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2 omimetic building blocks containing backbone-fluorinated 1,4-disubstituted 1,2,3-triazole moieties.
5 ta(5) -C5 Me5 )(dppe)] with an electrophilic fluorinating agent (NFSI) results in the formation of th
10 oselectivity in glycosylations with a set of fluorinated alcohols as well as carbohydrate acceptors.
11 s (SiPcs, 1-7) with non-, partially- and per-fluorinated aliphatic (linear or branched at the alpha-c
12 ence of fluorination on the lipophilicity of fluorinated aliphatic alcohols was determined, and the l
14 r for catalysts bearing one triflate and one fluorinated alkoxide than for catalysts bearing two trif
17 reaction is successful with a range of alpha-fluorinated alkyl sodium sulfinate salts and diarylphosp
19 5.1.0]octanes) based on a domino reaction of fluorinated alpha-bromoenones with beta-amino alcohols w
21 with sterically unhindered monomers using a fluorinated aluminum salph complex with a substoichiomet
22 nt synthesis methods for the construction of fluorinated amines rely on air and moisture sensitive re
26 g reaction at the C-terminal position of the fluorinated amino acid was conveniently performed under
28 arting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines
31 eatment of [LFe3(PhPz)3OFe][OTf]2 (1) or its fluorinated analog [LFe3(F2ArPz)3OFe][OTf]2 (5) with iod
32 ilable by this method serve as precursors to fluorinated analogs of sugars, amino acids, and other va
33 active compounds, and their enantioenriched fluorinated analogs should be of great interest in the s
34 2) /H(2) mixture, in comparison with the non-fluorinated analogue (43 h(-1) ) and a Au/TiO(2) heterog
35 lso report the synthesis and reactivity of a fluorinated analogue and the structure of its covalently
36 od was applied for gram-scale synthesis of a fluorinated analogue of G protein-coupled receptor antag
37 tituted azobenzene core and its tetra- ortho-fluorinated analogue, we have developed a set of uni- an
38 lysaccharide, LPS), we designed a library of fluorinated analogues aiming for an [(18)F]-labeled radi
40 eaction has been applied to the synthesis of fluorinated analogues of diltiazem and tiazesim, both th
42 application, the synthesis of a new class of fluorinated analogues of the neuroprotective tripeptide
43 port a new elemental ionization method where fluorinated analytes are introduced into an ICP to produ
44 ms are explored by ab initio calculations of fluorinated and hydrogenated diamond (111) surfaces inte
45 ted backbones, which incorporate hydrophobic fluorinated and hydrophilic sulfonic acid functional gro
48 rination approach enables the development of fluorinated and radiofluorinated compounds that can be d
49 is, heteroaryl-substituted acetaldehydes are fluorinated and then directly engaged in enantioselectiv
52 blished C(sp(2))-H oxidative addition of the fluorinated arene as the selectivity-determining step of
53 en dictated by the innate electronics of the fluorinated arene, limiting the synthetic utility of the
54 otocatalytic C-F functionalization of highly fluorinated arenes is a powerful method for accessing fu
55 The mechanism of C(sp(2))-H borylation of fluorinated arenes with B(2)Pin(2) (Pin = pinacolato) ca
56 )benzene, as well as a C-F bond in partially fluorinated arenes, to furnish borylation products under
60 inding protein) using commercially available fluorinated aromatic amino acids and fluorinated precurs
61 n/Prophenol-catalyzed Mannich reaction using fluorinated aromatic ketones as nucleophilic partners fo
62 C-H bond silylation is facile with partially fluorinated aromatic substrates containing two ortho flu
64 rst racemization-stable helicene derivatives fluorinated at terminal rings, 1,2,3,4-tetrafluoro[6]hel
66 LCE to analogs prepared from classical and m-fluorinated azobenzene derivatives, the origin of the pe
67 e findings demonstrate that incorporation of fluorinated azobenzenes not just may alter photophysical
69 non-covalent interactions between side-chain fluorinated benzyl esters and main-chain terminal arenes
72 alternative strategy, we present the use of fluorinated boronic acid-appended pyridinium salts in co
73 cal fluorination, we prepared a series of 11 fluorinated branched-chain amino acids and evaluated the
75 oute to the stereoselective synthesis of key fluorinated building blocks of high value for medicinal
76 ted by gold species meet species with either fluorinated building blocks or fluorinating reagents, ne
81 e calculated transition states show that the fluorinated catalysts have stronger N-H...O and C-H...F
83 e fluorine effect on the reactivity of alpha-fluorinated CH acids has remained largely unexplored.
84 th a C(12)-hydrogenated chain and a C(4)F(9)-fluorinated chain emerged as the most potent additive ex
85 sts of a hydrogenated chain, and a partially fluorinated chain made of a propyl hydrogenated spacer t
88 atalytic enantioselective synthesis of alpha-fluorinated chiral tertiary alcohols from (hetero)aryl m
91 when lactate was the electron donor, and the fluorinated compound was the sole electron acceptor.
94 mulate TCE dechlorination, while some of the fluorinated compounds in certain AFFF formulations can i
95 measurements due to the rising importance of fluorinated compounds in pharmaceutical, environmental,
96 e the occurrence and identity of replacement fluorinated compounds in surface water and sediment of t
98 c-pressure elemental ionization method where fluorinated compounds separated by gas chromatography (G
99 ented, enabling the measurement of log P for fluorinated compounds with or without UV activity regard
100 n provide refinement of such models with the fluorinated compounds, which allows the explanation of t
101 as altered, shorter-chain PFAS and volatile fluorinated compounds, which were scrubbed effectively w
105 of determining the sorption kinetics of any fluorinated contaminant, this work also highlights the s
106 yields (19)F T2 NMR relaxation values of any fluorinated contaminant, which are among the most danger
108 arboxylate substrates, highly functionalized fluorinated cyclobutenes were obtained in excellent yiel
109 les, zinc phthalocyanine and its eight-times fluorinated derivative, with tunable energy levels based
110 ography (PET) radioligand [(11)C]RSR-056, 38 fluorinated derivatives were synthesized and tested by i
112 a C-F bond driven Diels-Alder reaction of a fluorinated dienophile and a borole that shows remarkabl
113 ow that we can achieve the production of the fluorinated diketide 2-fluoro-3-hydroxybutyrate at appro
115 ition of silylated nucleobases onto model C2-fluorinated dithioacetal substrates resulted in 1,2-syn
117 successfully applied them to characterize a fluorinated drug molecule, aprepitant, and its commercia
118 sitive spin for probing molecular details of fluorinated drug substances in solid formulations, due t
120 ither artificially preformed or derived from fluorinated electrolytes, and thus, the effect of the Li
121 high-concentration electrolytes, and highly fluorinated electrolytes, surface coatings that can form
122 oping, core-shell hollow host structure, and fluorinated ether electrolytes enables ultrastable Li st
123 In this work, we synthesize a new class of fluorinated ether electrolytes that combine the oxidativ
124 work we explore how an electrolyte additive (fluorinated ethylene carbonate - FEC) mediates the thick
125 e with fluoromalonyl-CoA allows insertion of fluorinated extender units at 43% of the yield of the wi
126 sease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [(19)F]) gas magnetic resonance
127 lic alphagammaalpha-tripeptides derived from fluorinated-furanoid sugar amino acid frameworks act as
128 onic structure calculations, we predict half-fluorinated GaBi honeycomb under tensile strain to harbo
129 e computed the electronic spectrum of a half-fluorinated GaBi nanoribbon with zigzag edges, which sho
130 n MR imaging during inhalation of a normoxic fluorinated gas mixture (perfluoropropane) and by using
132 rs took potentially confounding medications (fluorinated glucocorticoids and/or intravenous immunoglo
136 on to more economically friendly small-chain fluorinated groups is leading to a resurgence in the syn
137 nes, esters, nitriles, primary amides, alpha-fluorinated halo-acetates and perfluoroalkyl iodides.
143 bust bonds; consequently, the degradation of fluorinated hydrocarbons is exceptionally difficult.
145 n conjunction with our previous work on PNAs fluorinated in backbone and at N-terminus, it is evident
149 e and pyrazole was shown by the synthesis of fluorinated Isocarboxazid and Mepiprazole analogues.
152 phosphorylated, hydroxylated), and labeled (fluorinated, isotopically labeled) side chains to be add
153 ullerene organic solar cells (OSCs) based on fluorinated ITIC-Th1 electron acceptor and a wide-bandga
155 perfluoropolyether (PFPE), formulated these fluorinated ligands as aqueous nanoemulsions, and then m
156 This work demonstrates the usefulness of fluorinated ligands in designing molecule-selective and
157 ce four fluorine atoms from OFCP to generate fluorinated macrobicyclic compounds that display dual-tu
158 copolymers, providing facile access to semi-fluorinated macromolecules using a single methodology wi
159 ssing, fabrication, and functionalization of fluorinated materials with easy removal of the volatile
161 y for the fabrication of a chemically stable fluorinated metal-organic framework (MOF) material (NbOF
162 rate construction of a hydrolytically stable fluorinated metal-organic framework (MOF), NbOFFIVE-1-Ni
164 current work ortho-fluorinated (OF) and meta-fluorinated (MF) analogs of (18)F-para-fluorinated (PF)-
165 ayer and intralayer space of two-dimensional fluorinated MOFs for capturing acetylene from ethylene.
167 Comparison of different monolayer-forming fluorinated molecules reveals important differences in r
168 Various applications could benefit from new fluorinated molecules that offer chemical handles for qu
169 literature associated with the metabolism of fluorinated molecules, focusing on examples where the pr
170 We have been investigating the mechanism of fluorinated monomer insertion by three of the six differ
172 control of the polymerization of main chain fluorinated monomers as exemplified by vinylidene fluori
173 TREN (TREN = tris(2-aminoethyl amine)), semi-fluorinated monomers with side chains containing between
175 roof-of-principle level with a library of 13 fluorinated monosaccharides to a set of three carbohydra
176 d potentially problematic outcomes with some fluorinated motifs and are enhancing our understanding o
179 NT mimic structures via the self-assembly of fluorinated nanohoops, which can be synthesized in a sca
181 report the identification of two subsets of fluorinated nonxanthine A(2B) adenosine receptor antagon
182 minium ions were successfully generated from fluorinated O-acetyl-N,O-acetal l-tartaric acid derivati
183 ), we investigated in the current work ortho-fluorinated (OF) and meta-fluorinated (MF) analogs of (1
184 nents that uses a mobile liquid interface (a fluorinated oil) to reduce the adhesive forces between t
185 The development of new fluids has focused on fluorinated olefins, known as hydrofluoroolefins (HFOs),
187 afer and shows higher thromboresistance than fluorinated, omniphobic catheter surfaces, produced by p
188 and highly efficient OPV devices using both-fluorinated or both-nonfluorinated donor/acceptor blends
189 ite the growing interest in the synthesis of fluorinated organic compounds, few reactions are able to
193 Given the wide use and emerging concerns of fluorinated organics (e.g., per- and polyfluoroalkyl sub
196 The utility of Tf2NH-TiCl4 activation of fluorinated oxazaborolidines is documented by examples i
197 ional functionalities and the formation of 3-fluorinated oxindoles exhibiting an array of four adjace
199 meta-fluorinated (MF) analogs of (18)F-para-fluorinated (PF)-NB1, a 3-benzazepine-based radiofluorin
200 AFFF primarily containing electrochemically fluorinated PFASs for 10 days, followed by a 6 day depur
202 oxy groups as bioisosteric replacements of a fluorinated phenyl ring and properties such as lipophili
204 soft hydrogel as a conductor and an elastic fluorinated photoresist as the passivation insulation la
205 d was demonstrated on both unfluorinated and fluorinated plastics, demonstrating high tracer recoveri
206 rse phase HPLC show higher hydrophobicity of fluorinated PNA oligomers, dependent on the number and s
207 ne and at N-terminus, it is evident that the fluorinated PNAs have potential to emerge as a new class
209 the authors show a highly efficient route to fluorinated poly(aryl thioethers) via an organocatalyzed
210 erein, we report a highly efficient route to fluorinated poly(aryl thioethers) via an organocatalyzed
211 remarkable reactivity enable rapid access to fluorinated poly(aryl thioethers), but also opens new av
212 of the volatile catalyst and TMSF byproducts.Fluorinated poly(aryl thioethers), unlike their poly(ary
213 can be used as a monomer in vivo to produce fluorinated poly(hydroxyalkanoate) (PHA) bioplastics wit
214 ize polymer mechanochemistry to synthesize a fluorinated polyacetylene, a long-sought-after air-stabl
216 ated by laser-desorption of the near-planar, fluorinated polycyclic aromatic hydrocarbon (PAH), C60H2
217 assembling giant surfactants consisting of a fluorinated polyhedral oligomeric silsesquioxane (FPOSS)
219 luorocarbon emulsion polyplexes containing a fluorinated polymeric CXCR4 antagonist (F-PAMD) as an si
220 cleaved from the backbone of the side-chain fluorinated polymers coated on the fibers and then trans
221 hat, among others, degradation of side-chain fluorinated polymers in the environment and landfills ca
224 n of these molecules, leading to a series of fluorinated polysubstituted imidazoles in gram scale.
225 ailable fluorinated aromatic amino acids and fluorinated precursors as example applications of the me
227 egarding the toxicity and adverse effects of fluorinated processing aids on humans and the environmen
231 analogues thus expand the scope of available fluorinated proline analogues as tools to tailor proline
233 uous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed
235 ave led to the ever-increasing popularity of fluorinated pyrazoles in various areas of science are di
237 w, analysis of novel synthetic approaches to fluorinated pyrazoles that appeared in recent years is p
241 observed in the presence of an electrophilic fluorinating reagent containing a weak N-F bond despite
244 ing materials and effectively replaces harsh fluorinating reagents by a combination of oxalyl chlorid
246 s with either fluorinated building blocks or fluorinating reagents, new opportunities arise for the d
249 lohexyl and linear aliphatic amines could be fluorinated selectively at the gamma-methyl and methylen
251 his, two cholesterol analogs with truncated, fluorinated side chains have been synthesized and shown
255 ce for forming cobalt-aryl bonds adjacent to fluorinated sites are the origin of the high regioselect
256 ne illustrates the potential ease with which fluorinated small molecules relevant to neuroscience dru
257 g the potential to generate a broad range of fluorinated small-molecule targets in living cells.
258 of the HFC solvent in tandem with the highly fluorinated, solubilizing, weakly coordinating [Al(OR(f)
259 y simply modulating the starting peptide and fluorinated solvent concentrations during synthesis.
261 omniphobic surface that can super-repel even fluorinated solvents, which highly wet all materials.
262 (19)F long-lived states in suitably designed fluorinated spy molecules allows one to perform competit
264 s is observed and calculated for planar ring-fluorinated stilbenes, trans-2,3,5,6,2',3',5',6'-octoflu
265 ) and difluoromethoxy (OCF(2) H) groups are fluorinated structural motifs that exhibit unique physic
267 luoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regul
269 yl)pyrrolidin-2-one derivatives, bearing the fluorinated substituent on a tetrasubstituted carbon.
270 presence of the highly electron-withdrawing fluorinated substituent, cyclic alpha-trifluoromethylate
271 e chemo- and stereoselective construction of fluorinated substituents, such as the trifluoromethyl (C
272 n, we employed (19)F NMR in conjunction with fluorinated substrate analogs to directly measure pK(a)
273 d herein, several alternative substrates and fluorinated substrate analogs were prepared to investiga
275 describe the field of reactions of partially fluorinated substrates with transition metal atoms, ions
277 e of substrates to give medicinally relevant fluorinated substructures with complete regiocontrol.
278 can be employed to synthesize unprecedented fluorinated sugars and steroids, and it can also be appl
279 lity, reactivity and interaction features of fluorinated sugars are described, as well as their appli
281 nly describes a new synthetic application of fluorinated sulfones, but also provides a new route to f
282 This work demonstrated the utilization of fluorinated sulfur ylides as versatile reagents for Core
283 ane at room temperature, gives rise to novel fluorinated tetrahydrofuran-fused tetrahydroquinolines i
286 for medicinal chemists to access a range of fluorinated therapeutic candidates with distinct physico
287 a wide bandgap polymer donor PM6 containing fluorinated thienyl benzodithiophene (BDT-2F) unit and a
288 The antiparallel self-assembled pore of the fluorinated tripeptides illustrates the selective ion-tr
290 metric properties of urea and thiourea-based fluorinated tripodal receptors are explored here for the
292 The aims of this study were to screen novel, fluorinated, TSPO radiotracers for susceptibility to the
293 n and metabolism of [(18)F]F-HPA-12, a radio-fluorinated version of the ceramide analog N-(3-hydroxy-
295 this protocol, we quantified the amount of a fluorinated xenobiotic (heptafluorobutyric acid, HFBA) i
299 onance imaging (iCEST MRI) and TF-BAPTA as a fluorinated Zn-binding probe with micromolar sensitivity
300 stances were tentatively identified, and non-fluorinated zwitterionic betaine compounds, which are co