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1 cal shift of the gingival margin (almost two-fold).
2 SC-CMs) in vitro can expand CMs modestly (<5-fold).
3 in previously non-GBS-vaccinated women (>=7-fold).
4 ic versus monomorphic (i.e., having just one fold).
5 t enhance molecular conductance more than 10-fold.
6 y cooperative, with the affinity reduced ~11-fold.
7 llowed us to expand the database more than 5-fold.
8 ate for ETR-3 RRM-3, which has canonical RRM fold.
9 nce for the binding mechanism of this unique fold.
10 ct same target with differences of up to 600-fold.
11 esses a new fold that we name the cantaloupe fold.
12 of sequences and selecting ones predicted to fold.
13 ased peak blood concentrations of SRF by 2.2-fold.
14 ked out (DeltahnRNPA2B1 cells) was reduced 3-fold.
15 increased the odds of obesity by more than 2-fold.
16 The pig's rostrum has three major skin-folds.
17 both ion retention and maintenance of the GQ folds.
18 does not construct classifiers in the inner folds.
19 XBP1s, which facilitates ER-mediated protein folding.
20 stiffening of the basement membrane promotes folding.
21 d intermediate that competes with productive folding.
22 evealed its distinct contributions to genome folding.
23 BM model for cerebral cortical expansion and folding.
24 onal tuning to balance protein synthesis and folding.
25 em increased the recoverable energy nearly 3-fold (0.009 kWh m(-3), compared to a 0.003 kWh m(-3)), w
26 m-neutralizing antibodies on day 43 were 0.7-fold (1-mug dose) to 3.5-fold (50-mug dose) those of the
27 of pure AR, AR + OMR, and AR + FMR were 1.25-fold, 1.76-fold, and 2.34-fold, respectively (all p <= 0
28 within the same calendar date, increased 5.3-fold (5.1-5.5) over the study period, with the highest i
29 on day 43 were 0.7-fold (1-mug dose) to 3.5-fold (50-mug dose) those of the recovered individuals.
30 g 1p+1b and 2p+0b schedules experienced 2.05-fold (95% CI, 1.12-5.00) and 3.33-fold (95% CI, 2.28-4.9
31 .2 to 2.6; observed, 559; EAR, 61.6) and 1.6-fold (95% CI, 1.4 to 1.7; observed, 473; EAR, 18.2) for
32 Overall, noncancer SMRs were increased 2.4-fold (95% CI, 2.2 to 2.6; observed, 559; EAR, 61.6) and
33 enced 2.05-fold (95% CI, 1.12-5.00) and 3.33-fold (95% CI, 2.28-4.93) greater odds, respectively, of
34 hapes and robotic behaviors, demonstrated by folding a letter shape "M," a dynamic gripper, and a dyn
37 pared to the free probe (p < .0001), and 2-4 fold accumulation compared to the non-targeting control
39 he derivative SH53d-acid shows superior (>40-fold) affinity selectivity and is a positive modulator.
40 ombination of cough and fever/chills has 4.2-fold amplification in COVID(pos) patients during the wee
41 nated, bringing new evidence that both the 3-fold and 4-fold channels can be functional in ferritin.
42 ) that increases the sequence contiguity 120-fold and annotate it using 6.5 million full-length trans
43 quivalents can introduce an error of up to 6-fold and recommend a class-equivalent approach instead.
48 ligand-binding affinity, monitoring protein folding and unfolding and determining hidden conformatio
50 l structural features such as architectures, folds and conformity to conserved structural motifs.
53 vertheless increases nuclear delivery ca 2.5-fold, and a non-destructive interaction with DNA is indi
54 es core elements that define the CARF domain fold, and the mechanistic basis for ring nuclease activi
59 ly that the cell should keep its proteome as folded as possible at the minimum possible energy cost.
61 odulus of the adhesive increased by nearly 4 folds at the interface as a result of oxidative cross-li
64 to also study interfacial proteins and their folding, binding, orientation, hydration, and dynamics.
65 homogenization drastically enhanced (about 5-fold) bioaccessibility of carotenoids including hardly b
66 a "smart" thymidine analog, exhibiting a 28-fold brighter fluorescence intensity when base paired wi
67 forming enzymes share a conserved structural fold but act on a wide range of substrates to catalyze r
69 only confirms that IrtAB has an ABC exporter fold, but also reveals structural peculiarities at the t
72 ion of hiPSC-CMs in vitro (i.e., 100- to 250-fold) by glycogen synthase kinase-3beta (GSK-3beta) inhi
74 is lesions versus in controls, respectively (fold change >= 2; false discovery rate [FDR] < 0.05).
77 all cases, tuning leads to trade-offs in the fold-change and the ability to distinguish cellular stat
78 nge compression), implying that conventional fold-change calculations directly using MS signal intens
79 r real metabolic concentration ratios (i.e., fold-change compression), implying that conventional fol
81 hase grown crystals and exhibit reversible 8-fold changes in conductivity upon illumination at modest
83 ximum power output per myosin-1C motor and 4-fold changes in the velocity and the resistive force at
84 rnal PTSD were in opposite directions, while fold changes of shared DEGs associated with both materna
88 idue (Pro-10) had little to no impact on the folded chemokine structure but diminished CXCR4 agonist
89 substrate to enter the active center and a "folded"/"closed" state that holds the NTP substrate in t
90 ) versus N(2) uptake at 298 K, except the 19-fold CO(2) uptake for CTH-12 containing Cu(II) dinuclear
91 o-noise (S/N) for analytes improved up to 19-fold compared to direct ESI-MS of single-phase droplets
93 helical peptidomimetics, which have similar folding conformation to alpha-peptides, making them an i
98 .71) and improved overall survival, with a 2-fold decrease in mortality rate (HR, 0.50; 95% CI, 0.27
99 ions suggests that pathogenesis results from folding defects and the disruption of autoinhibition and
100 -type A(1)-receptor and A(1)R-Y288A(7.53) (a folding-deficient variant used as a reference), respecti
101 rolysis of the sulfimide varied more than 10-fold depending on temperature and the site of the engine
105 bstitutions in the core alpha/beta hydrolase-fold domain and the hairpin, exhibited hormone-independe
110 G4s in living cells without perturbing their folding dynamics are required to understand their biolog
111 the polypeptide chain of MJ0366 increase the folding energy barrier in a magnitude close to the energ
112 ticular, we describe the characterization of folding energy landscapes at high resolution, studies of
113 nebulization gas to reduce discharge, 10-100-fold enhancement in signal intensity and 3-10-fold impro
114 e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra
115 ion of 0.55, representing a significant 38.3-fold enrichment as compared to the precision of 0.014 fo
116 en with the c.1592delT variant in PALB2 (242-fold enrichment in Finland, 336 carriers) and an average
119 vo, the dictionary method performed over 140-fold faster than curve fitting, obtaining whole volume p
120 nd nucleotide substitution rates up to forty-fold faster than observed over longer timescales in S. p
121 (Cu(I)-HjLPMO9A) is demonstrated to be 1,000-fold faster than the [Formula: see text] reaction while
122 mbrane subdomain, which has a novel all-beta-fold, followed by a secretin/TonB, short N-terminal subd
123 tructural platform alternative to the native fold for RNase P to bind and mature SRP RNA co-transcrip
125 an provide critical, detailed information on folding free energy landscapes, intermediates, and pathw
126 ), and urea (a neutral denaturant) alter the folding free energy remains indistinguishable whether pr
130 nts showed a striking genetic cline of seven-fold greater seed set at higher latitudes in the introdu
131 3TC-TP concentrations were on average 17-fold greater than TFV-DP concentrations in cervical tiss
133 U. prolifera growing at an approximately two-fold growth rate per day in optimum conditions, U. merid
134 irst trimester were, respectively, 24- and 6-fold higher (risk ratios, 24 [95% confidence interval {C
137 anic conditions, and SICE seamounts have two-fold higher fisheries catch relative to non-enhancing se
138 visual impairment associated with DR is two-fold higher in the African-American (AA) compared to non
139 h Bowman-Birk protease inhibitor was several fold higher in transgenic soybean plants when compared t
140 ctive hybrid displayed over threefold and 10-fold higher in vitro activity than ivermectin against he
141 a suboptimal stem length, accumulates to 40-fold higher levels when clustered with a helper hairpin.
142 had excellent biocompatibility, showing >50-fold higher sensitivity in GI tract, and migrated homoge
143 maternal plasma alpha-T concentration was 3-fold higher than in the adult nonpregnant female populat
145 spectively, achieving brain/blood ratio >300-fold higher than that of immunoglobulin G/liposomes.
147 s with carbon number and aromaticity up to 2-fold higher than the starting material, strongly suggest
148 pollutants (except PM(2.5)) were 1.1- to 4.8-fold higher than when the residence was not downwind of
152 nous HLA class I-associated ligands with 1.5-fold improvement in positive predictive value compared w
153 old enhancement in signal intensity and 3-10-fold improvement in S/N are achieved for various kinds o
154 ver-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at disease
155 diffusivity, which matches well with the 10-fold improvement of intrinsic OER activity, suggesting t
156 of the spatial frequencies demonstrates a 40-fold improvement, with respect to previous techniques, i
158 mal damage to the rat nerve, which grows 2.4-fold in diameter, and allowed chronic electrical stimula
159 e Bacteroides fragilis genome by 48- and 154-fold in mucus and tissue, respectively, allowing for hig
160 ulted in positive enhancements of up to ~100-fold in the (13) C NMR signal compared to thermal equili
161 e every year, with an overall increase of 30-fold in the last 50 years, mainly due to city population
162 rone, IPI binding to SHBG was reduced by ~20-fold in the presence of zinc, whereas DVT binding was al
165 f structurally complex multidomain proteins, folding in the presence of chaperones, and the ability t
169 5 and caused 6% of IPD during 2015-2019, a 7-fold increase compared with 2009-2014.The outbreak was c
171 the initial dose, which corresponds to a 94 fold increase in accumulation compared to the free probe
173 roduct water was characterized by an up to 5-fold increase in alkalinity, which indicates the success
176 by 50%-80%, resulting in a commensurate 3-5-fold increase in coral recruitment and reef fish communi
177 tions or in Balb/C mice and led to an over 2-fold increase in CTC attachment to ECs or Balb/C mouse l
180 red by >= 5 reads), leading to an average 14-fold increase in genome coverage when compared to unampl
182 ortin is coupled to iron binding, with an 80-fold increase in hepcidin affinity in the presence of ir
184 icon-incorporated perovskite exhibits a 12.8-fold increase in oxygen diffusivity, which matches well
185 ere defined as patients with at least a four-fold increase in P. aeruginosa TOL-TAZ MICs after exposu
189 in the frozen-hydrated state yields a 10 000-fold increase in signal intensity for polar molecules su
192 After fermentation by gut microbiota, a ten-fold increase in the antioxidant values and an important
193 est suPAR tertile was associated with a 9.15-fold increase in the odds of AKI (95% confidence interva
194 nterval [95% CI], 3.64 to 22.93) and a 22.86-fold increase in the odds of requiring dialysis (95% CI,
195 ion with 18-crown-6 is able to produce an 18-fold increase in the reaction rate in relation to crown
197 nitrite oxidation rates and stimulated a 33-fold increase of 2-methylhopanoid abundance, indicating
198 cant expansion of APCs, resulting in an 11.5-fold increase of dendritic cells and infiltration of lym
199 resonance with the optical excitation, a 12-fold increase of the amplitude of precession indicates e
201 ACE10 as compared to wild-type monocytes (~3-fold increase; P < 0.05) led to reductions in cerebral s
203 (topical natamycin or amphotericin) had 1.32-fold increased odds of 24-hour culture positivity, altho
204 The RFP intervention was associated with a 2-fold increased odds of being referred because of photogr
205 lin-binding protein PBP2X that conferred a 2-fold increased penicillin G and ampicillin MIC among the
207 file driven by significantly selective (>100-fold) inhibition of a subset of the eight bromodomains i
209 isingly, we found that population of the RNH folding intermediate is required to generate sufficient
211 proteins often fold via long-lived partially folded intermediates, whose structures, potentially toxi
214 found that the wild type hTERT core promoter folds into a stacked, three-parallel G-quadruplex struct
215 to demonstrate that XIST RNA-protein complex folds into an evolutionarily conserved modular architect
217 evels of Env on the surface of MT-4 cells, 2-fold less Env is incorporated into virus particles produ
219 0063 and GSE108134) had lower (1.04- to 1.12-fold) levels of lung CYP2A13, CYP2A6, and CYP2A7 (and hi
221 S-binding cleft region, (Sc)CRM1 exhibits 16-fold lower binding affinity than (Hs)CRM1 toward PKI-NES
222 ne during the 3 year-treatment period and 10-fold lower during the follow-up year (n = 18, P = .03).
226 e points, HVT-DeltavNr-13 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2
228 CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for cancer developm
229 ethyltransferases are SAM dependent Rossmann fold methyltransferases that convert A2058 of 23S rRNA t
230 d scanner using serially diluted stool was 5-fold more sensitive than manual examinations by multiple
233 rive a relation between the number of linear folding motions and the number of rigid body modes that
237 redicted silver concentrations were within 2-fold of observed blood and tissue silver concentrations
241 Here we have demonstrated the successful folding of the protein 1D3Z (to within 2.4 angstrom of t
242 and (c) RAG Designer: designs sequences that fold onto novel RNA motifs (described by tree graph topo
243 candidate structures that can lead to native folds or designable structures remains a challenge, sinc
245 n-binding primarily occurred through induced-folding pathways (in which intermolecular contacts form
248 protein design (CPD) can address the inverse folding problem, exploring a large space of sequences an
251 ored by NMR can be used to map epitopes onto folded protein surfaces, but only if the complex rapidly
253 on the potential mechanism of translocating folded proteins across a membrane, offer insights into t
255 unable to produce surfactin exhibited an ~50-fold reduction in viability after oxygen depletion.
256 Furthermore, the degree of local cortical folding relates systematically with the strength of loca
257 9 protein, with a resistance ratio of >588.0-fold relative to a susceptible population (SS) based on
258 tructures of delta revealed novel pentameric folding repeats, which we term beta-bracelets, in the in
259 FlaG (sFlaG), which reveals a beta-sandwich fold resembling the S-layer-interacting FlaF soluble dom
260 A has dramatically enhanced (sometimes >1000 fold) resistance to degradation by four different nuclea
262 fR and anti-ICAM counterparts by ~27- and ~8-fold, respectively, achieving brain/blood ratio >300-fol
265 fold-rise (D0 to D30) in anti-F IgG over the fold-rise in RSV-A-neutralizing antibodies was 1.01.
267 ptive signaling pathway that governs protein folding, secretion, and energy production and serves to
268 with an IC(50) of 72 nM and greater than 200-fold selectivity over off-target sodium channel isoforms
271 ogen (N) to the environment has increased 10-fold since 1860 and is expected to increase by a further
272 very little is known about the location and folding stability of functional elements within the mass
274 inary residual conformational entropy in the folded state, which provides a counterbalance to the abs
275 t challenge for CS is to overcome 4 to 6 log-folds stronger affinity for its natural inhibitor, serin
279 cross-kingdom structural analysis of the OTU fold that highlights commonalities among distantly relat
280 etic analogs of the collagen triple helix, a fold that is a hallmark of collagen-like sequences.
281 ric mean neutralizing titres reached 1.9-4.6-fold that of a panel of COVID-19 convalescent human sera
286 d DNs extends survival by up to another ~250-fold to >48 h during incubation with 2600 times the phys
287 ived from Abeta(17-23) and Abeta(30-36) that fold to form beta-hairpins and assemble to form trimers.
288 and storage systems that can be twisted and folded to multiple deformations while retaining their el
290 animals could be increased by more than 200-fold upon replacement of liposomes with bacteriophage Qb
292 DNA damage response and repair on 3D genome folding using Hi-C experiments on wild type cells and at
295 e isolated at low temperature and induced to fold via an increase in temperature, analogous to the te
297 n NDs and SUVs was the kinetics; the rate of folding was two- to threefold slower in NDs compared to
298 sence of tRFs, hBEX3 adopts compact globular fold, which is very distinct from the elongated high-ord
299 al structure of GP38, which revealed a novel fold with distant homology to another CCHFV glycoprotein
301 resulted from complex 3D spirals and vaginal folds with deep recesses, which may curtail the depth or