ライフサイエンスコーパス: foetal

1 rus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following

2 Increased maternal and foetal adverse outcomes are observed with uncontrolled a

3 subset, the presentation was consistent with foetal akinesia deformation sequence with severe intraut

4 The phenotype ranges from foetal akinesia resulting in in utero or neonatal mortal

5 itance and degrees of severity (ranging from foetal akinesia, through lethality in the newborn period

6 Foetal alcohol spectrum disorder (FASD) is a broad term

7 in prenatal impacts, such as prematurity and foetal alcohol spectrum disorder have shown abnormal fin

8 h diagnosed FASD, including 62 children with foetal alcohol syndrome (FAS), 34 children with partial

9 hol syndrome (FAS), 34 children with partial foetal alcohol syndrome (pFAS), and 28 children with alc

10 ystem to adapt and positively respond to the foetal allotype.

11 The joint genetic signal was enriched for foetal and adult brain cell-specific regulatory regions,

12 life with pronounced differences between the foetal and adult human brain.

13 the EpCAM(+) population of freshly isolated foetal and adult human liver identifies diverse gene exp

14 protection assays, the expression in several foetal and adult human tissues of genes encoding FMO1, F

15 s lacZ expression in transgenic mice to most foetal and adult long-term repopulating haematopoietic s

16 e performed a detailed analysis of both late foetal and adult muscle development in the absence of Me

17 In particular, we discover that Foetal and Adult Testis Expressed 1 (FATE1) is a key sur

18 The differences between the foetal and adult thymus TCR repertoires are consistent w

19 mRNA is present in low abundance in several foetal and adult tissues and thus the corresponding gene

20 Furthermore, comparison of human foetal and adult tissues indicates a developmental splic

21 Cell types of both foetal and maternal origin are profiled.

22 , which parallel the facilitative effects of foetal and MHP36 grafts in rats with ischaemic CA1 damag

23 placenta and has been shown to have roles in foetal and placental development in animal models.

24 A few genes are known that influence both foetal and placental growth and might therefore coordina

25 rnally-inherited allele and acts to restrict foetal and placental growth.

26 Furthermore, both foetal and postnatal DNA damage are prevented by prenata

27 ugh these findings imply that growth in both foetal and postnatal life influences cognitive performan

28 es are developmentally regulated during both foetal and postnatal mammary gland development.

29 Cultures of dissociated foetal and postnatal mouse gut gave rise to neurosphere-

30 d for BDNF-promoted neurite growth from both foetal and postnatal mouse sensory neurons, there is a d

31 by which intestinal cancer cells reactivate foetal and regenerative YAP-associated transcriptional p

32 These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and

33 morbidity burden and its effect on maternal, foetal, and newborn outcomes are limited in low- and mid

34 ry airway malformation (CPAM) is an uncommon foetal anomaly with a very wide range of ultrasound appe

35 Since foetal antiepileptic drug exposure is associated with lo

36 igation, we examined dose-related effects of foetal antiepileptic drug exposure on verbal and non-ver

37 d changes in the maternal immune response to foetal antigens.

38 However, the foetal blood-brain barrier to plasma proteins remained i

39 cylinders aged in Phosphate Buffered Saline, Foetal Bovine Serum, Dulbecco's - Minimum Essential Medi

40 Foetal brain and muscle are the tissues whose enhancers

41 Analysis of SLC12A2 expression in foetal brain at 16-18 weeks post-conception revealed hig

42 l) of cells dissected from the CA1 region of foetal brain at embryonic day 94-96, or of conditionally

43 We also found that foetal brain C3 deposition was associated with cortical

44 ticles bind within the inflamed placenta and foetal brain cortical tissue, causing a shortening of th

45 y, a critical period of iron need for normal foetal brain development.

46 ate that SARS-CoV-2 infection may affect the foetal brain during early gestation and highlight the ne

47 ), investigating the impact of SARS-CoV-2 on foetal brain health is of critical importance.

48 of specific cytokines induced by MIA in the foetal brain in disrupting hippocampal neural progenitor

49 ion of complement activation in placenta and foetal brain in vivo in utero.

50 transmission, reducing the ZIKV load in the foetal brain more than 20-fold.

51 We screened an array of 27 648 human foetal brain proteins with 12 well-expressed antibody fr

52 of SARS-CoV-2 in first and second trimester foetal brain tissue in association with cortical haemorr

53 In foetal brain, poly I:C produced no detectable immune-res

54 ptor null mouse shows extensive apoptosis in foetal brain.

55 ncrease in immune cell infiltration into the foetal brain.

56 rease the risk of altered development of the foetal brain.

57 Only the shortest 3R isoform is present in foetal brain.

58 Fluid from normal foetal brains did not have this effect.

59 CSF from the lateral ventricle of affected foetal brains not only inhibited in vitro proliferation

60 estational Day 21 (1 day prior to birth) and foetal brains were snap-frozen and genome-wide gene expr

61 odopsin+ rods develop in the presence of 10% foetal calf serum (FCS), large numbers develop in the ab

62 Reactivation of foetal cardiac genes is often associated with cardiac re

63 comere integrity, in the context of enabling foetal cardiomyocyte hypertrophy, maintenance of contrac

64 fibrils, and fibrils isolated from adult and foetal cartilage and vitreous humour.

65 Foetal cases (n = 25) represent the severe end of the sp

66 cts may reach the placenta and spread to the foetal circulation and amniotic fluid.

67 ere, we show that the mouse foetal liver and foetal circulation contain a transient population of Pax

68 ical forward planning resulted from maternal-foetal co-adaptation facilitated by co-expression of the

69 for maternal cardiovascular, obstetric, and foetal complications.

70 combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal

71 loci-gene regulatory connections within the foetal cortex, consistent with hypotheses suggesting a n

72 ls, when combined with analysis of available foetal cortical gene expression data, de novo rare varia

73 Foetal cytokine storm (two or more pro-inflammatory cyto

74 regnancies ending in delivery or spontaneous foetal death after 21 October 2009 and starting before 0

75 HD, and raises the possibility that cases of foetal death and CHD in humans could be caused by simila

76 n was assumed to be transient, the hazard of foetal death during gestational weeks 9 through 12 (HR(u

77 Hazard ratios of foetal death for vaccinated compared to unvaccinated pre

78 Foetal death occurred in 20% of all pregnancies.

79 ous abortion, sudden intrauterine unexpected foetal death syndrome and stillbirth.

80 A stillbirth was defined as a foetal death with a gestation period of >/=28 weeks wher

81 ancy does not appear to increase the risk of foetal death.

82 ituation where there is an imbalance between foetal demand and placental supply of nutrients (the ins

83 e is a mismatch between placental supply and foetal demand for nutrients during gestation.

84 ectoderm differentiation leading to abnormal foetal development and premature death.

85 r leptin in gut and immune regulation and in foetal development have been proposed.

86 ts development and organisation during human foetal development is largely unknown.

87 betacatenin signalling in oocyte biology and foetal development, and provides novel insights into the

88 ical extra-embryonic structure that supports foetal development, yet its ontogeny remains poorly defi

89 re generated during late embryonic and early foetal development.

90 e effect profile affecting metabolism and/or foetal development.

91 ntial nutrients each have important roles in foetal development.

92 v-src oncogene was introduced into the human foetal diploid fibroblasts MRC-5 and into MRC-SV1, a sim

93 Altered foetal DNA methylation (DNAm) has been proposed as a pot

94 To address this issue we transplanted foetal dopaminergic neurons from mice lacking the dopami

95 stoma cells were fused with cells from human foetal dorsal root ganglia and several continuously-grow

96 ess various antigens characteristic of human foetal dorsal root ganglion neurons.

97 lpha rearrangements occur less frequently in foetal DP cells.

98 We hypothesize that foetal drug exposure may alter normal cerebral lateraliz

99 lly-predicted birth weight, isolating direct foetal effects only, was associated with an increased ri

100 rth weight through the foetal genome (direct foetal effects), vs. variants influencing birth weight i

101 or incomplete erythroid differentiation and foetal/embryonic rather than adult globin expression.

102 red increased maternal feeding in advance of foetal energetic demands; the mammary glands are primed

103 morphological features comparable with human foetal epicardial explants and engrafted in the subepica

104 Our results illustrate how diet impacts the foetal epigenome, disturbing canonical and non-canonical

105 ssociations between maternal anxiety and the foetal epigenome.

106 l maturation of foetal organs, yet excessive foetal exposure is detrimental to adult cardiovascular h

107 Foetal exposure may also result in tissue damage, increa

108 language may be particularly susceptible to foetal exposure.

109 ype that is induced through abnormalities in foetal fibre formation.

110 in the heart also causing cardiac fibrosis, foetal gene reprogramming, and impaired mitochondrial bi

111 directly influence birth weight through the foetal genome (direct foetal effects), vs. variants infl

112 Foetal glomerular podocytes expressed Fras1 transcripts

113 we show that MIWI2 associates with TEX15 in foetal gonocytes.

114 cell grafts are as functionally effective as foetal grafts and appear to integrate into the host brai

115 Visualized by Nissl staining, foetal grafts formed clumps of pyramidal-like cells with

116 omparing foetal neural precursor and primary foetal grafts in both allo- and xenograft environments u

117 ts with richer axonal outgrowth than primary foetal grafts, and that this is independent of the immun

118 These maternal biomarkers are important to foetal growth and could be used in prenatal care as an a

119 In utero foetal growth has required increased maternal feeding in

120 The control of foetal growth is poorly understood and yet it is critica

121 ysiological changes during pregnancy support foetal growth, including adaptations in pancreatic islet

122 gy conservation during winter and sustaining foetal growth, which may also apply to other large herbi

123 there is a genetic link between diabetes and foetal growth.

124 ed placenta was more efficient in supporting foetal growth.

125 ith regular obstetric follow-up to safeguard foetal growth.

126 ritional status and related to pregnancy and foetal growth.

127 They remained neurogenic in vitro and in foetal gut grafts.

128 life, have a minimal or late contribution to foetal haematopoiesis but instead largely proliferate du

129 in both lymphoid and myeloid lineages during foetal haematopoiesis, contributing to the increased ris

130 a initiation by bystander-like signalling to foetal haematopoietic cells.

131 ast extracellular vesicles (STBEVs) and free foetal haemoglobin (HbF) into the maternal circulation.

132 he human syndrome, hereditary persistence of foetal haemoglobin (HPFH).

133 rticularly for reagents designed to increase foetal haemoglobin expression as we have additionally de

134 sickle cell disease phenotypes for potential foetal haemoglobin reactivation and conversion from sick

135 d group phenotype, hereditary persistence of foetal haemoglobin, borderline HbA(2), and congenital dy

136 reduces haemolysis and anaemia by increasing foetal haemoglobin, which leads to lower hypoxic transcr

137 oaches potentially compromising maternal and foetal health.

138 functional and biochemical maturation of the foetal heart is dependent on glucocorticoid signalling w

139 sidered a commonly practised means to assess Foetal Heart Rate (FHR) through visual inspection and in

140 (+) population, which was confirmed in human foetal hearts.

141 injections of wild-type CPCs into Speg(-/-) foetal hearts.

142 tain a transcriptional profile distinct from foetal hepatocytes, mature hepatocytes and mature BECs.

143 Finally, we FACS isolate foetal HHyPs and confirm their hybrid progenitor phenoty

144 vitro survival and proliferation studies of foetal human osteoblasts subsequently demonstrated good

145 E derived from another hiPSC source and from foetal human RPE.

146 a, the latter specifically in the setting of foetal hydantoin syndrome.

147 of the deficient cortical development in the foetal hydrocephalic rat brain, we conclude that the con

148 y-life exposures may act upon the developing foetal immune system and include infection, environmenta

149 foeto-placental compartment can stimulate a foetal immune/inflammatory response characterized by the

150 us transplacental infection (TPI)' to define foetal infection from a recrudescent maternal infection

151 ly prenatally) and 'exogenous TPI' to define foetal infection that occurs as a result of an infection

152 such as maternal genotype effects, maternal-foetal interactions and parent-of-origin (imprinting) ef

153 distinct cell types present at the maternal-foetal interface and advance our knowledge of dynamic ge

154 eages and impaired formation of the maternal-foetal interface in the placental labyrinth.

155 Foetal intestinal lymphoid subsets are capable of sponta

156 al spectral flow cytometry analysis of human foetal intestinal samples between 14 and 22 weeks of ges

157 At 14 weeks, the foetal intestine is mainly populated by myeloid cells an

158 local proliferation in the developing human foetal intestine, likely contributing to the development

159 increases in methylation levels relative to foetal kidney and reductions relative to the adult kidne

160 ildhood is more important than growth during foetal life in determining cognitive function.

161 was expressed in the cerebral cortex only in foetal life stages, while in the cerebellum it was also

162 s throughout adult life and are specified in foetal life, have a minimal or late contribution to foet

163 iation and progression of these tumours with foetal-like characteristics, consistent with their predi

164 ppressing the tumorigenic potential of these foetal-like progenitor cells.

165 tumours that develop in this model exhibit a foetal-like progenitor phenotype (Ly6a/Sca1(+)) and, imp

166 em towards cholesterol export and adopting a foetal-like transcriptional signature which promotes iro

167 ormation and preservation of the pluripotent foetal lineage.

168 e functionally differentiated progeny to all foetal lineages of chimaeras.

169 Current dogma asserts that the foetal liver (FL) is an expansion niche for recently spe

170 numbers of megakaryocytes in the c-myb(-/-) foetal liver also refute early suggestions that megakary

171 ession to haematopoietic progenitors in both foetal liver and adult bone marrow.

172 Here, we show that the mouse foetal liver and foetal circulation contain a transient

173 atomically restricted to the ductal plate of foetal liver and maintain a transcriptional profile dist

174 e of haematopoietic stem cells (HSCs) in the foetal liver at E12.5, the embryo contains only a few de

175 During foetal liver colonization, circulating HSCs remained wit

176 e large pool of definitive HSC/RUs in day 12 foetal liver is formed predominantly by recruiting 'read

177 hought that the burst of HSC activity in the foetal liver is underpinned by rapid maturation of immat

178 correlates with an absence in the c-myb(-/-) foetal liver of uni- and multilineage CFUs.

179 y self-renew and can be seeded from yolk sac/foetal liver progenitors with little input from monocyte

180 hybrid progenitor (HHyP) population in human foetal liver using single-cell RNA sequencing.

181 initive progenitors, initially populated the foetal liver, but are unable to expand like wild type pr

182 sis at aorta-gonad-mesonephros, placenta and foetal liver, but does not impair yolk sac haematopoiesi

183 By E12.5, in addition to apoptosis in foetal liver, endocardium and myocardium, the erythropoi

184 ere they undergo maximal expansion is in the foetal liver, making this tissue a rich source of data f

185 with hepatoblast proliferation in the human foetal liver, suggesting that the role for Wnt could be

186 ortion of CD34+CD45+ cells in the c-myb(-/-) foetal liver.

187 c macrophages was linked to the yolk sac and foetal liver.

188 population of definitive HSCs emerges in the foetal liver.

189 s the number of definitive HSCs in the E12.5 foetal liver.

190 use hepatoblast organoids derived from human foetal livers to investigate the importance of Wnt signa

191 sed levels of RUNX1, C-KIT and PU.1 in human foetal livers with T21.

192 The only association of foetal loss (during gestational weeks 11 to 27) was obse

193 To evaluate the risk of foetal loss associated with pandemic influenza vaccinati

194 There was no difference in the hazard of foetal loss during weeks 25 to 43 in either model.

195 ether the potential effect of vaccination on foetal loss might be transient (for ~4 weeks post vaccin

196 nated pregnancies also had a lower hazard of foetal loss than unvaccinated pregnancies in gestational

197 ral forms of reproductive suboptimality (viz foetal loss, preterm birth and low birth weight).

198 PCP genes Celsr1 and Vangl2 are required for foetal lung development thereby revealing a novel signal

199 en self-renewal and differentiation in human foetal lung epithelial progenitors controls the size and

200 Previously, we established a human foetal lung organoid system.

201 iption start sites are utilized in adult and foetal lungs.

202 f the most common indications for performing foetal magnetic resonance imaging (FMRI).

203 rus which emerged in Europe in 2011, causing foetal malformations in ruminants.

204 The scarcity of embryonic/foetal material as a resource for direct study means tha

205 sorder characterised by raised bile acids in foetal-maternal circulation, which threatens perinatal h

206 ave potential to influence the health of the foetal-maternal unit.

207 Foetal membranes possess distinctive properties which ca

208 nd had chorioamnionitis (inflammation of the foetal membranes) (OR 5.3, 95% CI 2.0-13.4), and 5 were

209 Intrastriatal transplants of human foetal mesencephalic tissue in Parkinson's patients have

210 A libraries from human embryonic, neural and foetal mesenchymal stem cells.

211 ls harvested from the subventricular zone of foetal mice were preconditioned with interleukin 6 in vi

212 isceral smooth muscle cells (visSMCs) of the foetal mid-gut, but not mesothelial cells, were labelled

213 l success of trials that used transplants of foetal midbrain dopaminergic tissue.

214 clampsia) are a major source of maternal and foetal morbidity and mortality, and may be due to excess

215 breech presentation, with increased risk of foetal morbidity and mortality.

216 resentation, (2) would be expected to reduce foetal mortality in breech presentation, and (3) would b

217 l3 knockout in Neuro2a cells in vitro and in foetal mouse brain in vivo was used to assess the effect

218 ected on foetal ultrasound, through abnormal foetal movements and a multisystem neonatal disorder, to

219 suggested the existence of adult as well as foetal multipotent progenitor cells with combined B cell

220 the degree of archaic variant depletion from foetal muscle enhancers, perhaps due to divergent select

221 o compensation by retained expression of the foetal NaV1.5 isoform was detected.

222 during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mec

223 n's and Parkinson's disease who had received foetal neural allografts.

224 e addressed this issue directly by comparing foetal neural precursor and primary foetal grafts in bot

225 We present clear evidence that foetal neural precursors produce grafts with richer axon

226 Hyperactivation of the mTOR pathway during foetal neurodevelopment alters neuron structure and func

227 dicting placental insufficiency and abnormal foetal neurodevelopment that leads to neuropsychiatric d

228 ative impact of the opioid substances on the foetal neurodevelopment.

229 nta, ultimately eliciting adverse effects on foetal neurogenesis.

230 ad associate with human myofibres resembling foetal niches.

231 A key feature of the foetal-onset hydrocephalus in this rat is obstruction in

232 They can be derived from foetal or adult germinal tissues and continuously propag

233 the structural and functional maturation of foetal organs, yet excessive foetal exposure is detrimen

234 For many diseases with a foetal origin, the cause for the disease initiation rema

235 Although the 'foetal origins of adult disease' hypothesis has signific

236 with increased risks of adverse maternal and foetal outcomes.

237 t common molecular defect found in the human foetal overgrowth syndrome, Beckwith-Wiedemann syndrome

238 expression of Igf2 in endodermal tissues and foetal overgrowth, demonstrating that methylation in viv

239 s but instead largely proliferate during the foetal period.

240 nal hypothalamus is hormonally primed by the foetal placenta for nest building and post-natal care.

241 Human foetal placental macrophages, or Hofbauer cells (HBC), a

242 oorganisms and/or their components reach the foetal-placental unit and one indirect, in which Inflamm

243 lammatory mediators circulate and impact the foetal-placental unit.

244 thotrexate can be injected directly into the foetal pole under transvaginal ultrasound guidance in or

245 with fewer non-template insertions, and all foetal populations contained more clonotypic expansions

246 ough ultrasound screening, the assessment of foetal presentation at term is often based on clinical e

247 entation, and (3) would be cost effective if foetal presentation could be assessed for less than poun

248 The strategy would be cost effective if foetal presentation could be assessed for pound 19.80 or

249 Foetal presentation was assessed and compared for the gr

250 Limitations to this study included that foetal presentation was revealed to all women and that t

251 Cytokine expression in mixed foetal primary cultures and hippocampus of adults with D

252 are, the origin and biological mechanisms of foetal programming are largely unknown.

253 Foetal repertoires showed bias towards 3'TRAV and 5'TRAJ

254 r to produce enough thyroid hormones to meet foetal requirements.In this work, a combined analytical

255 tory, cautious interpretation of skin tests, foetal Rh genotyping from maternal blood and, in some ca

256 gnature to a genomic bar code of the fate of foetal Sertoli cells.

257 omic profiling and spatial analysis of human foetal shoulder tissues identify MERTK + LYVE1 + MRC1+ m

258 utritional status had significant effects on foetal size and females in poor health had lower probabi

259 at neural crest-derived cells present within foetal small intestine explants migrate towards an exoge

260 in E17.5 GR(-/-) hearts, they are normal in foetal SMGRKO hearts.

261 d partly or entirely by incorporation of the foetal-specific gamma-subunit into end-plate AChR.

262 nitial reports on phase 1 clinical trials of foetal spinal cord grafts into patients with post-trauma

263 bnormal development of the caudal end of the foetal spine along with many associated anomalies.

264 gest that steroidogenic adrenal cells during foetal stages require Sf1 to give rise to the adult adre

265 is currently being assessed clinically using foetal striatal tissue in Huntington's disease.

266 ggests that neuronal precursors derived from foetal striatum may have a greater capacity than primary

267 tum may have a greater capacity than primary foetal striatum to project to the usual striatal target

268 All foetuses had normal foetal structural brain anatomy.

269 ting weaker impact of MHC-restriction on the foetal TCR repertoire.

270 The foetal TCRbeta repertoire was less diverse, less evenly

271 und chromatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse

272 In foetal testes, SOX9 modulates both transcription and dir

273 re with the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a ge

274 e identified TRIM28 as a new SOX9 partner in foetal testes.

275 similar half-lives, yet IgG2 displays lower foetal than maternal concentration at term, despite all

276 ymus TCR repertoires are consistent with the foetal thymus producing alphabetaT-cells with properties

277 roid pathology, 30 population controls, nine foetal thyroid tissues and nine foetal tissues of non-th

278 Epigenetic variation in foetal tissue may have a mechanistic role in metabolic d

279 cursor and primary grafts derived from human foetal tissue produced a significantly richer outgrowth

280 traverse the placenta, infect and persist in foetal tissues of AFBs, which results in distinct geneti

281 ntrols, nine foetal thyroid tissues and nine foetal tissues of non-thyroid origin, either kidney or l

282 women of South Asian origin were studied and foetal tissues sampled at term delivery.

283 e resource that provides human embryonic and foetal tissues to the scientific community, enabling gen

284 were expressed in a wide range of adult and foetal tissues.

285 be ubiquitously expressed in human adult and foetal tissues.

286 d is also present, in low abundance, in some foetal tissues.

287 larized organ comprised of both maternal and foetal tissues.

288 ntly, our data show that the transition from foetal to adult retina is characterised by a large incre

289 the extent and factors influencing maternal-foetal transfer in low transmission areas co-endemic for

290 Maternal-foetal transfer of anti-malarial IgG to Plasmodium spp.

291 acking the donor cells, whereas most primary foetal transplant studies have utilized an allograft par

292 tors presumably influence the development of foetal Tregs.

293 lated to the persistence or re-occurrence of foetal type 2 signalling.

294 y extended from ventriculomegaly detected on foetal ultrasound, through abnormal foetal movements and

295 bjective was to test whether the Society for Foetal Urology (SFU) and urinary tract dilatation (UTD)

296 We previously reported that foetal valproate exposure impairs intelligence quotient.

297 In this study, we transplanted murine foetal ventral mesencephalic cells into rats rendered he

298 en a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients

299 fection in these mice precludes the study of foetal (vertical) viral transmission.

300 s provide a mechanistic link between chronic foetal VPA exposure and neurodevelopmental disability me