of the ICD residues are in highly flexible regions, primarily in a large loop (loop L) wit
109                       Problems with internal flexible regions ranging from one or more loops or hinge
110  continuum of possible transitory states and flexible regions remains largely an open problem.
111 steines were introduced at the interfaces of flexible regions remote from the active site.
112                                            A flexible region (residues 60-85) couples the structured
113 , possessing a stable core flanked by highly flexible regions, some of which perform essential functi
114 are found in both the helices and disordered flexible regions, supporting the essential role of the I
115  in folding pathway and termini insertion in flexible regions than on the availability of proteostasi
116 a reveal the beta5-alpha11 loop of PBPA as a flexible region that appears important for acylation and
117 is not attached to F1 suggests that it has a flexible region that can serve as a stator during both A
118      These phosphates lie in an unstructured flexible region that functions as the allosteric effecto
119 ilizes the middle of Tm, resulting in a more flexible region that is important for the cooperative ac
120 ises an autonomous, functionally active, and flexible region that plays a key role in alpha polymer f
121 been found that some assemblies contain long flexible regions that adopt multiple structural conforma
122  edges of the core complex flanked by highly flexible regions that can interact with other repair pro
123         Intrinsically disordered regions are flexible regions that complement the typical structured
124  Remarkably, apart from minor differences in flexible regions, the backbone tertiary structure of the
125                              Enzymes require flexible regions to adopt multiple conformations during
126 gful conformational ensembles of the missing flexible regions to complete the full-length protein.
127 its atomic structure were challenging due to flexible regions unique to this family member.
128 , the distance and disorder in the protein's flexible regions using TR-FRET and DEER.
129 onstrates that SVHP lacks a conformationally flexible region (V-loop) present in all other villin-typ
130          The residue Y113 of synaptobrevin-2 flexible region was mutated to lysine and glutamate.
131 ailed biophysical studies of the exposed and flexible region, we synthesized three peptides including
132                             Replacement of a flexible region with alpha-helical residues (residues 59
133 e the two trefoil domains are connected by a flexible region with the monomer units being at variable
134 ya, M, C, and S) were all predicted to be in flexible regions with high accessibility, either in surf
135                             Interestingly, a flexible region within the N-terminal domain, which unde
136                              We identified a flexible region within the rigid beta-subdomain that giv
137 vide suggestive evidence for the location of flexible regions within 23S rRNA.
138 te "conformational priming" of AtPCO4, where flexible regions within or surrounding the active site a
139 ctional stability are concentrated in highly flexible regions within the PAI-1 structure.
140 gnition, reveal the functional importance of flexible regions within these HEAT domains.

 
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