ライフサイエンスコーパス: fluorine substitution

1 series of copolymers with varying amount of fluorine substitution.

2 ation are strengthened with increasing ortho fluorine substitution.

3 ss the generality of the effects produced by fluorine substitution.

4 ucture-activity relationships as a result of fluorine substitution.

5 luoromethanes also decreases with increasing fluorine substitution.

6 f varying sizes and shapes, with and without fluorine substitutions.

7 identical polymers, except for the number of fluorine substitutions (0, 1, or 2) on the repeat unit (

8 myl-gamma-glutamate to examine the effect of fluorine substitution adjacent to the scissile isopeptid

9 gonal reaction that can selectively displace fluorine substitutions alpha to amide bonds.

10 Fluorine substitution also enhanced SERT potency relativ

11 40 angstrom to 1.26 angstrom with increasing fluorine substitution and increasing s-character of the

12 represent a valuable tool for designing new fluorine substitutions and support ligand optimization i

13 In the present investigation, the effect of fluorine substitution at aziridine positions other than

14 anitrocubane, and (8) the effects of geminal fluorine substitution at C-2 of 1,3-diradicals.

15 Differences between fluorine substitution at the 3' and 2' positions may acc

16 strategic structural modifications, such as fluorine substitution at the bridgehead sp(3) carbon or

17 In a previous study we reported that fluorine substitution at the carbon positions of aziridi

18 Fluorine substitution can have a profound impact on mole

19 In general, fluorine substitution directly on the left-hand aromatic

20 introduction of a benzyl alcohol group and a fluorine substitution, each of which resulted in over 10

21 itution in SiH2FCH2 is consistent with other fluorine substitution effects.

22 ructure-property relationships, finding that fluorine substitution enhances crystallinity.

23 ers, dependent on the number and site of the fluorine substitution: fluorine on carbon adjacent to th

24 Multiple fluorine substitution for hydrogen in the alpha-methylen

25 The assays confirmed that fluorine substitution had marked effects on the affinity

26 Hydroxyl-by-fluorine substitution has proven its merits for chemical

27 ed cyclooctynes (OMe, Cl, F, CN) showed that fluorine substitution has the most dramatic effect on re

28 A study of the effect of fluorine substitution in Baylis-Hillman reactions of var

29 Fluorine substitution in SiH2FCH2 is consistent with oth

30 new N-heterocyclic carbene precursor bearing fluorine substitution in the backbone results in signifi

31 cts, our results suggest that the effects of fluorine substitution in the reactions of fluorinated ty

32 he conformational biases induced by a single fluorine substitution in the template can be enhanced by

33 cant structural perturbation imparted by the fluorine substitution in these complexes is a rotation o

34 3G (or both) mutations were compensated by 2'fluorine substitutions in the mRNA codon.

35 Fluorine substitution is a widely used approach to impro

36 We find that the stabilization imparted by fluorine substitution is additive over that obtained by

37 Increasing fluorine substitution leads to an increase in the entrop

38 Fluorine substitution lowers the inversion barrier impre

39 (X = H, F) as model systems, the effects of fluorine substitution on main-chain conformations, packi

40 synthesized in order to study the effects of fluorine substitution on monoamine oxidase inhibition.

41 our research program to study the effects of fluorine substitution on the biological activities of ne

42 Among nucleoside analogues, a fluorine substitution on the carbohydrate moiety or intr

43 This is reminiscent of the effect of fluorine substitution on the chemistry (inter- and intra

44 The effects of fluorine substitution on the Cope rearrangements of 1,5-

45 The effects of fluorine substitution on the cyclobutylcarbinyl to 4-pen

46 The degree and pattern of fluorine substitution on the inhibitor benzyl ring modul

47 dies of this class of antivirals showed that fluorine substitution on the left-hand phenyl ring in co

48 was used to gain insight into the impact of fluorine substitution on the overall protein structure a

49 The effects of fluorine substitution on the S-isomers were less predict

50 Unlike earlier PIs, these compounds have fluorine substitutions on the P2-P4 macrocycle and P1 mo

51 Finally, fluorine substitutions on the phenylazide ring did not c

52 xtension is highly dependent on the specific fluorine substitution pattern.

53 -band gap conjugated molecules with specific fluorine substitution patterns has been synthesized in o

54 oly(hydroxyalkanoate) (PHA) bioplastics with fluorine substitutions ranging from around 5-15 %.

55 Fluorine substitution resulted in a significant decrease

56 7% with PBnDT-DTffBT (2F) but also suggests fluorine substitution should be generally considered in

57 (cat)/K(M) = 30 M(1) s(1)) based on a single fluorine substitution that originates from differences i

58 A simple fluorine substitution to phenethylammonium for the organ

59 o systematically analyze the contribution of fluorine substitutions to inhibitor potency and resistan

60 sulfate with differing mixes of hydrogen and fluorine substitution was also observed.

61 Fluorine substitution was found to confer substantial st

62 Depending on the degree and pattern of fluorine substitution, we observe a face-to-face (aromat

63 Fluorine substitution which increases the contribution o

64 ated a remarkable electronic effect of the 4-fluorine substitution, while the effect of the 4-methyl

65 Although it is commonly thought that fluorine substitution will not result in any significant