ライフサイエンスコーパス: focal adhesion

1 of actin stress fibers and large peripheral focal adhesion.

2 uding mTOR, CDK/RB, cAMP/PKA, WNT, HKMT, and focal adhesion.

3 ell pair, intercellular force, and number of focal adhesions.

4 ar cues and is required for the recycling of focal adhesions.

5 tegrin alphaVbeta5 from clathrin lattices to focal adhesions.

6 face but on localized hotspots juxtaposed to focal adhesions.

7 echanically linked to actin dynamics through focal adhesions.

8 in adherens junctions, tight junctions, and focal adhesions.

9 e development along the adhesome within cell focal adhesions.

10 n-1 and N-WASP, but not pVASP, cortactin and focal adhesions.

11 folding at forces within the native range in focal adhesions.

12 al protein vinculin, they do not form mature focal adhesions.

13 cells expressing paxillin-EGFP to visualize focal adhesions.

14 ed targeted delivery of integrin vesicles to focal adhesions.

15 in deposits via talin1, a major component of focal adhesions.

16 regulating the formation and disassembly of focal adhesions.

17 rin mediated FAK activation and signaling at focal adhesions.

18 loss of wide F-actin stress fibers and large focal adhesions.

19 d this in turn blocks maturation of anterior focal adhesions.

20 sociates with alpha-actinin and localizes to focal adhesions.

21 podia, stress fibers, cytokinetic rings, and focal adhesions.

22 integrin binding and kindlin localization to focal adhesions.

23 tes nanoarchitectural and dynamic changes of focal adhesions.

24 mutant kindlin-3 the ability to localize to focal adhesions.

25 al features distinct from previously studied focal adhesions: 1) integrin beta5 and talin are present

26 reated podocytes show significant changes in focal adhesions, actin cytoskeleton, and morphology that

27 While the focal adhesion adapter protein paxillin is a well-charac

28 the actin cytoskeleton and mechanosensors at focal adhesions, adherens junctions, and the nuclear env

29 pikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family me

30 earrangements at the leading edge, increased focal adhesion and cellular stiffening, collectively pro

31 characterized by enhanced expression of ECM, focal adhesion and cytoskeletal genes and suppression of

32 ichment of Rho GTPase, extracellular matrix, focal adhesion and cytoskeleton pathways.

33 imarily down regulation of genes involved in focal adhesion and ECM-interaction pathways.

34 programme, which includes genes involved in focal adhesion and extracellular matrix interactions, su

35 Kindlin-1 localizes to focal adhesion and is known to contribute to the activat

36 e discovery rate (FDR) < 0.05], such as KEGG FOCAL ADHESION and KEGG AXON GUIDANCE, which had been de

37 the same frequency independently facilitate focal adhesion and mechanosensing of stem cells, which a

38 ells to be enriched with genes implicated in focal adhesion and mitogen-activated protein kinase (MAP

39 ites, such as dysregulation of ECM-receptor, focal adhesion and PI3k-Akt pathways.

40 days of differentiation and most notably in focal adhesion and PI3K-AKT signalling pathways.

41 human lymphatic endothelial cells increased focal adhesions and actin stress fibers whereas FOXC2-KD

42 We explicitly modeled focal adhesions and adherens junctions.

43 ociated with the down-regulation of existing focal adhesions and associated traction forces.

44 ligands, and the colocalization of DLC1 with focal adhesions and attenuates tumor suppressor activity

45 -pen showed disruption of filamentous actin, focal adhesions and caveolae-mediated membrane trafficki

46 a (CM) decreased the tensile forces in their focal adhesions and decreased their migratory potential.

47 these monolayers lack adherens junctions and focal adhesions and display a disorganized cortical acti

48 f the actin cytoskeleton, and a reduction of focal adhesions and microvilli.

49 ead (eventually polarized) cells with strong focal adhesions and stress fibers; very soft substrates

50 t paxillin phosphorylation and remodeling of focal adhesions and that PAK2 and paxillin are required

51 ng that regulated the cell cycle checkpoint, focal adhesion, and actin remodeling, as well as cell mi

52 ess fibers, increased the number and size of focal adhesions, and impaired cell migration.

53 thelial cells showed defective lamellipodia, focal adhesions, and repair after wounding, along with i

54 Our findings strongly support that forces in focal adhesions applied to FAK via known interactions ca

55 Focal adhesions are dynamic constructs at the leading ed

56 ia require cell-substrate attachment but not focal adhesion assembly and drive proliferation independ

57 ted by changes in mitochondrial positioning; focal adhesion assembly and stability was decreased in M

58 l adhesion complex but did exhibit intrinsic focal adhesion assembly as well as contractile differenc

59 inner nuclear membrane protein Sun2 promote focal adhesion assembly by activating the small GTPase R

60 ell morphology, calcium (Ca(2+)) influx, and focal adhesion assembly, could be visualized and quantif

61 C complexes and inhibits RhoA activation and focal adhesion assembly.

62 n force to promote actin retrograde flow and focal adhesion assembly.

63 ased heart via transcriptional activation of focal adhesion assembly.

64 the role of CD103 cytoplasmic domain and the focal adhesion-associated protein paxillin (Pxn) in down

65 The pSiNP-induced destabilisation of focal adhesions at the leading front may partially expla

66 Focal adhesion behavior is locally regulated by stiffnes

67 sis implicated signaling pathways regulating focal adhesions, cell junctions, and maintenance of the

68 ated with decreased cell spreading, abnormal focal adhesions, changes in the organization of the acti

69 ensional shapes with thick nuclei, and short focal adhesion cluster (FAC) lengths.

70 These effects are attributed to the "focal adhesion clutch," in which moving actin filaments

71 VopA also has potent modulating activity on focal adhesion complex (FAC) proteins, where VopA marked

72 of several proteins of the integrin-mediated focal adhesion complex as they experience intra- and ext

73 es in expression of proteins involved in the focal adhesion complex but did exhibit intrinsic focal a

74 indlin is a largely overlooked member of the focal adhesion complex whose roles in cellular mechanotr

75 fects on the force transduction layer of the focal adhesion complex, drives glioblastoma motility and

76 Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer

77 n events within proteins that constitute the focal adhesion complex, including focal adhesion kinase

78 e addressed the relationship of cavin-1 with focal adhesion complexes following nutritional stimulati

79 FAK localizes into focal adhesion complexes formed at the cytoplasmic side

80 Integrin-based focal adhesion complexes link the glial membrane to the

81 where it associates with the integrin-based focal adhesion complexes to ensure proper ensheathment o

82 ochondrial trafficking, turnover of membrane focal adhesion complexes, and enhanced tumor cell migrat

83 of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular

84 ese sliding focal adhesions contain standard focal adhesion constituents but completely lack classica

85 basement membrane components, these sliding focal adhesions contain standard focal adhesion constitu

86 n assembly based on stable or fixed-position focal adhesions containing alphaVbeta3 integrins plus al

87 1 enhanced CSD-dependent vinculin tension in focal adhesions, dampening force fluctuation and synchro

88 patterns, we show that the appearance of new focal adhesions directly in front of existing focal adhe

89 d sensitivity to Mg(2+)- and Ca(2+)-mediated focal adhesion disassembly in metastatic cells, rather t

90 protein Rab5 controls integrin trafficking, focal adhesion disassembly, and cell migration and has b

91 skeletal cross-talk, MT stability, and hence focal adhesion disassembly.

92 ects cell adhesion through the inhibition of focal adhesion disassembly.

93 icroenvironment topography coordinates their focal adhesion distribution and alignment.

94 hat AP-1B colocalized with beta1 integrin in focal adhesions during cell migration using confocal mic

95 e type III effector TarP, which localized to focal adhesions during infection and when expressed ecto

96 This results in defective actin and focal adhesion dynamics and increased 3D cell migration

97 otubule growth rate, which in turn modulated focal adhesion dynamics and ultimately promoted efficien

98 pport a role for Slac2-b in regulating local focal adhesion dynamics to support effective KC adhesion

99 s role in regulating the actin cytoskeleton, focal adhesion dynamics, and tumor cell motility, and id

100 sicle trafficking to the plasma membrane and focal adhesion dynamics.

101 c cancer cells by regulating microtubule and focal adhesion dynamics.

102 t demonstrated a role for PHIP in regulating focal adhesion dynamics.

103 its involvement in actin reorganization and focal adhesion dynamics.

104 e requiring stable actomyosin bundles, e.g., focal adhesion elongation or migratory front-back polari

105 in integrin-mediated mechanotransduction and focal adhesion (FA) dynamics.

106 IIbeta) regulates cell shape, migration, and focal adhesion (FA) number.

107 Focal adhesion (FA) turnover depends on microtubules and

108 Focal adhesion (FA)-stimulated reorganization of the F-a

109 Focal adhesions (FA) are a complex network of proteins t

110 Focal adhesions (FA) are large macromolecular assemblies

111 y an actin ring and large stable cornerstone focal adhesions (FA).

112 tein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signalin

113 that knockdown of Rab18 reduces the size of focal adhesions (FAs) and influences their dynamics.

114 Focal adhesions (FAs) are integrin-based transmembrane a

115 ssembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration.

116 edge, and showed that force distribution in focal adhesions (FAs) is off-centered and FA size-depend

117 on pattern is peripheral and associated with focal adhesions (FAs), where it is coupled with increase

118 nse, through the acto-myosin cytoskeleton at focal adhesions (FAs); however, FA actin cytoskeletal re

119 cavin-1 impairs focal complex remodeling and focal adhesion formation and causes a mechanical stress

120 In turn, focal adhesion formation and FAK/SRC signaling is activa

121 robed in vitro and significant modulation of focal adhesion formation and osteochondral lineage commi

122 Furthermore, we revealed enhanced focal adhesion formation and osteogenic differentiation

123 controls dynamic cellular processes, such as focal adhesion formation and turnover and cell division.

124 isrupt the binding of talin to the membrane, focal adhesion formation, and cell spreading.

125 viously demonstrated that Nischarin inhibits focal adhesion formation, cell migration, and invasion,

126 somal integrin alpha6beta4 exhibit increased focal adhesion formation, cell spreading, and traction-f

127 stress fiber reorganization, stimulation of focal adhesion formation, Yap activation, increases in t

128 REVERBalpha and TBPL1 altered integrinbeta1 focal-adhesion formation, resulting in increased myofibr

129 cial morphogenesis and represent both novel (focal adhesion, FoxO signaling, insulin signaling) and k

130 The focal adhesion group proteins are identified as new dise

131 The presence and regulation of PKD2 at focal adhesions identifies a novel function for this kin

132 ation and synchronously stabilizing cellular focal adhesions in a high-tension mode, paralleling effe

133 yl-6-carbamide (surfen) reduced invasion and focal adhesions in F98 cells encapsulated in COMP matric

134 Focal adhesions in FGF-2-stimulated fibroblasts of affec

135 (MMP14) is central to ECM degradation at the focal adhesions in human ARPE19 cells.

136 esion kinase (FAK) activity and the enhanced focal adhesions in the knockdown cells.

137 its coupling with local rigidity sensing at focal adhesions in the regulation of cell shape changes

138 Increased tension sensation at focal adhesions induced myofibroblast differentiation on

139 ions in mechanosensitive structures, such as focal adhesions, invadopodia, and podosomes, that are di

140 ative activity, but not the assembly, of the focal adhesion is regulated by chloride intracellular ch

141 ocal adhesions directly in front of existing focal adhesions is associated with the down-regulation o

142 y half, relative to wild-type cells, whereas focal adhesion kinase (FAK) activity and Rho/Rac/Cdc42 p

143 also had defects in alleviating the elevated focal adhesion kinase (FAK) activity and the enhanced fo

144 ), and subsequent simultaneous inhibition of focal adhesion kinase (FAK) and EGFR signaling pathways.

145 Focal adhesion kinase (FAK) and its close relative Pyk2

146 nt of vinculin, leading to the activation of focal adhesion kinase (FAK) and metalloproteinase expres

147 Specifically, the disruption of focal adhesion kinase (FAK) and paxillin interactions us

148 rix (ECM) through beta3-integrin to activate focal adhesion kinase (FAK) and phosphorylate the actin

149 by a decrease in the phosphorylation of both focal adhesion kinase (Fak) and protein kinase B (Akt).

150 We identified focal adhesion kinase (FAK) as a VHR-interacting molecul

151 We previously identified focal adhesion kinase (FAK) as an important regulator of

152 we identify the adhesion proteins talin and focal adhesion kinase (FAK) as proteolytic targets of ca

153 MET proto-oncogene receptor tyrosine kinase/focal adhesion kinase (FAK) axis leads to CDK4/6-indepen

154 Specific inhibitors of focal adhesion kinase (FAK) blocked phosphorylation of T

155 be prevented by pharmaceutical inhibition of focal adhesion kinase (FAK) both in vitro and ex ovo.

156 arr1 (beta-arrestin1) promotes activation of focal adhesion kinase (FAK) by the chemokine receptor CX

157 ogical inhibitors of major PTKs: Src and the focal adhesion kinase (FAK) family kinases - FAK and pro

158 The focal adhesion kinase (FAK) gene protein tyrosine kinase

159 n and a ligand resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C depend

160 Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is

161 Focal Adhesion Kinase (FAK) inhibitors are currently und

162 Focal adhesion kinase (FAK) is a central regulator of in

163 Focal adhesion kinase (FAK) is a key component of the me

164 Focal adhesion kinase (FAK) is a key signaling molecule

165 suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulat

166 , we generated fibroblast-specific inducible focal adhesion kinase (FAK) knockout (cKO) mice in a bre

167 horylation of the integrin signaling kinases focal adhesion kinase (FAK) or integrin-linked kinase.

168 s, where VopA markedly reduced the levels of focal adhesion kinase (FAK) phosphorylation at Ser910, w

169 Both Pyk2 and the closely related focal adhesion kinase (FAK) regulate tumor cell invasion

170 Inhibition of focal adhesion kinase (FAK) rescued SERT function in syn

171 ced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576).

172 ological inhibition of integrin-ECM binding, focal adhesion kinase (FAK) signaling, or TGF-beta signa

173 d alphavbeta3 integrins to activate integrin-focal adhesion kinase (FAK) signaling.

174 The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motili

175 we report that Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway

176 mbrane lipid raft with caveolin-1 (CAV1) and focal adhesion kinase (FAK) which then interact with AKT

177 direct HDAC5 tyrosine 642 phosphorylation by focal adhesion kinase (FAK), a HDAC5 post-translational

178 erexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has im

179 atics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synt

180 sphorylation of myosin light chain (MLC) and focal adhesion kinase (FAK), supporting a role for ROCK

181 operation between different AKT isoforms and focal adhesion kinase (FAK)-dependent adhesion signaling

182 A metabolism, and cell adhesion, including a focal adhesion kinase (FAK)-regulated network mediating

183 this residue blocks PKD2's interaction with Focal Adhesion Kinase (FAK).

184 promote exocytosis through interactions with focal adhesion kinase (FAK).

185 subunits, and a primary signaling kinase is focal adhesion kinase (FAK).

186 phosphorylated forms of paxillin (pPXN) and focal adhesion kinase (pFAK).

187 onse program that involved the activation of focal adhesion kinase 1 (FAK1), protein kinase C-delta (

188 iffness regulates vascular integrity through focal adhesion kinase activity.

189 titute the focal adhesion complex, including focal adhesion kinase and Crk-associated substrate.

190 embrane protein integrin beta1 and activates focal adhesion kinase and downstream PI3K/AKT signaling.

191 A induced cytoskeletal changes and activated focal adhesion kinase and ERKs 1/2, and decreased Src ki

192 r tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and localizes to postsynaptic site

193 entify an ITGA2-dependent phosphorylation of focal adhesion kinase and mitogen-activated protein kina

194 metastasis, including the phosphorylation of focal adhesion kinase and myeloid cell recruitment to th

195 remodelling, mechano-transduction (e.g. PTK2/Focal Adhesion Kinase and Phospholipase D- following chr

196 A proteomics screen revealed that focal adhesion kinase bound PI(4,5)P2, biochemical assay

197 Distinct motifs of the focal adhesion kinase differentially regulate tumor bloo

198 We have found that focal adhesion kinase expression is downregulated under

199 ls the vertical displacement of paxillin and focal adhesion kinase from the signaling layer of focal

200 on also decreased the phosphorylation of the focal adhesion kinase in Tyr925.

201 er, inhibition of integrin signaling through focal adhesion kinase inhibition caused disruption of ce

202 PI(4,5)P2, biochemical assays disclosed that focal adhesion kinase is preferentially activated by wea

203 Previous studies have shown that the focal adhesion kinase Pyk2 plays a critical role in mono

204 hanotransduction after injury with increased focal adhesion kinase signaling and nuclear translocatio

205 sin light chain kinase or phosphorylation of focal adhesion kinase was ineffective.

206 uence (which we believe is the activation of focal adhesion kinase) is controlled by the binding ener

207 ain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin-linked kinase, enhan

208 sion, and motility via cleavage of paxillin, focal adhesion kinase, and talin).

209 mTORC2 targets included focal adhesion kinase, proto-oncogene tyrosine-protein k

210 Inhibition of focal adhesion kinase, which is required for basal const

211 previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor

212 d invasion, leading to reduced activation of focal adhesion kinase.

213 gement of the extracellular matrix (ECM) via focal adhesion kinase.

214 ch required the activation of Rho GTPase and focal adhesion kinase.

215 However, inhibition of focal-adhesion-kinase activity not only attenuates Fyn a

216 The focal adhesion kinases inhibitor (FAKi 14) and cell inte

217 activity and colocalizes with phosphorylated focal adhesion kinases.

218 ase in the number of actin stress fibers and focal adhesions, leading to enhanced cell migration.

219 hanosensitive, talin- and vinculin-mediated, focal adhesion-like molecular clutch, which couples inte

220 1 protein product is a critical component of focal adhesions linking signaling between the extracellu

221 n the actomyosin network resulted in smaller focal adhesions, lower tension within the network, and s

222 ous components of the actin cytoskeleton and focal adhesion machineries whose activity is critical fo

223 enriched for; pathways-in-cancer (including; focal adhesion, MAPK signaling, PI3K-Akt-mTOR signaling,

224 ogen treatment was associated with decreased focal adhesion marker expression with rescue by amilorid

225 tivated alphavbeta3 integrin in podosome and focal adhesion matrix adhesion sites.

226 cross-linked elastomers supported efficient focal adhesion maturation and fibroblast spreading becau

227 Bis-T-23 promoted stress fiber formation and focal adhesion maturation in a dynamin-dependent manner.

228 f the essential and autonomous regulators of focal adhesion maturation suggests a molecular mechanism

229 cell mechanics by limiting cytoskeletal and focal adhesion maturation to enable persistent cell moti

230 gement with the traction force machinery and focal adhesion maturation.

231 nsor to quantitatively evaluate the force in focal adhesions of the tumor cell.

232 he clustering of mechanosensors into nascent focal adhesions on this contact ring.

233 the extracellular matrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of

234 k between the LRP4-MuSK pathway and integrin-focal adhesion pathway.

235 and alpha5beta1-specific blockade inhibited focal adhesion phosphorylation and IL-13-enhanced contra

236 ather than changes in integrin expression or focal adhesion phosphorylation.

237 ctin, inhibited ASM adhesion, and attenuated focal adhesion phosphorylation.

238 of phospho-Src and phospho-FAK accumulate at focal adhesions, positively regulating adhesion and inva

239 plasma membrane, such as cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coate

240 ation of extracellular matrix remodeling and focal adhesion processes in tumors with high TF, support

241 a physiological interaction between DLC1, a focal adhesion protein and tumor suppressor, with SRC an

242 l homing, cardiac fibroblast activation, and focal adhesion protein expression via hyperactivated YAP

243 indlin-2, which is primarily recognized as a focal adhesion protein in EC, was not anticipated to hav

244 proteins desmoglein-2 and desmocollin-3, the focal adhesion protein integrin-alpha2beta1, the recepto

245 class of small molecules aimed at targeting focal adhesion protein interactions that are essential f

246 In line with this finding, the focal adhesion protein PTK2 displays aberrant localizati

247 Src kinase-dependent pY14Cav1 regulation of focal adhesion protein stabilization, focal adhesion ten

248 Talin is a focal adhesion protein that is known to extend under mec

249 g in force generated across the load-bearing focal adhesion protein vinculin within MSCs using an FRE

250 ocytic cup that contained beta(2) integrins, focal adhesion proteins and tyrosine kinases.

251 Kindlins are focal adhesion proteins that regulate integrin activatio

252 lted in significant down-regulation of these focal adhesion proteins, along with zyxin (ZYX), and pro

253 lay a key role in regulating the activity of focal adhesion proteins.

254 of glioblastoma cells, together with several focal adhesion proteins: vinculin (VCL), talin 1 (TLN1),

255 ascent adhesions (NAs), focal complexes, and focal adhesions, ranked here ascendingly based on size a

256 1 signaling promoted F-actin disassembly and focal adhesion reduction by activating the small guanosi

257 on through reciprocal actomyosin tension and focal adhesion reinforcement, but continued motility req

258 ctedly independent of the orientation of the focal adhesions relative to the direction of strain.

259 fects of TarP, including its localization to focal adhesions, required a post-invasion interaction wi

260 The assembly of focal adhesions requires the recruitment and activation

261 uorescent imaging for adherens junctions and focal adhesions show the progressive loss of cell-cell b

262 th PDAC development and metastasis including focal adhesion signaling and extracellular matrix organi

263 se type 6 (ACP6), leading to upregulation of focal adhesion signaling in an LPA-dependent manner.

264 ancer cell-collagen interaction or targeting focal adhesion signaling may present an opportunity for

265 d to decreased epithelial beta1 integrin and focal adhesion signaling, as well as reduced thrombospon

266 nformational changes, which in turn, trigger focal adhesion signaling.

267 n cytoskeletal architecture and reduction of focal adhesion size and number, all of which were rescue

268 sembly mechanism, alpha5beta1 integrin-based focal adhesions slide actively on the underlying matrix

269 atterning by modulating the cytoskeleton and focal adhesion structures(3-5).

270 tracellular matrix through interactions with focal adhesion structures.

271 Focal adhesion tension in tumor cells was also affected

272 Overall, this study demonstrates that focal adhesion tension is involved in altered migratory

273 t, randomly oriented mimetics did not change focal adhesion tension sensation or enrich for p38-YAP-T

274 ion of focal adhesion protein stabilization, focal adhesion tension, and cancer cell migration is CSD

275 cytoskeletal tension and over-maturation of focal adhesions, tethering cells to their matrix.

276 belonging to strongly interacting pathways (focal adhesion, TGFbeta, and Hippo, respectively).

277 the formation of unusually stable and mature focal adhesions that resisted disassembly induced by the

278 vel mechanism, Chlamydia inserts TarP within focal adhesions to alter their organization and stabilit

279 itched to alpha5beta1 integrin-based sliding focal adhesions to assemble fibronectin matrix.

280 mportant for angiogenic sprouting that links focal adhesions to polarity signaling in ECs.

281 duces the amount of stress fibers and mature focal adhesions to result in the reorganization of actin

282 that Basigin associates with integrin at the focal adhesions to uphold the structure of the glia-extr

283 These changes are coupled to reduced focal adhesion turnover and enhanced paxillin phosphoryl

284 cling of EGFR and beta1 integrins, increased focal adhesion turnover, and cell migration.

285 /threonine kinase (Akt) activation, membrane focal adhesion turnover, and increased epithelial cell m

286 of cell adhesions by adherens junctions and focal adhesions, two features affected during EMT.

287 Focal adhesion tyrosine kinase (PTK2) is often overexpre

288 nsitive and can strengthen integrin-mediated focal adhesions under force by shifting the interactions

289 The consequence of Chlamydia-stabilized focal adhesions was restricted cell motility and enhance

290 Because Rap activity affects formation of focal adhesions, we hypothesized that Nephrin transmits

291 in (BMP) signaling, chemokine signaling, and focal adhesion were activated by JQ1 to promote invasion

292 the leading edges of migrating cells and in focal adhesion, where it forms a signaling complex with

293 adhesion kinase from the signaling layer of focal adhesions, whereas vinculin remained in its normal

294 endent paxillin activation and remodeling of focal adhesions, which are necessary for local activatio

295 particles are enriched in proteins found in focal adhesions, which attach macrophages to the substra

296 t results in activation of Integrin beta1 at focal adhesions, which may affect podocyte attachment to

297 tion forces by promoting dynamic turnover of focal adhesions, which may then regulate processes such

298 s of cell-cell borders and the appearance of focal adhesions with the increase in ECM stiffness (conf

299 ovide buffering to allow extension of FAK in focal adhesions without compromising functionality.

300 state but is activated upon recruitment into focal adhesions, yet how this occurs or what induces str