ライフサイエンスコーパス: forge

1 the GPLv3 license through Bioconductor and R-Forge.

2 organic photovoltaic devices is still being forged.

3 ted, cultural norms shaped, and social bonds forged.

4 rically encumbered carbon-carbon bonds to be forged.

5 lly congested natural product could never be forged.

6 lobionts." As such, their collective genomes forge a "hologenome," and models of animal and plant bio

7 th electron-deficient olefins to selectively forge a C(sp(3))-C(sp(3)) bond with the more-crowded a-a

8 Moreover, direct reductive elimination to forge a C-F bond at Au(III) was explored and substantiat

9 e the experiences that led to my decision to forge a career as an academic molecular animator, and ho

10 be mediated, which holds great potential to forge a connection between chemical reactivity and supra

11 Furthermore, its integration mode can forge a consensus network from gene expression data and

12 The challenge is to forge a consensus on ethical guidelines and safeguards t

13 step annulation process was then designed to forge a conserved tetracyclic bis-pyrrole architecture a

14 We conclude that lst-1 and sygl-1 forge a critical link between Notch signaling and GSC ma

15 Specifically, we forge a direct link between the PTEN-Akt-FOXO axis and t

16 These results altogether forge a framework for our deep understanding into snakes

17 from the two major existing algal groups to forge a highly successful, species-rich protist lineage.

18 Here, we forge a link between the problem of path integration and

19 wever, unfortunately the author's attempt to forge a middle way between internalism and externalism f

20 which is intercepted by boryl aniline 31 to forge a new C-N bond.

21 via bimolecular nucleophilic substitution to forge a new carbon-carbon bond.

22 directors), the project collaborators helped forge a new national consensus on the learning agenda fo

23 nt and progression of tauopathies could help forge a path for the establishment of effective immunomo

24 As research continues to forge a path forward for PDT in the clinic, direction is

25 ging brain-based measures in psychiatry will forge a path toward better treatment personalization, re

26 ria between the different specialties and to forge a pathway for patients who may need dual organ tra

27 pecialized tools are required to efficiently forge a peptide bond in a chemoselective manner with fas

28 These findings forge a potential mechanistic link between impaired SPW-

29 In this issue of Neuron, Misic et al. (2015) forge a promising new direction by modeling the propagat

30 ethods that transcend proteomic platforms to forge a quantitative link between protein target-selecti

31 tation of an intermediate dihydropyranone to forge a stereochemically defined (E,Z)-dienamide unit.

32 Its goals are to forge a strategy to accelerate the diagnosis of rare or

33 The results forge a strong link between PPIases and the transcriptio

34 air and a rare, two-turn 310 helix, together forge a substrate-binding pocket with an open clamshell

35 hibitory signaling in the autistic brain and forge a translational path between animal and human mode

36 cycloaddition between two dehydroalanines to forge a trisubstituted pyridine core.

37 tyrosine kinase/adaptor protein signaling to forge a unique approach for selectively killing leukemic

38 erosion coupled to sedimentary P-enrichment forged a markedly nutrient-rich crust at the dawn of the

39 The study also forges a bridge with the face recognition literature.

40 The exercise forges a collaborative research agenda emphasising four

41 effective in intramembrane footprinting and forges a connection between material science and biology

42 The core scaffold of the phenolic ligand forges a hydrogen-bonding network involving the 4-hydrox

43 indicate a mechanism of PTEN regulation that forges a link between distinct cancer-relevant pathways

44 This work forges a link between kinetic models describing biologic

45 Thus, our study forges a mechanistic link between KRAS* signalling and a

46 This work forges a new link between statistical and biophysical mo

47 ssociates with active promoters, the finding forges a new link between transcription, epigenetics, an

48 This brainstem link forges a new understanding of the relationship between t

49 by endogenous ligand, Ro60-associated ssRNA, forges a nexus between TLR ligation and fibrosis instiga

50 implement a challenging cationic cyclization forging a bond between two sterically encumbered quatern

51 ishes C-F tertiary benzylic stereocentres by forging a C-C bond via a Pd-catalysed enantioselective H

52 sequence generation, and spatial navigation, forging a direct link between cellular and systems neuro

53 PGC-1alpha and PGC-1beta promoters, thereby forging a direct link between telomere and mitochondrial

54 steps in the network (closeness centrality), forging a geographically diverse international profile (

55 icant part of an active hammerhead ribozyme, forging a link between nonenzymatic polymerization and t

56 g how neural circuits change over phylogeny, forging a link from genes to circuits to behaviour.

57 onstrain conformationally mobile motifs, but forging a macrocycle bond typically becomes more difficu

58 folio of single-crystal optical actuators is forging a new class of photonic materials that hold pros

59 de materials and nanostructured coatings are forging a path toward more sustainable water treatment t

60 lluminates novel microRNA attenuators of RB, forging a promising new path for microRNA mimic chemothe

61 Despite significant advances in forging a single bond via C-H activation in the past dec

62 ed Kingdom may soon become a world leader in forging a smoke-free generation.

63 constituting a putative neural mechanism for forging active multisensory perception.

64 ave led to the use of PET and the ability to forge advances in the field of oncology.

65 Finally, as we forge ahead we must construct measurements of our safety

66 iatrics and pediatric cardiology continue to forge ahead with better diagnoses, medical care, and sur

67 ensates for this aversion, allowing flies to forge ahead.

68 As insight in fungal immunopathogenesis forges ahead, interventions for boosting immune function

69 Many researchers are forging ahead with projects to sequence a range of speci

70 who compete over mates, while simultaneously forging alliances between opposite-sex siblings.

71 that a vision surveillance system should be forged among federal agencies.

72 ves challenge the surgical "personality" and forge an evolving and more open professional surgical id

73 ns in flies provides a unique opportunity to forge an integrated mechanistic understanding of biochem

74 : We review recent literature with a view to forge an integrative understanding of the molecular, cel

75 tein FANCD2 by monoubiquitylation; this then forges an association with the BRCA1 protein at sites of

76 This work forges an important link between the FMR1 gene, altered

77 Professional integrity is vital in forging an ethically sound relationship between investig

78 rug discovery, it is intriguing to precisely forge and manipulate ring systems in synthetic chemistry

79 k for assisting surgeons in their efforts to forge and sustain collaborations with the highest potent

80 ctive we examine how these linkages might be forged and how the new science of the mind might serve a

81 In contrast, nature effortlessly forges and breaks amide bonds using precise arrays of Le

82 on was markedly reduced for both solid-glass forging and liquid-melt molding.

83 and enables message sending ensured against forging and repudiation.

84 between two tolerant elm varieties, 'Valley Forge' and 'Princeton,' also indicated that tolerance ag

85 Terminal/internal olefins are amenable to forge aromatic/aliphatic, cyclic/acyclic, secondary/tert

86 Our methodology forges aromatic and aliphatic, cyclic and acyclic, and s

87 ) have emerged as promising methodologies to forge aryl C-N bonds under mild conditions.

88 Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmi

89 Robust Zr(IV)-carboxylate bonds are forged between the Zr clusters of NU-1000 and carboxylic

90 ptide (Nepsilon-Gly-L-homothiaLys) bonds are forged between two molecules of Ub, demonstrating the po

91 Their widespread use to forge bonds between two aromatic rings has enabled every

92 enabled by a Ni-catalyzed radical relay that forges both C(sp(3))-C(sp(3)) and C(sp(2))-C(sp(3)) link

93 n contrast, we argue that mirror neurons are forged by domain-general processes of associative learni

94 the future of organ transplantation will be forged by progress occurring in RM.

95 Biomolecular associations forged by specific interaction among structural scaffold

96 eins, with the isodityrosine links primarily forged by Tyr151-Tyr151 coupling.

97 idely used polar cross-coupling chemistry to forge C(sp(2))-C(sp(2)) bonds (such as Suzuki, Negishi a

98 s-electrophile coupling (XEC) reactions that forge C(sp(2))-C(sp(3)) bonds have received considerable

99 zed cross-coupling is a powerful strategy to forge C(sp(3))-C(sp(3)) bonds.

100 organic synthesis, but their application to forge C(sp(3))-heteroatom bonds, particularly C(sp(3))-N

101 symmetric versions of this transformation to forge C(sp(3))-N bonds have remained elusive due to the

102 coupling of alcohols with N-nucleophiles to forge C(sp(3))-N bonds, a linkage of high value in pharm

103 led that a putative reductive elimination to forge C(sp(3))-OC(sp(3)) using I(2) might not be operati

104 intermediates present a powerful strategy to forge C-N bonds with high site- and stereoselectivity.

105 then readily trap the aryne intermediate to forge C-N bonds, an essential bond in pharmaceutical and

106 es in C-C fragment couplings, the ability to forge C-O bonds in a general fashion via nickel catalysi

107 ation of an alcohol/alkoxide to the recently forged C(sp(3))-I bond.

108 al tools in the modern synthetic toolbox for forging C-C and C-X bonds.

109 Synthesis of allylic functionalized motifs forging C-O, C-C, and C-S bonds has been achieved via vi

110 e groups are able to direct C-H cleavage and forge carbon-aryl bonds on the strained cycloalkanes fra

111 Reactions that forge carbon-carbon (C-C) bonds are the bedrock of organ

112 phile transfer of intermediate ate complexes forge carbon-carbon bonds with unactivated primary, seco

113 lication of Suzuki-Miyaura cross-coupling to forge carbon-carbon bonds, the structure of the reactive

114 Metal-catalyzed transformations that forge carbon-heteroatom bonds are of central importance

115 have evolved as a new effective strategy to forge carbon-heteroatom bonds that are difficult to acce

116 this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by dir

117 gnized as an increasingly viable strategy to forge challenging C-C and C-heteroatom bonds for complex

118 onda (package name "simservice" on the conda-forge channel).

119 ity initiative, the next steps will focus on forging collaboration with groups working on obesity-rel

120 He forged collaborations between these 2 organizations whic

121 dicine and mental health professionals might forge collaborative relationships to provide more access

122 cing equal access to kidney health care, and forging collaborative partnerships with academic centers

123 s and provides a framework for measuring and forging collective memories in communities of individual

124 eric hindrance and allowed us to efficiently forge congested C-C bonds.

125 Forging customizable compounds into arbitrary shapes and

126 ubstituent at each position around the newly forged cyclohexene ring.

127 rge inherits all features provided by Tissue Forge, delivering open-source, extensible vertex modelin

128 rticularly appealing when multiple rings are forged during this process.

129 ertiary azide, obviates the need to directly forge either a congested C-N or C-C bond at the new nitr

130 Such cross-disciplinary research, by forging empirical links in causal chains from risk genes

131 s have enabled semiconductor electronics and forging enabled introduction the of iron age.

132 with the particle-based formalism of Tissue Forge, enabling an environment for developing mixed-meth

133 lishes that the SPHENOL-derived CPA catalyst forges enantioselective desymmetrization of 3,3-substitu

134 encode information for long-term storage by forging excitatory and inhibitory links between event re

135 omena and collaborations with new facilities forge exciting, often unexpected discoveries.

136 was achieved, but this agreement was rarely forged explicitly.

137 those of small-molecule antibiotics, must be forged first.

138 cision in moderately degraded DNA and can be forged for high throughput analysis.

139 y generated chiral Pd enolate was developed, forging four contiguous stereocenters in a single transf

140 Geometrically constrained radical cations, forged from the one-electron oxidation of transiently ge

141 mproved understanding of NK cell biology has forged greater awareness that these cells play integral

142 Our work forges ground in showing that the mutability of RNA viru

143 icacy of anti-inflammatory treatments, while forging guidelines for future intelligent clinical trial

144 tron stars are a long-sought production site forging heavy elements by r-process nucleosynthesis.

145 attractive but underutilized methodology to forge hindered C-C bonds in complex molecules.

146 for defining the neuropathology of CTE were forged in 2015 and published in 2016.

147 ow that Ostrom's design principles that were forged in the context of managing natural resources are

148 s the specific linkages of the micromere GRN forged in the evolutionary process by which the skeletog

149 sed on the model of genetics and inheritance forged in the modern synthesis that they will require re

150 sting helices in proteins; coiled coils were forged in unison with the fold of the whole protein.

151 Our methodology in Tissue Forge inherits all features provided by Tissue Forge, de

152 lementary, researchers and policy makers can forge interdisciplinary, international, and intergenerat

153 for substrates with existing stereocenters, forging interesting chiral tricyclic scaffolds.

154 a common type of endogenous DNA damage, can forge interstrand DNA-DNA cross-links via reaction with

155 Antibody fragments have been forged into multivalent and multi-specific reagents, lin

156 ric histone Cse4 from its host yeast cell to forge its own centromere and finally revealing how the 2

157 owered by a unique C-H arylation reaction to forge its polycyclic core.

158 ursor, a double reductive amination of which forges its central piperidine unit.

159 our its own maintenance, a case of evolution forging its own path.

160 us attention on three specific contexts: (i) forging linkages between the engineering and health comm

161 This observation begins the process of forging links between genetic analysis of RNAi from dive

162 uncertainty is largely due to the hurdle of forging links between theory and brain [7-9].

163 ses and fabrication technologies such as hot forging, machining and casting.

164 ary tract and worked closely with urologists forged major advances in urinary tract imaging and inter

165 icacy of these processes, researchers aim to forge materials systems that exhibit the self-sustained

166 affected by application of multi-directional forging (MDF) as a well-known severe plastic deformation

167 eukaryotes and showcases the role of LGT in forging metabolic mosaics of ancestral and newly acquire

168 create -n metacerberus -c bioconda -c conda-forge metacerberus.

169 compared directly to commercially die-upset forged (MQIII-F) material made from the same MQU-F powde

170 orts to reconstruct the ancient mergers that forged multiple lines of photosynthetic microbial eukary

171 However, its inability to forge N-aryl amides has been a longstanding problem, one

172 dynamic system, together with the ability to forge N-substituted quaternary carbon centers and implem

173 c and engineering challenges that remain for forging nanolasers into powerful tools for nanoscience a

174 ere, we report a concise asymmetric route to forging natural and unnatural (enantiomeric) C19 and C20

175 l aryl migrations are powerful techniques to forge new bonds in aromatic compounds.

176 their high stereoselectivity and ability to forge new C-C bonds on unprotected alpha-amino acid subs

177 The ability to forge new carbon-carbon bonds between reagents typically

178 clinicians and behavioral health specialists forge new collaborative relationships that enhance the d

179 rbon serves as an ideal coupling material to forge new connections at room temperature.

180 ent an ideal starting material with which to forge new connections.

181 These findings forge new links between cell-fate specification and morp

182 out the evolutionary time scales required to forge new ones.

183 unities and challenges to physicians as they forge new relationships with NPCs and as their own spect

184 in studying transition metal signalling has forged new links between researchers of different discip

185 rene transfer, a valuable transformation for forging new C-N bonds.

186 of the most direct and versatile methods for forging new carbon-carbon bonds onto basic heteroarenes:

187 Resources for Biodefense Research program is forging new collaborations between immunologists and inf

188 Forging new memories for facts and events, holding criti

189 Our laboratory at Rice University has forged numerous collaborations with clinicians and basic

190 inite element (FE) model was developed using Forge NxT 3.2 FE code to simulate the multi-step deforma

191 Rapid sinter-forging of a green compact to near theoretical density w

192 OxPhos and energy production to promote the forging of a path into tissues by leading macrophages.

193 (3) tetracycle formation by stereoselective forging of the C9-C10 bond, and (4) group-selective oxid

194 Two models have been forged on the basis of clinical observations: a first mo

195 ites and combined with additional domains to forge one of the largest bacteriophage genes to date (14

196 means of sending a message, which cannot be forged or repudiated, with security verified by informat

197 hrough complex layers of genetic regulation, forged over a developmental lifetime.

198 This partnership, forged over many millennia of coevolution, is based on a

199 nitial substrate ubiquitylation (priming) or forging poly-ubiquitin chains.

200 Nevertheless, nature forged populations adapted to these challenges.

201 Efforts to elucidate mechanisms and forge prognostic and therapeutic strategies must therefo

202 ides internal flexibility to the polymer and forges protein-binding sites to ensure polymer function.

203 Our work forges quantitative links between synthesis and performa

204 The process, which provides a direct way to forge quaternary stereocenters with high fidelity, relie

205 lrgpr is an R package available from lrgpr.r-forge.r-project.org.

206 cophoric saturated ring systems were readily forged, representing a three-dimensional alternative to

207 ces of remote control of selectivity through forging reversible covalent interactions.

208 nd a reductive hydroxyketone ring closure to forge ring V.

209 r and nonsmallholder agriculture are keys in forging rural-urban links, where both farm and nonfarm a

210 llaboration networks, where people prefer to forge social ties with people who have professions diffe

211 , thus unlocking a new catalytic platform to forge sp(3)-sp(3) linkages, even in the context of late-

212 ive Ni-catalyzed chain-walking strategy that forges sp(3)-sp(3) architectures at remote, yet previous

213 A dual platform for forging sp(2)-sp(3) and sp(3)-sp(3) carbon bonds via cat

214 how its constituents communicate with us to forge stable and mutually advantageous relationships.

215 New C(sp(3))-C(sp(2)) bonds are forged starting from abundant and inexpensive natural am

216 Prized for their ability to reliably forge stereocenters with precise regiocontrol from simpl

217 ntense emotions, shape group identities, and forge strong bonds.

218 st an intentional and systematic approach to forging strong, sustained partnerships between public se

219 icroorganisms has emerged as a key factor in forging such communities.

220 ic picture for a strikingly different way of forging such functional groups.

221 s, originally introduced via the folding and forging techniques of skilled blacksmiths-we produced a

222 of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.

223 chemical reactions in one-pot, can smoothly forge that domain and ultimately enable a 15-step, 11-po

224 followed by an intramolecular alkylation to forge the 9-membered ring.

225 ate alkylation cascade-also unprecedented-to forge the [4.3.1] propellane motif of cyclodammaranes wi

226 ties, and a unique skeletal rearrangement to forge the aminocyclitol core.

227 halide and a p-methoxy semiquinone aminal to forge the anthraquinone moiety of the molecule.

228 y orchestrated and efficient cyclizations to forge the architecturally complex natural product scaffo

229 , using both radical and polar strategies to forge the bicyclic system.

230 quence and a SmI(2)-mediated C-C coupling to forge the bridged framework of the natural products.

231 and an HAT-mediated alkene hydroazidation to forge the C-N bond of the tertiary isonitrile.

232 and subsequent nucleophilic ring opening to forge the C-N bond.

233 3))-H alkenylation reaction to strategically forge the C1-C2 bond, and (3) a ring-closing metathesis

234 uthenium-catalyzed alkene-alkyne coupling to forge the C15-C16 bond.

235 r (HAT)-initiated Minisci C-H cyclization to forge the C20-C22 bond with desired stereochemistry at C

236 amolecular cyclization of a N-chloroamine to forge the C6-N bond, a transannular Mannich-type reactio

237 Two parallel strategies were exploited to forge the carbazole core: 6pi-electrocyclization/aromati

238 key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natur

239 nd an intermolecular Diels-Alder reaction to forge the carbocyclic core in a concise and stereoselect

240 tones by a Stille cross-coupling approach to forge the central diene moiety and demonstrate this stra

241 mediated strategy for the key cyclization to forge the central region of the molecule, ring C.

242 llowed by epoxidation and epoxide opening to forge the challenging syn-a,a'-dihydroxyketone functiona

243 rm the dimer interface, the strategy used to forge the channel for electrostatic recognition of super

244 g intramolecular alkenylation of a ketone to forge the congested central cycloheptene ring at the bri

245 rically diverse aryl iodides and bromides to forge the corresponding C-N bonds, which are of high int

246 and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system.

247 specialization that supports infants as they forge the foundational links between human language and

248 e aimed to compare the selective forces that forge the IgG4 and IgE repertoires in allergic asthma.

249 electron steps: radical addition to metal to forge the initial carbon-metal bond followed by redox-pr

250 f cells into the "bulldozer" aggregates that forge the interconnecting furrows.

251 This strategy allowed us to efficiently forge the intricate 5-8-5 fused ring systems found in nu

252 the pyran unit, and a Suzuki homocoupling to forge the key biaryl bond.

253 he various implicit learning operations that forge the learning curve.

254 cular Horner-Wadsworth-Emmons olefination to forge the macrocyclic ring.

255 core, a key Fischer indolization reaction to forge the natural product's carbon framework, and a seri

256 yama-Kishi cyclization of iodoaldehyde 56 to forge the oxacyclononane ring and the C6 hydroxyl stereo

257 lessons learned that, in our opinion, helped forge the path for the field that we now call immuno-onc

258 uctive olefin cross-coupling was realized to forge the pentasubstituted cyclopropane ring with excell

259 ed cascade rearrangement of epoxyketone 6 to forge the polyoxygenated 2,7-dioxabicyclo[2.2.1]heptane

260 inate that reacts with the anomeric amide to forge the S-N bond.

261 ducts so obtained were further elaborated to forge the second macrocycle of the molecule.

262 zation-aromatization cascade was utilized to forge the tetracyclic core of this natural product, and

263 scade ene-yne-ene ring closing metathesis to forge the tetracyclic morphine core.

264 and confirms the need for continuing work to forge the way for new drug discovery.

265 by an oxidative quench was used instead and forged the abeo-framework, while the 9,11-seco-motif was

266 e-dependent non-heme Fe(II) dioxygenase that forged the azetidine ring on the okaramine skeleton.

267 spatial unit of the Australian census, we re-forged the Cutter's classic vulnerability measuring fram

268 a samarium-induced cyclization process that forged the final ring of the carbon framework.

269 a, putamen, and thalamus, which collectively forged the formation of the functional speech connectome

270 diazenes with an iridium photocatalyst then forges the C-C bond.

271 zed isomerization/rearrangement process that forges the central core of the molecule and (2) two faci

272 llenging Zn-mediated Barbier allylation then forges the final C-C bond and also establishes two vicin

273 three readily available building blocks and forges the majority of the carbon framework present in 1

274 amolecular annulative fluoride displacement, forges the nucleoside analog.

275 e subsequent electrocyclic ring opening that forges the pyridine core, due to a compensatory homoarom

276 oration of two distinct synthetic routes for forging the flavanoid C-ring by reducing a sterically en

277 be operative, with a key 1,2-insertion step forging the new C-C bond and forming a nickel alkoxide t

278 Extensive studies aimed at forging the signature cyclobutane revealed a beta-silyl

279 o reviews the origins and strategies used in forging the WHO FCTC, from the perspective of one who wa

280 Ac) shell, the key cellular adaptations that forge this link are unclear.

281 I forge this missing linkage by presenting the ways in whi

282 with 4-hydroxy-1,6-enynes by a process that forges three C-C bonds, one C-H bond, and two new stereo

283 + 2 + 2] cycloisomerization reaction, which forges three new C-C bonds and one or more rings in a si

284 e in the formation of a fluorescent product, forged through a Au(I) -catalyzed hydroamination reactio

285 e final two bonds of the core structure were forged through a samarium diiodide-mediated ketyl radica

286 The central seven-membered ring was forged through sequential Mukaiyama-Michael/aldol reacti

287 Forged through strong evolutionary pressures, pathogenic

288 ing of these petrogenetic processes has been forged through the accessory mineral zircon, which has c

289 bis-spirocyclic tetrahydrothiophene ring was forged through the Stevens rearrangement of a sulfonium

290 ic specialization and cross feeding, thereby forging trophic relationships between members of the gut

291 eactions, an efficient aldol condensation to forge two elaborate fragments, and a challenging ring-cl

292 In a single step, these reactions (1) forge two new C-C bonds under mild conditions, (2) produ

293 The cascade process forges two bonds en route to spirocyclized oxindole and

294 is a photochemical [2+2] cycloaddition that forges two of the quaternary stereocenters present in th

295 By forging two new carbon-carbon bonds and introducing two

296 The R package for MPCBS is registered on R-Forge under project name MPCBS.

297 The challenging 11-membered ring was forged via a diastereoselective thionium ion initiated c

298 e family, containing a bridgehead alkene, is forged via a vicinal difunctionalization/Diels-Alder str

299 ermodynamically unfavored 7-membered ring is forged via the kinetically favored 6-endo-dig attack of

300 esis allowed a 13-membered cycloalkyne to be forged, which was selectively reduced during an involved