ライフサイエンスコーパス: folate

1 SNPs were associated with total breast-milk folate.

2 omen consuming >=800 mug/day of supplemental folate.

3 those with lower intake of dietary fiber and folate.

4 y also consumed <800 mug/day of supplemental folate.

5 esize or salvage pABA to meet the demand for folates.

6 a viable way to improve the daily intake of folates.

7 yclononane-N,N',N"-triacetic acid conjugated folate ((18)F-FOL) is a PET tracer targeting folate rece

8 p < 0.01 (95% CI - 2.54 to - 0.66), red cell folate 33.6 nmol/l p < 0.001 (95% CI - 43.64 to - 23.55)

9 nd preclinical evaluation of [(68)Ga]Ga-NOTA-folate ((68)Ga-FOL).

10 ative not previously identified to have anti-folate activity, was found to have a K(i) of 34 muM, wel

11 min multimineral supplements versus iron and folate alone at treatment doses (usual care), and to co-

12 GP) and serum vitamin B-12 and serum and RBC folate among nonpregnant women of reproductive age (WRA;

13 of genes associated with the biosynthesis of folate, an essential B-vitamin.

14 Folate, an essential nutrient found naturally in foods i

15 , 5-methyl tetrahydrofolate (THF), and total folate and a child's ASD risk.

16 er, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzym

17 ompared with controls, tau mice fed with low folate and B vitamins diet had a significant increase in

18 is influenced by nutritional factors such as folate and creatine.

19 gly, we found a negative association between folate and DNA methylation.

20 udies indicate severely reduced affinity for folate and dramatically impaired enzyme activity in Forr

21 After adjusting for covariates, high plasma folate and high plasma vitamin B-12 were each positively

22 p-aminobenzoyl-l-glutamate (pABG) moiety of folate and inhibit cooperatively with ligands that targe

23 anges in placental transport of amino acids, folate and ions.

24 mine the relation of the coexistence of high folate and low vitamin B-12 status with cognitive functi

25 Cord total folate and maternal supplement intake during second trim

26 d metabolite analysis revealed that both the folate and methionine cycles were affected in these muta

27 In noninteraction models, when high folate and normal vitamin B-12 status was the reference

28 lic content, antioxidant activity, nitrogen, folate and putrescine content were found for small scale

29 The positive relationship of maternal folate and TC and LDL-C concentrations may indicate the

30 whether the availability of vitamin B-12 and folate and the expression or activity of the target enzy

31 r understand the determinants of breast-milk folate and the impact they might have on milk folate bio

32 in B-12 and, in Kenya, a lower prevalence of folate and vitamin A deficiencies.

33 Hemoglobin, iron, ferritin, folate and vitamin B(12), in addition to many other labo

34 S per 1 SD increase in genetically predicted folate and vitamin B(6) levels were 0.49 (95% CI, 0.34-0

35 Folate and vitamin B-12 are essential micronutrients inv

36 We studied folate and vitamin B-12 concentrations and activity, exp

37 ge-scale epigenome-wide association study of folate and vitamin B-12 intake was performed on DNA from

38 vel epigenetic loci that are associated with folate and vitamin B-12 intake.

39 Folate and vitamin B-12 intakes were calculated from foo

40 We examined dietary and plasma folate and vitamin B-12 status, and their interaction, i

41 4: Laboratory findings can include elevated folate and, less commonly, vitamin B-12 deficiency, or o

42 The aim of this study was to assess whether folate and/or vitamin B-12 intake are asssociated with g

43 ient growth contained 93.09 +/- 6.2 ug/100 g folates and 18.55 +/- 0.5 mg/100 g vitamin C as bioacces

44 ioxidant capacity, beta-glucans, pyridoxine, folates and silicon were quantified.

45 tate while, elevated growth enhanced soluble folates and vitamin C up to 188.63 +/- 7.5 ug/100 g and

46 lement, 1911 (96%) of 1986 assigned iron and folate, and 1922 (96%) of 1994 assigned co-trimoxazole s

47 Only 3 surveys measured RBC folate, and among them, correlations for WRA ranged from

48 status (iron, zinc, vitamin D, vitamin B-12, folate, and fatty acid status)?

49 tration of vitamin B-12 (P = 0.003), but not folate, and the activity (P = 0.001), transcriptional le

50 binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response

51 Folates are critical for central nervous system function

52 Thus, folates are critical for establishing and preserving epi

53 Folates are vital cofactors for the regeneration of S-ad

54 the absence of an arylamine substrate using folate as a cofactor.

55 oncentrations may indicate the importance of folate as a methyl donor for lipoprotein synthesis durin

56 ry cells ex vivo, CDN uptake is inhibited by folates as well as two medications approved for treatmen

57 The most significant folate-associated DMR was a 400-base pair (bp) spanning

58 Regional analysis showed 74 folate-associated DMRs, of which 73 were negatively asso

59 The B vitamins folate, B-6, and total B-12 are key for the methyl group

60 for vitamin B-12 deficiency and high plasma folate, because there were too few individuals (<1% of t

61 late AMD: vitamin A, vitamin B6, vitamin C, folate, beta-carotene, lutein and zeaxanthin, magnesium,

62 0.08, and correlations between AGP and serum folate between -0.21 and 0.02.

63 studies, this cp-Fab/CAR-T system targeting folate binding proteins on the cell surface mediated pot

64 The NSAIDs target a region of the folate binding site that interacts with the p-aminobenzo

65 olate and the impact they might have on milk folate bioavailability.

66 tions between CRP or AGP and vitamin B-12 or folate biomarkers, there is no rationale to adjust for i

67 arget DNA gyrase, the cell wall, tryptophan, folate biosynthesis and RNA polymerase, as well as inhib

68 suggests that the main role of chorismate is folate biosynthesis despite ubiquinone biosynthesis bein

69 for ZTP activated GTPase A) supports de novo folate biosynthesis under conditions of zinc limitation,

70 sor in the synthesis of p-aminobenzoic acid (folate biosynthesis), p-hydroxybenzoic acid (ubiquinone

71 subtypes, which revealed the mevalonate and folate biosynthetic pathways as MESN-selective dependenc

72 de novo purine biosynthesis, and the flux of folate-bound methyl groups.

73 d panel identified SLC19A1, a feline reduced folate carrier (RFC) and potential receptor for TG35-2-p

74 ort is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter

75 -interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antip

76 ent of up to 5 kGy reduced the loss of total folates caused by 7 days of storage.

77 provide a historical perspective, delve into folate chemistry that is often overlooked, and point out

78 thyl-group carrier database (MGDB) including folate, choline, betaine and methionine, for use in the

79 akes of vitamins D, C, and E; beta-carotene; folate; choline; and n-3 and n-6 polyunsaturated fatty a

80 referential maternal-fetal transfer of iron, folate, cobalamin, and zinc; limited transfer of fat-sol

81 Ferritin, folate, cobalamin, zinc, and thyroglobulin averaged 1.57

82 05 (95% CI 0.32 to 8.87) CONCLUSION: The low folate concentration and higher levels of homocysteine a

83 Blood folate concentrations in the US population overall and i

84 tions between CRP or AGP and vitamin B-12 or folate concentrations were examined, taking into account

85 panic persons showed increased serum and RBC folate concentrations, whereas non-Hispanic black person

86 d supplement nonusers showed increased serum folate concentrations.

87 chanisms of action, we synthesized EC2629, a folate conjugate of a DNA crosslinking agent based on a

88 ligonucleotides administered in complex with folate-containing liposomes dramatically inhibit primary

89 ed nutritional supplementation with iron and folate-containing multivitamin multimineral supplements

90 dent enzymes are associated with breast-milk folate content in a cohort of mothers enrolled in the Ma

91 We measured FA and folate content in dietary staples (bakery bread and tort

92 -day storage period did not affect the total folate content of buckler sorrel (while the 2 kGy dose d

93 Total folate content, expressed as folic acid equivalent, was

94 ication of various folate vitamers and total folate content, which could be a proper substitute to th

95 years but target different enzymes from the folate cycle (mainly dihydrofolate reductase and thymidy

96 a novel 2-carbon transporting variant of the folate cycle and modify human chromatin via ethylation.

97 sults in retention of 1-carbon groups in the folate cycle at the expense of transfer to the methylati

98 The two-carbon folate cycle of commensal Lactobacillus reuteri 6475 giv

99 We show that the 2C folate cycle of L. reuteri is capable of transferring 2

100 tetrahydrofolate reductase (MTHFR) links the folate cycle to the methionine cycle in one-carbon metab

101 on of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione sys

102 ply of glycine-derived 1-carbon units to the folate cycle.

103 All participants received 1 mg of folate daily.

104 We examined cross-sectional serum and RBC folate data from the NHANES 1999-2016.

105 Enzymes of the folate de novo synthesis pathway in malaria parasites ar

106 Folate deficiencies are prevalent in countries with insu

107 Vitamin B-12 and folate deficiencies in women and children have important

108 ing population prevalence of vitamin B-12 or folate deficiencies in WRA or PSC.

109 chastic noise in FOCM that results from both folate deficiency and a common variant in the methylenet

110 istidine degradation pathway and a marker of folate deficiency, formiminoglutamate, was increased mor

111 s indicated that they had metabolic signs of folate deficiency.

112 8 pmol/L or MMA > 271 nmol/L), but none were folate deficient (plasma folate < 4.53 nmol/L).

113 Cerebral folate delivery primarily occurs at the choroid plexus t

114 of FRalpha led to a substantial decrease of folate delivery to the brain and that pretreatment of Fo

115 indicating a remarkable enhancement in brain folate delivery.

116 al single nucleotide polymorphisms (SNPs) in folate-dependent enzymes are associated with breast-milk

117 ge form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecar

118 of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which de

119 ate that MiDAS does occur at FRAXA following folate deprivation but proceeds via a pathway that shows

120 These findings provide insights into how folate deprivation drives instability in the human genom

121 Folate deprivation drives the instability of a group of

122 association between cord 5-methyl THF, total folate, DHFR genotype, and ASD risk.

123 re, we co-reconstituted ECF transporters for folate (ECF-FolT2) and pantothenate (ECF-PanT) into prot

124 ne population-level intake of FA and dietary folate equivalent (DFE) accounting for geographic differ

125 g the efficient therapeutic behavior through folate/exosome complex remains elusive.

126 Folate (FA) receptor is a cell surface glycoprotein over

127 on of HT 29 colorectal cancer cells based on folate (FA)/folate receptor (FR) interactions.

128 ently and in an interactive manner with high folate for certain cognitive performance tests among old

129 oped LC-MS/MS method for quantification of 6 folate forms.

130 mendations for prevention of NTD risk beside folate fortification or supplementation.

131 ron, vitamin A, vitamin D, vitamin B-12, and folate from 0 to 35 d post-norovirus exposure.

132 nstrated fast clearance of [(18)F]fluoro-PEG-folate from heart and blood vessels and no dose limiting

133 Serum folate geometric means increased from 2007-2010 to 2011-

134 ently blocked by a nonlabeled FR-beta ligand folate glucosamine in vivo.

135 Ga-FOL was assessed in a blocking study with folate glucosamine.

136 up versus 509 (26%) children in the iron and folate group (HR 0.95, 95% CI 0.84-1.07; p=0.40), and 50

137 oup versus 169 (9%) children in the iron and folate group had died (hazard ratio [HR] 0.97, 95% CI 0.

138 folic acid (UMFA) > 1 nmol/L or serum total folate > 74.1 nmol/L, and low vitamin B-12 status as met

139 We evaluate serum and red blood cellular folate, homocysteine, alpha fetal protein cholesterol, t

140 rboxypeptidase II (GCPII), coded by the gene folate hydrolase 1 (FOLH1), regulates the amount of NAAG

141 g (CD), tea consumption (UC), high levels of folate (IBD), high levels of vitamin D (CD), and H pylor

142 his study explored whether specific types of folate in cord blood have differential association with

143 e specific folate vitamers to estimate total folate in foods is not standardized.

144 is and kinetic properties of [18F]fluoro-PEG-folate in RA patients.

145 or serum (~70 nmol/L) and RBC (~1800 nmol/L) folate in supplement nonusers aged >=60 y was similar to

146 e bacterium produces a 2-carbon-transporting folate in the form of 5,10-ethenyl-tetrahydrofolyl polyg

147 developed to characterize the reactivity of folates in cowpea seeds during germination at 30 degrees

148 accessibility of polyphenols, vitamin C and folates in fresh and frozen fruits using HPLC-UV analyse

149 tatus is critical to prevent diseases due to folate inadequacy (e.g., anemia, birth defects, and canc

150 is evidence that low plasma vitamin B-12 and folate individually, as well as an imbalance of high fol

151 The folate insufficiency prevalence (RBC folate <748 nmol/L;

152 nd in women have not decreased recently, and folate insufficiency rates are ~20%.

153 ted folate status resulting from any form of folate intake affect vitamin B-12 function and its roles

154 g this association in populations with lower folate intake and/or higher exposure to air pollution.

155 o establish whether high folic acid or total folate intake contributes to disease risk.

156 High supplemental folate intake might protect against the adverse reproduc

157 We evaluated whether folate intake modified the relationship between air poll

158 ricted to mothers with estimated daily total folate intake of >=400 mug during periconception.

159 Supplemental folate intake significantly modified the association of

160 dietary staples leads to unpredictable total folate intake without adequately impacting the intended

161 ir pollutants and livebirth were modified by folate intake, adjusting for age, body mass index, race,

162 the possibility of unmeasured confounding by folate intake, and the importance of examining this asso

163 Ps, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1,

164 3) Does elevated folate intake, regardless of form, affect biological pat

165 of which 73 were negatively associated with folate intake.

166 Folate intakes based on the MGDB and those generated usi

167 assess relative validity, calculated dietary folate intakes were compared between the MGDB and the EP

168 Folate is a fundamental vitamin for metabolism in plants

169 o FRalpha is one of several methods by which folate is taken up by cells; however, this receptor is a

170 1.13x10(-3)), but not with those related to folate levels in pregnancy.

171 ese transport systems can result in very low folate levels in the cerebrospinal fluid causing childho

172 At the same time, blood folate levels were not changed and the total folate pool

173 ial role in the maintenance of intracellular folate levels.

174 opulation could be selectively targeted with folate-linked drugs.

175 l/L), but none were folate deficient (plasma folate < 4.53 nmol/L).

176 The folate insufficiency prevalence (RBC folate <748 nmol/L; NTD risk) in women decreased from 20

177 t-packaging irradiation for preserving total folates may depend not only on the applied dose but also

178 Cord folate (mean: +26.8%; 95% CI: 19.6, 34.5%), cobalamin (m

179 In folate-mediated one-carbon metabolism (FOCM), 5-formylte

180 -79797 has two independent cellular targets, folate metabolism and bacterial membrane integrity, and

181 as well as shared signals of selection, with folate metabolism and the related ultraviolet response a

182 In conclusion, a defect in folate metabolism can lead to prenatal aqueduct stenosis

183 us missing links and underdeveloped areas in folate metabolism for future exploration.

184 Not surprisingly, abnormal folate metabolism has been causally linked with a myriad

185 etrahydrofolate dehydrogenase), an enzyme of folate metabolism highly expressed in liver, metabolizes

186 l methylation following conditions affecting folate metabolism in novel dynamic sperm CpGs.

187 ction/cycling, isoprenoids biosynthesis, and folate metabolism in response to chloroquine.

188 These findings imply widespread effects on folate metabolism in soybean cv.

189 Folate metabolism is crucial for many biochemical proces

190 development of drugs targeting intracellular folate metabolism, such as methotrexate and pemetrexed.

191 tenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redo

192 leavage system, a mitochondrial component of folate metabolism, whose malfunction results in accumula

193 f AMPK, the PPP, and reductive glutamine and folate metabolism.

194 est its ability to detect effects of altered folate metabolism.

195 sclerosis, basal transcription factors, and folate metabolism.

196 ectrometry and NMR spectroscopy, we analyzed folate metabolites of L. reuteri strain 6475 and discove

197 phisms (SNPs) associated with tHcy (n = 18), folate (n = 3), vitamin B(6) (n = 1), and vitamin B(12)

198 There was no effect modification of folate on the associations between other air pollutants

199 the Estimated Average Requirement (EAR) for folate or above the Tolerable Upper Intake Level (UL) fo

200 mma radiation treatment for preserving total folates or vitamin B(9) in watercress (Nasturtium offici

201 entify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transp

202 UMFA; P-interaction = 0.0071) and AF (serum folate; P-interaction = 0.0078) for low vitamin B-12 and

203 l interactors of BRD4, which converge on the folate pathway enzyme MTHFD1 (methylenetetrahydrofolate

204 genomic and epigenomic variants influencing folate pathway genes (mRNA, miRNA, copy number alteratio

205 The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MT

206 of these compounds does not work through the folate pathway, as other antimicrobial sulfonamides; ind

207 (Arabidopsis thaliana) for deconjugation of folates (PE-LC-MS/MS), or animal-origin deconjugase (rat

208 The Aspirin/Folate Polyp Prevention Study previously found folic aci

209 folate levels were not changed and the total folate pool in the liver was decreased by only 20%.

210 t have a regulatory function towards reduced folate pools, de novo purine biosynthesis, and the flux

211 bility and reproducibility of the method for folate quantification in foods using the plant-origin ga

212 imilarly, correlations between CRP and serum folate ranged from -0.13 to 0.08, and correlations betwe

213 RBC folate (RBF) is an indicator of folate status and risk o

214 colorectal cancer cells based on folate (FA)/folate receptor (FR) interactions.

215 Folate receptor (FR)-targeted small molecule drug conjug

216 Here, we describe a protease-activated anti-folate receptor 1 TCB (Prot-FOLR1-TCB) equipped with an

217 Folate receptor alpha (FRalpha) came into focus as an an

218 d to induce Th17 responses to the OC antigen folate receptor alpha (FRalpha).

219 roton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regul

220 eceptor alpha proteins, and suggest exosomal folate receptor alpha as a potential biomarker for early

221 CD24, epithelial cell adhesion molecule and folate receptor alpha proteins, and suggest exosomal fol

222 Folate receptor beta (FR-beta), a marker expressed on ma

223 folate ((18)F-FOL) is a PET tracer targeting folate receptor beta (FR-beta), which is expressed on ac

224 uppressive population by its upregulation of folate receptor beta (FRbeta) within the TME and its res

225 his tracer showed excellent targeting of the folate receptor beta on activated macrophages in synovia

226 However, delivery of siRNA directly through folate receptor mediated endocytosis for gene silencing

227 mediated potent and specific eradication of folate-receptor-expressing cancer cells in vitro and in

228 such a paclitaxel (PTX) prodrug that targets folate receptors.

229 Five folate-related SNPs-MTHFR 677C>T (rs1801133), MTHFR 1298

230 tients with PVT showed lower levels of serum folate, respect HCC patients without PVT, with an averag

231 tions of vitamin B(1), B(6), B(12), C and D, folate, selenium, zinc, copper, iron, carnitine and 22 a

232 olecular defect underlying most of the known folate-sensitive fragile sites in the genome.

233 Although folate-sensitive RFSs share many features with common fr

234 culated from whole blood folate (WBF), serum folate (SFOL), and hematocrit (Hct).

235 35.3 compared with 37.0 nmol/L), whereas RBC folate showed no significant change.

236 Secondly, [(18)F]fluoro-PEG-folate showed uptake in arthritic joints with significan

237 tent with an in vitro IC50 ~ 100x lower than folate SMDCs constructed with various microtubule inhibi

238 ion status through a direct interaction with folate status and (indirectly) with total homocysteine (

239 y is to investigate the relationship between folate status and portal vein thrombosis.

240 RBC folate (RBF) is an indicator of folate status and risk of neural-tube defects.

241 omen aged 12-49 y and to characterize recent folate status by demographic group and use of folic acid

242 were to assess postfortification changes in folate status in the overall US population and in women

243 ed in the United States for >20 y to improve folate status in women of reproductive age and reduce th

244 despread agreement that maintaining adequate folate status is critical to prevent diseases due to fol

245 2) Does elevated folate status resulting from any form of folate intake a

246 eriods suggest applicability to low and high folate status situations, but should be confirmed elsewh

247 levated folic acid intake, UMFA, and/or high folate status to adverse health outcomes are lacking.

248 High folate status was defined as unmetabolized serum folic a

249 ects from excess folic acid intake, elevated folate status, and unmetabolized folic acid (UMFA) remai

250 nts of CFBs and vitamin D, vitamin B-12, and folate status, or the relation between lower-iron-contai

251 of excess folic acid intake and/or elevated folate status, with the original concern focused on exac

252 tion = 0.0078) for low vitamin B-12 and high folate status.

253 ion, utilizing various definitions of "high" folate status.

254 required for the replication of FRAXA under folate stress and define a cellular function for human S

255 ocesses jointly modulate the function of the folate stress-sensing Fusobacterium ulcerans ZTP riboswi

256 The majority of participants were folate sufficient; all received As-removal water filters

257 Changes in homocysteine after folate supplementation correlated with changes in fastin

258 educed salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardio

259 Folate supplementation is recognized as a way to lower h

260 When compared with placebo, folate supplementation lowered fasting insulin (WMD: -13

261 Folate supplementation might be beneficial for glucose h

262 m of this study was to examine the effect of folate supplementation on IR and T2D outcomes.

263 Only 2 studies examined folate supplementation on risk of T2D, and they found no

264 ZagA and FolE, and thereby helps to sustain folate synthesis despite declining zinc availability.

265 A key precursor for folate synthesis is para-aminobenzoate (pABA).

266 Delivery of a folate-targeted TLR7 agonist to these cells (i) reduced

267 arger conformational changes upon binding of folate than pantothenate, which could explain the kineti

268 ethyl-THF (R2 = 0.008, P = 0.04) and reduced folates (THF + 5-methyl-THF + 5-formyl-THF + 5,10-methen

269 ha=0.05 significance level included calcium, folate, thiamin, vitamin B6, and vitamin C, with nutrien

270 onstrates the potential of [(18)F]fluoro-PEG-folate to image arthritis activity in RA with favourable

271 B12, folate, total homocysteine (tHcy), methionine, MMA, meta

272 Folate transport is mediated by 3 major pathways, reduce

273 etabolic disorders caused by defective brain folate transport.

274 reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FR

275 RFC, a folate transporter, is a potential receptor for the nove

276 amin multimineral supplement versus iron and folate treatment or co-trimoxazole prophylaxis improved

277 ly compensate for the loss of Folr1-mediated folate uptake at the choroid plexus, providing a therape

278 could provide an alternative route for brain folate uptake.

279 S/MS provides fast quantification of various folate vitamers and total folate content, which could be

280 wed intense enzymatic interconversion of all folate vitamers into 5-methyltetrahydrofolate before 14

281 Quantification of the specific folate vitamers to estimate total folate in foods is not

282 he homogenization step was included, and six folate vitamers were analyzed using LC-MS/MS.

283 Plasma folate, vitamin B-12, and methylmalonic acid (MMA) were

284 , we explored the association between plasma folate, vitamin B-6 in the form of pyridoxal 5'-phosphat

285 abolism provides a direct link among dietary folate/vitamin B(12) exposure, the activity of the enzym

286 5(OH)D, and zinc, while maternal and newborn folate, vitamins B-12, D, and E, zinc, and iodine biomar

287 vitamin B-12, high UMFA or high serum total folate was associated with higher risk of scoring low on

288 he novel macrophage tracer [(18)F]fluoro-PEG-folate was developed.

289 Among B vitamins, only plasma folate was positively associated with TC (beta = 0.244,

290 al" vitamin B-12, higher UMFA or serum total folate was protective on the CERAD-DR.

291 After covariate adjustment, RBC folate was significantly lower in all age groups (by ~10

292 It is calculated from whole blood folate (WBF), serum folate (SFOL), and hematocrit (Hct).

293 To explore the role of polyglutamylation of folate, we eliminated both isoforms of FPGS in human cel

294 ustment for potential confounders, including folate, we observed an inverse association for intake of

295 emely high concentrations of maternal plasma folate were associated with increased risk of autism spe

296 l amino acids, trace elements, vitamin C and folate were detectable in effluent fluid.

297 Low plasma vitamin B-12 and low plasma folate were each associated with worse cognitive functio

298 ons between inflammation and vitamin B-12 or folate were weak, with no clear pattern of association i

299 Comparable amounts of total folates were found in fresh, non-stored samples of both

300 of cord UMFA, but not 5-methyl THF or total folate, were associated with a greater risk of ASD in Bl

301 g to increase the production of bioavailable folates within the seed for human consumption.