ライフサイエンスコーパス: focal

1 re heterogeneous; the seizure onset zone was focal.

2 st in diffuse lesions [245 (175-376) cm/s vs focal 120 (34-242) cm/s vs multifocal 93 (36-313) cm/s;

3 Transmission is highly focal: 85% of mean distances from inferred infectors to

4 the gastric folds (ie, gastric cardia) using focal ablation in a circumferential fashion.

5 ablation, (2) combined PF and radiofrequency focal ablation, and (3) PF delivered directly atop the e

6 ordant due to probe design differences, with focal abnormalities detectable using one technique not o

7 Furthermore, focal activation of two distinct striatal regions induce

8 idences by reducing Ca(2+)-mediated EADs and focal activity during isoproterenol perfusion (at 30 nmo

9 No sustained focal activity was observed.

10 in integrin-mediated mechanotransduction and focal adhesion (FA) dynamics.

11 ichment of Rho GTPase, extracellular matrix, focal adhesion and cytoskeleton pathways.

12 the same frequency independently facilitate focal adhesion and mechanosensing of stem cells, which a

13 ells to be enriched with genes implicated in focal adhesion and mitogen-activated protein kinase (MAP

14 l adhesion complex but did exhibit intrinsic focal adhesion assembly as well as contractile differenc

15 ased heart via transcriptional activation of focal adhesion assembly.

16 Focal adhesion behavior is locally regulated by stiffnes

17 es in expression of proteins involved in the focal adhesion complex but did exhibit intrinsic focal a

18 Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer

19 Integrin-based focal adhesion complexes link the glial membrane to the

20 of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular

21 ese sliding focal adhesions contain standard focal adhesion constituents but completely lack classica

22 ects cell adhesion through the inhibition of focal adhesion disassembly.

23 icroenvironment topography coordinates their focal adhesion distribution and alignment.

24 pport a role for Slac2-b in regulating local focal adhesion dynamics to support effective KC adhesion

25 t demonstrated a role for PHIP in regulating focal adhesion dynamics.

26 sicle trafficking to the plasma membrane and focal adhesion dynamics.

27 e requiring stable actomyosin bundles, e.g., focal adhesion elongation or migratory front-back polari

28 controls dynamic cellular processes, such as focal adhesion formation and turnover and cell division.

29 isrupt the binding of talin to the membrane, focal adhesion formation, and cell spreading.

30 somal integrin alpha6beta4 exhibit increased focal adhesion formation, cell spreading, and traction-f

31 The focal adhesion group proteins are identified as new dise

32 Focal adhesion kinase (FAK) is a key component of the me

33 , we generated fibroblast-specific inducible focal adhesion kinase (FAK) knockout (cKO) mice in a bre

34 direct HDAC5 tyrosine 642 phosphorylation by focal adhesion kinase (FAK), a HDAC5 post-translational

35 promote exocytosis through interactions with focal adhesion kinase (FAK).

36 phosphorylated forms of paxillin (pPXN) and focal adhesion kinase (pFAK).

37 entify an ITGA2-dependent phosphorylation of focal adhesion kinase and mitogen-activated protein kina

38 ls the vertical displacement of paxillin and focal adhesion kinase from the signaling layer of focal

39 er, inhibition of integrin signaling through focal adhesion kinase inhibition caused disruption of ce

40 Previous studies have shown that the focal adhesion kinase Pyk2 plays a critical role in mono

41 hanotransduction after injury with increased focal adhesion kinase signaling and nuclear translocatio

42 gement of the extracellular matrix (ECM) via focal adhesion kinase.

43 ch required the activation of Rho GTPase and focal adhesion kinase.

44 activity and colocalizes with phosphorylated focal adhesion kinases.

45 ogen treatment was associated with decreased focal adhesion marker expression with rescue by amilorid

46 cross-linked elastomers supported efficient focal adhesion maturation and fibroblast spreading becau

47 l homing, cardiac fibroblast activation, and focal adhesion protein expression via hyperactivated YAP

48 Kindlins are focal adhesion proteins that regulate integrin activatio

49 lted in significant down-regulation of these focal adhesion proteins, along with zyxin (ZYX), and pro

50 of glioblastoma cells, together with several focal adhesion proteins: vinculin (VCL), talin 1 (TLN1),

51 atterning by modulating the cytoskeleton and focal adhesion structures(3-5).

52 t, randomly oriented mimetics did not change focal adhesion tension sensation or enrich for p38-YAP-T

53 /threonine kinase (Akt) activation, membrane focal adhesion turnover, and increased epithelial cell m

54 in (BMP) signaling, chemokine signaling, and focal adhesion were activated by JQ1 to promote invasion

55 enriched for; pathways-in-cancer (including; focal adhesion, MAPK signaling, PI3K-Akt-mTOR signaling,

56 uding mTOR, CDK/RB, cAMP/PKA, WNT, HKMT, and focal adhesion.

57 that knockdown of Rab18 reduces the size of focal adhesions (FAs) and influences their dynamics.

58 ssembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration.

59 edge, and showed that force distribution in focal adhesions (FAs) is off-centered and FA size-depend

60 f the actin cytoskeleton, and a reduction of focal adhesions and microvilli.

61 basement membrane components, these sliding focal adhesions contain standard focal adhesion constitu

62 hat AP-1B colocalized with beta1 integrin in focal adhesions during cell migration using confocal mic

63 e type III effector TarP, which localized to focal adhesions during infection and when expressed ecto

64 Focal adhesions in FGF-2-stimulated fibroblasts of affec

65 its coupling with local rigidity sensing at focal adhesions in the regulation of cell shape changes

66 1 protein product is a critical component of focal adhesions linking signaling between the extracellu

67 sembly mechanism, alpha5beta1 integrin-based focal adhesions slide actively on the underlying matrix

68 the formation of unusually stable and mature focal adhesions that resisted disassembly induced by the

69 itched to alpha5beta1 integrin-based sliding focal adhesions to assemble fibronectin matrix.

70 pikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family me

71 ions in mechanosensitive structures, such as focal adhesions, invadopodia, and podosomes, that are di

72 plasma membrane, such as cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coate

73 adhesion kinase from the signaling layer of focal adhesions, whereas vinculin remained in its normal

74 al protein vinculin, they do not form mature focal adhesions.

75 rin mediated FAK activation and signaling at focal adhesions.

76 n-1 and N-WASP, but not pVASP, cortactin and focal adhesions.

77 Focal administration of D-serine to the MEA attenuates n

78 Focal amplifications that affected chromosomes 1q21 (whi

79 ints and, at 24 hours, discriminated between focal and diffuse injuries.

80 in murine models of adriamycin (ADR)-induced focal and segmental glomerulosclerosis (FSGS) and strept

81 plasmid DNAs and stimulated the cells with a focal and transient electrical stimulus that promotes th

82 Conversely, a global or focal area of low T2 signal intensity and a low or an in

83 ith neuromyelitis optica spectrum disorders, focal areas of spinal cord atrophy at MRI were topograph

84 rly found hypermuscularization of the TS and focal arteriolar SMC loss in brain tissues from patients

85 In AD subjects, focal asymmetric uptake was evident in temporal and pari

86 pal dysfunction-focal cerebral blood volume, focal atrophy, and evidence of elevated glutamate concen

87 ination of sleep physiology in patients with focal bilateral hippocampal damage and amnesia could sup

88 tion, we investigated if human patients with focal bilateral hippocampal damage and amnesia engaged i

89 micropapillary growth of biliary epithelium, focal bile duct stricture formation and bile duct obstru

90 ical and spatiotemporal context within which focal biological responses occur.

91 This study emphasizes that 'non-focal' biotic interactions between hosts and other organ

92 Using data from patients with focal brain damage, we demonstrate that there is a stron

93 ipolar disorder, it can also occur following focal brain damage.

94 The functional consequences of focal brain injury are thought to be contingent on neuro

95 Endocardial-epicardial dissociation and focal breakthroughs in humans with atrial fibrillation (

96 cells with heterozygous mutations, causing a focal, canonical DNA hypomethylation phenotype; this phe

97 ogeneous saccular flow areas associated with focal capillary hypo perfusion areas.

98 In focal cases, the regions with highest OI and PI correspo

99 We present a case of focal cerebral arteriopathy and ischemic stroke in a ped

100 ls had high glutamate/glutamine and elevated focal cerebral blood volume on functional magnetic reson

101 vivo pathologies of hippocampal dysfunction-focal cerebral blood volume, focal atrophy, and evidence

102 antagonist MK801-in mouse and rat models of focal cerebral ischaemia.

103 apoptosis and autophagy following transient focal cerebral ischemia.

104 nia (78, generalised; 34, segmental; and 32, focal cervical) were included in this comprehensive anal

105 Epilepsy, is one of the most common forms of focal childhood epilepsy.

106 Focal chromosomal amplification contributes to the initi

107 izures" (HP: 0011172; p = 2.1 x 10(-5)) and "focal clonic seizures" (HP: 0002266; p = 8.9 x 10(-6)),

108 ncer type shows specific ranges of broad and focal CNA scores.

109 e individuals within a two-month period as a focal coastal event (<1 km radius).

110 of bend-free textures akin to the packing of focal conic domains in smectic liquid crystals.

111 Focal copy number alterations of ERG, IKZF1, PAX5, ETV6,

112 mosomal DNA (ecDNA) as the primary driver of focal copy number amplification (fCNA) - enabling gene a

113 high replication stress and an abundance of focal copy-number alterations associated with activation

114 Focal copy-number gain in CCNE1 and CDKN2A deletion was

115 Focal copy-number increases (genomic amplification) pinp

116 anisms of visual selective attention involve focal cortical changes in alpha power not only for simpl

117 comes at 2 years were seen for patients with focal cortical dysplasia type I or mild malformation of

118 tudy of 159 patients with widely distributed focal cortical impairments, we derive lesion-deficit map

119 of neuronal activity-in the area surrounding focal cortical injuries.

120 isk is less pronounced further away from the focal CpG and modulated by regional GC content.

121 te affects mutation dynamics not only at the focal cytosine but also at neighboring nucleotides.

122 nd visual exploration.SIGNIFICANCE STATEMENT Focal damage to the right cerebral hemisphere may result

123 d choriocapillaris vascular perfusion showed focal defects in every layer.

124 fter nominal return of intraocular pressure, focal defects in flow persisted, which may result in lon

125 3' untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci o

126 NMT3-deficient cells, including reproducible focal demethylation at thousands of normally methylated

127 enriched only in areas overlying this multi-focal dermal field.

128 COVID-19 autopsied lung studies identified focal disease and, congruent with culture data, SARS-CoV

129 oughput printing of microlenses with tunable focal distance.

130 ed, and high-resolution platform technology, focal dynamic thermal imaging (FDTI), for delineating ma

131 Focal dysgenesis is a consistent feature of testicular d

132 ous cord development, including induction of focal dysgenesis, as described in TDS.

133 ion during the MPW results in development of focal dysgenesis.

134 ients with three different forms of isolated focal dystonia and 220 healthy controls.

135 Initial body region affected in isolated focal dystonia has differential risk and patterns of spr

136 d in recently diagnosed adult-onset isolated focal dystonia patients.

137 t only suppressed growth and colonisation by focal E. coli but also prevented it from evolving antibi

138 e and intrasexual competition - representing focal effects of imbalanced sex ratios.

139 s of over 500 seizures from 31 patients with focal epilepsy (mean 16.5 seizures per patient).

140 adults (age >=18 years) with drug-resistant focal epilepsy followed at 35 centres across the USA bet

141 enetic generalized epilepsy and non-acquired focal epilepsy formed disease modules.

142 Focal epilepsy in adults is associated with progressive

143 the most common form of medication-resistant focal epilepsy in adults.

144 Drug-resistant focal epilepsy is a large-scale brain networks disorder

145 nt (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monitoring unit

146 estigated epilepsy types, including lesional focal epilepsy patients, showed an increase in CNV burde

147 ncephalopathy patients but also for lesional focal epilepsy patients.

148 In every patient with refractory focal epilepsy presumed to be lesional, evaluation for s

149 cal evaluation, patients with drug-resistant focal epilepsy were instructed to overtly explain, in a

150 lepsy, lesional focal epilepsy, non-acquired focal epilepsy, and developmental and epileptic encephal

151 For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is th

152 this strategy can effectively treat acquired focal epilepsy, focusing on ion channels because their m

153 with genetic generalized epilepsy, lesional focal epilepsy, non-acquired focal epilepsy, and develop

154 In a patient with focal epilepsy, simultaneous intracranial stereoencephal

155 in 27 patients (13 female) with intractable focal epilepsy, that were tracked throughout multiple se

156 orodeoxyglucose PET imaging in patients with focal epilepsy-that inherently capture disconnection eff

157 s one of the most common causes of inherited focal epilepsy.

158 accepted treatment option for drug-resistant focal epilepsy.

159 odies among unselected people with new-onset focal epilepsy.

160 ion outcomes in a cohort of 36 patients with focal epilepsy.

161 The ADCC was analyzed by focal expansion assay and CD107 cytotoxicity assay.

162 ermore, in one PDGFRbeta line, we found that focal eye drop application of tamoxifen led to an exclus

163 dividuals with PNES and 448 individuals with focal (FE) or generalized (GE) epilepsy.

164 F ablations were grossly identified based on focal fibrosis.

165 able to assess the location and severity of focal glaucoma damage with good agreement with VF.

166 In summary, the impact of focal glioblastoma lesions on the functional connectome

167 kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular

168 Focal glutamate uncaging confirms MNTB neurons as a sour

169 agnetic resonance imaging, but only baseline focal hippocampal atrophy predicted progression to syndr

170 with MmuPV1 mouse papillomavirus and display focal histopathological abnormalities resembling those o

171 image Parkinson's disease, brain tumors, and focal hyperinsulinism of infancy.

172 ner myelin profiles), as well as substantial focal hypermyelination reflected by the formation of rem

173 during adolescence was associated with more focal hyporeactivity in the nucleus accumbens, while dep

174 ct the entire brain circuitry or remain more focal in the specific brain regions and neuronal network

175 interacts with the oxytocin genotype of the focal individual (G(i)) in the regulation of its social

176 Learning was beneficial for survival when focal individuals had fewer than four associates, but su

177 Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal

178 We used mixed models including focal inflammatory activity (the presence of at least on

179 halamic volumes in patients with and without focal inflammatory activity in 161 patients followed ove

180 Focal inflammatory activity is associated with neurodege

181 To quantify the impact of focal inflammatory activity on the rate of neuro-axonal

182 Importantly, we observed that the focal intervention over the left auditory cortex also de

183 Small focal intracerebral hemorrhages only visible on exquisit

184 Finally, MEK5 silencing combined with focal irradiation causes strong inhibition of tumor grow

185 onfidence interval, 35.3-38.8]), followed by focal ischemic (41.8% [40.0-43.6]), myopic glaucoma (42.

186 Four glaucoma phenotypes were assessed: focal ischemic (n = 45), generalized cup enlargement (n

187 es the entire landbird fauna of the combined focal islands.

188 We identified focal kidney fibrin thrombi in 6 of 42 (14%) autopsies.

189 ooperative (or more competitive) behavior in focal larvae.

190 i-vascular endothelial growth factor [VEGF], focal laser treatment, steroids, or observation), no tre

191 ; bevacizumab: OR = 1.40; 95% CI, 1.04-1.87; focal laser: OR = 1.39; 95% CI, 1.01-1.89; P < 0.001).

192 20 pre-operative neurosurgical patients with focal lesion to the pre- and post-central area correspon

193 , particularly the presence and evolution of focal lesions - the pathological hallmark of MS.

194 ting liver fibrosis and in the assessment of focal lesions in other organs, like breast and thyroid g

195 gs were relapsing, large, contrast-enhancing focal lesions in the brain and spinal cord observed on M

196 rganization and cognitive function, and even focal lesions may be associated with distributed functio

197 In the group of 547 women, 593 focal lesions were diagnosed.

198 Focal liver lesions (FLLs) are a common finding during r

199 dels (SSD with a ResNet50 backbone, SSD with focal loss, and RetinaNet) yielded lower sensitivities o

200 Skin biopsy revealed acanthosis and focal lymphocytes with moderate perivascular lymphocyte

201 ed to evaluate the effectiveness of reactive focal mass drug administration (rfMDA) and reactive foca

202 2015-2017), followed by one year of reactive focal mass drug administrations (rfMDAs) (phase II, Sept

203 Non-invasive, molecularly-specific, focal modulation of brain circuits with low off-target e

204 o an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are

205 PET images showed focal myocardial (18)F-FOL uptake colocalizing with infl

206 Lesions classified as focal (n = 70, 56%); multifocal (n = 47, 38%) or diffuse

207 cement suggestive of replacement fibrosis or focal necrosis.

208 chanism, because alpha is thought to reflect focal neural excitability.

209 Moreover, they present with focal neurodegeneration in the anterior temporal lobe, a

210 lly extubated cognitively intact and without focal neurologic deficits.

211 The second most common reason was focal neurologic symptoms (16%); only 16% of these studi

212 help promote tissue survival in response to focal neuronal stress.

213 In zymosan-induced lung inflammation, focal neutrophil infiltrates were increased in CGD compa

214 tension in the plane of the synapse through focal nucleation of actin via Wiskott-Aldrich syndrome p

215 ural oscillations may be a key signature for focal object individuation versus distributed ensemble g

216 th white matter microstructure might be more focal on frontal areas of the brain, as opposed to globa

217 eneralization, and mortality observed during focal onset status epilepticus.

218 OI and PI were more variable in focal-onset than generalised-onset cases.

219 population imaging of projection neurons and focal optogenetic inactivation, we studied mice performi

220 sensitive and specific for the detection of focal or diffuse infections within the kidney in compari

221 yes showed IOI with variable combinations of focal or elongated segmental sheathing and discontinuity

222 low to quantify to which extent a seizure is focal or generalised.

223 resources are focused on a limited number of focal organisms.

224 ings included renal proximal tubular injury, focal pancreatitis, adrenocortical hyperplasia, and lymp

225 ive cenobamate in patients with uncontrolled focal (partial)-onset epilepsy.

226 Adjunctive cenobamate reduced focal (partial)-onset seizure frequency, in a dose-relat

227 The lattice-tip catheter can deliver focal PF to durably isolate veins and create linear lesi

228 he preclinical feasibility and safety of (1) focal PF-based thoracic vein isolation and linear ablati

229 Using the focal PFA catheter, acute cavotricuspid isthmus block wa

230 they offer separate realizations of the same focal phenomenon.

231 rication of Se(0.32) Te(0.68) -based 42 x 42 focal plane arrays with good pixel uniformity, demonstra

232 aperture >n(2)) and be separated in the back focal plane by Fourier filtering.

233 Super-resolution SERS images at different focal planes show evidence of internalized particles and

234 was high, resulting in higher growth of the focal plant in all but the frozen soils.

235 the responses of soil biota and growth of a focal plant to these disturbances.

236 uently, electron microcopy analyses showed a focal podocyte foot process effacement.

237 rected with (i) trial lenses at the anterior focal point (near constant inter-participant RIS in mm),

238 ronounced focusing peak takes place when the focal point aligns with an on-chip detector.

239 tures around 1 were pinpointed by convergent focal point analysis targeting the AE-CCSDT(Q)/CBS level

240 f, at a single lysine (RPB1 K(1268)), is the focal point for DNA-damage-response coordination.

241 ith a concrete goal may provide an essential focal point for this integrative process.

242 veloping erythroid cells and is an important focal point in systemic iron regulation.

243 protein synthesis, and the ribosome TE is a focal point of gene expression control in the molecular

244 The diversity of Ig and TCR repertoires is a focal point of immunological studies.

245 and identify the neuromuscular junction as a focal point of mTORC1-driven muscle aging.

246 epithelium's interactions with H. pylori The focal point of this Brief Review will be on how T cell c

247 eet cherry, new SNPs were chosen following a focal point strategy, grouping six to eight SNPs within

248 a longitudinally-polarized super-resolution focal point.

249 ntify and deploy recovered individuals(8) as focal points for sustaining safer interactions via inter

250 n rebalancing and amino acid metabolism were focal points of the metabolic adjustments to maintain em

251 s with an average of 0.6 cM (627 kb) between focal points.

252 rganising phases, with five patients showing focal pulmonary microthrombi.

253 acteremia (SAB) is uniquely characterized by focal pyogenic complications that might not be apparent

254 thin a relatively small field of view in the focal region, but produce spatial averaging in the other

255 Stimulation of focal regions of thermally responsive systems with a nar

256 framework for relating genome organization, focal RF accumulation and transcription activation.

257 of 1,024 metastatic samples revealed that 13 focal SCNAs were enriched in metastatic samples, includi

258 In GEC(HO-1) rats, lesions of focal segmental and global glomerulosclerosis as well as

259 se plasminogen activator receptor (suPAR) in focal segmental glomerulosclerosis (FSGS) as the circula

260 lop glomerular lesions that mimic collapsing focal segmental glomerulosclerosis (FSGS) in humans with

261 lar plasmin (ogen) was found in PAN rats and focal segmental glomerulosclerosis (FSGS) patients.

262 frequencies of minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), LN and hepati

263 iologies, including diabetic kidney disease, focal segmental glomerulosclerosis and polycystic kidney

264 le to the biopsies from patients with AS and focal segmental glomerulosclerosis, possibly indicating

265 uric patients with reduced renal function or focal segmental glomerulosclerosis.

266 result in epilepsy of infancy with migrating focal seizures (EIMFS) and several other forms of epilep

267 es who presented in infancy with intractable focal seizures and severe developmental delay.

268 and the differences between generalized and focal seizures.

269 sters were quantified based on comparing the focal set of cluster results with 10 other cluster sets.

270 e, which is characterized by large-scale yet focal shifts of chromatin from a compacted to a relaxed

271 etter match to the background over small (or focal) spatial scales, which could be the result of habi

272 Reproduction in the third focal species appears to be primarily driven by overall

273 Our focal species included the meltwater stonefly, Lednia tu

274 er effects among 20 coexisting species (nine focal species) of an avian community in east-central Ill

275 ed by increasing the laser intensity and the focal spot size, while its direction can be changed by t

276 o which interstate characteristics influence focal states to adopt similar policies.

277 d these linear effects, we further find that focal stimulation causes more distributed modifications

278 LANDD EPSPs can be evoked by both focal stimulation near GC proximal dendrites and by acti

279 also known components of the aforementioned focal structures.

280 In this study, we investigate if focal sub-threshold neuromodulation to the rATL facilita

281 tic calls elicited aggressive responses from focal subjects and caused a downregulation in genes asso

282 hat behavioral stimulation likewise elicited focal synaptic responses within grafts.

283 Early TMS trials lacked a focal target and thus positioned the TMS coil over the p

284 Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed bra

285 splants to identify features consistent with focal testicular dysgenesis.

286 disease site (103/382, 27%), toward local or focal therapy (56%) for locoregional disease (126/382, 3

287 CT/MRI/bone scanning, or PSA response after focal therapy.

288 Dysplasia of corpus callosum with focal thinning of the posterior part and characteristic

289 Focal to bilateral tonic-clonic seizures are associated

290 us history, those with positive histories of focal to bilateral tonic-clonic seizures, including both

291 Accordingly, it has been found that the focal topologies S1 and S4 remain predominant in the bul

292 Here, using focal trans-synaptic anterograde tracing, we show that t

293 The focal treatment minimizes concerns about off-target effe

294 Each of the focal trophic groups responded differently to these driv

295 patients with advanced breast cancer showed focal uptake of (131)I-GMIB-anti-HER2-VHH1 in metastatic

296 negative predictive values of 18F-FDG-PET/CT focal uptake were 93%, 90%, 89%, and 94%, respectively,

297 of expanded beta cell mass and function: the focal variant of congenital hyperinsulinism.

298 ass drug administration (rfMDA) and reactive focal vector control (RAVC) in the low malaria-endemic s

299 classified as rotations, single wavefronts, focal waves, or disorganized activity as per standard cr

300 the clinical utility of this model to detect focal white matter injury.