ライフサイエンスコーパス: fluorine atom

1 ne carbon atom as well as the absence of the fluorine atom.

2 diate containing an aromatic nitro-activated fluorine atom.

3 entre bound to a trifluoromethyl group and a fluorine atom.

4 ms resulting from the difference of a single fluorine atom.

5 oselective and directed by the presence of a fluorine atom.

6 for a drug molecule to include at least one fluorine atom.

7 allosteric binding site and the addition of fluorine atoms.

8 axial arrangement of the C2' and C3' vicinal fluorine atoms.

9 1a lacks the stabilizing effect of the three fluorine atoms.

10 9-11 when the ArF group possesses two ortho fluorine atoms.

11 uents, and the positions and number of vinyl fluorine atoms.

12 ckbone hydrogen bonding), are substituted by fluorine atoms.

13 e center of the bilayer corresponding to the fluorine atoms.

14 se relaxation properties, compared to single fluorine atoms.

15 ectron withdrawal induced by the neighboring fluorine atoms.

16 rcially available compounds with one or more fluorine atoms.

17 entirely dictated by the substitution of the fluorine atoms.

18 despite the lack of strongly electronegative fluorine atoms.

19 cement of the bromine atom in 4BP-TQS with a fluorine atom [4FP-TQS (4-(4-fluorophenyl)-3a,4,5,9b-tet

20 represents a rare example of a carbon linked fluorine atom acting as a hydrogen bond acceptor.

21 arch was extended to nicotinamides, a single fluorine atom addition was found to significantly enhanc

22 Tetrahydropyran acetals bearing a fluorine atom adjacent to the acetal carbon atom can und

23 tivity was further enhanced by addition of a fluorine atom adjacent to the phenolic hydroxyl group as

24 The electron-withdrawing fluorine atoms allowed us to measure peptide binding dow

25 Moreover, incorporating a fluorine atom and alkyl peroxy group at the C4 and C3 po

26 s a possible hydrogen bonding between the 3'-fluorine atom and Asp185, which correlates with its pote

27 with a significant -ve charge density on the fluorine atom and correspondingly a +ve charge density o

28 reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products.

29 timal RNA affinities were observed with a 3'-fluorine atom and nucleobase in a trans-diaxial orientat

30 from a destabilizing interaction between the fluorine atom and phosphate anion during general acid-ca

31 9.8 +/- 0.5 A, and the distance between the fluorine atom and the 3'-methine carbon was 10.3 +/- 0.5

32 clo-DNA series, no short contact between the fluorine atom and the H6 of the base, reminiscent of a n

33 We also introduced fluorine atoms and long alkyl chains into polymer backbo

34 itional hydrogen-bonding interaction between fluorine atoms and proton carriers (H(3)PO(4)), the CTF-

35 ols and molecular oxygen, which retains both fluorine atoms and provides beta-phenoxy-beta,beta-diflu

36 ric interaction between one of the two ortho fluorine atoms and the methyl group [-N=C(CH3)] on the k

37 een the geminal hydroxyl groups, the geminal fluorine atoms, and the active-site aspartate residues.

38 ues by systematically changing the number of fluorine atoms, and we determined high-resolution crysta

39 sten centers induces an upfield shift of the fluorine atom appended on the arylimido group, the exten

40 nes induces distinct (19)F NMR shifts of the fluorine atoms appended on the ligand that defines a chi

41 Tertiary stereogenic centres containing one fluorine atom are valuable for medicinal chemistry becau

42 uted) is described in which the nitrogen and fluorine atoms are attached to sp(3)-hybridized carbons.

43 Molecules that contain one or more fluorine atoms are crucial to drug discovery.

44 much as a factor of 2, depending on how the fluorine atoms are distributed within the molecule.

45 Fluorine atoms are known to display scalar (19)F-(19)F c

46 Fluorine atoms are similar in size to hydrogen atoms but

47 zene ring with fluorine scan of mono- or bis-fluorine atoms around DRV's scaffold.

48 ting (19)F-(19)F cross peaks associated with fluorine atoms as far as ~10 angstroms apart.

49 are attributed to steric interactions of the fluorine atoms associated with 5-FTrp146 and 5-FTrp214 i

50 ved in the active site complex, with the CXF fluorine atom at a approximately 3 A (bonding) distance

51 inkage) was ascertained for congeners with a fluorine atom at C-6.

52 Second, the introduction of a fluorine atom at C3 also interrupts the sigmatropic shif

53 Introduction of a fluorine atom at C3 of 3DUrd shifts its antimetabolic ac

54 rected toward the common area defined by the fluorine atom at position 6 and the beta-ketoacid moiety

55 The addition of an electronegative fluorine atom at the 2-position of dI lowered the oligon

56 interest to investigate the influence of the fluorine atom at the 3'-position.

57 n of the benzylamine moiety, combined with a fluorine atom at the 3-position of the aniline ring, we

58 esults suggest that introduction of a single fluorine atom at the beta,gamma-bridging carbon atom of

59 e dinucleotide (TAD) analogue 7 containing a fluorine atom at the C2' arabino configuration of the ad

60 van der Waals semiconductor, introduction of fluorine atoms at the (2,6) position of the phenyl ring

61 ine is a modified cytidine analog having two fluorine atoms at the 2'-position of the ribose ring.

62 The presence of two fluorine atoms at the beta-position of the enamide moiet

63 ine atoms in the molecule, (2) the number of fluorine atoms at the C2 and C6 positions, and (3) the n

64 One electron-deficient linker has four fluorine atoms attached directly to a thiophenyl unit.

65 ch is facilitated by the presence of several fluorine atoms attached the ring.

66 iffers by the number and position of pendant fluorine atoms attached to the backbone.

67 haped primary coordination of xenon to three fluorine atoms (AX3E2 VSEPR arrangement) and a secondary

68 The fluorine atom-benzene complex is predicted to be a sigma

69 racterized by a greater number of carbon and fluorine atoms but fewer chlorine and bromine atoms may

70 trometry studies confirm the displacement of fluorine atoms by hydrogen.

71 icinal stereogenic centers, one containing a fluorine atom, by forming the connecting carbon-carbon b

72 One approach entails incorporation of a fluorine atom (C-F bond formation) or an organofluorine

73 n between a phenanthridinyl C-H and a single fluorine atom can be observed by (19)F-(1)H NOE NMR spec

74 ecause the size and electronegativity of the fluorine atom can be used to make defined structural alt

75 The fluorine atom caused a small deviation from planarity in

76 an increase in MW as a result of introducing fluorine atoms does not lead to higher risk of P-gp medi

77 ally substituted with hydrogen (H12SubPc) or fluorine atoms (F12SubPc).

78 These electron-withdrawing pendant fluorine atoms fine tune the energetics of the polymers

79 , novel BP ethers armed with a total of four fluorine atoms for their subsequent analysis by EI-GC-MS

80 s of consensus sequence YXCXXC displace four fluorine atoms from OFCP to generate fluorinated macrobi

81 itution in position 4 of the tricycle with a fluorine atom gave the best result.

82 Azobenzene functionalized with ortho-fluorine atoms has a lower energy of the n-orbital of th

83 enzyme A esters, possessing one or more beta-fluorine atoms, have been synthesized using Wittig, conj

84 As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact

85 utes the signal to tunnelling of the central fluorine atom in a quasi-linear [F(2) F F(2)](-) complex

86 ectly bonded to the cyclopropane ring, and a fluorine atom in a relationship cis to the amino group w

87 to measure a relative anchimeric role of the fluorine atom in hydrolysis versus mu-hydrido bridging.

88 A fluorine atom in paraposition and one ortho-methyl group

89 The smaller fluorine atoms in [Fe(dftpy)2](2+) enable spin crossover

90 s or by incorporating multiple nonequivalent fluorine atoms in a single receptor.

91 ale, which involves a rapid incorporation of fluorine atoms in an exotic photochemical cascade whose

92 geometric deformation and/or the rotation of fluorine atoms in anionic sites, thereby enabling ZU-61

93 signals are created by strategically placing fluorine atoms in close proximity to bound analytes so t

94 lly, clustering three highly electronegative fluorine atoms in close proximity.

95 Two of the compounds examined contained fluorine atoms in either the arabino or xylo disposition

96 ce of two adjacent TT units (or two opposing fluorine atoms in PTBF2) with opposite orientations or i

97 Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (

98 es have determined that incorporation of two fluorine atoms in the central phenyl group, as in 20 and

99 nzenes with multiple magnetically equivalent fluorine atoms in the form of a tetrafluorophenyl core o

100 bination of three factors: (1) the number of fluorine atoms in the molecule, (2) the number of fluori

101 FAS were used, and when PFAS contained fewer fluorine atoms in the molecule.

102 The third compound also incorporated fluorine atoms in the xylo configuration on the furanose

103 Cyclophilin A (CypA) protein, with a single fluorine atom incorporated in the sole tryptophan residu

104 (19)F NMR can overcome this issue, as fluorine atoms incorporated in proteins can be detected

105 h reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity,

106 l any m/z ratios relating to the presence of fluorine atoms, indicating that 4-F-GlcNAc did not incor

107 ly, we also found that as little as a single fluorine atom influenced the equilibrium by up to 0.8 kc

108 As carbon sites are occupied with surface fluorine atoms, intermediate C=O bonding is vastly minim

109 that the nonplanar compound extends with its fluorine atom into a pocket, which coincides with a regi

110 The incorporation of fluorine atom into a stereogenic center is a highly chal

111 cal composition--incorporation of one or two fluorine atoms into a single proline residue in the 99 a

112 ect this method to allow the introduction of fluorine atoms into advanced, highly functionalized inte

113 ingly aware of the benefits of incorporating fluorine atoms into bioactive molecules.

114 mployed as a means to incorporate high-value fluorine atoms into drug-like molecules.

115 The strategic incorporation of fluorine atoms into molecules has become a cornerstone o

116 nitroxides revealed that the introduction of fluorine atoms into the benzene ring enhances the acidit

117 However, due to the incorporation of fluorine atoms into the ferroelectric-insulator films, u

118 A fluorine atom introduced in the para-position of phenyla

119 ed functionality (hydroxy and alkoxy) with a fluorine atom is a commonly used bioisosteric replacemen

120 Since the fluorine atom is a suitable probe for structural analysi

121 IR intensity for C-F stretches in which the fluorine atom is bonded to the carbon that is bonded to

122 Whereas a fluorine atom is found not to bind covalently to the con

123 We evidenced that if a sole fluorine atom is not able to balance the loss of the 3-O

124 nt of methods allowing the introduction of a fluorine atom is of great importance.

125 eliminary study of two molecules, in which a fluorine atom is positioned proximately above the pi-orb

126 However, the fluorine atom itself is nonpolarizable, and thus, despit

127 presence of triptycene functional groups and fluorine atoms, JUC-596 exhibits an exceptional performa

128 Blocking this position with a fluorine atom led to 6-fluoro-3-(4-fluoropiperidin-3-yl)

129 Nucleocidin contains a fluorine atom located at the 4'-position of its ribose r

130 The first sublattice is due to fluorine atoms located in Ba(2+) double layers and is ri

131 assignments of the resonances, and that the fluorine atoms located next to the tin atoms are extreme

132 orbital level: (1) increasing the number of fluorine atoms lowers the energy of the pi*(M identical

133 In all structures, the fluorine atoms made surprisingly close contacts to the o

134 th the bacterial ribosome revealing that its fluorine atom makes an additional van der Waals contact

135 uorinated PC monolayers, indicating that the fluorine atoms modified the binding of this hydrophobic

136 aldehyde hydrate, or ketone bearing several fluorine atoms next to a carbonyl group.

137 When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin

138 )'s have been calculated, revealing that the fluorine atoms notably lowered their basicity, which is

139 Depending on the carbon and fluorine atom number, the fluoroalkylamines were shown t

140 The fluorine atom of [1-F](+) is connected to one of the for

141 arrangement) and a secondary contact to the fluorine atom of HF in [H5F4][SbF6].2[XeF3.HF][Sb2F11] a

142 F3.HF][Sb2F11] and [XeF3.HF][Sb2F11] or to a fluorine atom of SbF6(-) in [XeF3][SbF6].

143 Molecular modeling study shows that the 3'-fluorine atom of the d-2',3'-unsaturated cytidine tripho

144 imidate-NH(2) forms a hydrogen bond with the fluorine atom of the tetrafluoroborate ion.

145 bonds with the essential divalent cation and fluorine atoms of BeF(3)(-).

146 M(+) interactions between negatively charged fluorine atoms of R134a and positively charged metal ato

147 The fluorine atoms of the 3-fluorotyrosine interact primaril

148 rofile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za,

149 To evaluate the effect of fluorine atom on molecular shapes, X-ray data for 5- and

150 Introduction of a fluorine atom on the 2-methyl group markedly alters the

151 The fluorine atom on the active-site Tyr6 is located near th

152 ization of the position para (or ortho) to a fluorine atom on the aromatic ring using an electron-wit

153 nNOS provide insights into the effect of the fluorine atoms on binding.

154 In fact, by introduction of fluorine atoms on defined positions and methoxy groups o

155 On the other hand, the addition of fluorine atoms on gemcitabine alters the proper conforma

156 l, to further understand the impact of these fluorine atoms on open circuit voltage (V(oc)), short ci

157 e carbon increases with increasing number of fluorine atoms on the alkoxide ligands for both molecula

158 ation occurs with a low barrier, despite the fluorine atoms on the alpha-carbon, due to coordination

159 Strategic placement of the fluorine atoms on the chromophores can result in either

160 Fluorine atoms on the meso-pentafluorophenyl groups are

161 methyl groups on the one hand and (ii) four fluorine atoms on the other, at the 3,5,3',5'-positions

162 Introduction of two fluorine atoms on the phenyl ring yielded analogue 4y th

163 hesis of perhexiline analogues incorporating fluorine atoms onto the cyclohexyl ring(s) provided a ra

164 etween four and six carbons in length, and a fluorine atom ortho to the aromatic OCH3 provides compou

165 the structure of this ion is fluxional; the fluorine atom oscillates between the former methylium ce

166 nated pharmaceuticals often contain only 1-3 fluorine atoms, our results indicate that they can contr

167 are in inverse ratio to the total number of fluorine atoms per anion.

168 mpt to define the roles that the two vicinal fluorine atoms play in the puckering preferences of the

169 reover, the introduction of an electrophilic fluorine atom, positioned ortho or para to the benzoic a

170 tetrad in which pyrene residues replace the fluorine atoms present on the conventional BODIPY-based

171 nt at the 6-position, i.e., on the number of fluorine atoms present.

172 side chains containing between three and 21 fluorine atoms readily polymerize under controlled condi

173 The fluorine atoms reduce the pK(a) of the nucleophilic alph

174 f a novel DBO, ANT3310, which uniquely has a fluorine atom replacing the carboxamide and stands apart

175 placement of one or more hydrogen atoms with fluorine atom(s) is a common tactic to improve potency a

176 amined how the site-specific introduction of fluorine atom(s) modifies the thermal properties in the

177 The subtle effects of fluorine atom(s) on the course of asymmetric reactions a

178 edict that replacing one hydroxyl group by a fluorine atom should considerably suppress the major met

179 hat the unique internal addition of a single fluorine atom significantly alters the metal-metal bondi

180 Three fluorine atoms significantly increased the affinity by w

181 ility of the proton to bind the nitrogen and fluorine atoms simultaneously in a bifurcated arrangemen

182 r this transformation have used bench-stable fluorine atom sources; however, many still rely on the u

183 The tags have a minimum number of total fluorine atoms, starting at zero and increasing in incre

184 These ligands contained fluorine atom substituents to allow their interactions w

185 en the Ba(2+) and Sn(2+) layers, and the few fluorine atoms that inhabit the Sn(2+)-Sn(2+) double lay

186 he strong electron-withdrawing effect of the fluorine atoms the role of the negative charge of the di

187 It is further evident that, of the two fluorine atoms, the pro-R alpha-fluorine interacts with

188 For similar numbers of fluorine atoms, their absorption of radiation in the IR

189 a(2) -N(4) (C(6) F(5) )(2) ), expulsion of a fluorine atom to afford ((Tr) L)CoF, and N-group transfe

190 fluorobenzonitrile (2) substituting its para-fluorine atom to form 2-(4-cyanotetrafluorophenyl)-4,4,5

191 of the enantioselective substitution of one fluorine atom to form a stereogenic centre(5,6).

192 Tethering a fluorine atom to the aminoquinoline C(3) position afford

193 the pK(a) of the basic nitrogen, by adding a fluorine atom to the piperidine ring, leading to 3-(4-fl

194 fluoride in turn can be used to transfer the fluorine atoms to a small array of compounds.

195 couples of complexes containing 4, 12, or 24 fluorine atoms to balance fluorine signal-to-noise ratio

196 ing strategically placed hydroxyl groups and fluorine atoms to further probe the SAR of 2-azetidinone

197 combined electron withdrawing effects of two fluorine atoms to modulate the electronic density of the

198 gem-dimethyl substructure with deuterium or fluorine atoms to slow Phase I metabolism and swapping t

199 tion at C-5'', and in some cases addition of fluorine atoms to the aniline ring allowed for the ident

200 of organic compounds containing one or more fluorine atoms together with an alcohol group in their m

201 The Ph-N=N- group activates ortho fluorine atoms toward alkylthiolation under mild conditi

202 ediated C-F bond forming pathways via either fluorine atom transfer or an S(N)2 process.

203 Installation of the fluorine atom was accomplished using nonafluorobutanesul

204 The fluorine atom was used as the leaving group for the form

205 tically exchanging every hydroxyl group by a fluorine atom, we developed a strategy combining chemica

206 containing the diamine ring structure and a fluorine atom were subsequently analyzed.

207 In this work, varying amounts of fluorine atoms were introduced into the outer side chain

208 econdary amines bearing different numbers of fluorine atoms, were synthesized and used as phase tags

209 drug discovery, due to the unique effects of fluorine atoms when incorporated into molecules.

210 C6 positions, and (3) the number of pairs of fluorine atoms which are ortho to one another.

211 f the decrease in pK(a) brought about by the fluorine atom, which affects the ionization state of the

212 This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-ca

213 c linear acene contains electron-withdrawing fluorine atoms, which lower the molecular orbital energi

214 , the controllable replacement of one or two fluorine atoms while maintaining high chemoselectivity r

215 ing conformation but two orientations of the fluorine atom with a ratio of 7:3, revealing that the pr

216 the replacement of a single trifluoromethyl fluorine atom with a silylated hemiaminal functional gro

217 dox protocol for the replacement of a single fluorine atom with hydrogen in electron-deficient triflu

218 dendron containing 243 chemically identical fluorine atoms with a MW of 9082 Da.

219 from which the nature of the interactions of fluorine atoms with the rest of the protein can be evalu

220 as established by tracking surface-localized fluorine atoms with XPS, by monitoring changes in carbon

221 The presence of fluorine atoms within the pyranose ring slightly increas