ライフサイエンスコーパス: focus forming

1 PI3K pathway, were undetectable, colony and focus forming abilities of the v-Src-RIE cells were only

2 of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of

3 tive than ca Rac or ca Cdc42 in rescuing the focus forming ability of the mutants.

4 However, MAPK is not essential for the focus forming ability of the three oncogene-transformed

5 K stimulation by Vav, as well as reduces the focus-forming ability of Vav in NIH3T3 murine fibroblast

6 anced, whereas a dn PAK mutant inhibited the focus-forming ability of Vav3-(6-10).

7 We observed a striking cooperative effect on focus-forming ability when Galpha12 and c-raf-1 cDNAs we

8 Despite having potent focus-forming ability, Vav3-(6-10) has very weak colony-

9 d the transformation phenotype and inhibited focus-forming ability.

10 dimers displayed a five- to sevenfold higher focus-forming ability.

11 resulted in synergistic cooperation of their focus-forming activities, indicating that Ras activates

12 n of Dbs with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP.RhoA i

13 intracellular domain that confers the higher focus forming activity mediated by the beta PDGFR.

14 expression of full-length RalGDS reduced the focus forming activity of activated TC21.

15 ted from human placenta markedly reduced the focus forming activity of cotransfected, malignantly act

16 l residues showed a several 100-fold greater focus forming activity than that seen with deletion of 6

17 In addition to its potent focus forming activity, constitutive overexpression of P

18 ant negative Rho most potently inhibited the focus forming activity, whereas Cdc42 was most effective

19 We have previously purified a protein, focus-forming activity 1 (FFA-1), which is involved in t

20 ve identified and purified a 170-kD protein, focus-forming activity 1 (FFA-1), which is required for

21 ensity, lower cell-doubling times, increased focus-forming activity and higher ability to grow on sem

22 ition, an Ad9 E1 region plasmid demonstrated focus-forming activity in both low-passage-number and es

23 n from a Ras-responsive promoter element and focus-forming activity in NIH 3T3 cells.

24 inhibition of either IKK-1 or IKK-2 reduced focus-forming activity in Ras-transformed RLEs.

25 potent mitogenic effect of thrombin and the focus-forming activity of one of its receptors, protease

26 The observed inhibitory effect of C3G on focus-forming activity of Ras and Sis was always higher

27 Activated PI3K enhanced the focus-forming activity of Vav3-(6-10).

28 of Stat3 resulted in a 60% inhibition of the focus-forming activity of Vav3-(6-10).

29 Compared to wild-type GRF1, the focus-forming activity on NIH 3T3 cells of the GRF1 DH c

30 2 cooperated with Raf and showed synergistic focus-forming activity, both quantitative and qualitativ

31 ial MEK5-ERK5 effectors that might influence focus-forming activity.

32 LV) that is derived from the ampho-mink cell focus-forming (AMP/MCF) retrovirus in the serum of one r

33 The focus-forming and anchorage-independent growth activitie

34 tures were also assayed for infectivity in a focus-forming assay, and a correlation (P = 0.0002) was

35 asal swabs were negative for viable virus by focus-forming assay.

36 lymorphic respiratory isolate, using a novel focus-forming assay.

37 transforming activity in a Rat-2 fibroblast focus-forming assay.

38 rphologically transformed NIH 3T3 cells in a focus-forming assay.

39 We demonstrate RT-PCR and focus-forming assays on-chip to detect mosquito DNA, Zik

40 NIH3T3 cells were used to screen for focus-forming genes using the ERM strategy.

41 photropic (4070A), and amphotropic-mink cell focus-forming hybrid (10A1) envelope constructions have

42 ptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumul

43 Mink cell focus-forming (MCF) murine leukemia viruses (MLVs) are t

44 exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs).

45 To examine the possible role of mink cell focus-forming (MCF) recombinant virus in raising levels

46 classic toxicity of the polytropic mink cell focus-forming (MCF) retrovirus in mink cells.

47 MuLVs comprised ecotropic and mink lung cell focus-forming (MCF) virus classes and are termed Rausche

48 nce to infection by the polytropic mink cell focus-forming (MCF) virus subgroup of murine leukemia vi

49 the sequence similarity of XMRV to mink cell focus-forming (MCF) viruses and the enhanced leukemogeni

50 gence of recombinant polytropic or mink cell focus-forming (MCF) viruses.

51 0002) was measured between the percentage of focus-forming microsporidia and the percentage of expect

52 nexpectedly, at least two types of mink cell focus-forming MuLV elements, arising from endogenous ret

53 Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerate

54 ction of thymic lymphocytes by the mink cell focus-forming murine leukemia virus (MCF MLV) during the

55 fection of thymic lymphocytes by a mink cell focus-forming murine leukemia virus induces apoptosis du

56 of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for vir

57 Using high-throughput focus-forming reduction or luciferase-based neutralizati

58 rmore, the amount of viral nucleoprotein per focus forming unit differed markedly whether viruses wer

59 rved: replication defective (dead; titer < 1 focus-forming unit [FFU]/ml), replication compromised (R

60 assay) and 11.7 h (by replating fluorescent focus-forming unit assay).

61 H77-S particles (5.4 x 10(4) RNA copies per focus-forming unit) was significantly lower than JFH-1 v

62 than JFH-1 virus (1.4 x 10(2) RNA copies per focus-forming unit).

63 on, animals were challenged with 5.0 log(10) focus forming units (FFU) of a wild-type dengue-2 virus.

64 a 50% mouse lethal dose (MLD(50)) of ~10(5) focus forming units (FFUs), ZIKV-Paraiba infection resul

65 ity of infection, similarly to how plaque or focus forming units (PFU, FFU) are used.

66 The assay's analytical sensitivity was 10 focus forming units, and respiratory specimens with thre

67 deposition of baboon semen containing 10(6) focus-forming units (FFU) of ZIKV (n = 3 for FP isolate

68 netics and an infectivity titer of 6.7 log10 focus-forming units (FFU)/ml.

69 ce inoculated with greater than 2 x 10(5) R7 focus-forming units (FFUs).

70 ood agreement with the ratio of particles to focus-forming units determined by infectivity assays.

71 ually at immunization titers as low as 10(3) focus-forming units for both RV vaccine vectors.

72 transformation in vitro with an abundance of focus-forming units in monolayer cultures and anchorage-

73 end virus complex was determined to be 10(3) focus-forming units of attenuated virus.

74 trols were infected intranasally with 10 000 focus-forming units of influenza A/WSN/33 (H1N1) per mou

75 , handwashing water must contain <2 x 10(-6) focus-forming units of rotavirus, <1 x 10(-4) CFU of Vib

76 days after subcutaneous inoculation of 10(6) focus-forming units of SFTSV.

77 npregnant female C57BL/6 mice with 5 x 10(5) focus-forming units of ZIKV intravaginally.

78 hing HCV infectivity titers of 3.9-4.5 log10 focus-forming units per milliliter.

79 ectious particles of approximately 5 log(10) focus-forming units per mL; passaged TNcc did not requir

80 More R7Delta447 than R7Delta447K focus-forming units were detected in both NIH3T3 and mou

81 nd J8 achieved infectivity titers >4.5 log10 Focus-Forming Units/mL.

82 elded approximately 4.5 x 10(4) to 1 x 10(5) focus-forming units/ml.

83 of up to 10(6) alkaline phosphatase-positive focus-forming units/ml.

84 each group was challenged orally with 10(5) focus-forming-units of virulent HRV at 33 days of age.

85 The spleen focus forming virus (SFFV) gp55-P envelope glycoprotein

86 ority of tumors induced by the murine Spleen Focus Forming virus (SFFV), while fli-1 proved to be the

87 der control of the strong, ubiquitous Spleen Focus Forming Virus promoter within a self-inactivating

88 tor (pSFF) derived from murine Friend spleen focus forming virus was used to transduce murine hematop

89 growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin

90 ene of the polycythemic strain of the spleen focus forming virus.

91 Constructs containing the viral spleen-focus-forming virus (SF), ubiquitous promoters, or cell

92 Friend spleen focus-forming virus (SFFV) causes rapid erythroleukemia

93 The Friend spleen focus-forming virus (SFFV) encodes a unique envelope gly

94 The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope gly

95 The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope pro

96 The Friend spleen focus-forming virus (SFFV) env gene encodes a 409-amino-

97 The Friend spleen focus-forming virus (SFFV) env gene encodes a glycoprote

98 erythroid progenitor cells by Friend spleen focus-forming virus (SFFV) leads to acute erythroid hype

99 on of erythroid cells with the Friend spleen focus-forming virus (SFFV) leads to the interaction of t

100 throid cells infected with the Friend spleen focus-forming virus (SFFV) proliferate in the absence of

101 dies enhanced the expression of Sfpi1 spleen focus-forming virus (SFFV) proviral integration 1 (PU.1)

102 inkins osteosarcoma oncogene (c-fos), Spleen focus-forming virus (SFFV) proviral integration 1 (PU.1)

103 Infection of mice with Friend spleen focus-forming virus (SFFV) results in a multistage eryth

104 Spi-1) by retroviral insertion of the spleen-focus-forming virus component of Friend virus.

105 The gp55 envelope proteins of the spleen focus-forming virus initiate erythroleukemia in adult mi

106 nd virus-induced erythroleukemia, the spleen focus-forming virus integrates into the PU.1 locus betwe

107 rus envelope glycoprotein (F-gp55) of spleen focus-forming virus or specific mutations in the extrace

108 nt binding sites for CCAAT/CEBPalpha, spleen focus-forming virus, proviral integration oncogene (SPI1

109 oviral insertion in nearly all Friend spleen focus-forming virus-transformed murine erythroleukemia c

110 her MuLV complex but do not include a spleen focus-forming virus.