ライフサイエンスコーパス: fluorine

1 ntaining either bromine or iodine instead of fluorine.

2 rs by substituting their 2'-OH group with 2'-fluorine.

3 ening as well as hydrogen fluoride and total fluorine.

4 formula generation for compounds containing fluorine.

5 dient-echo MRI was performed to quantify MH, fluorine 18 ((18)F) flortaucipir (AV-1451) PET was perfo

6 Background National guidelines endorse fluorine 18 ((18)F) fluciclovine PET/CT for the detectio

7 cyte-M-CSF (GM-CSF) and its implications for fluorine 18 ((18)F) fluorodeoxyglucose (FDG) imaging of

8 sessment of tissue-specific insulin-mediated fluorine 18 ((18)F) fluorodeoxyglucose (FDG) influx rate

9 D), mild cognitive impairment, or neither at fluorine 18 ((18)F) fluorodeoxyglucose (FDG) PET of the

10 onents of glucose metabolism, exemplified by fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron em

11 Purpose To assess whether dynamic fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron em

12 iodine studies, as well as PET studies using fluorine 18 ((18)F) fluorodeoxyglucose, gallium 68 ((68)

13 that positron emission tomography (PET) with fluorine 18 ((18)F) fluorthanatrace (FTT) depicts activa

14 Background Fluorine 18 ((18)F)-fluorodeoxyglucose (FDG) PET/CT is a

15 out tumor metabolism, which is measured with fluorine 18 fluorodeoxyglucose (FDG) PET.

16 s and possible CS who were investigated with fluorine 18 fluorodeoxyglucose (FDG) PET/CT and cardiac

17 he correlation between metabolic activity at fluorine 18 fluorodeoxyglucose (FDG) positron emission t

18 Purpose To assess the diagnostic accuracy of fluorine 18 fluorodeoxyglucose (FDG) positron emission t

19 It has been reported that fluorine 18 fluorodeoxyglucose (FDG) positron emission t

20 Conclusion By using fluorine 18 fluorodeoxyglucose PET of the brain, a deep

21 public data set of multimodality images (CT, fluorine 18 fluorodeoxyglucose PET, and T1-weighted MRI)

22 t (Fig 1), bilateral breast MRI (Fig 2), and fluorine 18 fluorodeoxyglucose PET/CT (Fig 3) were perfo

23 ure to compare the diagnostic performance of fluorine 18 fluorodeoxyglucose PET/CT and diffusion-weig

24 ted MRI is comparable or superior to that of fluorine 18 fluorodeoxyglucose PET/CT in the differentia

25 serial cross-sectional imaging (CT, MRI, or fluorine 18 fluorodeoxyglucose PET/CT) between April 201

26 -grade tumors, they were also evaluated with fluorine 18 fluorodeoxyglucose PET/CT, with imaging find

27 ighted MRI showed significant agreement with fluorine 18 fluorodeoxyglucose PET/MRI for treatment res

28 ing of malignancy, bone marrow activity from fluorine 18-fluorodeoxyglucose (FDG) PET may be informat

29 onclusion A model that includes pretreatment fluorine 18-fluorodeoxyglucose PET texture features from

30 anatomic localization and classification of fluorine 18-fluorodeoxyglucose PET uptake patterns in fo

31 Molecules labeled with fluorine-18 ((18)F) are used in positron emission tomogr

32 Here, we disclose a mild method for the fluorine-18 ((18)F)-fluorination of aromatic C-H bonds b

33 Fluorine-18 (t(1/2) = 109.8 min) is a major radionuclide

34 We compared fluorine-18 [(18)F]-Florbetapir uptake in the 5xFAD brai

35 galectin-3 inhibitors were radiolabeled with fluorine-18 and used as surrogate PET tracers of TD139 a

36 zinone derivatives labeled with carbon-11 or fluorine-18 as PDE5-specific PET tracers.

37 ing optimal interpretative criteria (IC) for Fluorine-18 fluorodeoxyglucose (FDG) Positron Emission T

38 Fluorine-18 flurpiridaz is a novel positron emission tom

39 sthetic group was synthesized to incorporate fluorine-18 for PET imaging.

40 lled modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building

41 by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a b

42 Fluorine-18 is the most widely used radioisotope for PET

43 Fluorine-18 labeling of favipiravir was achieved in a on

44 overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.

45 or selection of a synthetic approach for new fluorine-18 labelled PET tracers.

46 [(18)F]PF-NB1 is a promising fluorine-18 PET tracer for imaging the GluN2B subunits o

47 (PTC) (e.g. kryptofix 2.2.2) associated with fluorine-18 preparation has been found to be detrimental

48 The new procedures are effective for fluorine-18 radiochemistry and, as proof of concept, hav

49 challenging to synthesize using traditional fluorine-18 radiochemistry.

50 series of candidates, radiolabeled them with fluorine-18 radioisotope, and determined their physicoch

51 Fluorine-18 radiolabeling typically includes several con

52 ctively targeting the ghrelin receptor using fluorine-18 tagged entities would allow localization and

53 The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomogra

54 Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission

55 investigate whether the magnitude of in vivo fluorine 19 ((19)F) magnetic resonance (MR) imaging sign

56 Background MRI with fluorine 19 ((19)F) probes has shown an ability to track

57 by using free-breathing dynamic fluorinated (fluorine 19 [(19)F]) gas magnetic resonance (MR) imaging

58 arvested at day 2, 7 and 14 for whole-sample fluorine-19 ((19)F) NMR to quantitatively measure the pr

59 2 levels were measured on days 0 and 7 using fluorine-19 magnetic resonance relaxometry and a fiber-o

60 Fluorine-19 MRI was used to determine the locations of c

61 in quantifiable PFAS and extractable organic fluorine (a proxy for unquantified PFAS).

62 le, ionic, and precursor fraction, and total fluorine after extraction indicate that mass balance was

63 Fluorine also enables assignment of tautomeric states in

64 Total organic fluorine analysis proved useful for PFAS-loaded GAC in s

65 While fluorine and chlorine atoms are often added to enhance p

66 ional Theory to investigate the influence of fluorine and chlorine doping on the electronic propertie

67 The significance of fluorine and fluoroalkyl substitution and its prominent

68 erts a stereoelectronic effect comparable to fluorine and introduce oxime ligation as a tool for the

69 Various fluorine and Ln-containing high-mass fragments were obse

70 ists have exploited the unique properties of fluorine and produced countless fluoro-organic compounds

71 stereogenic centers bearing moieties such as fluorine and the trifluoromethyl group.

72 and sulfur atoms, weak hydrogen bonding with fluorine as acceptor, and different types of dipolar int

73 a facile approach for such analyses by using fluorine as an elemental tag.

74 Moreover, fluorine assistance has enabled a mass interference betw

75 Using a fluorine mass balance, 77% of the fluorine associated with the parent PFOA and 58% of the

76 sociated with the parent PFOA and 58% of the fluorine associated with the parent PFOS were identified

77 s sialidases and hNEU2, compounds with axial fluorine at C-3 were better inhibitors (up to 100-fold)

78 arch was extended to nicotinamides, a single fluorine atom addition was found to significantly enhanc

79 reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products.

80 from a destabilizing interaction between the fluorine atom and phosphate anion during general acid-ca

81 Tertiary stereogenic centres containing one fluorine atom are valuable for medicinal chemistry becau

82 inkage) was ascertained for congeners with a fluorine atom at C-6.

83 A fluorine atom introduced in the para-position of phenyla

84 Depending on the carbon and fluorine atom number, the fluoroalkylamines were shown t

85 f a novel DBO, ANT3310, which uniquely has a fluorine atom replacing the carboxamide and stands apart

86 fluorobenzonitrile (2) substituting its para-fluorine atom to form 2-(4-cyanotetrafluorophenyl)-4,4,5

87 of the enantioselective substitution of one fluorine atom to form a stereogenic centre(5,6).

88 containing the diamine ring structure and a fluorine atom were subsequently analyzed.

89 dox protocol for the replacement of a single fluorine atom with hydrogen in electron-deficient triflu

90 icinal stereogenic centers, one containing a fluorine atom, by forming the connecting carbon-carbon b

91 tically exchanging every hydroxyl group by a fluorine atom, we developed a strategy combining chemica

92 ms resulting from the difference of a single fluorine atom.

93 ally substituted with hydrogen (H12SubPc) or fluorine atoms (F12SubPc).

94 ols and molecular oxygen, which retains both fluorine atoms and provides beta-phenoxy-beta,beta-diflu

95 Fluorine atoms are similar in size to hydrogen atoms but

96 zene ring with fluorine scan of mono- or bis-fluorine atoms around DRV's scaffold.

97 , novel BP ethers armed with a total of four fluorine atoms for their subsequent analysis by EI-GC-MS

98 s of consensus sequence YXCXXC displace four fluorine atoms from OFCP to generate fluorinated macrobi

99 The smaller fluorine atoms in [Fe(dftpy)2](2+) enable spin crossover

100 ale, which involves a rapid incorporation of fluorine atoms in an exotic photochemical cascade whose

101 geometric deformation and/or the rotation of fluorine atoms in anionic sites, thereby enabling ZU-61

102 Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (

103 orbital level: (1) increasing the number of fluorine atoms lowers the energy of the pi*(M identical

104 M(+) interactions between negatively charged fluorine atoms of R134a and positively charged metal ato

105 hesis of perhexiline analogues incorporating fluorine atoms onto the cyclohexyl ring(s) provided a ra

106 side chains containing between three and 21 fluorine atoms readily polymerize under controlled condi

107 When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin

108 This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-ca

109 ectron withdrawal induced by the neighboring fluorine atoms.

110 Despite the notion of fluorine being a poor acceptor, computational and IR stu

111 dation because of the strength of the carbon-fluorine bond and the need to achieve low nanogram per l

112 The carbon-fluorine bond engenders distinctive physicochemical prop

113 Ab initio calculations suggest that carbon-fluorine bond formation proceeds via a concerted transit

114 The carbon-fluorine bond functionalization reaction is highly selec

115 indicating that an oxidative carbon-chlorine/fluorine bond scission has occurred during the autocatal

116 re able to break HFPO-DA's persistent carbon-fluorine bonds.

117 rings of five to six atoms, and a variety of fluorine, bromine, and hydride leaving groups.

118 le precursors (TOP) ~10(2)-10(5) ng/L, total fluorine by combustion ion chromatography ~10(2) to 5 x

119 However, the carbon-fluorine (C-F) bond is among the most chemically robust

120 ivations of carbon-bromine (C-Br) and carbon-fluorine (C-F) bonds and cyclodehydrogenation.

121 etrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group(3).

122 emonstrate here that, somewhat surprisingly, fluorine can be incorporated into the bulk of disordered

123 dopa analogues and show that the presence of fluorine can further fix the position of the ligand in t

124 + RY with X and Y denoting the halogen atoms fluorine, chlorine and iodine.

125 thesized a library of 36 peptoids containing fluorine, chlorine, bromine and iodine atoms, which vary

126 emical properties of the four halogen atoms (fluorine, chlorine, bromine, and iodine) and the diversi

127 e, and ketones, aromatic residues containing fluorine, chlorine, bromine, NO(2), methyl, dimethyl, an

128 (2)), nitrogen-doped (N_TiO(2)) and nitrogen-fluorine co-doped titanium dioxide nanoparticles (NF_TiO

129 HFG) is demonstrated whose relative hydrogen/fluorine concentrations can be tailored between the extr

130 ples, EOF was not significantly greater than fluorine concentrations derived from sum target PFASs.

131 own organofluorine accounted for <1% in most fluorine-containing AFFFs, and it was confirmed that the

132 Herein, we report new fluorine-containing aromatic monomers that can control p

133 ntrols the configuration at the nucleophilic fluorine-containing carbon.

134 yl esters are useful for the construction of fluorine-containing carboxylic acid derivatives.

135 kylammonium cyanide and phenoxide salts) and fluorine-containing electrophiles (e.g., acid fluoride,

136 ng structural properties of a broad range of fluorine-containing materials.

137 previously unrecognized interaction between fluorine-containing motifs and groups or molecules conta

138 vant molecules or pharmaceuticals possessing fluorine-containing pharmacophores with their targets.

139 ties across a variety of fields that exploit fluorine-containing polymers for tailored bulk, interfac

140 he research, development, and application of fluorine-containing reagents in protein structural studi

141 In this Minireview, we describe several fluorine-containing reagents that can be applied in stru

142 pped with novel structural motifs, including fluorine-containing residues, 12,13-difluorocyclopropyl

143 ontain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extr

144 oroalkanes on the carbon chain length as the fluorine content decreases and the interaction geometrie

145 measuring the sign and magnitude for proton-fluorine couplings (J(HF)) from major and minor isomer p

146 Proton-fluorine couplings ranging from 51.5 to -2.6 Hz could be

147 les suggest how the stereoelectronics of the fluorine-cysteine interaction, rather than sterics alone

148 of the carbon chain, as well as one- and two-fluorine 'deletions' within perfluoroalkyl groups.

149 Among the numerous screening techniques, fluorine-detected NMR has gained popularity owing to its

150 ion of targeted PFAS analysis, EOF and total fluorine determination, and suspect screening.

151 :6',2''-Terpyridyl (tpy) ligands modified by fluorine (dftpy), chlorine (dctpy), or bromine (dbtpy) s

152 cidated the significant influence of the one-fluorine difference on the corresponding intermediates,

153 Additionally, the presence of fluorine differentiates between C-H bonds at different p

154 Fluorine does not belong to the pool of chemical element

155 Fluorine doped tin oxide (FTO) electrochemical immunosen

156 en-doped graphene/gold nanoparticles (AuNPs)/fluorine doped tin oxide (FTO) glass electrode.

157 xide/platinum-palladium (ZnO/Pt-Pd) modified fluorine doped tin oxide (FTO) glass plate was fabricate

158 graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO).

159 il, the sensing layer for CEA consisted of a Fluorine-doped Tin Oxide (FTO) conductive glass substrat

160 TeNPs were successfully electrodeposited on fluorine-doped tin oxide (FTO) substrate using [BMIM][Ac

161 Glass/fluorine-doped tin oxide (FTO) substrates have been used

162 ide and nickel hydroxide electrodeposited on fluorine-doped tin oxide coated glass slide (CdS/Ni(OH)(

163 1006, containing formate dehydrogenase, on a fluorine-doped tin oxide glass electrode modified with C

164 Furthermore, (19)F NMR identifies selective fluorine dynamics in K(16)[Mo(3)O(4)F(9)](2)[TiF(6)](3).

165 t mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisition) methodology

166 roaryl cobalt intermediates due to the ortho fluorine effect, a phenomenon whereby ortho fluorine sub

167 hat unusually double beta-F eliminations and fluorine effect-induced regioselective reductive elimina

168 Fluorine elemental analysis using inductively coupled pl

169 thy control individuals (n = 20) underwent a fluorine F 18-labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-

170 been designed and synthesized by introducing fluorine (F) atoms onto the end-capping group 1,1-dicyan

171 We report that activation of the carbon (C)-fluorine (F) bond is a reliable and versatile tool enabl

172 eals a large diffuse negative density on the fluorine face and a focused positive density on the hydr

173 in perfluoroalkane dimers mainly stems from fluorine-fluorine interactions.

174 A), are not placed into the context of total fluorine for papers and textiles.

175 Despite the many advantages provided by fluorine for tuning key molecular properties, it is rare

176 it was confirmed that the foams marketed as fluorine-free did not contain measurable amounts of orga

177 oams marketed as containing PFASs as well as fluorine-free foams were included.

178 icating attenuation by biodegradation of the fluorine-free moiety, supported by the observation of li

179 The sum fluorine from targeted analyses accounted for 54% of the

180 step in the determining regioselectivity in fluorine functionalization is fluoride fragmentation fro

181 r Waals heterostructures of graphene and its fluorine-functionalized derivative is presented.

182 thin films of Cu, Zr, and ZrCuAg alloy in a fluorine gas atmosphere provided by an in situ gas injec

183 to water vapor and over 2 times faster when fluorine gas was supplied.

184 vapor coinjection and 510 times when using a fluorine gas).

185 tive anode materials, with in situ generated fluorine gas, by using a fluoropolymer, CYTOP, as the pr

186 r", avoiding direct handling of highly toxic fluorine gas.

187 ns as well as under an exposure to water and fluorine gases.

188 ifluoromethanesulfonamide (2)) revealed that fluorine gauche effects are a function of ionization.

189 Fluorine has become an important element for the design

190 However, efficient ionization of fluorine has been an ongoing challenge.

191 (2)), the precursor to hydrogen fluoride and fluorine, has embarked on an industrial initiative to lo

192 ene group, tertiary stereocentres containing fluorine have not yet been constructed by the analogous

193 of heptafluoro-2-methylpentene in which five fluorines have been selectively replaced with hydrogens.

194 These previously unrecognized fluorine-heteroatom interactions likely play a significa

195 ructural and physicochemical properties that fluorine imparts.

196 The applications of fluorine in drug design continue to expand, facilitated

197 h compounds are lacking due to the rarity of fluorine in nature.

198 accounted for 54% of the extractable organic fluorine in sediment, and 9-108% in biota.

199 Introduction of a m-fluorine in the benzyl moiety eventually led to the disc

200 ntagonism profile and (ii) introduction of a fluorine in the piperidine ring to reduce its basicity,

201 First, we showe that fluorine incorporation into SH3 causes only minor struct

202 However, enzymatic methods of fluorine incorporation into such compounds are lacking d

203 Fluorine incorporation is ideally suited to many NMR tec

204 ence reduction on the anion site, offered by fluorine incorporation, opens up significant opportuniti

205 , focusing on examples where the presence of fluorine influences the metabolic profile.

206 re is considerable interest in incorporating fluorine into agrochemicals and pharmaceuticals to impro

207 The incorporation of fluorine into amino acids established a completely new c

208 to many NMR techniques, and incorporation of fluorine into proteins and fragment libraries for drug d

209 Fluorine is a key element in the synthesis of molecules

210 Here, the authors show that incorporating fluorine is an effective strategy which substantially im

211 Fluorine is an element with unusual properties that has

212 Fluorine is known to promote ortho-C-H metalation.

213 mical properties through the introduction of fluorine is of paramount importance in medicinal chemist

214 al origin of this distinction was probed via fluorine K-edge X-ray absorption spectroscopy.

215 Fluorine-labeled analogs, that could be developed as PET

216 ilibrium thermodynamics for the binding of a fluorine-labeled Src homology 3 (SH3) protein domain to

217 geting of an anti-PD-L1 adnectin after (18)F-fluorine labeling.

218 Rather, the fluorine lone pairs of the CF(4) often act as an electro

219 f a bioartificial pancreas, we have combined fluorine magnetic resonance imaging and unsupervised mac

220 from the Northern Hemisphere, we performed a fluorine mass balance on liver tissues from 11 different

221 Using a fluorine mass balance, 77% of the fluorine associated wi

222 ithin analytical error) of the initial total fluorine measured by PIGE.

223 there is an increasing demand for ppb level fluorine measurements due to the rising importance of fl

224 sible or IR irradiation rearranges via a 1,2-fluorine migration from boron to carbon.

225 stabilizes the zwitterion and suppresses the fluorine migration, thus providing a convenient and effi

226 itor analogue with a single-atom hydrogen-to-fluorine modification can selectively target a spastin a

227 Fluorine MRI data were acquired at the resonance frequen

228 Results Fluorine MRI demonstrated high sensitivity and high spec

229 The fluorine nanoemulsion is a clinically applicable cell la

230 MS/MS, and precursors were compared to total fluorine (nmol F/cm(2)) determined by particle-induced g

231 Fluorine NMR analysis of 2a-e demonstrates predominant f

232 We tested this idea using fluorine NMR and DNA containing 2'-fluoro-substituted nu

233 Ligand-based fluorine NMR screening has gained popularity in drug dis

234 lity of this device for nanoscale proton and fluorine NMR spectroscopy, as well as for the detection

235 n agreement with other scales are oxygen and fluorine, now somewhat less electronegative, but in bett

236 h a variety of nitrogen, oxygen, sulfur, and fluorine nucleophiles afforded chiral 3,4-disubstituted

237 pi* carbon atom in benzene ring attached to fluorine of levofloxacin was investigated by C K-edge X-

238 raction to exist between the electronegative fluorines of the CF(3) group and the ring oxygen in this

239 roviding deeper insights into the effects of fluorine on metabolic pathways, distribution, and dispos

240 Detection limits of 3.5-19.4 pg of fluorine on-column are obtained using the reported GC-DB

241 PhF2,6), which differ by the arrangement of fluorines on the phenylene structural unit, were designe

242 Fluorine- or Lewis-acid-assisted formation of reactive i

243 rved during 100 day incubations, while total fluorine (organic plus fluoride) remained constant throu

244 th distinct resonance frequencies and a high fluorine payload were characterized in terms of size, st

245 ntained approximately 240 and 1300 mug total fluorine per square meter (mug F/m(2)) were released fro

246 should be relevant to drug discovery, where fluorine plays a prominent role.

247 Fluorine positions in the precursor structure unambiguou

248 sensitivity for dual-probe imaging, optimal fluorine probes are needed.

249 Fluorine recovery of 47 to 117% was obtained in six SB s

250 at was generated with the same high ortho-to-fluorine regioselectivity associated with the overall ca

251 nd the origins of the uniquely high ortho-to-fluorine regioselectivity observed in these reactions.

252 ned by PIGE, indicating that the majority of fluorine remains associated with the papers and textiles

253 trating the potency enhancing effects of the fluorine residues and the aziridinyl moiety within the s

254 Near-uniform fluorine response factors are obtained for a wide range

255 Taking advantage of fluorine's unique gauche effect as a strategy for molecu

256 e (or -oxazole), and/or P1-benzene ring with fluorine scan of mono- or bis-fluorine atoms around DRV'

257 developed, as evidenced by the high ortho-to-fluorine selectivity observed in the C(sp(2))-H borylati

258 s and are enhancing our understanding of how fluorine should be deployed.

259 In vivo high fluorine signal was observed in the bone marrow (SNR > 1

260 Fluorine signal-to-noise ratio (SNR) was compared by usi

261 ).2H(2)O (3) and to assign the nine distinct fluorine sites in the oxyfluoride clusters.

262 but have a single hydrogen substituted for a fluorine someplace in their structure.

263 onstrated with mineral fluoride both as only fluorine source (i.e. substrate of the pathway) and as i

264 From just this simple fluorine source, difluorocarbene transfer enables access

265 luoroacetic acid as a stable and inexpensive fluorine source.

266 s and pyrrolidines contain a tertiary carbon-fluorine stereocenter.

267 beta-fluoro amines bearing tetrasubstituted fluorine stereocenters is described via a direct Zn/ProP

268 talyst allows the control of tertiary carbon-fluorine stereocenters with up to 96% ee.

269 sialidase inhibition was affected by the C-3 fluorine stereochemistry and derivatization at C-5 and/o

270 palladium have allowed the installation of a fluorine substituent at C(sp(2) ) and C(sp(3) ) sites, e

271 -F bond, thus, demonstrating the role of the fluorine substituent in stabilizing the U-shaped conform

272 ted aromatic substrates containing two ortho fluorine substituents adjacent to the C-H bond and 1,2,3

273 The addition of fluorine substituents creates large electron affinities

274 Fluorine substituents gave rise to increasingly more sta

275 lboronates (Ar(F)-Bpin) containing two ortho-fluorine substituents is very difficult, as the reaction

276 fluorine effect, a phenomenon whereby ortho fluorine substituents stabilize transition metal-carbon

277 am in which the positions of the bromine and fluorine substituents were varied.

278 Using 2'-deoxy-2'-fluorine substituted cytidines, we show that a 2'-endo s

279 ehydes for the preparation of phosphorus and fluorine substituted gamma-lactam derivatives is present

280 synthesized, and evaluated a novel series of fluorine-substituted cyclohexene analogues, thereby iden

281 e of mechanism in which chain extension with fluorine-substituted extender units switches largely to

282 Hydroxyl-by-fluorine substitution has proven its merits for chemical

283 A simple fluorine substitution to phenethylammonium for the organ

284 sulfate with differing mixes of hydrogen and fluorine substitution was also observed.

285 ation are strengthened with increasing ortho fluorine substitution.

286 oly(hydroxyalkanoate) (PHA) bioplastics with fluorine substitutions ranging from around 5-15 %.

287 s, nontarget screening analysis (NTA), total fluorine (TF) analysis, and inorganic fluoride (IF) anal

288 ldehydes, with exclusive (3S)-selectivity at fluorine that is rationalized by DFT calculations on a m

289 tionally observed for hydrodefluorination of fluorines that can undergo intramolecular hydrogen bonds

290 Addition of fluorine to organic structures represents a unique strat

291 s simulations show that the proximity of the fluorine to the diamine ring hinders the dihedral angle

292 bility of a range of anions, some containing fluorine, to block (99m)TcO4(-) uptake in hNIS-expressin

293 ctively, and (3)J(obs) represents the proton-fluorine vicinal coupling constant observed at the midpo

294 acids), (3)J(AH) and (3)J(A) are the proton-fluorine vicinal coupling constants of the standard acid

295 The bulk of the remaining fluorine was determined to be sorbed to reactor walls an

296 The fate of PFAS and fluorine was quantified with soil and emission analyses,

297 Fluorine, well-known to exert profound effects on the ph

298 ide to activate the involved substitution of fluorine, which leads to high yields through rapid react

299 lver reactor that retains carbon, oxygen and fluorine whilst releasing hydrogen gas for stable isotop

300 dinary enhancement of the oxidizing power of fluorine with strong Lewis acids had previously not been