ライフサイエンスコーパス: folding of

1 collagen assembly begins with the oxidative folding of ~30-kDa C-terminal propeptide (C-Pro) domains

2 uggest that many rRNA-folding steps, such as folding of 5.8S rRNA, occur at a very specific stage of

3 ing of various design rules, and demonstrate folding of a 6-kb template by as few as 10 unique strand

4 Our model system is the binding and folding of a chaperone substrate, immunity protein 7 (Im

5 have used molecular dynamics to simulate the folding of a complex lasso glycoprotein, granulocyte-mac

6 Here, we asked whether folding of a complex RNA can be understood from its stru

7 phorylation of T37 and T46 in 4E-BP2 induces folding of a four-stranded beta-fold domain, partially s

8 ght have evolved to ensure efficient, timely folding of a highly abundant and essential protein.

9 resence of multiple intermediates during the folding of a model polypeptide, polyproline.

10 The concomitant folding of a nascent protein domain with its synthesis c

11 ons are generated and transmitted during the folding of a neuroepithelial layer.

12 Spontaneous folding of a polypeptide chain into a knotted structure

13 ity to investigate real-time cotranslational folding of a polypeptide.

14 es to control the simulated, cotranslational folding of a protein in a user-prescribed manner.

15 The structure and folding of a protein in solution depends on noncovalent

16 resence of C-mannoses promoted the oxidative folding of a reduced and denatured TSR in vitro.

17 t if this assumption is true, we compare the folding of a ribosome-bound, multi-domain calcium-bindin

18 olecular dynamics in describing the unbiased folding of a simple RNA secondary structure motif.

19 ults identify a key role for ADAT2-dependent folding of ADAT3 in wobble inosine modification and indi

20 Here, we study the cotranslational folding of adjacent domains from the cytoskeletal protei

21 nterface is sufficiently stable to drive the folding of adjacent E and G5 domains along a parallel fo

22 s A-E (TBCA-E), and GTP are required for the folding of alpha- and beta-tubulin subunits and assembly

23 mitochondrial chaperones and assists in the folding of alpha-ketoglutarate dehydrogenase (OGDH), a r

24 or this finding was obtained by showing that folding of an enhanced green fluorescent protein variant

25 Self-folding of an information-carrying polymer into a define

26 nd master equation analysis to elucidate the folding of an RNA pseudoknot structure.

27 mutations are likely to disrupt the correct folding of an RNA secondary structure required for viral

28 e how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences,

29 r pifithrin-mu (an HSP70 inhibitor) restored folding of, and hence dopamine transport by, dDAT-G108Q

30 ntified a phase transition event, namely the folding of antigenic peptides from random coils to alpha

31 lding stress rather than achieving efficient folding of any single component of the proteome, (ii) ho

32 fugation techniques, we observed spontaneous folding of AT-IN nucleosome arrays into highly compact s

33 , it has remained infeasible to simulate the folding of atomistic proteins at room temperature using

34 Here, we report the folding of atomistic, implicitly solvated protein system

35 so enables thiol/disulfide exchange-mediated folding of bacterial cell envelope proteins during perio

36 Using magnetic tweezers, we show that the folding of BapA BIg domains requires calcium binding and

37 emerged as a powerful tool for studying the folding of biological macromolecules.

38 Although the folding of both proteins exhibited similar kinetics, the

39 e X-ray scattering (SAXS) support the proper folding of both the 14-3-3 and ACD dimers within the chi

40 To explain this phenomenon, we show that the folding of c-Myb is templated by the structure of KIX.

41 are being developed: correctors that improve folding of CFTR and potentiators that recover the functi

42 proteostatic mechanism that couples protein folding of channels to forward trafficking in the secret

43 of folding mechanisms centres on reversible folding of chemically denatured membrane proteins.

44 ications in cancer, the in-situ higher-order folding of chromatin structure during malignant transfor

45 hese findings indicate that the higher order folding of chromatin topology may act as a molecular-pat

46 gnal transduction in EC resulted in impaired folding of collagen IV and its retention in the endoplas

47 1 is critical for regulating translation and folding of collagen polypeptides.

48 of long-range interactions to assist in the folding of complex cellular machineries such as the ribo

49 DE6 and that it enables low yield functional folding of cone PDE6C in cultured cells.

50 erone Cosmc through assisting of the correct folding of Core 1 beta3 Galactosyltransferase (T-synthas

51 interaction governed by the binding-coupled folding of disordered regions in both interacting partne

52 so be retained, which enhances the oxidative folding of disulfide-rich cyclic proteins such in the ca

53 rage shape of transition paths, studying the folding of DNA hairpins as a model system for folding re

54 the first step in the in vitro pathway, the folding of DNA into a single loop.

55 e precludes tyrosine autophosphorylation and folding of DYRK1, resulting in a kinase unable to preser

56 participate in a quality control pathway for folding of EGF repeats in proteins such as Notch.

57 PBI dimer pairs and accordingly template the folding of even-membered PBI macrocycles into ropelike f

58 iments reveal that systematic stretching and folding of fluid elements are produced in the pore space

59 suppressor mutations also partially restores folding of full-length CFTR.

60 Folding of G-protein coupled receptors (GPCRs) according

61 Detailed biophysical characterization of folding of G-Quadruplex (GQ)-based light-up aptamers suc

62 ty of co-replicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery

63 reveals previously unknown principles of the folding of G-rich oligonucleotides that could be applied

64 PC4 did not enhance the rate of folding of G4DNA, and formation of the PC4-G4DNA complex

65 Whereas folding of genomes at the large scale of epigenomic comp

66 The folding of genomic DNA from the beads-on-a-string-like s

67 been performed for G-quadruplexes formed by folding of GGG(TTAGGG)3 single strands in buffered solut

68 bic effect is the primary effect driving the folding of globular proteins is nearly universally accep

69 ole played by native contacts in determining folding of globular proteins.

70 We investigate the folding of GlpG, an intramembrane protease, using perfec

71 are believed to be indispensable for proper folding of gp120 and for viral infectivity.

72 t with experiment, suggesting that oxidative folding of guanylin in vitro occurs under kinetic contro

73 In addition, we have simulated oxidative folding of guanylin within the 94-aminoacid prohormone p

74 upon binding lipids, and shows lipid-induced folding of h3.

75 force microscopy technique that monitors the folding of helical membrane proteins in vesicle and bice

76 lix association is a fundamental step in the folding of helical membrane proteins.

77 teraction is a critical driving force in the folding of helical membrane proteins.

78 beta2M is essential for proper folding of HFE, CD1, and MHC class I and their surface e

79 Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructure

80 molecular dynamics simulations to study the folding of Htt-exon-1 across five different polyQ-length

81 nd cytoarchitectonic regions relative to the folding of human visual cortex, a unifying principle lin

82 ese results provide a physical basis for the folding of individual chromosomes at the nanoscale.

83 Folding of individual domains in large proteins during t

84 s support elevated tensions that promote the folding of interfaces along paths that can be predicted

85 sister chromatid cohesion, and higher order folding of interphase chromatin are mediated by condensi

86 (Minimal Chromatin Model) that explains the folding of interphase chromosomes and generates chromoso

87 ith the emerging features of binding-induced folding of intrinsically disordered proteins.

88 ses the aggregation and maintains the proper folding of its substrate proteins (i.e., clients).

89 the self-association of bovine IF(1) and the folding of its unfolded region.

90 for Tsc1 as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients-including Tsc2-

91 Folding of knots is encoded by the arrangement of module

92 The folding of knotted proteins is on the timescale of minut

93 erized theoretically and experimentally, the folding of large multidomain proteins is less well known

94 ew native-centric methods for simulating the folding of large proteins.

95 The folding of larger proteins has been studied using native

96 t self-association assays to study intrinsic folding of linear and circular nucleosome arrays with li

97 glycosylation of N582, suggesting that rapid folding of local conformation prevents glycosylation of

98 tions and as a model system for the study of folding of long polypeptide chains, including related ph

99 We found that the folding of M6A correlates with the detection of mineral

100 open up potential new avenues to control the folding of macromolecules.

101 The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understoo

102 Folding of mammalian genomes into spatial domains is cri

103 al functions, and are crucial for productive folding of many glycoproteins.

104 aperonins are ATP-ases indispensable for the folding of many proteins that play a crucial role in Arc

105 x association is essential for understanding folding of membrane proteins and formation of their func

106 chanism is introduced to achieve robust self-folding of microscale origami by separating actuation in

107 mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the neg

108 ctions, single-molecule FRET measurements of folding of model RNAs revealed constant DeltaDeltaGtert

109 The absence of intermediates in the folding of monomeric SOD1 suggests that the unfolded ens

110 onlocal folds, such as all-beta, whereas the folding of more local, all-alpha proteins typically exhi

111 d, which may be particularly relevant to the folding of multidomain proteins.

112 Our study reveals folding of N-glycosylated membrane proteins in the ER as

113 he endoplasmic reticulum (ER) to promote the folding of N-glycosylated membrane proteins.

114 bosome-bound nascent chains should match the folding of nascent chains in real time.

115 Co-translational secondary folding of nascent chains inside the ribosome has profou

116 hanisms that prevent aggregation and promote folding of nascent G protein-coupled receptors (GPCRs) r

117 vation of G-protein signaling as well as the folding of nascent Galpha proteins.

118 at interacts with the ribosome to assist the folding of nascent polypeptides.

119 disulfide rearrangements required for proper folding of nascent proteins synthesized in the endoplasm

120 We hypothesize that strong folding of nascent RNA weakens R-loops and hence decreas

121 by Ssb1/2/RAC chaperones by ensuring proper folding of nascent Sup35p, thus preventing its joining a

122 The folding of natural proteins typically relies on hydropho

123 labeling modification might affect rates of folding of near-neighbor structural elements, and thus l

124 s played a transformative role in growth and folding of neocortex as well as archicortex.

125 nserved molecular chaperone critical for the folding of new and denatured proteins.

126 , facilitates protein homeostasis, including folding of newly synthesized polypeptides and clearance

127 protein, a disordered structure found before folding of newly synthesized protein or after protein de

128 Hsp70 chaperones assist de novo folding of newly synthesized proteins in all cells.

129 RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these

130 -regulated in cancer and is required for the folding of numerous signaling proteins.

131 This strategy could be used to design folding of other knotted programmable polymers such as R

132 articular disulfide bond impairs the correct folding of other single LU domain-containing proteins?

133 aman spectroscopy to confirm the spontaneous folding of outer membrane protein A (OmpA) into preforme

134 2/cyclin A complex is accompanied by partial folding of p27 in the KID domain, with the retention of

135 Proper folding of PDE6 relies on the chaperone activity of aryl

136 5-fold, we demonstrate that slow spontaneous folding of PepQ is not caused by aggregation.

137 d anaerobic electron acceptors for oxidative folding of periplasmic proteins.

138 lmonella undergoing oxidative stress impairs folding of periplasmic proteins.

139 cing of Polycomb target genes and in spatial folding of Polycomb domains.

140 The folding of polypeptide side chains into alpha-helices dr

141 Folding of polypeptides begins during their synthesis on

142 pproach demonstrate that the main barrier to folding of pp32 is quite broad and lies near the unfolde

143 ail how assembly factors regulate the timely folding of pre-18S rRNA.

144 he role of modest free energy changes in the folding of pre-integration forms of a hyperstable outer

145 The unfolding and folding of protein barnase has been extensively investig

146 the rates of translation and cotranslational folding of protein domains monitored in real time by For

147 etics of protein self-association, affecting folding of protein monomers, or changing aggregation pat

148 Molecules that correct the folding of protein mutants, restoring their functional t

149 Folding of proteins entering the secretory pathway in ma

150 Broader implications related to the folding of proteins in energy-transducing membranes are

151 Proper folding of proteins is critical to producing the biologi

152 are molecular chaperones that facilitate the folding of proteins or target misfolded proteins for cle

153 tems, ranging from those mediating oxidative folding of proteins required for infection to those cont

154 ce the amount of required data in successful folding of proteins to unprecedented levels.

155 cooperativity and downhill, or barrier-free, folding of proteins under highly stabilizing conditions

156 Folding of proteins usually involves intermediates, of w

157 Experiments have compared the folding of proteins with different amino acid sequences

158 ying amino-groups, glycation interferes with folding of proteins, increasing their aggregation potent

159 leus to maintain cell homeostasis via proper folding of proteins.

160 ful means of interrogating the structure and folding of proteins.

161 ational changes as well as the synthesis and folding of proteins.

162 Insertion is initiated by the folding of residues 3-11 into an alpha-helix, and mediat

163 sponses involving mechanisms such as dynamic folding of riboswitches during translation initiation or

164 d, the pseudoknot, which plays a key role in folding of ribozymes and riboswitches, is not addressed

165 tain knowledge about approximate topological folding of RNA.

166 s, we assayed the force generated during the folding of RNH on the ribosome.

167 The rpf2Delta255-344 mutation affects proper folding of rRNA helices H68-70 during anchoring of the R

168 omplex multistep process, results in correct folding of rRNAs, incorporation of >50 ribosomal protein

169 mic reticulum (ER) activity to enable proper folding of secreted proteins and prevent ER stress.

170 ium homeostasis as well as the synthesis and folding of secretory and membrane proteins.

171 he molecular chaperone HSP90 facilitates the folding of several client proteins, including innate imm

172 ed model allows us to predict accurately the folding of several RNA molecules in a mixture containing

173 cleation core that initiates Ag(+) -mediated folding of SilE.

174 ilibrium processes through the unfolding and folding of single DNA hairpins.

175 hat allows, for the first time, the study of folding of single proteins during week-long experiments.

176 Although the folding of single-domain proteins is well characterized

177 e more effective than the BAM complex in the folding of some substrate proteins.

178 o follow in real time the co-transcriptional folding of SRP RNA.

179 n the assembly process and contribute to the folding of the 3' domain of 16S rRNA.

180 (2010) PLoS Comput Biol 6:e1000731] for the folding of the [Formula: see text]-knotted alpha-haloaci

181 atured, transition, and native states in the folding of the activation domain of human procarboxypept

182 independently refold, thereby templating the folding of the alpha-subunits, which then chaperone the

183 Here, we show that the biosynthesis and folding of the AML1-ETO protein is facilitated by intera

184 end of the aptamer followed by a directional folding of the aptamer around its target from 5'-end to

185 ggests that the mutational robustness of the folding of the beta-barrel protein is underpinned by its

186 00 nM concentration of calcium is needed for folding of the BIg domains, and the stability of the fol

187 imposes a posttranslational mechanism on the folding of the C-terminal part of EF-G.

188 , revealing that the ligand prevents optimal folding of the C-terminal region of VDR.

189 The data reveal that folding of the central pseudoknot (T1), the most crucial

190 However, U3 must be removed to allow folding of the central pseudoknot, a key feature of the

191 he same equation that predicts the degree of folding of the cerebral cortex, given the clade-specific

192 sociated both regionally and temporally with folding of the cerebral cortex.

193 BG have been implicated in the expansion and folding of the cerebrum and cerebellum, respectively.

194 sal progenitors in the evolution of cortical folding of the cerebrum and cerebellum.

195 gene regulation and refine global polymeric folding of the chromatin fiber.

196 extent that thermally induced unfolding and folding of the collagen triple helix take place at the s

197 The folding of the cortex in mammalian brains across species

198 Brain gyrification, or folding of the cortex, is as highly evolved and variable

199 ment microscopically defined by an excessive folding of the cortical mantle resulting in small gyri w

200 ion and AP-1 binding are dependent on proper folding of the cytoplasmic domains, the signal provides

201 ncy for bound GDP, suggesting an induced-fit folding of the donor-binding subsite.

202 n identity-could coordinate co-translational folding of the encoded protein.

203 n synonymous codon substitutions that impair folding of the encoded protein.

204 ms that result in the regularity of cortical folding of the entire brain.

205 ved in AD patients may explain the increased folding of the entorhinal cortex.

206 Here, we slowed the folding of the Escherichia coli beta-barrel protein, Lpt

207 e optical properties are attributable to the folding of the even-membered macrocycles into exciton-vi

208 In vitro, folding of the extension takes months, implying a cataly

209 the beta 2-adrenergic receptor (beta 2-AR), folding of the FiP35 WW domain, and dimerization of the

210 hich in turn relies on the three-dimensional folding of the first 750 nucleotides of the molecule.

211 th mutations almost completely destroyed the folding of the FLNA5 domain, where the mutation is locat

212 Beyond intradomain misfolding, folding of the full-length protein is further slowed by

213 to neutralizing antibodies by perturbing the folding of the fusion machinery.

214 a disulfide bridge essential for the proper folding of the G protein-coupled receptor proteolytic si

215 xperiments, we followed the co-translational folding of the G-domain, encompassing the first 293 amin

216 The relationship between the 4D folding of the genome and its function is an outstanding

217 A range of methods that probe the folding of the genome in space and time with unprecedent

218 Cohesin catalyses the folding of the genome into loops that are anchored by CT

219 changes, and lead to aggregation or abnormal folding of the gluten proteins.

220 f apertures for the elastic response and the folding of the grain.

221 The Hsc70/Hsp70 chaperones assist the folding of the hERG cytosolic domains.

222 at most CDC73 missense mutations disrupt the folding of the hydrophobic core of hCDC73-NTD, while oth

223 h monomeric and aggregated alpha-syn enhance folding of the i-motif sequence of telomeric DNA.

224 tions with a protein partner lead to partial folding of the IDR.

225 structural role in orchestrating the proper folding of the Igkappa locus in preparation for V(D)J re

226 Non-center-involving folding of the ILM flap was present in 4 eyes (24%).

227 Using NMR spectroscopy, we show that folding of the inhibitory helix requires a buried charge

228 opposing distribution bands is echoed by the folding of the inner membrane.

229 However, an increased degree of folding of the insular cortex was specifically associate

230 pendent on salt-bridge formation and correct folding of the intact protein receptor.

231 Here we present a study of the folding of the intrinsically disordered transactivation

232 ere, we describe in detail the structure and folding of the isolated pseudoknot, which forms a compac

233 In contrast, in aromatic solvents folding of the macrocycles with a distinct odd-even effe

234 posterior frontal region, and dysplastic in-folding of the mesial occipital cortex.

235 s at the beta-signal motif to the unassisted folding of the model beta-barrel protein PagP.

236 tponed cleavage of gp160 enhances functional folding of the molecule.

237 suggest that this delay improves the correct folding of the mutant capsid precursor protein to permit

238 r reduce inter-domain misfolding, permitting folding of the N-terminal G-domain.

239 Folding of the nascent chain already occurs during synth

240 integration is an essential prerequisite for folding of the nascent chain.

241 ule telomerase assays, we discovered that GQ folding of the nascent DNA product during processive add

242 the forces generated by the cotranslational folding of the nascent polypeptide chain can also enhanc

243 ap optical tweezers and observe simultaneous folding of the nascent polypeptide chain in real time.

244 in response to translation, processing, and folding of the nascent RNA.

245 the mutation is located, and also affect the folding of the neighboring FLNA4 domain.

246 cleoli to the nuclear lamina facilitates the folding of the neutrophil genome into a confined geometr

247 n of this step is a crucial prerequisite for folding of the next domain.

248 rocyclization proceeds efficiently, inducing folding of the o-phenylenes.

249 Further, we followed the folding of the P4-P6 RNA and showed that differences in

250 %) partially folded intermediate in tertiary folding of the P5abc subdomain of the 'Tetrahymena' grou

251 moves in the hydrophobic groove formed after folding of the peptide in the presence of zinc ions.

252 on only during voluntary orienting; rearward folding of the pinna's upper-lateral edge exhibited such

253 e a change in the tertiary structure and the folding of the polyanionic backbone influences the carri

254 This is the first evidence that folding of the polypeptide chain precedes disulfide form

255 Early folding of the predominantly beta-sheet ATIII domain in

256 he improved core algorithm in the successful folding of the protein 1A1Z with as high as +/-4 Hz of a

257 Here we have demonstrated the successful folding of the protein 1D3Z (to within 2.4 angstrom of t

258 sidues is disrupted lead to major changes in folding of the protein and the size and shape of the sub

259 e second cleavage, which is dependent on the folding of the protein.

260 significant effects on the structure and the folding of the protein.

261 disulfide bond, which assists the functional folding of the protein.

262 A only transiently, likely due to non-native folding of the rRNA during transcription.

263 me orientations reveals new detail about the folding of the S. cerevisiae genome.

264 gp160 chain termination and is dependent on folding of the soluble subunit gp120 to a near-native co

265 hile it evidently plays a role in the proper folding of the SPOR domain of FtsN, this domain is non-e

266 Folding of the structure drives its synthesis in 95% yie

267 6-enynes, which result from different chiral folding of the substrates based on attractive aryl-aryl

268 This protein modification can alter the folding of the target protein; can affect binding intera

269 analysis mainly detects selection for proper folding of the TCR receptor protein.

270 The improved stability and folding of the TCRs reduces glycosylation, perhaps throu

271 a-sheet catalytic core but likely assist the folding of the TIKI domain.

272 s in a stepwise, hierarchic fashion from the folding of the triple helix to the assembly of fibrils i

273 The folding of the triple-labeled mutant is monitored by the

274 st fluctuations could be associated with the folding of the unfolded state to an intermediate state,

275 constraints imposed upon them by the native folding of the viral spike.

276 We show that folding of the Wnt signaling coreceptor LRP6 is promoted

277 e time required for beta 2-AR activation and folding of the WW domain are greatly diminished using ev

278 lity to resolve fine differences in rates of folding of these elements.

279 as an important structural concept, and the folding of these peculiar structures still poses conside

280 mechanisms and the energetics that drive the folding of these proteins are poorly understood.

281 Proper folding of these proteins is monitored by the unfolded p

282 lipids are generally involved in the proper folding of these proteins.

283 rum by focused-ion-beam based patterning and folding of thin film nanostructures.

284 s to be important for ligand recognition and folding of this domain to potentiate DNA binding but doe

285 y crucial for EF-G function, complicates the folding of this large multidomain protein.

286 Folding of this multi-layered trophectoderm induces spre

287 Mutations designed to disrupt folding of this region into amphipathic helices (AHs) si

288 r, our results indicate that cotranslational folding of this viral protein generates a tension that s

289 n-canonical ER quality control mechanism for folding of thrombospondin type 1 repeats by protein O-fu

290 abilizes unfolded states and facilitates the folding of Twister, including the formation of hydrogen

291 s sufficient for successful co-translational folding of two bacterial alpha-helical membrane proteins

292 y desirable to be able to study the rates of folding of two or more neighboring subdomain structures

293 les scanning complexes, requires the correct folding of two rRNA elements in the subunit head and the

294 We also showed that FKBP22 catalyzed the folding of type III collagen through its prolyl isomeras

295 ciated with it, significantly slows down the folding of UCH-L1.

296 volves VCP/p97, an AAA ATPase regulating the folding of various cellular substrates including ubiquit

297 lp explain how chaperones can facilitate the folding of various unrelated proteins.

298 The folding of wild type Pin1 WW domain, which has two posit

299 ant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic retic

300 how evidence that this role is in the proper folding of Wnt3a, BAFF, IL-7, and perhaps other factors