ライフサイエンスコーパス: focal adhesion kinase

1 GAP, GRAF1 (GTPase Regulator Associated with Focal Adhesion Kinase).

2 line using mass spectrometry, including FAK (focal adhesion kinase).

3 ch required the activation of Rho GTPase and focal adhesion kinase.

4 otransduction in primary hepatocytes through focal adhesion kinase.

5 ously expressed non-receptor tyrosine kinase focal adhesion kinase.

6 llin independently of upstream regulation by focal adhesion kinase.

7 tent and showed increased phosphorylation of focal adhesion kinase.

8 of PI3K signaling mediated by integrins and focal adhesion kinase.

9 integrin-linked kinase but is independent of focal adhesion kinase.

10 rylation of N-WASP at the Tyr-256 residue by focal adhesion kinase.

11 cytoskeleton and reduced phosphorylation of focal adhesion kinase.

12 d invasion, leading to reduced activation of focal adhesion kinase.

13 gement of the extracellular matrix (ECM) via focal adhesion kinase.

14 oteolysis of the adhesion proteins talin and focal adhesion kinase.

15 activity and colocalizes with phosphorylated focal adhesion kinases.

16 onse program that involved the activation of focal adhesion kinase 1 (FAK1), protein kinase C-delta (

17 nt change in mass but a 3-fold increase in P-focal adhesion kinase, 1.5-fold increase in P-Akt, and 5

18 ellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-depe

19 previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor

20 eptor (CXCR) 1, and the intracellular kinase focal adhesion kinase-1.

21 consists of the integrin subunit betanu and focal adhesion kinase 56 (Fak56), both of which are requ

22 Focal adhesion kinase activation and satellite cell numb

23 es several oncogenic pathways, such as early focal adhesion kinase activation upstream of PI3K-mTOR,

24 Additionally, integrin beta1d expression and focal adhesion kinase activation were increased in this

25 SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension b

26 actin concomitant with a decrease in Rho and focal adhesion kinase activity.

27 iffness regulates vascular integrity through focal adhesion kinase activity.

28 However, inhibition of focal-adhesion-kinase activity not only attenuates Fyn a

29 beta3 and the concomitant phosphorylation of focal adhesion kinase and AKT in podocytes.

30 ion of integrin-beta3 and phosphorylation of focal adhesion kinase and AKT, known mediators of integr

31 rite extension in vitro by signaling through focal adhesion kinase and Akt.

32 f angiogenic factors and mechanotransducers (focal adhesion kinase and beta1-integrin) ex vivo A 3-we

33 titute the focal adhesion complex, including focal adhesion kinase and Crk-associated substrate.

34 omes that could be reversed by knocking down focal adhesion kinase and depleting it from the MVs or b

35 embrane protein integrin beta1 and activates focal adhesion kinase and downstream PI3K/AKT signaling.

36 cones and forms a multiprotein complex with focal adhesion kinase and ERK.

37 igh-affinity conformation and an increase in focal adhesion kinase and ERK1/2 activation.

38 A induced cytoskeletal changes and activated focal adhesion kinase and ERKs 1/2, and decreased Src ki

39 f transcription 3-mediated activation of the focal adhesion kinase and its associated focal adhesion

40 r tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and localizes to postsynaptic site

41 evealed that integrin beta5 mediates the Src-focal adhesion kinase and MEK-extracellular signal-regul

42 entify an ITGA2-dependent phosphorylation of focal adhesion kinase and mitogen-activated protein kina

43 t in SHP-2 exhibited decreased activation of focal adhesion kinase and mitogen-activated protein kina

44 metastasis, including the phosphorylation of focal adhesion kinase and myeloid cell recruitment to th

45 1 integrin, which subsequently regulates Src/focal adhesion kinase and paxillin and prevents anoikis.

46 ion formation and reduced phosphorylation of focal adhesion kinase and paxillin, which could be resto

47 sly identified PTP-zeta downstream effectors focal adhesion kinase and paxillin.

48 remodelling, mechano-transduction (e.g. PTK2/Focal Adhesion Kinase and Phospholipase D- following chr

49 3a were dependent on TGF-beta1 activation of focal adhesion kinase and PI3K/Akt.

50 process required integrin signaling through focal adhesion kinase and relied on an intact microtubul

51 eta3 integrin surface expression, activating focal adhesion kinase and Src kinases, and promoting cel

52 ls, TNFalpha-treated cells exhibited reduced focal adhesion kinase and subsequent plasma membrane per

53 ICOS-Fc downmodulated the phosphorylation of focal adhesion kinase and the expression of beta-Pix in

54 ate that integrin-mediated signaling through focal adhesion kinase and the p38 mitogen-activated prot

55 on integrin beta-3 signals that activate the focal-adhesion kinase and c-Src kinase and their downstr

56 ain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin-linked kinase, enhan

57 he migratory proteins rho-associated kinase, focal adhesion kinase, and matrix metalloproteinases.

58 mpaired by inhibitors of NADPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase

59 lving vasodilator-stimulated phosphoprotein, focal adhesion kinase, and protein-disulfide isomerase i

60 he focal adhesion complex signaling pathway, focal adhesion kinase, and rac1.

61 as phosphorylation of cortactin, activity of focal adhesion kinase, and small GTPases.

62 sion, and motility via cleavage of paxillin, focal adhesion kinase, and talin).

63 dynamic competitive interactions between E6, focal adhesion kinase, and the GIT1 ARF-GAP protein for

64 n Shp2 depends on hyperactivation of Akt and focal adhesion kinase as well as mammalian target of rap

65 volves stimulation of Src-family kinases and focal adhesion kinase, as well as the localized accumula

66 on of beta1-integrins and phosphorylation of focal adhesion kinase at synaptic sites, and were preven

67 amily kinases (SFKs), and phosphorylation of focal adhesion kinase at Y397 (pFAK(Y397)), the latter b

68 A proteomics screen revealed that focal adhesion kinase bound PI(4,5)P2, biochemical assay

69 tein phosphatase 2A (PP2A) and inhibition of focal adhesion kinase by MEK/ERK to allow the binding be

70 lecularly supported by the regulation of the focal adhesion kinase by p38delta in the human breast ce

71 to adopt a structure similar to that of the focal adhesion kinase C-terminal focal adhesion-targetin

72 ent of vinculin and the formation of a novel focal adhesion kinase complex in response to ErbB2 activ

73 n of ACF7, whose phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin

74 alpain 1, the primary enzyme responsible for focal adhesion kinase degradation, which becomes induced

75 Distinct motifs of the focal adhesion kinase differentially regulate tumor bloo

76 The intricate interplay of this "MEK/ERK-focal adhesion kinase-DLC1-PP2A" quartet provides a nove

77 molecular changes, such as reduced levels of focal adhesion kinase expression and a misbalance in foc

78 We have found that focal adhesion kinase expression is downregulated under

79 ion in both cell motility and phosphorylated focal adhesion kinase expression, suggesting a defect in

80 rrent FA assembly and Src activation leading focal adhesion kinase (FAK) activation by 42.6 +/- 12.6

81 In addition, vinculin is necessary for Focal Adhesion Kinase (FAK) activation in 3D as vinculin

82 ase in cell adhesion, as well as in integrin/focal adhesion kinase (FAK) activation, and exhibit an e

83 cular mechanism, whereby adiponectin targets focal adhesion kinase (FAK) activity and disrupts key fe

84 y half, relative to wild-type cells, whereas focal adhesion kinase (FAK) activity and Rho/Rac/Cdc42 p

85 also had defects in alleviating the elevated focal adhesion kinase (FAK) activity and the enhanced fo

86 We identified hyperactivated focal adhesion kinase (FAK) activity in neoplastic PDAC

87 nctly control force transmission to regulate focal adhesion kinase (FAK) activity, a crucial molecula

88 type I receptor (AT1R) signaling and abated focal adhesion kinase (FAK) activity.

89 Focal adhesion kinase (FAK) acts as an adaptor at the fo

90 However, some of these kinases like focal adhesion kinase (FAK) also possess scaffolding fun

91 with increased activating phosphorylation of focal adhesion kinase (FAK) and breast cancer anti-estro

92 ), and subsequent simultaneous inhibition of focal adhesion kinase (FAK) and EGFR signaling pathways.

93 on and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading.

94 Sorafenib dephosphorylated focal adhesion kinase (FAK) and extracellular signal-reg

95 illin at the centrosome that is dependent on focal adhesion kinase (FAK) and identify an important co

96 siRNA knockdown to block phosphorylation of focal adhesion kinase (FAK) and increase the size of foc

97 Focal adhesion kinase (FAK) and its close relative Pyk2

98 GIV interacts with focal adhesion kinase (FAK) and ligand-activated beta1 i

99 nt of vinculin, leading to the activation of focal adhesion kinase (FAK) and metalloproteinase expres

100 he Gas6/Axl signalling pathway recruits Src, focal adhesion kinase (FAK) and NFkappaB.

101 ainst LD2 and LD4 that are binding sites for focal adhesion kinase (FAK) and other proteins.

102 emporal relationship between the dynamics of focal adhesion kinase (FAK) and paxillin at FAs in the p

103 Specifically, the disruption of focal adhesion kinase (FAK) and paxillin interactions us

104 a1 integrin and decreased phosphorylation of focal adhesion kinase (FAK) and paxillin resulting in FA

105 and PTP-PEST, with consequent activation of focal adhesion kinase (FAK) and paxillin.

106 ntracellular signaling pathways that include focal adhesion kinase (FAK) and phosphoinositide 3-kinas

107 rix (ECM) through beta3-integrin to activate focal adhesion kinase (FAK) and phosphorylate the actin

108 We demonstrate that Lyn association with focal adhesion kinase (FAK) and phosphorylation of FAK a

109 by a decrease in the phosphorylation of both focal adhesion kinase (Fak) and protein kinase B (Akt).

110 Pharmacological inhibition of both focal adhesion kinase (FAK) and Raf also induced regress

111 ibition results in altered signaling through focal adhesion kinase (FAK) and RhoA GTPase and a transf

112 Focal adhesion kinase (FAK) and Src family kinases (SFK)

113 urbation of the key IAC signaling components focal adhesion kinase (FAK) and Src.

114 creases tyrosine phosphorylation of p130Cas, focal adhesion kinase (FAK) and the downstream adaptor p

115 deletion of gH prevented phosphorylation of focal adhesion kinase (FAK) and the transport of viral c

116 e cell through a pathway including paxillin, focal adhesion kinase (FAK) and vinculin.

117 hanges in subcellular distribution of active focal adhesion kinase (FAK) are associated with the fusi

118 beta4 integrin and focal adhesion kinase (FAK) are often associated with a

119 We identified focal adhesion kinase (FAK) as a VHR-interacting molecul

120 We previously identified focal adhesion kinase (FAK) as an important regulator of

121 we identify the adhesion proteins talin and focal adhesion kinase (FAK) as proteolytic targets of ca

122 STRADalpha have increased phosphorylation of focal adhesion kinase (FAK) at Tyr(397)/Tyr(861) and enh

123 C family kinase-dependent phosphorylation of focal adhesion kinase (FAK) at tyrosine 925, FAK associa

124 nhibited alpha3beta1 signaling downstream of focal adhesion kinase (FAK) autoactivation at the point

125 MET proto-oncogene receptor tyrosine kinase/focal adhesion kinase (FAK) axis leads to CDK4/6-indepen

126 TrxR linkage to sF-actin requires focal adhesion kinase (FAK) based on immunoprecipitation

127 Specific inhibitors of focal adhesion kinase (FAK) blocked phosphorylation of T

128 be prevented by pharmaceutical inhibition of focal adhesion kinase (FAK) both in vitro and ex ovo.

129 arr1 (beta-arrestin1) promotes activation of focal adhesion kinase (FAK) by the chemokine receptor CX

130 ue to the reduced expression and activity of focal adhesion kinase (FAK) by this cell type.

131 yperoxia were abrogated in cells depleted of focal adhesion kinase (FAK) by treatment with small inhi

132 imulate FN matrix assembly and activation of focal adhesion kinase (FAK) compared with the level of a

133 pathways regulated by keratinocyte-specific focal adhesion kinase (FAK) control dermal remodeling vi

134 ogical inhibitors of major PTKs: Src and the focal adhesion kinase (FAK) family kinases - FAK and pro

135 investigate the proposal that integrins and focal adhesion kinase (FAK) form a complex that has stru

136 mics, and release the cell motility effector focal adhesion kinase (FAK) from inhibition by the autop

137 The focal adhesion kinase (FAK) gene protein tyrosine kinase

138 A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to

139 n and a ligand resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C depend

140 5beta1 integrin and downstream signalling to focal adhesion kinase (FAK) in an endoglin-dependent man

141 ation of membrane-associated adaptor protein focal adhesion kinase (FAK) in Caco-2 monolayers.

142 Here, we show that conditional deletion of focal adhesion kinase (FAK) in embryonic mammary epithel

143 Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is

144 Focal adhesion kinase (FAK) in platelets regulated their

145 Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor gr

146 Focal Adhesion Kinase (FAK) inhibitor can bypass extrusi

147 Addition of a focal adhesion kinase (FAK) inhibitor reduces disassembl

148 Focal Adhesion Kinase (FAK) inhibitors are currently und

149 Focal adhesion kinase (FAK) is a central regulator of in

150 Focal adhesion kinase (FAK) is a critical regulator of s

151 Focal adhesion kinase (FAK) is a cytoplasmic tyrosine ki

152 Focal adhesion kinase (FAK) is a key component of the me

153 Focal adhesion kinase (FAK) is a key signaling molecule

154 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

155 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

156 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

157 Nuclear focal adhesion kinase (FAK) is a potentially important r

158 Focal adhesion kinase (FAK) is considered as an attracti

159 Focal Adhesion Kinase (FAK) is essential for cell migrat

160 suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulat

161 Focal adhesion kinase (FAK) is overexpressed in many HCC

162 d dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tum

163 , we generated fibroblast-specific inducible focal adhesion kinase (FAK) knockout (cKO) mice in a bre

164 horylation of the integrin signaling kinases focal adhesion kinase (FAK) or integrin-linked kinase.

165 s, where VopA markedly reduced the levels of focal adhesion kinase (FAK) phosphorylation at Ser910, w

166 Focal adhesion kinase (FAK) promotes anti-tumor immune e

167 Both Pyk2 and the closely related focal adhesion kinase (FAK) regulate tumor cell invasion

168 Focal adhesion kinase (FAK) regulates different cellular

169 Inhibition of focal adhesion kinase (FAK) rescued SERT function in syn

170 directly bind paxillin, which in turn bound focal adhesion kinase (FAK) resulting in FAK activation

171 ced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576).

172 was invasion, which was mediated by both Src-focal adhesion kinase (FAK) signaling and Forkhead box p

173 ssays revealed that S100A4 activates Src and focal adhesion kinase (FAK) signaling events, and inhibi

174 ficantly dysregulated expression of genes in focal adhesion kinase (FAK) signaling, a key pathway reg

175 ological inhibition of integrin-ECM binding, focal adhesion kinase (FAK) signaling, or TGF-beta signa

176 RhoA also activates focal adhesion kinase (FAK) signaling.

177 tor (uPAR), and beta1-integrin, which affect focal adhesion kinase (FAK) signaling.

178 d alphavbeta3 integrins to activate integrin-focal adhesion kinase (FAK) signaling.

179 The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motili

180 tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase (FAK) subfamily of cytoplasmic tyr

181 we report that Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway

182 Activated integrins recruit focal adhesion kinase (FAK) that mediates metastatic dow

183 Activation of the tyrosine kinase focal adhesion kinase (FAK) upon cell stimulation by the

184 Inhibition of focal adhesion kinase (FAK) using pharmacological inhibi

185 nteractions, as did inhibiting intracellular focal adhesion kinase (FAK) using Y15.

186 The gamma-Pcdhs bind to and inhibit focal adhesion kinase (FAK) via a constant C-terminal cy

187 Signaling from focal adhesion kinase (FAK) was blocked using FAK inhibi

188 We demonstrate that the host cell focal adhesion kinase (FAK) was necessary for the invasi

189 mbrane lipid raft with caveolin-1 (CAV1) and focal adhesion kinase (FAK) which then interact with AKT

190 We examined interactions of the focal adhesion kinase (FAK) with protein-tyrosine phosph

191 direct HDAC5 tyrosine 642 phosphorylation by focal adhesion kinase (FAK), a HDAC5 post-translational

192 We now report that focal adhesion kinase (FAK), a key regulator of focal ad

193 Focal adhesion kinase (FAK), a key transmitter of growth

194 We demonstrate that focal adhesion kinase (FAK), a major component of integr

195 and subsequently to partial inactivation of focal adhesion kinase (FAK), a major effector kinase of

196 nger isoforms exhibited increased binding to focal adhesion kinase (FAK), a molecule important for mi

197 Focal adhesion kinase (FAK), a nonreceptor protein tyros

198 Furthermore, focal adhesion kinase (FAK), a nonreceptor tyrosine kina

199 e is similar to that produced by deletion of focal adhesion kinase (FAK), a signaling partner of paxi

200 hat COUP-TFII also reduces the activation of focal adhesion kinase (FAK), an integrin downstream regu

201 ecrease in invasion, less phosphorylation of focal adhesion kinase (FAK), and an approximately 2-fold

202 A and invadopodia-associated proteins talin, focal adhesion kinase (FAK), and cortactin and reduced c

203 Without Focal Adhesion Kinase (FAK), developing murine Schwann c

204 microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP.

205 in beta1-integrin activation with vinculin, focal adhesion kinase (FAK), FAK(PY397), F actin, and pa

206 erexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has im

207 MUCL1 silencing abrogated phospho-focal adhesion kinase (FAK), Jun NH2-terminal kinase (JN

208 Net1A interacts with focal adhesion kinase (FAK), localizes to focal adhesion

209 er, mifepristone inhibited the expression of focal adhesion kinase (FAK), paxillin, and the formation

210 -mediated protease-independent function; and focal adhesion kinase (FAK), Rac-1, and NF-kappaB were i

211 atics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synt

212 egrin-associated signaling molecules such as focal adhesion kinase (FAK), Src, c-Cbl, phosphoinositid

213 we show that a signaling axis consisting of focal adhesion kinase (FAK), Src, phosphatidylinositol 3

214 Vbeta5), and EphrinA2 (EphA2), and activates focal adhesion kinase (FAK), Src, phosphoinositol 3-kina

215 sphorylation of myosin light chain (MLC) and focal adhesion kinase (FAK), supporting a role for ROCK

216 ways, leading to tyrosine phosphorylation of focal adhesion kinase (FAK), the tyrosine kinase Src, an

217 both RACK1 and vimentin have been linked to focal adhesion kinase (FAK), we investigated whether thi

218 ve conformations of the kinase domain of the focal adhesion kinase (FAK), which are distinguished by

219 operation between different AKT isoforms and focal adhesion kinase (FAK)-dependent adhesion signaling

220 A metabolism, and cell adhesion, including a focal adhesion kinase (FAK)-regulated network mediating

221 how that fibronectin adhesion stimulation of focal adhesion kinase (FAK)-Src signaling is another ups

222 ied by down-regulation of phosphorylated (p)-focal adhesion kinase (FAK)-Tyr(397) and retention of ne

223 We reported previously that the CXCL12-focal adhesion kinase (FAK)-VLA4 pathway plays an import

224 including CRK-like proto-oncogene (CRKL) and focal adhesion kinase (FAK).

225 cessary for promoting autophosphorylation of focal adhesion kinase (FAK).

226 lso led to the incorporation of activity for focal adhesion kinase (FAK).

227 y and tumor progression via interaction with focal adhesion kinase (FAK).

228 We also found that IL-33 activated focal adhesion kinase (FAK).

229 subunits, and a primary signaling kinase is focal adhesion kinase (FAK).

230 reen revealed that RABV P interacts with the focal adhesion kinase (FAK).

231 dentified another cellular partner of P, the focal adhesion kinase (FAK).

232 elial growth factor receptor 2 (VEGF-R2) and focal adhesion kinase (FAK).

233 s, a reaction that is partially dependent on focal adhesion kinase (FAK).

234 ignal-regulated kinases 1/2 to phosphorylate focal adhesion kinase (FAK).

235 bling the focal adhesion targeting region of focal adhesion kinase (FAK).

236 PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK).

237 this residue blocks PKD2's interaction with Focal Adhesion Kinase (FAK).

238 promote exocytosis through interactions with focal adhesion kinase (FAK).

239 orylation, which is known to be regulated by focal adhesion kinase (FAK).

240 le activated tyrosine kinases, we identified focal adhesion kinase (FAK, PTK2) as a candidate target

241 We establish that specific targeting of focal adhesion kinase (FAK; also known as PTK2) in endot

242 ed kinase (ERK1/2; by approximately 44%) and focal adhesion kinase (FAK; by approximately 46%) as wel

243 IGFBP-1 acts via beta1-integrin and focal-adhesion-kinase (FAK), which are strongly overexpr

244 ne receptor 4 (CXCR4) and PTK2 (encoding for focal adhesion kinase [FAK]).

245 cell motility itself, which instead utilizes focal adhesion kinase-fibronectin signalling.

246 ls the vertical displacement of paxillin and focal adhesion kinase from the signaling layer of focal

247 serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signali

248 on also decreased the phosphorylation of the focal adhesion kinase in Tyr925.

249 n, fibronectin, and impaired accumulation of focal adhesion kinase, indicating that the GPR56-TG2 int

250 er, inhibition of integrin signaling through focal adhesion kinase inhibition caused disruption of ce

251 The focal adhesion kinases inhibitor (FAKi 14) and cell inte

252 Focal adhesion kinase is an intracellular protein kinase

253 PI(4,5)P2, biochemical assays disclosed that focal adhesion kinase is preferentially activated by wea

254 uence (which we believe is the activation of focal adhesion kinase) is controlled by the binding ener

255 l-regulated kinase 1 and 2, Elk-1, p38, Akt, focal adhesion kinase, mechanistic target of rapamycin,

256 invadopodia formation through PDGFRalpha and focal adhesion kinase-mediated (FAK-mediated) activation

257 -2 (Has2) are also enhanced upon PN/INTEGRIN/focal adhesion kinase-mediated activation of PI3K and/or

258 hibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of I

259 w that LKB1 kinase activity is essential for focal adhesion kinase-mediated cell adhesion and subsequ

260 -WASP via activation of small Rho GTPase and focal adhesion kinase mediates TGF-beta1-induced paracel

261 luding transforming growth factor-beta/SMAD, focal adhesion kinase, MRTFs, Wnt/beta-catenin and YAP/T

262 pha resulted in increased phosphorylation of focal adhesion kinase on Tyr-407, which induced the recr

263 otein tyrosine kinase 2 (ptk2, also known as focal adhesion kinase or FAK), is reduced in the neuromu

264 simultaneous depletion of alpha-catenin and focal adhesion kinase or p21-activated kinase eliminates

265 However, modulation of focal adhesion kinase or Src, the major downstream compo

266 gration away from the lipid raft-independent focal adhesion kinase pathway and toward a lipid raft-de

267 ocal adhesion turnover via a PKCbeta-Calpain-focal adhesion kinase pathway.

268 Shc, phospholipase Cgamma, protein kinase C, focal adhesion kinase, paxillin, and mitogen-activated p

269 dingly, BA caused an increase in the size of focal-adhesion-kinase/paxillin-positive peripheral adhes

270 initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin an

271 phosphorylated forms of paxillin (pPXN) and focal adhesion kinase (pFAK).

272 Focal adhesion kinase phosphorylation indicated that CCL

273 T lymphocytes, which induces ATP secretion, focal adhesion kinase phosphorylation, cell polarization

274 However, all peptides increased focal adhesion kinase phosphorylation, OSE2 transcriptio

275 hesion kinase expression and a misbalance in focal adhesion kinase phosphorylation, which may lead to

276 ractions, in part dependent on activation of focal adhesion kinases, promote delivery of basophil-der

277 s and myosin phosphatase activity, including focal adhesion kinase, protein tyrosine kinase-2, Janus

278 mTORC2 targets included focal adhesion kinase, proto-oncogene tyrosine-protein k

279 the present study show the importance of the focal adhesion kinase Pyk2 downstream of G-protein-coupl

280 yze the contribution of the Ca(2+)-dependent focal adhesion kinase Pyk2 in platelet activation and th

281 Previous studies have shown that the focal adhesion kinase Pyk2 plays a critical role in mono

282 Herein, we show that focal adhesion kinase-related nonkinase (FRNK) plays a k

283 ein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wisko

284 Focal adhesion kinase's (FAK) role in regulating cell mi

285 s proliferation of CPCs via beta(1)-integrin-focal adhesion kinase-signal transducer and activator of

286 hanotransduction after injury with increased focal adhesion kinase signaling and nuclear translocatio

287 can bind to INTEGRINs and activate INTEGRIN/focal adhesion kinase signaling pathways and downstream

288 matrix stiffness and activation of the FAK (focal adhesion kinase)/SRC-signaling pathway, with a sti

289 Importantly LAMB1 stimulated ITG-dependent focal adhesion kinase/Src proto-oncogene non-receptor ty

290 terference (RNAi) depletion of myosin II and focal adhesion kinase, suggesting that this behavior req

291 mTOR mutations that clustered in focal adhesion kinase targeting domain (FAT) and kinase

292 lving vasodilator-stimulated phosphoprotein, focal adhesion kinase, the H(+)/K(+) ATPase beta (flippa

293 uding vasodilator-stimulated phosphoprotein, focal adhesion kinase, the membrane phospholipid translo

294 l-ECM adhesion nor cell-ECM adhesion-induced focal adhesion kinase Tyr-397 phosphorylation.

295 rombin treatment led to increases in phospho-focal adhesion kinase (tyrosine 397), ERK1/2 phosphoryla

296 sin light chain kinase or phosphorylation of focal adhesion kinase was ineffective.

297 rgets, epidermal growth factor receptors and focal adhesion kinase, were significantly reduced in c-C

298 eral application, here we apply the model to focal adhesion kinase, which initiates the chemical sign

299 Inhibition of focal adhesion kinase, which is required for basal const

300 nd activate the non-receptor tyrosine kinase focal adhesion kinase, which plays a key role in signali