ライフサイエンスコーパス: fluoro

1 tic fragment ion is formed via the loss of 2-fluoro-1,3,2-dioxaborale (MW of 88 Da) only in the case

2 ected toward 2-fluoro-1,4-benzoxazines and 2-fluoro-1,4-benzoxazepin-5-ones.

3 S(N)V) reaction, which was directed toward 2-fluoro-1,4-benzoxazines and 2-fluoro-1,4-benzoxazepin-5-

4 ed very rapidly and selectively, affording 5-fluoro-1,4-pyrazoles with bimolecular rate constants up

5 have culminated in the discovery of 4-({5-[4-fluoro-1-(2H-indazol-6-yl)-1H-1,2,3-benzotriazol-6-yl]-1

6 vel estrogen receptor (ER) PET radiotracer 4-fluoro-11beta-methoxy-16alpha-(18)F-fluoroestradiol ((18

7 16alpha-(18)F-fluoro-17beta-estradiol ((18)F-FES) is a PET tracer for

8 [(18)F]9) and (1S,3S,4R)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]28)

9 c amino acids (1S,3R,4S)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]9) a

10 o-1H-imidazol-2-yl)methyl)pyrrolidin-3-yl)-5-fluoro-1H-benzo [d]imidazole (42) with IC50 values of 44

11 assays, the most potent agonists being di(5-fluoro-1H-indole-3-yl)methane (38, PSB-15160, EC50 80.0

12 that dietary thymidine and serine enhance 5-fluoro 2'deoxyuridine (FUdR) toxicity in C. elegans thro

13 tors in Arabidopsis thaliana revealed that 2-fluoro 2-l-fucose (2F-Fuc) reduces root growth at microm

14 Because 2'-deoxy-2'-fluoro (2'-F) nucleotides are not known to occur natural

15 or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-

16 based on the suicide substrate arabinosyl-2'-fluoro-2'-deoxy NAD(+) (F-araNAD(+)), dimeric F-araNAD(+

17 achieved by labelling cells with 2'-[(18)F]-fluoro-2'-deoxy-D-glucose ((18)F-FDG).

18 MK-8591 (4'-ethynyl-2-fluoro-2'-deoxyadenosine [EFdA]) is a novel reverse tran

19 In preclinical studies, 5-fluoro-2'-deoxycytidine (FdCyd), an inhibitor of DNA met

20 Here, a stabilized 2'-fluoro-2'-deoxyribose analog of N(2),3-epsilonG was used

21 of 0.4-4.7 muM), which contain one or two 2'-fluoro-2'-deoxyriboses and/or bis-phosphorothioate linka

22 otherapeutic drugs: 5-fluorouracil (5-FU), 5-fluoro-2'-deoxyuridine (FUDR), and camptothecin (CPT).

23 and sofosbuvir, which get metabolized to 2'-fluoro-2'C-methylcytidine-5'-triphosphate and 2'-fluoro-

24 ro-2'C-methylcytidine-5'-triphosphate and 2'-fluoro-2'C-methyluridine-5'-triphosphate, respectively.

25 se to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol.

26 found to spontaneously cyclize to singlet 4-fluoro-2,1-benzisoxazole.

27 Construction of protected 2,3-dideoxy-2-fluoro-2,3-endo-methylene-pentofuranoses from d-glyceral

28 etric transformations can be coupled using N-fluoro-2,4,6-trimethylpyridinium triflate as a terminal

29 ing materials by the F(+) transfer reagent N-fluoro-2,4,6-trimethylpyridinium triflate followed by tr

30 derivatization with a new chiral reagent, (5-fluoro-2,4-dinitrophenyl)-N(alpha)-l-tryptophanamide (FD

31 -d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[

32 which resulted in the identification of 5-[4-fluoro-2-(1-methyl-4-piperidyl)phenyl]-2-oxo-N-pentyl-ox

33 Acyclic nucleosides containing a 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) side chain are

34 idin-5-yl)methanone (compound 29) and (S)-(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1-(5-fluoropyrim

35 of the even more sterically demanding rac-2-fluoro-2-benzyl acetic acid proceeded similarly.

36 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly use

37 ly related to lactate production and (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake.

38 rocess by which tumor cells take up 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) is heterogeneous and infl

39 on tomography after an injection of [(18)F]2-fluoro-2-deoxy-d-glucose before the OGTT, and the rate o

40 to age- and sex-matched controls using 18F-2-fluoro-2-deoxy-d-glucose PET (n = 20 per group) and voxe

41 abolism in these subjects by means of [(18)F]fluoro-2-deoxy-d-glucose Positron Emission Tomography/Co

42 tissue (ATGU) glucose uptake with [(18) F]2-fluoro-2-deoxy-D-glucose/positron emission tomography, l

43 argeting TKIs are evaluated through 2-[(18)F]fluoro-2-deoxy-glucose ((18)FDG)-PET uptake, which is de

44 sociation between increased normalized (18)F fluoro-2-deoxyglucose PET SUVmax, outcome, and EMT in NS

45 data set that contained fluorine 18 ((18)F) fluoro-2-deoxyglucose positron emission tomography (PET)

46 m of the alkylation of indolphenol, 2, 4-[(4-fluoro-2-methyl-1 H-indol-5-yl)oxy]-6-methoxyquinazolin-

47 ic amount of iron(II) triflate (Fe(OTf)2), N-fluoro-2-methylbenzamides undergo chemoselective fluorin

48 up on the alpha-carbon, (S)-2-amino-7-[(18)F]fluoro-2-methylheptanoic acid ((S)-[(18)F]FAMHep, (S)-[(

49 881 [5-((7-benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol-hydrochloride] (20 mug/mL) was dri

50 S,2S)-2-({5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbo

51 The lead analogue, [Inp(1),Dpr(3)(6-fluoro-2-naphthoate),1-Nal(4),Thr(8)]ghrelin(1-8), posse

52 (TBBA) was synthesized in three steps from 1-fluoro-2-nitrobenzene.

53 ghly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described.

54 be the use of a mechanism-based inhibitor, 2-fluoro-2-nitrovinylbenzene, to trap the putative cyclo-a

55 A novel 6-fluoro-2-pentafluorophenyl naphthoate (PFPN) prosthetic

56 PA1163) has been studied by subjecting rac-2-fluoro-2-phenyl acetic acid to the defluorination proces

57 (18)F-MK-6240 ((18)F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-a

58 allows the straightforward synthesis of a 3'-fluoro-3'-deoxytetrose adenine phosphonate and can be ex

59 A new synthetic route to a 3'-fluoro-3'-deoxytetrose adenine phosphonate has been deve

60 ion reaction allows access to the desired 3'-fluoro-3'-deoxytetrose moiety.

61 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

62 A novel synthetic approach to 6-(18)F-fluoro-3,4-dihydroxy-L-phenylalanine ((18)F-DOPA), invol

63 opa seems to improve the accuracy of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) PET f

64 nder factors, T(2) relaxometry and L-6-(18)F-fluoro-3,4-dihydroxyphenylalnine ((18)F-FDOPA) PET data

65 l-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indolin-2-one).

66 Two of these compounds, (S)-(2-fluoro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2

67 tivity in the nanomolar range and one, 2-((4-fluoro-3-(trifluoromethyl)phenyl)amino)-3-(methylthio)na

68 PET/CT imaging with 9-(4-[(18)F]-fluoro-3-[hydroxymethyl]butyl)guanine ([(18)F]FHBG) of B

69 oses from d-glyceraldehyde and 2,3-dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranos

70 es the pK(a) of the bound substrate analog 4-fluoro-3-hydroxybenzoate (4F3HB) by 1.6 pH units, consis

71 the production of the fluorinated diketide 2-fluoro-3-hydroxybutyrate at approximately 50 % yield.

72 -C center of spiro-epoxyoxindole furnishes 3-fluoro-3-hydroxymethyloxindoles, whereas TBAF-mediated f

73 Favipiravir (T705; 6-fluoro-3-hydroxypyrazine-2-carboxamide) is a pyrazine an

74 LHP is synthesized from readily available 4-fluoro-3-methylphenol in six steps featuring a palladium

75 mbrane based off-matrix was achieved using 4-fluoro-3-nitro-azidobenzene (FNAB) cross-linker.

76 x was achieved via azide group activity of 4-fluoro-3-nitro-azidobenzene (FNAB), which act as cross-l

77 c organic crystal, 2,6-dichlorobenzylidine-4-fluoro-3-nitroaniline (DFNA), which also shows thermosal

78 lead structure, (3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)ethyl)amino)methyl)piperi

79 aniline ring, we generated Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbam

80 ural cyclic amino acids (1S,3R,4S)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([

81 lic acid ([(18)F]9) and (1S,3S,4R)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([

82 The probes were: alpha-methyl-4-[F-18]-fluoro-4-deoxy-d-glucopyranoside (Me-4FDG), a substrate

83 PAH), revealing depression of the pK(a) of 3-fluoro-4-hydroxyphenylacetate by 2.5 pH units upon bindi

84 (trifluoromethyl)pyridin-2-yl)oxy)phenyl)(3- fluoro-4-hydroxypyrrolidin-1-yl)methanone 28, a potent i

85 r, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinoli

86 ically 'rare' functional groups, such as the fluoro(5), chloro(6,7), bromo(7,8), phosphonate(9), ened

87 '-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosine (5'-FDA).

88 ered when analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine synthase, the only known enzyme

89 the pharmacokinetics of (18)F-FPEB (3-(18)F-fluoro-5-(2-pyridinylethynyl)benzonitrile), a selective

90 of a clinically useful PET tracer, 3-[(18)F]fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([(18)F]FP

91 (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

92 stribution volume of the radioligand (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

93 , to prepare the radiopharmaceutical (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

94 oazomycin arabinoside (or (18)F-1-alpha-D-[5-fluoro-5-deoxyarabinofuranosyl]-2-nitroimidazole [(18)F-

95 '-deoxy-3'-(18)F-fluorothymidine or 2'-(18)F-fluoro-5-methyl-1-beta-d-arabinofuranosyluracil may also

96 reomerically pure 6R- and 6S-3'-aza-2'-(18)F-fluoro-5-methyltetrahydrofolate (MTHF) (6R-(18)F-1 and 6

97 suggest that both 6R- and 6S-3'-aza-2'-(18)F-fluoro-5-MTHF are promising reduced radiofolates for ima

98 ully radiolabeled 6R- and 6S-3'-aza-2'-(18)F-fluoro-5-MTHF with (18)F using the integrated approach.

99 -axis in CRPC, using (18)F-FDG, (18)F-16beta-fluoro-5alpha-dihydrotestosterone ((18)F-FDHT), and a va

100 2'-Fluoro-6'-methylene-carbocyclic adenosine (FMCA, 12) and

101 tential ERbeta-selective PET tracer: 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-F

102 We recently developed the tracer 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-F

103 WZB117 (2-fluoro-6-(m-hydroxybenzoyloxy) phenyl m-hydroxybenzoate)

104 We applied this method to 2-[2-(18)F-fluoro-6-(methylamino)-3-pyridinyl]-1-benzofuran-5-ol ((

105 yl]amin o}-3-quinolinecarboxamide (72) and 7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-{[(1S)-1-(1-m

106 Additional modifications yielded 2-fluoro-6-methoxybenzamide derivatives (26a-c), which pos

107 preclinical candidate compound containing 7-fluoro-6-oxybenzoxaborole (15, AN11251) was shown to hav

108 e palmitic acid surrogate tracer 14(R,S)-18F-fluoro-6-thia-heptadecanoic acid ([18F]-FTHA), consisten

109 Oral 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid was used to determine w

110 (8S,9R)-47 (talazoparib; BMN 673; (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5

111 als injected with 2-chloro-2'-deoxy-2'-(18)F-fluoro-9-beta-d-arabinofuranosyl-adenine ((18)F-CFA), a

112 8)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-adenine ([(18)F]CFA) an

113 -adenine ([(18)F]CFA) and 2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-guanine ([(18)F]F-AraG)

114 at a novel PET radiotracer, 2'-deoxy-2'-[18F]fluoro-9-beta-D-arabinofuranosylguanine ([18F]F-AraG), t

115 lyze the formation of C5-azido analogue of 3-fluoro(a)-sialic acid.

116 The chemoenzymatically synthesized 3-fluoro(a/e)-sialic acid analogues were purified and chem

117 EcAldolase could catalyze the synthesis of 3-fluoro(a/e)-sialic acids and their C-9 analogues althoug

118 nctionalities, such as halides, alkyl ether, fluoro-alkyl ether, and thioether, and substituted amine

119 ction of aryl thiols to trisubstituted alpha-fluoro-alpha,beta-unsaturated esters both in racemic and

120 arbanions and, upon protonation, ethyl alpha-fluoro-alpha-nitroarylacetates.

121 thylene phosphono analogues (7 and 8), and 6-fluoro-alphaG1P (9), were synthesized and assessed as po

122 yl alkyl fluorides embedded within a vicinal fluoro amine functional group.

123 eparation of a range of enantioenriched beta-fluoro amines (alpha,beta-disubstituted) is described in

124 The preparation of acyclic beta-fluoro amines bearing tetrasubstituted fluorine stereoce

125 ow diet or chow containing 0.14% (wt/wt) des-fluoro-anacetrapib for 6 weeks.

126 to control, dietary supplementation with des-fluoro-anacetrapib reduced plasma CETP activity by 89 +/

127 performed 2 weeks after starting dietary des-fluoro-anacetrapib supplementation.

128 Des-fluoro-anacetrapib treatment was also associated with de

129 er transfer protein (CETP) activity with des-fluoro-anacetrapib, an analog of the CETP inhibitor anac

130 We also report an X-ray structure of the fluoro analogue bound to the spastin mutant.

131 vity of JWH-122, JWH-210, and PB-22, their 5-fluoro analogues (MAM-2201, EAM-2201, and 5F-PB-22, resp

132 t the synthesis of benzylated 3-fluoro and 4-fluoro analogues of phenyl 1-thioglucosazide and galacto

133 f the yet-unsynthesized bromo-, chloro-, and fluoro- analogues show a progressive lowering of the bar

134 therwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modificati

135 ere, we report the synthesis of benzylated 3-fluoro and 4-fluoro analogues of phenyl 1-thioglucosazid

136 report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphil

137 benzene substituted as 2- or 4-methyl, or 4-fluoro, and defined the significance of thiophene substi

138 essing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

139 ong reported method to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

140 We report the application of fluoro- and nitrogen-walk approaches to enhance the drug

141 These 2'-fluoro aptamers, FB9s-b and FB9s-r, were markedly resist

142 Overall, these results establish fluoro as a through-space directing/activating group tha

143 fy a novel agonist, the synthetic analogue 2-fluoro-ATP, and to confirm its agonist activity on rat P

144 As one of them, tetra- ortho-fluoro azobenzene is well compatible for the design of v

145 d 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[(18)F]fluoro-benzamidoethylpiperazine [(18)F]MPPF uptake in th

146 ields the corresponding syn-configured alpha-fluoro beta-hydroxy carboxylic acids which have >98 % ee

147 limination, the resulting transoid alpha-(1'-fluoro)-beta-(phenylsulfonyl)vinyl AA-esters undergo smo

148 ly give the corresponding transoid alpha-(1'-fluoro)-beta-(tributylstannyl)vinyl AA-esters.

149 n templates composed entirely of 2'-deoxy-2'-fluoro-beta-d-arabino nucleic acid (FANA) and alpha-l-th

150 (18)F-FAC (2'-deoxy-2'-(18)F-fluoro-beta-d-arabinofuranosylcytosine) has close struct

151 Two isomeric aryl 2-deoxy-2-fluoro-beta-glucosides react with a beta-glucosidase at

152 A successful synthesis of alpha-fluoro-beta-ketosulfides using an electrophilic fluorina

153 The resulting products, alpha-fluoro-beta-ketosulfides, are easily oxidized to the cor

154 e easily oxidized to the corresponding alpha-fluoro-beta-ketosulfones, which can be used for further

155 hyllithium with boronic esters to give alpha-fluoro-boronic esters.

156 The C7-fluoro, C6-CD(3)O substitution pattern of the P2* isoqui

157 eadily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), m

158 coupling reactions of aryl groups with alpha-fluoro carbonyl compounds catalyzed by palladium complex

159 g reactions of aryl electrophiles with alpha-fluoro carbonyl compounds have yet to be disclosed.

160 ws the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating m

161 es formulated with numerous hydrocarbon- and fluoro-containing surfactants.

162 transferase inactivator (1R,3S,4S)-3-amino-4-fluoro cyclopentane-1-carboxylic acid (1), in this work,

163 AT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT.

164 Uptake of 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluor

165 -d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluor

166 estimated using alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside (Me-4FDG).

167 estimated using alpha-methyl-4-deoxy-4-(18)F-fluoro-d-glucopyranoside (Me-4FDG).

168 mor xenografts in mice using 2-deoxy-2-[F-18]fluoro-D-glucose ((18)F-FDG) PET imaging.

169 o-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fl

170 2-Deoxy-2-(18)F-fluoro-d-glucose (2-FDG) with PET is undeniably useful i

171 2-Deoxy-2-[18F]fluoro-D-glucose (2-FDG) with positron emission tomograp

172 te for SGLTs and GLUTs; and 2-deoxy-2-[F-18]-fluoro-d-glucose (2-FDG), a substrate for GLUTs.

173 DG), a substrate for SGLTs; 4-deoxy-4-[F-18]-fluoro-d-glucose (4-FDG), a substrate for SGLTs and GLUT

174 glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studied in EMT6 cell

175 tion and 15% per MBq/ml of 2-deoxy-2-[(18)F]-fluoro-d-glucose ([(18)F]FDG).

176 [F] fluoro-D-glucose positron emission tomography/computed t

177 Finally, 2-deoxy-2-[F-18]fluoro-d-sorbitol ((18)F-FDS) can be easily synthesized

178 g positron emission tomography with 4-[(18)F]fluoro-dapagliflozin (F-Dapa).

179 mission tomography with (11)C-acetate, (18)F-fluoro-deoxyglucose ((18)FDG), and (18)F-fluoro-thiahept

180 ations in metabolism and volume using [(18)F]fluoro-deoxyglucose (FDG) and simultaneous time-of-fligh

181 um ions; however, in the cases of chloro and fluoro derivatives, open forms are more preferable.

182 sis of our results, we designed the di-ortho-fluoro di-ortho-chloro (dfdc) azobenzene and provided co

183 cal withC(C6H4)CH3)DPFN]NTf2 (DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; NTf2(-) =

184 H5, 3,5-(CF3)2C6H3, and C6F5; DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; X = BAr4(

185 ally simple reaction affords enantioenriched fluoro-diphenidine (up to 50 g scale) using 0.5 mol % of

186 scrimination against the incorporation of 2'-fluoro dNMPs during transcription elongation.

187 ect the yield of RNA and incorporation of 2'-fluoro-dNMPs by Syn5 RNA polymerase have been identified

188 ther decreases the discrimination against 2'-fluoro-dNTPs during RNA synthesis.

189 The fluoro effect overrides the effect of the ring size that

190 the appropriate palladium catalyst and alpha-fluoro enolate precursor were used.

191 re included: brain tumor studies using (18)F-fluoro-ethyl-tyrosine ((18)F-FET) (n = 31) and (68)Ga-DO

192 evaluated if additional postoperative (18)F-fluoro-ethyl-tyrosine ((18)F-FET) PET in children and ad

193 a[5]helicenes are accessed from common ortho-fluoro-ethynylarene precursors, allowing the heteroatoms

194 ewis acid conditions to afford a series of 1-fluoro-exo,exo-furofurans in moderate yields.

195 4 weeks after injection of retrograde tracer Fluoro-Gold (FG), True Blue (TB) or Fluoro-Ruby (FR) in

196 Retrograde tracer Fluoro-Gold injected into the RTN labelled a subset of c

197 onnectivity of the mouse RE using retrograde Fluoro-Gold tracing.

198 mouse, this technique was achieved with only Fluoro-Gold, a neurotoxic fluorescent dye with membrane

199 ster) were infused with a retrograde tracer, Fluoro-Gold, and tested for affiliation and aggression t

200 neurons were responsive to GH in the PVH of Fluoro-Gold-injected mice.

201 ment and noncovalent interaction between the fluoro group and the aromatic proton on the thiophene si

202 It is known that the fluoro group has only a small effect on the rates of ele

203 t of the 5-iodo group with chloro, bromo, or fluoro groups led to losses in potency, as did the intro

204 five fluoro, two fluoro, one fluoro, and no fluoro groups.

205 However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented.

206 on of diverse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino groups at the beta position o

207 Here, we employed a 2'-fluoro isostere approach to synthesize an oligonucleotid

208 orris Water Maze and a reduction in positive Fluoro-Jade B stained injured neurons and microglial act

209 thology characterized by positive silver and Fluoro-Jade B staining, and microglial proliferation and

210 Furthermore, decreased Fluoro-Jade C and NeuroSilver staining suggested inhibit

211 ation in cortex and hippocampus indicated by Fluoro-Jade C in the different brain areas examined afte

212 Fluoro-Jade C staining showed significant neurodegenerat

213 ssessments, including neurological deficits, Fluoro-Jade C staining, brain edema, Evans blue extravas

214 Brains were stained with Fluoro-Jade C to assess neurodegeneration.

215 ion utilizes branched vinyl or alkynyl alpha-fluoro ketones that can be coupled with a range of aryl,

216 (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomogr

217 [(18)F]6-fluoro-L-DOPA ([(18)F]FDOPA) is a diagnostic radiopharma

218 We obtained baseline 6-[(18)F]fluoro-L-DOPA (FDOPA)-PET scans in 15 nonsmokers and 30

219 and dopamine synthesis and storage ((18)F-6-fluoro-L-dopa; (18)F-FDOPA).

220 amine synthesis capacity (Ki) using 6-[(18)F]fluoro-l-m-tyrosine ([(18)F]FMT; a substrate for aromati

221 Using the PET tracer 6-[(18)F]fluoro-l-m-tyrosine, we found strong support for upregul

222 00%, respectively, for 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA); and 100% and 70%-8

223 Using 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine ([(18)F]-DOPA) positron emission

224 esis of each possible stereoisomer of a beta-fluoro lanicemine illustrates the potential ease with wh

225 n with hydroxy, cyano, nitro, acetamido, and fluoro led to high inhibitory activities toward ABCG2.

226 This was achieved using [(18)F]fluoro-levo-dihydroxyphenylalanine dynamic positron emis

227 of novel imaging techniques (6-[fluoride-18]fluoro-levodopa [(18)F-DOPA] PET-CT and glucagon-like pe

228 Herein, a unimolecular chemo-fluoro-luminescent reporter (CFR) is synthesized for dup

229 nnoimidazole, or 2,4-dinitrophenol 2-deoxy-2-fluoro-mannoside reveal the residues essential for speci

230 Incorporation of 2'-fluoro-modified C- and U-nucleotides is shown to increas

231 ion, and the presence or absence of an alpha-fluoro moiety.

232 Screening of commercially available fluoro monosaccharides as putative growth inhibitors in

233 e utility of N-(2,5-dimethoxybenzyl)-2-(18)F-fluoro-N-(2-phenoxyphenyl)acetamide ((18)F-PBR06) for de

234 dimethyl-4-oxo-2-thioxoimidazolidin -1-yl)-2-fluoro-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide] and 10

235 etylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were prepared u

236 iphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-

237 ch analogue, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (57) was chosen f

238 Addition of methyl, fluoro, naphthyl, and benzothiadiazolyl units does not a

239 e catalyst that can deliver beta-amino-alpha-fluoro nitroalkanes with high enantio- and diastereosele

240 uence to highly stereoselectively give alpha-fluoro-nitroalkenes as Z-isomers only.

241 in the formation of the corresponding alpha-fluoro-nitroalkenes in isolated yields up to 92%.

242 ed toward the synthesis of other types of 3'-fluoro nucleoside phosphonates.

243 trates modified at their 2' positions with a fluoro, O-methyl, or azido substituent.

244 zations possessing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

245 N, N-DABOs carrying 2,6-difluoro, 2-chloro-6-fluoro, or 2,6-dichloro substituted benzyl moieties.

246 roperties of fluorine and produced countless fluoro-organic compounds without which our everyday live

247 ormations resulted in the formation of novel fluoro-organics of the thiophene family, namely, product

248 Compounds 4g and 4i, bearing a m-fluoro-p-methoxyphenyl or p-ethoxyphenyl moiety at the 5

249 bution demonstrated fast clearance of [(18)F]fluoro-PEG-folate from heart and blood vessels and no do

250 ing arthritis and kinetic properties of [18F]fluoro-PEG-folate in RA patients.

251 Secondly, [(18)F]fluoro-PEG-folate showed uptake in arthritic joints with

252 n study demonstrates the potential of [(18)F]fluoro-PEG-folate to image arthritis activity in RA with

253 Recently, the novel macrophage tracer [(18)F]fluoro-PEG-folate was developed.

254 CP) was synthesized using (19)F-labeled 2-(5-fluoro-pentyl)-2-methyl malonic acid ((19)F-FPMA) as the

255 tionally, the formation of 8-membered organo(fluoro)phosphate rings in lithium ion battery electrolyt

256 Since the high toxic potential of organo(fluoro)phosphates has emerged interest in safety assessm

257 (2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4 -ylmethyl]-benzamide, a selective T-t

258 -(2,2-dimethyltetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide (TTA-P2).

259 ion Findings with 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-penta

260 ET agents such as 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-penta

261 Specifically, we demonstrate that a fluoro-pyridine group can be used to circumvent the need

262 or (18)F-DCFPyL (2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl) PET/CT.

263 etic analysis of 2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-penta

264 g (18)F-DCFPyL ([2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-penta

265 re studied using 2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-penta

266 , (18)F-DCFPyL (2-(3-(1-carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-penta

267 st (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p ent

268 le, MIP-1404, PSMA-11, 2-(3-{1-carboxy-5-[(6-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-penta

269 ed (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-penta

270 g sessions using 2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-penta

271 (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-penta

272 e tracer Fluoro-Gold (FG), True Blue (TB) or Fluoro-Ruby (FR) in the tibial nerve in adult Spague-Daw

273 hiation/elimination sequence starting from 2-fluoro-SF5-benzene.

274 we have identified that carbamate-modified 3-fluoro sialic acid inhibitors are more efficiently metab

275 id expression, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors.

276 the synthesis of such glycans, especially 3-fluoro-sialic acid (3F-Neu5Ac) containing sialosides, ha

277 Counterintuitively, the axial fluoro substituent in 3 did not change chemical shift up

278 The P-fluoro substituent is exchanged for hydride by treatment

279 erved by NMR and crystallography with a para-fluoro substituent on the 4-phenylimidazole, but a para-

280 ity to COX-2 (6k = 70 nM, 8e = 60 nM) have a fluoro substituent, making them promising candidates for

281 ly genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resulting in compounds with high To

282 or novel influenza inhibitors we evaluated 7-fluoro-substituted indoles as bioisosteric replacements

283 dea using fluorine NMR and DNA containing 2'-fluoro-substituted nucleotides.

284 studying the regio- and chemoselectivity of fluoro-substituted thienothiophene and benzodithiophene

285 ign and synthesis it was discovered that cis-fluoro substitution on 4-hydroxy- and 4-methoxypiperidin

286 ine unit attached to a biphenyl carbamate, 5-fluoro substitution was responsible for M(3) subtype sel

287 d by introducing bulkier N-substituents, a 2-fluoro substitution, and additional hydroxyl groups at p

288 These studies identified aryl-fluoro sulfates as likely the most suitable electrophile

289 8)F-fluoro-deoxyglucose ((18)FDG), and (18)F-fluoro-thiaheptadecanoic acid ((18)FTHA), a fatty acid t

290 In addition, we determined that 5'-(2-fluoro)thiophenyl derivatives all failed to generate a s

291 ethyl-tryptophan, 5-methyl-tryptophan, and 5-fluoro-tryptophan were efficient substrates of VioA.

292 ent derivatizations possessing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

293 s; namely, a family of quaternary, alpha-(1'-fluoro)vinyl amino acids, bearing the side chains of the

294 beta-difluorovinyl phenyl sulfone, a new (1'-fluoro)vinyl cation equivalent, and an electrophile that

295 The alpha-(1'-fluoro)vinyl trigger, a potential allene-generating func

296 +/- 20 muM; t1/2 = 2.8 min) and D-alpha-(1'-fluoro)vinyllysine (Ki = 470 +/- 30 muM; t1/2 = 3.6 min)

297 arameters for the two antipodes, L-alpha-(1'-fluoro)vinyllysine (Ki = 630 +/- 20 muM; t1/2 = 2.8 min)

298 test of this new inhibitor class, alpha-(1'-fluoro)vinyllysine is seen to act as a time-dependent, i

299 2'-fluoro was the most compatible modification whereas bulk

300 A conformational analysis of o-fluoro Z-azobenzene reveals a slight preference for arom