ライフサイエンスコーパス: forkhead

1 ture a conserved DNA-binding domain known as forkhead.

2 recently identified Saccharomyces cerevisiae Forkhead 1 (Fkh1) and Forkhead 2 (Fkh2) as required for

3 ccharomyces cerevisiae Forkhead 1 (Fkh1) and Forkhead 2 (Fkh2) as required for the clustering of a su

4 Forkhead-associated (FHA) and von Willebrand type A (vWA

5 r (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding t

6 ated XRCC1 stimulates PNKP by binding to its forkhead-associated (FHA) domain, whereas nonphosphoryla

7 Forkhead-associated (FHA) domains are modules that bind

8 Forkhead-associated (FHA) domains are phosphopeptide rec

9 , and demonstrate that the GGDEF and sensory forkhead-associated (FHA) domains form an asymmetric dim

10 The cytoplasmic domain of PscD forms a forkhead-associated (FHA) fold, like that of its homolog

11 Rad53 binds to forkhead-associated (FHA) interaction motifs in an unstr

12 It harbors both a plant homeodomain and a forkhead-associated domain implicated in epigenetic reco

13 on-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP.

14 A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104(bris), im

15 tein MxiG (MxiG(C)), which is a noncanonical forkhead-associated domain, and MxiK has an elongated st

16 n the Dun1 activation loop, but not the Dun1 forkhead-associated domain.

17 ule consisting of 2 phosphothreonine-binding Forkhead-associated domains joined by an intrinsically d

18 I109 is a highly conserved residue in the forkhead box (Fox) domain of FOXF2, a member of the Fox

19 ne expression profiling revealed a subset of Forkhead box (Fox) genes that are regulated by Shh signa

20 Forkhead Box (Fox) proteins share the Forkhead domain, a

21 The Saccharomyces cerevisiae Forkhead Box (FOX) proteins, Fkh1 and Fkh2, regulate div

22 Forkhead box (Fox) transcription factors are evolutionar

23 Aberrant expression of Forkhead box (FOX) transcription factors plays vital rol

24 The pioneer forkhead box (FOX)A2 transcription factor is specificall

25 tion of glucocorticoid receptor signaling or forkhead box (FOXO) 1/3 inhibition abolished the rapamyc

26 letion of another P subfamily members of the forkhead box (Foxp) subfamily member Foxp1 in Treg cells

27 We utilized the requirement of Forkhead box A1 (Foxa1) for transcriptional activation o

28 Forkhead box A1 (FOXA1) is a pioneer factor that facilit

29 Forkhead box A1 (FOXA1) is a pioneer transcription facto

30 Forkhead box A1 (FOXA1) is an FKHD family protein that p

31 some and the pioneering transcription factor forkhead box A1 (FOXA1), both of which are implicated in

32 FOXA1 (forkhead box A1) is a transcription factor known to regu

33 essive activity in an enhancer-specific, but forkhead box A1-dependent and active, ER-independent man

34 Additionally, conditional ablation of forkhead box a2 ( Foxa2) in the glands of the uterus alt

35 Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometri

36 Forkhead box a2 (FOXA2) is a transcription factor expres

37 Forkhead box A2 (FOXA2) is expressed specifically in the

38 with NK2 homeobox 1 (Nkx2.1) for binding to forkhead box A2 (Foxa2) to drive hepatic differentiation

39 homeobox 1 (PDX1), NK6 homeobox 1 (NKX6.1), forkhead box A2 (FOXA2), and NK2 homeobox 2 (NKX2.2) - f

40 n in the developmental transcription factor, forkhead box A2, FOXA2 (c.505T>C, p.S169P) in a child wi

41 tionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (

42 The Forkhead Box C1 (FOXC1) gene encodes a forkhead/winged h

43 The Forkhead box C1 (FOXC1) transcription factor has been sh

44 The Forkhead box C1 (FOXC1) transcription factor is involved

45 factors-mesogenin 1 (Msgn1), T-box 6 (Tbx6), forkhead box C1 (Foxc1), paired box 3 (Pax3), Paraxis, m

46 tosis by activating the transcription factor forkhead box class O1 (FOXO1).

47 genetic variants in apolipoprotein E (APOE), forkhead box class O3a, clusterin, and phosphatidylinosi

48 factor (TEAD) to activate the expression of forkhead box D1 (FOXD1), a geroprotective protein.

49 The locus also comprises the forkhead box E1 (FOXE1) gene, which is implicated in thy

50 rachromosomal origin and fine structure of a Forkhead box E1 (FOXE1)-containing hybrid amplicon.

51 Forkhead box F1 (FOXF1) is a lung embryonic mesenchyme-a

52 ion factor FOXM1 (forkhead box M1) or FOXF1 (forkhead box F1), both downstream targets of VEGF, can i

53 this study, we examined the role of FoxM1, a forkhead box family member transcription factor in tubul

54 Forkhead box N1 (FOXN1) is a member of the forkhead box family of transcription factors and plays a

55 FOXF1, a member of the forkhead box family of transcription factors, has been p

56 Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent ac

57 Lindau tumor suppressor (VHL) protein in the forkhead box FOXD1 cell lineage, from which stromal prog

58 erozygous for a loss-of-function mutation in forkhead box I3 (FOXI3), a candidate gene within the com

59 se-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds.

60 The mechanistic role of cross talk between Forkhead box M1 (FOXM1) and HGF/Met signaling in promoti

61 Further analysis revealed forkhead box M1 (FOXM1) as a key effector of the p300-MI

62 Forkhead box M1 (FOXM1) is a transcription factor recent

63 elated gene-1 (Brg1) chromatin remodeler and forkhead box M1 (FoxM1) transcription factor cooperate w

64 Conversely, Forkhead box M1 (FOXM1) was required for the induction o

65 Forkhead box M1 (FOXM1), a nuclear transcription factor

66 endothelial reparative transcription factor Forkhead box M1 (FoxM1).

67 ncubation with thiostrepton (an inhibitor of forkhead box M1 [FOXM1]) or verteporfin (inhibitor of th

68 s, including the GRB2 interactome as well as Forkhead Box M1 and its downstream target, the tryptopha

69 of proangiogenic transcription factor FOXM1 (forkhead box M1) or FOXF1 (forkhead box F1), both downst

70 by modulating transcription factors p53 and forkhead box M1, which was not observed with sequential

71 s involved in mitotic progression, including Forkhead Box M1.

72 By using this resource, we identified a forkhead box MI (FOXM1) regulatory network as a major pr

73 Forkhead box N1 (FOXN1) is a member of the forkhead box

74 The forkhead box N1 (Foxn1) protein is the key regulator of

75 ents with compound heterozygous mutations in forkhead box N1 (FOXN1), a transcription factor essentia

76 ional regulator of epithelial cell function, Forkhead Box N1 (Foxn1), and its two regulated targets,

77 uses, and with loss-of-function mutations in forkhead box N1 (FOXN1).

78 Evasion of forkhead box O (FOXO) family of longevity-related transc

79 activity of the DAF-16 transcription factor (forkhead box O (FOXO) homologue), whose global targets w

80 -dependent protein kinase (PKG2) to activate forkhead box O (FoxO) in colon cancer cells and in the c

81 Forkhead box O (FoxO) proteins and thyroid hormone (TH)

82 ification appeared to be abnormally elevated forkhead box O (FOXO) signaling in the ETC-deficient ISC

83 Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an e

84 ds are scarce, skeletal progenitors activate forkhead box O (FOXO) transcription factors, which bind

85 which results in the activation of mammalian forkhead box O (FOXO) transcription factors.

86 nsing pathways, including sirtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMP

87 ectin-5'-AMP-activated protein kinase (AMPK)-forkhead box O (FOXO)-signaling axis stemming from at th

88 nder the control of the transcription factor Forkhead box O (Foxo).

89 Alternatively, decreased forkhead box O 1 (FOXO1) and increased K48 polyubiquitin

90 The regulation of catabolic signalling via forkhead box O 1 and protein ubiquitination is SIRT1 dep

91 eptor PPARalpha and nuclear translocation of forkhead box O 1, which cause cardiomyopathy.

92 cose starvation, and methylated Pontin binds Forkhead Box O 3a (FOXO3a).

93 rt that tribbles homologue 2 (TRIB2) ablates forkhead box O activation and disrupts the p53/MDM2 regu

94 ed new PERK substrates transcription factors Forkhead box O protein and diacyglycerol a lipid signali

95 ements of insulin signaling pathways such as forkhead box O transcriptional signaling or glucose tran

96 antagonist, which led to p-Tie2 suppression, forkhead box O1 (FOXO1) activation, increased ANG2 expre

97 arget insulin-regulated transcription factor forkhead box O1 (FoxO1) and, accordingly, expression of

98 phosphorylation of the transcription factor forkhead box O1 (FOXO1) at Ser-249, leading to transcrip

99 Concomitant deletion of Forkhead Box O1 (Foxo1) in these livers rescued the decr

100 Because forkhead box O1 (FOXO1) is a major effector of this path

101 Dhh both opens the BBB via the modulation of forkhead box O1 (FoxO1) transcriptional activity and ind

102 As a result, forkhead box O1 (FoxO1), a transcription factor that is

103 ), Glucagon (GCG)], differentiation markers [Forkhead box O1 (FOXO1), Paired box 6, SRY box 9, NK6 Ho

104 xins and was reinforced by the expression of forkhead box O1 (FOXO1).

105 PAX3-FOXO1 (paired box gene 3 fused with forkhead box O1) fusion RNA, which is considered a hallm

106 rophy by inhibiting the transcription factor forkhead box O1.

107 f the stress-responsive transcription factor forkhead box O3 (FoxO3) in mediating injury-induced prox

108 -223-3p directly repressed the expression of forkhead box O3 (FOXO3), and FOXO3 negatively regulated

109 y, overexpression of a transcription factor, forkhead box O3 (FoxO3), which is implicated in aging, b

110 Mechanistically, transcription factor forkhead box O3 (Foxo3a) physically interacts with Tet2

111 JNK3 acts through Forkhead box O3 (Foxo3a) to suppress the activity of Egr

112 tion 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repression of proap

113 The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1

114 vated Akt1 increased both GSK3alpha/beta and forkhead box of the O class transcription class 3 (FoxO3

115 Forkhead box P (FoxP) proteins are unique transcription

116 Forkhead Box P (FOXP) transcriptional repressors play a

117 shown that loss of the transcription factors forkhead box P1 (Foxp1) and Foxp4, which are critical fo

118 enetic approaches to investigate the role of forkhead box P1 (FOXP1) in transcriptional control of MS

119 High expression of the forkhead box P1 (FOXP1) transcription factor distinguish

120 errant AKT activity and decreased downstream forkhead box P1 (FOXP1)/FGF and NOTCH1/EPHB2 signaling,

121 n the gene encoding the transcription factor forkhead box P2 (FOXP2) result in brain developmental ab

122 Mutations in the human forkhead box P2 gene, FOXP2, cause developmental verbal

123 red for differentiation of T(h)17 cells) and forkhead box P3 (Foxp3) (required for the differentiatio

124 allergic responses linked to Smad3-dependent forkhead box P3 (Foxp3) expression and IL-10 production.

125 CD25 regulatory T cells (Treg) and increased forkhead box P3 (Foxp3) expression in tolerant grafts.

126 ve insights into to the demethylation of the forkhead box P3 (Foxp3) locus during the induced T regul

127 an receptor gammat, and demethylation of the forkhead box P3 (FOXP3) locus.

128 on of the Treg cell key transcription factor forkhead box p3 (Foxp3) was observed.

129 , splenocyte cytokine production and splenic forkhead box P3 (FOXP3)(+) regulatory T (Treg) cells wer

130 okine production by splenocytes, and splenic forkhead box P3 (FOXP3)(+) regulatory T (Treg) cells wer

131 and IL-10-producing regulatory CD4(+)CD25(+) forkhead box p3 (Foxp3)(+) T cells.

132 immunologic conditions, lymphocyte subsets, forkhead box P3 (FOXP3)(+) Treg cell levels, and phenoty

133 We analyzed CD4(+) forkhead box P3 (Foxp3)(+) Treg cells that were isolated

134 Although forkhead box P3 (FOXP3)(+)CD4(+) regulatory T (Treg) cel

135 ocyte activation gene 3 (LAG3)(+), CD49b(-), forkhead box P3 (Foxp3)(-) regulatory T cells in vitro,

136 oliferation and increased mRNA expression of forkhead box P3 (FOXP3), a transcription factor which is

137 X) syndrome, which is caused by mutations in forkhead box P3 (FOXP3), and IPEX-like disorders caused

138 reg lineage-determining transcription factor forkhead box P3 (FOXP3), and Treg-specific deletion of m

139 ance through the master transcription factor forkhead box P3 (FOXP3), which is crucial for Treg cell

140 came robust T-regulatory cells (Tregs) in WT forkhead box P3 (Foxp3)-green fluorescent protein mice,

141 3, interleukin-6, tumor necrosis factor, and forkhead box P3 prominently placed in a regulatory conne

142 xperiments, ex vivo hapten presentation, and forkhead box p3 regulatory T-cell conversion.

143 xpression of interleukin (IL)-17, IL-10, and forkhead box P3 than group EP (P < 0.05).

144 etal DCs effectively primed antigen-specific forkhead box P3(+) regulatory T cells after in vitro coi

145 sed tissue Il6 levels and loss of intestinal forkhead box p3(+) regulatory T cells.

146 Forkhead box P3(+) T regulatory cells (Tregs) are key pl

147 ory circuit encompassing tolerogenic DCs and forkhead box P3(+) Treg cells that could be targeted for

148 s through generation of strongly suppressive forkhead box P3(+) Treg cells.

149 n accumulation of activated CD4(+) Foxp3(-) (forkhead box P3) IFN-gamma(+) T cells in the heart-drain

150 essed the T(reg) transcription factor FoxP3 (Forkhead Box P3) protein as detected by flow cytometry.

151 ssion of the immunoregulatory markers IL-10, forkhead box P3, and cytotoxic T lymphocyte-associated p

152 Interestingly, 5% of AMs expressed forkhead box P3, and depletion of these cells abolished

153 response and accumulation of IL-10-producing forkhead box P3-negative effector CD4(+) T cells in the

154 Elevated CD4(+) forkhead box P3-positive (Foxp3+) T cells were evident i

155 lung injury is mediated by a novel subset of forkhead box P3-positive AMs that limits inflammation, f

156 er of differentiation 25-positive (CD25(+) ) forkhead box P3-positive CD4(+) regulatory T-cell freque

157 of effector CD4(+) T cells and inhibition of forkhead box P3-positive regulatory T (Treg) cells, but

158 ficacy were evaluated alongside PNA-specific forkhead box P3-positive regulatory T cells and IL-10(+)

159 caused a reduction in IL-13(+) CD4 T cells, forkhead box P3-positive regulatory T cells, and IL-5(+)

160 tinaldehyde dehydrogenase and specialized in forkhead box p3-positive regulatory T-cell conversion.

161 e and were regulated specifically by p53 and forkhead box P3.

162 Adoptive transfer of forkhead box protein (FOX)3 regulatory T (Treg) cells of

163 ptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors i

164 totic neutrophil-derived proteins, including forkhead box protein 1 (FOXO1), to T cells.

165 ressor that is transcriptionally silenced by forkhead box protein 1 (FOXP1) in the aggressive, activa

166 ession of the oncogenic transcription factor forkhead box protein 1 (FOXP1) is a common feature of di

167 ave a dysfunction or lack of gluten-specific forkhead box protein 3 (FOXP3)(+) Treg cells.

168 challenge, symptoms, Treg cell numbers, and forkhead box protein 3 (Foxp3), TH2 and TH17 cytokine, a

169 ing on a farm and increased peripheral blood forkhead box protein 3 expression and correlated inverse

170 ere are 2 main subsets of Treg cells: FOXP3 (forkhead box protein 3)-positive Treg cells, which do no

171 IL-35(+)CD4(+)CD25(+) forkhead box protein 3-negative T (IL-35-inducible regul

172 , promote the expansion of immunosuppressive forkhead box protein 3-positive CD8+ regulatory T cells,

173 elevance, HuMoSCs induce long-lasting memory forkhead box protein 3-positive CD8+ regulatory T lympho

174 tolerance restoration, favoring expansion of forkhead box protein 3-positive regulatory T cells along

175 lbumin, suppressing the normal generation of forkhead box protein 3-positive Treg cells while promoti

176 ermining transcription factors including ER, forkhead box protein A1 (FOXA1) and GATA-binding factor

177 Forkhead box protein A1 (FOXA1) is a pioneer factor of e

178 Importantly, the transcription factor forkhead box protein A1 (FOXA1) was critical in SMAD4-in

179 d active SFK was observed more frequently in forkhead box protein A1 (FOXA1)(-) TNBCs.

180 tion of invasion genes through inhibition of Forkhead box protein A1 (FOXA1), an invasion suppressor

181 The forkhead box protein A2 (FOXA2) is a transcription facto

182 We have recently shown that the forkhead box protein A3 (Foxa3) is a calorie-hoarding fa

183 MAPK signaling, and the transcription factor Forkhead Box Protein C2 (FOXC2) known to promote cancer

184 the converse experiment and lineage-labeled forkhead box protein L1(Foxl1)-positive hepatic progenit

185 eatured upstream binding sites recognized by forkhead box protein M1 (FoxM1), a key transcription fac

186 was associated with inhibited expression of forkhead box protein M1 (Foxm1), a reparative transcript

187 f the promitotic transcription factor FOXM1 (Forkhead box protein M1).

188 hat insulin-like peptide receptor (INSR) and forkhead box protein O (FoxO) are important genetic driv

189 transcription factors such as T-cell factor, forkhead box protein O, and hypoxia inducible factor 1al

190 effector genes and the transcription factors forkhead box protein O1 (Foxo1) and Klf2 in DP thymocyte

191 rtant role of the antioxidant defense factor forkhead box protein O1 (FoxO1) in the KSHV life cycle.

192 Forkhead box protein O1 (FOXO1) is a transcription facto

193 Forkhead box protein O1 (FoxO1) is an insulin-sensitive

194 The forkhead box protein O1 (FOXO1) is considered to be a ke

195 we show that the antioxidant defense factor forkhead box protein O1 (FoxO1) maintains KSHV latency b

196 Signaling to regulate forkhead box protein O1 (FOXO1) may be the most importan

197 PGE2, through PI3K/AKT activation, promoted Forkhead box protein O1 (FOXO1) phosphorylation and FOXO

198 Moreover, forced expression of forkhead box protein O1 (FoxO1), an antagonist for activ

199 3-kinase (PI3K) signaling involving PTEN and forkhead box protein O1 (Foxo1), supporting autoantibody

200 ition or expression of constitutively active forkhead box protein O1 (FoxO1).

201 ductive effects of the transcription factor, forkhead box protein O1 (FoxO1).

202 ia deacetylation of the transcription factor Forkhead box protein O1 (FoxO1).

203 ficiency resulted in nuclear accumulation of Forkhead box protein O1 and subsequently promoted hepati

204 ivation and enhanced nuclear localization of forkhead box protein O1 transcription factors and glycog

205 y preventing nuclear translocation of FoxO1 (Forkhead box protein O1) and beta-catenin, which contrib

206 etic mice with cardiomyocyte-specific FOXO1 (Forkhead box protein O1) deletion showed that FOXO1 boun

207 e B) signaling and phosphorylation of FOXO1 (forkhead box protein O1) suppressing its transcriptional

208 am through protein kinase B (AKT) and FOXO1 (forkhead box protein O1) to drive synergistic expression

209 n sequencing screens led to the discovery of forkhead box protein O4 and signal transducer and activa

210 The prognostic value of forkhead box protein P1 (FOXP1) protein expression in tu

211 The gene coding for the forkhead box protein P2 (FOXP2) is associated with human

212 oligomerization of the transcription factor, forkhead box protein P2 (FOXP2).

213 ositive for the nuclear transcription factor Forkhead box protein P2 (FoxP2).

214 enotype in Vdelta2 T cells, characterized by forkhead box protein P3 (FoxP3) expression and suppressi

215 14; sparse mast cell degranulation; numerous forkhead box protein P3 (FoxP3)+ regulatory T cells and

216 rphan nuclear receptor gamma (RORgammat) and Forkhead box protein P3 (Foxp3).

217 ory response and enhanced the recruitment of forkhead box protein P3-positive immunosuppressive regul

218 Moreover, Forkhead box signaling and Fanconi anemia pathways were

219 eport that nuclear AURKA can be recruited by Forkhead box subclass M1 (FOXM1) as a co-factor to trans

220 monstrate that pharmacological inhibition of Forkhead box subclass O (FoxO) transcription factors usi

221 y decreasing ROS through increased levels of forkhead box transcription factor 3a (FOXO3a) and a down

222 The forkhead box transcription factor FOXC1 plays a critical

223 Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause

224 The potent oncogenic forkhead box transcription factor, FOXM1 is is regulated

225 found that heightened expression of FoxM1, a Forkhead box transcription factor, is regulated during d

226 of AMPKalpha and down-stream targets 4E-BP, Forkhead box transcription factors O (Foxo) and Peroxiso

227 By lineage-specific deletion of the forkhead box-O 1 (FOXO1) transcription factor, we demons

228 Forkhead-box domain (Fox) containing family members are

229 asis.SIGNIFICANCE STATEMENT Mutations of the Forkhead-box protein 2 (FOXP2) gene in humans are the fi

230 A rare mutation affecting the Forkhead-box protein P2 (FOXP2) transcription factor cau

231 k the esophageal gland due to knockdown of a forkhead-box transcription factor, Sm-foxA, which blocks

232 This enhancer is dependent on Forkhead-Box transcription factors and functionally inte

233 el), and the disease suppression depended on forkhead-box-protein-P3(foxp3)(+) Treg cells.

234 Forkhead boxO is necessary for the activation of key pro

235 In addition, inhibiting forkhead boxO transcription attenuated the mechanical ve

236 ound that leptin inhibited the expression of forkhead-boxP3 (FoxP3) and its splicing variants contain

237 The forkhead domain (FHD) is the key driver of DNA binding.

238 the stop codon location) or the DNA-binding forkhead domain (Fisher exact test, P = 0.021).

239 The forkhead domain of FOXC1 is essential for the competitio

240 librium folding and binding mechanism of the forkhead domain of wild-type FoxP1, and of two mutants t

241 Forkhead Box (Fox) proteins share the Forkhead domain, a winged-helix DNA binding module, whic

242 within the wing-2 region of the DNA-binding forkhead domain, enable enhanced chromatin mobility and

243 222/217 amino acid (aa) region and the FOXM1 Forkhead domain.

244 state cancers, we define two hotspots in the forkhead domain: Wing2 (around 50% of all mutations) and

245 Forkhead factors do not regulate TAD formation, but do p

246 Here, we find that forkhead family (FOXO) transcription factors are critica

247 The forkhead family of transcription factors (Fox) controls

248 Foxp1 is a member of the Forkhead family of transcription factors expressed selec

249 FOXM1 is a transcription factor of the Forkhead family that is required for cell proliferation

250 FOXA1 is a transcription factor of the forkhead family that is required for prostate epithelial

251 ough most forkhead TFs recognize a canonical forkhead (FKH) motif, RYAAAYA, some forkheads recognize

252 is different from the more widely recognized forkhead (FKH) sequence RYAAAYA (where R is purine, and

253 In this study, we identified three forkhead (Fkh)-binding sites in the 140-bp region of the

254 ave examined the binding properties of three Forkhead (FOX) transcription factors, FOXK2, FOXO3 and F

255 rm (CM) as eliminating the functions of both Forkhead genes in the same Drosophila embryo results in

256 cification phenotype in embryos lacking both Forkhead genes.

257 he FOX family that recognizes an alternative forkhead-like (FHL) consensus sequence (GACGC) that is d

258 Forkhead O transcription factors (FOXOs) have been impli

259 2) one type-restricted transcription factor (Forkhead) only regulates receptor expression, and (3) an

260 distinct roles for SMAD2 and SMAD3 with the forkhead pioneer factor FOXH1 as a partner in the regula

261 Bispecific forkhead proteins recognize both motifs, but the molecul

262 anonical forkhead (FKH) motif, RYAAAYA, some forkheads recognize a completely different (FHL) motif,

263 the transcriptional level directly through a Forkhead response element (FHRE) in its promoter.

264 y transactivate the FOXM1 promoter through a Forkhead response element, whereas FOXM1 can activate AU

265 nd antagonizing Foxo1 binding to a consensus forkhead site in this cis-regulatory element that we sho

266 Interestingly, solved forkhead structures of members from the P subfamily (Fox

267 Our analysis confirms known Forkhead targets from available ChIP-chip studies and hi

268 Here, we show that the Forkhead TFs Checkpoint suppressor homologue (CHES-1-lik

269 and illustrate the pleiotropic functions of Forkhead TFs in different aspects of cardiogenesis.

270 Although most forkhead TFs recognize a canonical forkhead (FKH) motif,

271 This process is mediated by the Forkhead TFs regulating the fibroblast growth factor rec

272 terns determining growth outcomes, including Forkhead TFs, FOSL1, and PLAG1.

273 to do so by converging on the regulation of forkhead transcription factor (FOXO).

274 Forkhead transcription factor class O (FOXO)3a, which pl

275 The activity of the forkhead transcription factor FKH-9 in neurons is requir

276 nic stem to epiblast cells and uncovered the forkhead transcription factor FOXD3 as a major regulator

277 Here, we describe mutations in the forkhead transcription factor FOXE3 that predispose muta

278 Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+

279 We identify the forkhead transcription factor Foxh1, in part through Eom

280 membrane transport proteins regulated by the forkhead transcription factor FOXI1.

281 The forkhead transcription factor FOXM1 has a key role in DN

282 nstrate that the expression of the oncogenic forkhead transcription factor FOXM1 is upregulated by GO

283 the key nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to int

284 ce, but Akt-dependent phosphorylation of the forkhead transcription factor FoxO1 at serine 256, which

285 The forkhead transcription factor FoxO6 is prominently expre

286 ating both AKT and MAPK signaling to inhibit forkhead transcription factor O3a (FOXO3a) function and

287 mitotic genes in close proximity to Fkh2, a forkhead transcription factor previously implicated in r

288 Here, we study the function of the Tc-foxQ2 forkhead transcription factor, a key regulator of the an

289 osphorylation of FOXO3a, a tumor suppressive forkhead transcription factor, leading to its cytoplasmi

290 Forkhead transcription factors are evolutionarily conser

291 Our work highlights Forkhead transcription factors as hubs that integrate mu

292 Foxc1 belongs to the forkhead transcription factors family, which plays a cri

293 t early origins through its interaction with forkhead transcription factors Fkh1 and Fkh2.

294 Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also

295 e closely related fasting/starvation-induced forkhead transcription factors FOXK1 and FOXK2 induce ae

296 J1, which encodes a well-known member of the forkhead transcription factors important for ciliogenesi

297 d Hi-C experiments on cells depleted for the Forkhead transcription factors, Fkh1 and Fkh2, previousl

298 t of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from t

299 Forkhead transcriptional factor O1 (FoxO1) in the hypoth

300 The Forkhead Box C1 (FOXC1) gene encodes a forkhead/winged helix transcription factor involved in e