ライフサイエンスコーパス: focally

1 l membrane antigen (EMA) (one diffusely, one focally).

2 2 wave fronts, activation was mapped arising focally.

3 43 carcinomas (49%) were completely (35) or focally (8) negative for p16.

4 netic resonance-ultrasound fusion imaging to focally ablate low-intermediate-grade tumors within the

5 These lesions focally ablated PRs, with minimal collateral damage to c

6 ned 30% reduction in intraocular pressure by focally ablating and cauterizing the trabecular meshwork

7 es; positron emission tomographic scans were focally abnormal in 3 of 3 cases.

8 lthough the histopathological appearance was focally abnormal in all cases.

9 ed as the absence of any large (> 1.5 cm) or focally abnormal lymph node.

10 AV-Cre markedly reduced A1 receptor mRNA and focally abolished the postsynaptic response to adenosine

11 deposits in both vaccinated individuals were focally absent in some regions.

12 protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading protease

13 glutamate uncaging was used to randomly and focally activate neurons in the granule cell layer, hilu

14 ted tumor models, expression of p16(LUC) was focally activated by early neoplastic events, enabling v

15 Laser-scanning photo-uncaging of glutamate focally activated neurons in layer II while excitatory s

16 activation; (c) cortical surface stimulation focally activates layer I axons, and (d) there is an opt

17 This study evaluated the effects of focally administered acetylcholine on AVN conduction and

18 tion of epithelial and mesenchymal HSPG will focally affect epithelial proliferation rates.

19 une limbic encephalitis-a condition known to focally affect the hippocampus-were tested on how they e

20 delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment

21 rexpressed or endogenous VCP did not seem to focally aggregate inside neurons, TDP-43 and ubiquitin a

22 Initial CAST depletion focally along dendrites coincides topographically with c

23 Focally altered functional connectivity also was observe

24 by more advanced strategies for directly and focally altering neural activity.

25 , and NRAS) is discovered, along with common focally amplified and deleted genes involved in regulati

26 We identify focally amplified extrachromosomal DNA (ecDNA) in four o

27 One such gene, PAX8, is focally amplified in 16% of high-grade serous ovarian ca

28 Myc enhancers coincide with a region that is focally amplified in approximately 3% of acute myeloid l

29 hat were pathogenic in three genomic regions focally amplified in oestrogen receptor-positive breast

30 screening assays, we identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose c

31 discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several

32 a tool to reconstruct the fine structure of focally amplified regions using whole genome sequencing

33 or symptoms in the limbs consistently emerge focally and asymmetrically and, whilst variable, the pat

34 ttern, in which endocardial activation arose focally and either had a propagation sequence similar to

35 dence depends most on recent incidence, both focally and in the wider district, consistent with high

36 n in vitro model of angiogenesis, as well as focally and intensely expressed at sites of pathological

37 that inflammatory lung injury may also begin focally and propagate sequentially via the airway networ

38 inflammatory lung injury may sometimes begin focally and propagate sequentially via the airway networ

39 xamined to determine whether mutations arose focally and spread or whether they emerged independently

40 as designed to explore the dynamics of Tregs focally and systemically in lung transplant recipients.

41 that the beta-catenin mutations were present focally and therefore may occur during tumor progression

42 visual cortical area V5/MT to reduce the SNR focally and thus disrupt visual motion discrimination pe

43 NV, and eotaxin was usually present but more focally and with less intense staining.

44 With a view to creating a focally applicable genetic calcium channel blocker, we o

45 he putative sensory neuron transmitter, were focally applied (0.1 Hz) to solitary motor neurons in cu

46 e preparation, Ca(2+) mobilization evoked by focally applied artificial sweeteners was significantly

47 In this report, we show that focally applied BDNF increases the number of action pote

48 In this study, we show that focally applied forces of this magnitude using a newly d

49 Focally applied GABA and glycine onto outside-out patche

50 as the proximal axon based on the actions of focally applied gabazine and GABA near this region.

51 how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it ac

52 ctively responded to L-glutamate when it was focally applied to the apical chemosensitive tips of rec

53 Diffuse mesangial sclerosis (focally approaching nodular glomerulosclerosis), focal a

54 fluorescent changes of L(0) were followed by focally arising Ca(2+) waves (L(2)), which propagated at

55 d that the host immune response is modulated focally around areas with biofilm, but inflammation with

56 sylated PrP fragment (type 2) in all brains, focally associated with a 21 kDa (type 1) fragment in 53

57 VPF/VEGF mRNA was also expressed focally at lower levels by infiltrating inflammatory cel

58 1pdm virus-infected ferret lung globally and focally at sites of infection.

59 e at enhancer regions, being anti-correlated focally at transcription factor-binding sites but positi

60 eceptor blockade for 14 days after BA in the focally atherosclerotic rabbit significantly reduced res

61 balloon angioplasty limits restenosis in the focally atherosclerotic rabbit.

62 A measured 24 hours after angioplasty in the focally atherosclerotic rabbit.

63 iles, and standardized uptake value (SUV) in focally avid lesions.

64 at the neural plate is flexible enough to be focally bent and shaped into a neural tube, while retain

65 Cartilage develops focally between areas of epithelial proliferation and su

66 ced most effectively when it was inactivated focally, bilaterally, and continually with infused TTX.

67 Enhancing activity by focally blocking cortical GABAergic inhibition had a sim

68 lly pigmented, whereas the other 5 were only focally brown-black.

69 ALS begins focally but disseminates to cause paralysis and death.

70 sis, according to which TAU pathology begins focally but expands catastrophically under the influence

71 MDLs too may be replaced focally by cytoplasmic pockets, sometimes in the same qu

72 dermal tumors, AKT activity can be activated focally by up-regulation and phosphorylation of the AKT2

73 ganization of pVHL.HIF-1alpha recognition is focally centered on Gln(145) within the L7 loop, and its

74 ixty percent of the tumors revealed at least focally clear-cell cytology.

75 sed an endothelial monolayer, and reappeared focally compacted on its distal surface, away from the a

76 fection, which was followed by steatosis and focally confluent necrosis.

77 ntly, CTLA-4-positive cells are present, and focally contact HRS cells, in recurrent cHL tumors follo

78 Rapamycin was focally, continuously, and unilaterally infused into the

79 The patients presented with vascularized, focally cystic, nonulcerated eyelid margin lesions.

80 ts the chromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56.

81 rescence (FIAF), geographic atrophy (GA) and focally decreased autofluorescence (FDAF) was analyzed i

82 (18)F-FDG PET images of AD demonstrate focally decreased cerebral metabolism involving especial

83 loss of peritubular capillaries (as noted by focally decreased RECA-1 and OX-2 staining) in areas of

84 Focally decreased thickness was seen in the superior tem

85 n myotubularin-deficient muscle fibers, with focally defective areas recapitulating the global altera

86 nd an adeno-associated viral (AAV) vector to focally delete endogenous adenosine A1 receptors in the

87 STK25 is significantly focally deleted across a wide spectrum of human cancers,

88 Finally, human Sds22 is focally deleted and downregulated in multiple carcinomas

89 e their roles in thalamocortical rhythms, we focally deleted synaptic, gamma2 subunit-containing GABA

90 We have used the method to focally deliver agrin (a molecule implicated as a postsy

91 We used a microfluidic device to focally deliver agrin to protosynaptic AChR clusters in

92 A contact force-sensing catheter was used to focally deliver PFA/radiofrequency at the pulmonary vein

93 sy-to-fabricate perfusion device designed to focally deliver pharmacological agents to brain slices.

94 i-osmotic pumps were used to continually and focally deliver TTX.

95 ith six serial subconjunctival injections of focally delivered carboplatin chemotherapy (100 microg/d

96 Potential toxicity of focally delivered carboplatin was assessed by histology

97 idence of ocular toxicity was detected after focally delivered Carboplatin.

98 hether constitutively exocytosed membrane is focally delivered to the cleavage furrow.

99 ecules or other molecules of interest can be focally delivered to the myotubes using heterogeneous mi

100 In a randomized preclinical study, focally delivered unipolar/biphasic PFA guided by contac

101 ion durability and collateral damage between focally delivered unipolar/biphasic PFA versus radiofreq

102 However, identification of focally demyelinated lesion had been difficult and usual

103 Our previous work introduced a technique for focally denervating the olfactory bulb soon after birth

104 and its metabolite, cholestanol, which were focally deposited at the apical and basal sides of the r

105 acellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where i

106 ions, whereas Mel-CAM expression can only be focally detected in 12 of 72 (17%) breast carcinomas.

107 hat the polycomb H3K27me3-repressive mark is focally diminished in TAL1(+) T-ALLs.

108 MTg neurons enriched in GAD67 mRNA, and were focally directed to a distinctive DR subdivision immunoh

109 Although parenchymal amyloid was focally disaggregated, vascular deposits were relatively

110 Although senile plaques focally disrupt neuronal health, the functional response

111 Second, rodents with focally disrupted MFC D1 dopamine receptor (D1DR) signal

112 EGFR amplification was focally distributed in lung cancer specimens, mostly in

113 ficult to detect because they are scarce and focally distributed in multiple sites.

114 orders of brain development and suggest that focally distributed mutations are also prevalent in norm

115 If wave fronts ever arise focally during VF, it should be possible to map them app

116 These regions included focally dysgenetic cortex, the cortex lining schizenceph

117 imaging at the choriocapillaris level showed focally enlarged vessels in 8 of 15 eyes (53%).

118 of PLC that activates conventional PKCs, is focally enriched at the up-gradient leading edge of fibr

119 This focally evoked activity powerfully suppressed distant gr

120 Focally evoked calcium waves in astrocyte cultures have

121 on seizure susceptibility in a rat model of focally evoked complex partial seizures.

122 rographic seizure patterns in a rat model of focally evoked limbic epilepsy.

123 study examined the functional role of MD in focally evoked limbic motor seizures in the rat.

124 D, the enhancement of which protects against focally evoked limbic motor seizures.

125 approach, multiphoton excitation is used to focally excite noncytotoxic photosensitizers that promot

126 as bulky, polypoid intraluminal masses that focally expand the esophagus without causing obstruction

127 led bulky, polypoid intraluminal masses that focally expanded the esophagus without causing obstructi

128 are positioned on a laminin-rich matrix and focally express vimentin and Lewis(x) and show up-regula

129 In addition, the corneal epithelial cells focally expressed Fn mRNA.

130 By IHC, Bmi-1 was focally expressed in the basal layers of almost all esop

131 stochemical staining revealed GSK3beta to be focally expressed in the invasive portions of 12 and 33%

132 wever, unlike most renal carcinomas, it also focally expressed melanocytic proteins.

133 Focally folded myelin has been recognized as a distincti

134 ral neuropathy characterized by distinctive, focally folded myelin sheaths.

135 to be examples of hereditary neuropathy with focally folded myelin sheaths.

136 stains were positive for CD34, vimentin, and focally for CD68, but were negative for S100 and SMA.

137 large- and small-vessel endothelium stained focally for defensin.

138 lly for epithelial markers but instead label focally for melanocytic markers HMB45 and Melan A.

139 ected rats from limbic motor seizures evoked focally from area tempestas, an epileptogenic site in th

140 ipant in the generation of seizures elicited focally from piriform cortex; (2) transmission via AMPA

141 ral collector nerve and (2) from single PGNs focally from the caudal ventral artery of the tail.

142 Synaptic responses were recorded focally from the diaphragm synapses during electrical st

143 e DMS suppressed goal-directed behaviors, as focally genetic knockdown of striatopallidal A(2A)Rs in

144 in the epididymis, spermatogenic arrest, and focally germ cells expressing the osteoblast marker Oste

145 alpha-hydroxylase for de novo synthesis of a focally high 1,25-dihydroxyvitamin D concentration in th

146 CpG-rich retention elements are focally hypomethylated.

147 ined by cuboidal, ciliated epithelial cells, focally immunopositive for cytokeratin and S-100 protein

148 s expressed diffusely in 12 of 17 tumors and focally in 3 and was undetectable in 2 tumors.

149 3 patients, and nuclear grade 3 was observed focally in 8 patients.

150 usually express heat shock protein 70 except focally in a few tumors.

151 This receptor is also expressed focally in brain areas that affect reward circuits and a

152 early multiple sclerosis, and present mainly focally in cortical lesions, whereas more diffusely in w

153 MSCTs originated focally in dendritic regions <1 microm in length and dec

154 ger RNA and fibrils appeared transiently and focally in forming cleft regions of submandibular saliva

155 MIG mRNA expression was detected initially focally in infiltrating neutrophils (15 hours after IA e

156 As SDs are likely induced focally in many disease conditions, these studies suppor

157 In contrast, when bicuculline was applied focally in the dendritic region, the NMDA-mediated respo

158 an T cells around dermal porcine vessels and focally in the epidermis.

159 goblet, and intermediate cells were present focally in the ileum of SAMP1/YitFc mice by 4 weeks of a

160 na cava, or tricuspid annulus or by ablating focally in the lateral RA.

161 brainstem tumors originating at the tectum, focally in the midbrain, dorsal and exophytic to the bra

162 rns 96% of the time, one potentially arising focally in the Purkinje system that was prevented with a

163 Administration of 4-CIN focally in the retrotrapezoid nucleus (RTN), a medullary

164 When bicuculline was applied focally in the somatic region, the feedback IPSP was blo

165 1), with >25% to 50% of cells being positive focally in the splenic white pulp of six septic but in n

166 tissue enhanced diffusely in two and weakly focally in two.

167 We then focally inactivated kinesin-5 in various regions of the

168 Ten patients demonstrated preoperatively a focally increased (18)F-FDG uptake at the level of the s

169 cose uptake in all ZL control rats, while no focally increased (18)F-FDG uptake was detected in all Z

170 Diffuse or focally increased (18)F-florbetapir uptake was noted in

171 In contrast, CD36 expression focally increased at sites of cartilage injury and coloc

172 The relationship between focally increased autofluorescence (FIAF), geographic at

173 with several MMI characteristics, including focally increased choroidal thickness.

174 These data indicate that focally increased expression of NGF in one part of a syn

175 cell adhesion molecule (VCAM)-1 staining was focally increased in two of three specimens.

176 Examinations exhibiting focally increased radiotracer uptake were considered pos

177 artilage is different in appearance than the focally increased T2 observed in damaged articular carti

178 The photodamage focally increased the duration of microglia-neuron conta

179 On PET, focally increased uptake in the prostate was suggestive

180 (18)F-AFETP demonstrated focally increased uptake in tumors with good visualizati

181 Paraspinal regions of focally increased uptake of [18F]FDG were quantified usi

182 in all patients with cardiac pacemakers and focally increased uptake of mild intensity in 8 of 27 pa

183 CT-corrected PET images revealed focally increased uptake of moderate intensity in all pa

184 us cell carcinoma tissues, both signals were focally increased where high proliferative activity was

185 Each scanning impediment focally increases RAG activity on potential substrate se

186 We show that focally increasing mTORC1 activity during late corticoge

187 sed two-photon glutamate uncaging/imaging to focally induce spinogenesis in the medial prefrontal cor

188 ed regions and was able to detect regions of focally induced demyelination.

189 induced Ca(2+)-release mechanism, and allows focally induced hyperpolarization, including that initia

190 or the propagation and downstream effects of focally induced SD but are less important when the ionic

191 eous synaptic activity that is a hallmark of focally induced SD.

192 tetrodotoxin (TTX) restricted propagation of focally induced SDs, and significantly reduced the ampli

193 propagation and downstream neural effects of focally induced spreading depolarization (SD).

194 e rejection episodes, DR3 and SODD were more focally induced, generally at sites of mononuclear cell

195 This neuropathy phenotype is associated with focally infolded myelin loops that protrude into the axo

196 Focally infused or systemic rapamycin inhibits the mamma

197 B-334867 (OX(1)R antagonist) into the RTN to focally inhibit OX(1)R and studied the effects of both t

198 To focally inhibit p11 expression in the dorsal striatum, w

199 and NBQX (15 nmol) or vehicle (VEH) solution focally injected into the injury site 15 min later.

200 ural substrates of fluid intelligence in the focally injured brain.

201 ost robust investigation of AR and DR in the focally injured brain.

202 There was focally intense deposition of eosinophil peroxidase in t

203 s, when administered either systemically, or focally into substantia nigra.

204 converts this into biphasic current injected focally into tissue by a pair of integrated microwires.

205 atypical cells that fill the lumen and bulge focally into, and frequently compromise, the fibromuscul

206 mative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of al

207 We focally introduced chemogenetic constructs in 34 control

208 s progressed into the subarachnoid space and focally invaded the brain.

209 ologically these tumors consisted largely of focally keratinizing squamous cell carcinoma with high-g

210 secretion and decreased spreading of focally labeled A-Exo.

211 wing sustained astrocytic Nrf2 activation in focally-lesioned male mice yet is restored by either cho

212 medulloepitheliomas were either diffusely or focally LIN28A positive (weak, moderate, or strong).

213 ufficient to initiate selective autophagy by focally localizing and activating the ULK1 complex.

214 that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on

215 To address this issue, we focally lowered the temperature of distinct cortical reg

216 incorporate into nascent thrombi, which are focally lysed from within, an attractive thromboprophyla

217 We focally manipulated activity within the CeA or BLA in ma

218 Here we tested this idea by focally manipulating the brain activity of juvenile zebr

219 oninvasively, transiently, reproducibly, and focally mediate BBB opening in the hippocampus/EC in hum

220 antagonists, or a GABA-elevating agent were focally microinfused into MD before evoking seizures by

221 alpha1 noradrenergic agonist (phenylephrine) focally microinjected into DLSC as compared to effects i

222 a, the present study evaluated the effect of focally microinjecting a NMDA antagonist into the amygda

223 us fibroblasts in the perinodal region would focally modify AV nodal conduction and that this modulat

224 experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the ac

225 We conclude that tFUS can be used to focally modulate human cortical function.

226 Flicker focally modulated local field potentials in expected can

227 S) is an emerging non-invasive technique for focally modulating human brain function.

228 ular injury is common in sepsis but presents focally; most renal tubular cells appear normal.

229 ies revealed a severe intensity, diffuse and focally nodular lymphocytic infiltrate composed predomin

230 Eleven gorilla mother-infant dyads were focally observed in weekly 1-hr sessions for 12 months.

231 After treatment, mother-infant pairs were focally observed.

232 ation-associated alterations recurrently and focally occur at topologically associating domain reside

233 se individual mtDNA deletions can accumulate focally, occur with multiple mixed breakpoints, and in t

234 f strength, the first few activations appear focally on the epicardium at almost the same site at the

235 The first global activation cycle appeared focally on the left ventricular apical epicardium 78+/-3

236 persal, BRCA1, BARD1, and Rad51 accumulated, focally, on PCNA+ replication structures, implying an in

237 associated with weight loss, often beginning focally or asymmetrically in the thigh or leg but usuall

238 By focally photolyzing a novel caged IP3 compound in dendri

239 ecurrent inhibitory circuits in layer II, we focally photostimulated interneurons while recording inh

240 r and developed ascites; the tumor cells are focally positive for CA125 and mesothelin.

241 epithelial markers tested, whereas four were focally positive for cytokeratin and two were reactive f

242 A minority of the fibrotic areas stained focally positive for fibrin/fibrinogen (16% of cases), v

243 Normal valve cusps were only focally positive for smooth muscle actin and LAP.

244 ases; MYB was negative in 5 cases and weakly focally positive in 2 cases.

245 had an LR rate of 27%, whereas patients with focally positive margins had an intermediate rate of LR

246 Among the 45 patients with focally positive margins who received systemic therapy,

247 Immunohisto-chemically, focally positive p53 staining was found in four papillar

248 Focally positive scans often indicate disease requiring

249 es of DVT obtained with 123I-bitistatin were focally positive within 1 hr and improved by 4 hr.

250 n) as one of the following: negative, close, focally positive, or extensively positive.

251 ve, and in 2 of the 79 (3%) the labeling was focally positive.

252 ith intracytoplasmic lipid and glycogen were focally present in tumors of 94% papillary renal cell ca

253 ring spindles; and (3) thalamic spindles are focally projected back to cortex, arriving during the do

254 resulting in short-range connectivity and a focally protrusive, non-degradative state.

255 e multiple VMs in individuals with HHT occur focally, rather than manifesting as a systemic vascular

256 Miniature end-plate potentials (MEPPs) were focally recorded from the cytoplasmic surface of electro

257 [(11) C]ABP688 BP(ND) was focally reduced in the epileptogenic hippocampal head an

258 Focally reduced mGluR5 availability in the EZ might refl

259 , where theoretical studies suggest they may focally regulate cellular activity.

260 availability is nonuniformly distributed and focally regulated.

261 surface of the endoplasmic reticulum, which focally reorganizes close to the immobilized mitochondri

262 We focally restored OX2R expression in specific brain regio

263 opathologic examination demonstrated uneven, focally severe neuronal loss and gliosis in the substant

264 ose that H3.3-G34R promotes tumorigenesis by focally stabilizing the expression of key progenitor gen

265 uidic device and surface microengineering to focally stimulate muscle cells with agrin at a small por

266 Ca(2+) entry in L5 pyramidal cell axons when focally stimulated with NMDAR agonists.

267 APPS-tDCS also more focally stimulates the cortex at the intended target, us

268 damental precepts, we developed a method for focally stimulating the living hearing organ with light.

269 s progresses toward deeply invaginated buds, focally synthesized phosphoinositides are dephosphorylat

270 foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection o

271 e drug delivery of therapeutic agents in new focally targeted ways.

272 , either sham or active (1Hz, 1,200 pulses), focally targeting the malformations of cortical developm

273 mplanted unilaterally in the NDB to activate focally the projections to PC in unanesthetized rats.

274 reased laminin function are characterized by focally thick and redundant myelin.

275 he tube (52 [19%] cases), and development of focally thickened small-bowel folds (24 [9%] cases).

276 echanism that underlies this effect operates focally to enhance neuronal sensitivity and improve tuni

277 When cobalt or kynurenic acid was applied focally to inhibit electrical activity at the site of pl

278 elevation of PKC appears to contribute only focally to subnormal retinal DeltaPO(2).

279 ependently when arachidonic acid was applied focally to the abluminal surface of the vessels.

280 ewer "core" parvalbumin neurons that project focally to the middle cortical layers and more "matrix"

281 Right atrial streak artifact focally traversed the right coronary artery in only one

282 he graft did not have biomechanical strength focally until 18 months, but the patient has not needed

283 sed in UGS mesenchyme during budding and was focally up-regulated as buds emerged from the anterior,

284 Cholestasis, present focally, was manifested as dilated bile canaliculi, part

285 carcinomas were positive either diffusely or focally, whereas staining was primarily focal or absent

286 evealed that a fraction of GATA1 is retained focally within mitotic chromatin.

287 ndicator of wnt pathway activation, was seen focally within roughly one third of the tumors, though a

288 e initiated toxic expression of human TDP-43 focally within small groups of glial cells.