ライフサイエンスコーパス: formamide

1 it becomes that of bulk (in the presence of formamide).

2 equencing matrix (denaturing gels containing formamide).

3 t remove the resulting formyl group from the formamide.

4 2Se6](4-), and [GeSe4](4-) in both water and formamide.

5 buffers containing 7.2M urea plus 40% (v/v) formamide.

6 sport uncharged solutes such as glycerol and formamide.

7 odium, and chloride ions in liquid water and formamide.

8 s) and failed to grow on media containing 3% formamide.

9 ences lose their structure at less than 15 M formamide.

10 supercoiled DNA template in the presence of formamide.

11 nitriles and their formylated derivatives in formamide.

12 fy deleted loci that make cells sensitive to formamide.

13 op formation is increased in the presence of formamide.

14 dependence of the thermophoretic behavior of formamide.

15 oped by the dehydration of the corresponding formamide.

16 e spectral signatures of the dimeric form of formamide.

17 tes isocyanides to yield the corresponding N-formamide.

18 ound to be strongly inhibited by substituted formamides.

19 of ethanol in mice was inhibited by several formamides.

20 series of cyclic, linear, and disubstituted formamides.

21 ced reaction between carbon tetrabromide and formamides.

22 the preparation of optically active allylic formamides.

23 nservation of its tertiary structure in 20 M formamide?

24 16); (13)CH3NO2 (9, 19); N,N-dimethyl((13)C)formamide (10, 20); ((15)N)pyrrole (21, 23); CH3(15)NO2

25 was further identified as N-(4-methoxyphenyl)formamide 2-O-beta-D-xyloside and was revealed to have t

26 alyzed by N-methylvaline-derived Lewis-basic formamides 3a-d with high enantioselectivity (< or =95%

27 es): ((13)C)paraformaldehyde (1, 11); ((13)C)formamide (4, 14); triethyl ((13)C)orthoformate (5, 15);

28 We identified 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F) as a pathogen-inducible, tryptophan

29 nucleotide (ZMP) and N-(beta-D-ribofuranosyl)formamide 5'-phosphate (FAR-P) have been identified as p

30 The high degree of formamide accumulation is due to an unusual temperature

31 rogen from ammonium, nitrate, nitrite, urea, formamide/acetamide, purines, pyrimidines, polyamines, a

32 ey sequence features a highly chemoselective formamide activation that triggered a Vilsmeier-Haack cy

33 The prebiotic chemistry of formamide affords in a single and simple physical-chemic

34 n at 60 degrees C with buffer containing 50% formamide allow cells containing the LNA-bound mRNA to b

35 s on the use of polar solvents revealed that formamide also provided significant acceleration and the

36 for thioformamide substrates than for their formamide analogues.

37 ed by the N-methylvaline-derived Lewis basic formamide anchored to a polymeric support (5a and 5b) wi

38 bon source for the formation of C-N bonds in formamide and acetamide over the Ni-Fe nitride heterostr

39 served N-dealkylation, and to the identified formamide and aldehyde derivatives via several intermedi

40 hich are formed in a direct reaction between formamide and CN(*) radicals upon the high-energy impact

41 looping remains elusive, FRET experiments in formamide and dimethyl sulfoxide suggest that interactio

42 and commonly used denaturing agents such as formamide and DMSO.

43 n and H-addition channels chemically linking formamide and HNCO, the H addition to CH(3)NCO produced

44 mines 32-33 were obtained in two steps using formamide and hydrazine, respectively.

45 our results indicate a similar stability of formamide and hydrogen cyanide in solution as well as th

46 strong correlation between the abundance of formamide and isocyanic acid (HNCO), indicating that the

47 the hydrolysis of N-formimino-L-glutamate to formamide and L-glutamate.

48 n of gDNA with NaOH is instead achieved with formamide and maintains denaturation during subsequent s

49 barrier from amide hydrogen bonding between formamide and N(6) of adenine.

50 The products of this reaction, N-formamide and N,N'-diformamide, are hydrogenated back to

51 1 per cent in cases) and predicts binding in formamide and nucleobases.

52 tone-d(6) showed a slight deviation, whereas formamide and pyridine-d(5) exhibited distinctly differe

53 on the amidation of esters with mixtures of formamide and sodium methoxide are described.

54 tic resolution of amine derivatives based on formamide and thioformamide substrates.

55 address these issues, we decided to focus on formamide and undertook an extensive study of low molecu

56 The gel solvent included formamide and urea.

57 A eutectic electrolyte consisting of formamide and water is formulated with a high ion conduc

58 pling of amines with MeOH and EtOH affording formamides and acetamides.

59 bamoyl anions derived from N,N-disubstituted formamides and LDA to N-tert-butyl nitrones is described

60 oyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high d

61 reaction was demonstrated with a variety of formamides and nitrones and provided a direct route to a

62 g copper-catalyzed oxidative C-O coupling of formamides and salicylaldehydes.

63 aluated ethylene glycol, dimethyl formamide, formamide, and methanol for their freezing point suppres

64 it was found that methanol, triethanolamine, formamide, and water all provided additional acceleratio

65 CO(2) in the presence of amines to formate, formamides, and methanol (MeOH) is a promising approach

66 l amides, carbamates, thiocarbamates, ureas, formamides, and their derivatives is reported herein.

67 this study that retains so much structure in formamide; and (c) DNA analogs of formamide resistant HD

68 pore organization, whereas those prepared in formamide are long-range ordered with hexagonal symmetry

69 oton transfers from the 5-amino group to the formamide are simultaneous with nucleophilic attack by t

70 Formamides are aldehyde analogues that have demonstrated

71 st, the linear, alkyl (n-propyl and n-butyl) formamides are better inhibitors of EqADH and MmADH1 tha

72 Monosubstituted formamides are good inhibitors of class I and II enzymes

73 Subsequently, the formamides are hydrogenated in situ to methanol in the p

74 of class I and II enzymes, and disubstituted formamides are selective for the alpha enzyme.

75 Formamides are unreactive analogues of aldehydes and bin

76 Formamides are unreactive analogues of the aldehyde subs

77 ereoselectivities are good to excellent when formamides are used to trigger the key step, bearing eit

78 erimental and theoretical evidence points to formamide as a possible hub in the complex network of pr

79 ace in a tandem manner with the formation of formamide as a sole byproduct.

80 sulfoxide, polyethylene glycol, betaine and formamide as cosolvents has been found to be very helpfu

81 s switched on and identifies formic acid and formamide as key intermediate products of the early step

82 aqueous solution of LaCl3.7H2O with N-methyl formamide as porogen and propylene oxide as initiator.

83 tial stage of the reaction allows avoiding N-formamides as resting intermediates.

84 water permeability but transported glycerol, formamide, as well as larger solutes that were impermeab

85 sured for the urease-catalyzed hydrolysis of formamide at pH 6.0 and 25 degrees C.

86 bon dioxide and pinacolborane to yield the N-formamides (average yield 91.6%, TOF 25.9 h(-1)).

87 demonstrated a high degree of reliability of formamide-based denaturation and bisulfite conversion th

88 This formamide-based method was applied to 46 formalin-fixed/

89 The formamide-based synthesis of nucleic acids is considered

90 rcury-sensitive permeability to glycerol and formamide, but not urea, suggesting that NOD 26 also flu

91 ation and decomposition reaction channels of formamide by means of ab initio molecular dynamics.

92 and trimethylaluminum efficiently activates formamide C-H bonds under mild conditions providing pyrr

93 f DNAs linearly by 2.4-2.9 degrees C/mole of formamide (C(F)) depending on the (G+C) composition, hel

94 including incubation at 95 degrees C in 50% formamide can be used without disrupting the streptavidi

95 Formamide can serve as a key building block for the synt

96 s such as N-Boc-amines and the parent chiral formamide compounds.

97 pression], exhibits a biphasic dependence on formamide concentration.

98 The initial drop of -0.8 kcal/mol bp at low formamide concentrations is attributable to a delta delt

99 Thus, we suggest the possibility that formamide could have jointly provided the main component

100 rees C) in the presence of additives such as formamide, cyanamide, urea, guanidine, 2-aminoimidazole,

101 ammonium formate is produced as an important formamide decomposition byproduct in solution.

102 offering an alternative to the conventional formamide dehydration route.

103 Subsequent treatment with HCl yielded free formamide, demonstrating that an important organic molec

104 The current article features novel use of formamide denaturant during bisulfite conversion of a su

105 ed size of the expanded adenine, we tested a formamide deoxynucleoside, which Leonard proposed as a s

106 binding domain of streptococcal protein G, a formamide dimer was generated from the crystallographic

107 Justification for the use of formamide dimers is provided by almost identical interre

108 C) contributions to interresidue coupling in formamide dimers with systematic variation of these stru

109 N,N-dimethyl formamide (DMF) is an extensively used organic solvent b

110 aimed to test two cryoprotectants, dimethyl formamide (DMFA) and dimethyl sulfoxide (DMSO), in combi

111 (dA.dT) exhibits a much lower sensitivity to formamide, due to the specific pattern of tightly bound,

112 ects were measured at the reactive center of formamide during acid-catalyzed hydrolysis in water at 2

113 he high-energy synthesis of nucleobases from formamide during the impact of an extraterrestrial body.

114 ero temperatures and their components (DMSO, Formamide, EG, PG) and binary mixtures at room temperatu

115 s, including guanidine thiocyanate, ethanol, formamide, ethylenediaminetetraacetic acid (EDTA), and p

116 s form readily from aldehydes and cyanide in formamide, even in the absence of added ammonia, suggest

117 The results in three organic solvents, formamide (FA), N-methylformamide (NMF), and N,N-dimethy

118 sulfoxide (DMSO), propylene glycol (PG), and formamide (FMD), routinely employed in ice-free cryopres

119 ds by formal C-H bond cleavage of an allylic formamide followed by construction of a new C-C bond in

120 are consistent with a fast deprotonation of formamide followed by two reversible acyl transfers affe

121 We evaluated ethylene glycol, dimethyl formamide, formamide, and methanol for their freezing po

122 bromoalkenes play a dual role with different formamides forming novel oxidative amidation products an

123 -formyldehydroalanine nitrile is observed in formamide from glycolaldehyde and cyanide without interv

124 The use of formamide further improved the performance of the new pr

125 Using formamide, further acceleration was achieved in the pres

126 ore frequently with V114 and F193, while its formamide group interacted more frequently with C191.

127 el to the fifth transmembrane helix with the formamide group of fMLF hydrogen-bonded to both Asp-106

128 The lability of the formamide group required that nucleoside triphosphate fo

129 Formamide (H(2)NCHO) is the smallest molecule possessing

130 Results indicate that formamide has a destabilizing effect on the helical stat

131 Liquid formamide has been irradiated by high-energy proton beam

132 ctrospray ionization compatibility; however, formamide has potential to be a superior modifier if det

133 Mineral-assisted thermal decomposition of formamide (HCONH(2)) is a heavily studied model prebioti

134 HCHO reacts preferentially with NH(3) to a formamide (HCONH(2)) surface intermediate.

135 enatured DNA, the cosolvent condition of 40% formamide hydration is very different: it becomes that o

136 -Pr/Cy/ t-Bu) for both amine formylation and formamide hydrogenation, only catalyst Ru-Macho (R = Ph)

137 e identification and characterization of the formamide hydrolase that catalyzes the second step in th

138 ve found that the spectrum of the evaporated formamide ices is dominated by the spectral signatures o

139 , we scrutinized the chemical composition of formamide ices mixed with an FeNi meteorite material tre

140 The electronic spectrum of formamide in aqueous solution is computed using TDDFT us

141 Furthermore, use of formamide in the ligation buffer also increased ligation

142 itrides serve as nitrogen sources to produce formamide in the temperature range of 25-100 degrees C u

143 of amines at 90 degrees C selectively gave N-formamides in good to excellent yields.

144 ding aldehydes, ketones, formate esters, and formamides, in an overall process that efficiently conve

145 Formamide-induced detubulation of rat ventricular myocyt

146 vity for this unique isoenzyme of any of the formamide inhibitors.

147 h small aliphatic isonitriles to form N-acyl formamides inside the cavity.

148 oters, which capture carbon monoxide to give formamide intermediates, which then undergo manganese-ca

149 e reaction proceeds through the formation of formamide intermediates.

150 The pH optimum for formamide is at pH 5.3, whereas for urea, it is near 8.0

151 In the second step the generated formamide is further hydrogenated with 2 more equiv of H

152 Formamide is one of the important compounds from which p

153 t acyl transfer between the ester and sodium formamide is rate-determining.

154 onization mass spectrometry (CI-TOFMS) where formamide, isocyanic acid as well as higher order produc

155 Formamide lowers melting temperatures (Tm) of DNAs linea

156 enine stabilizing the E configuration of the formamide moiety is also observed for the AFB-beta-FAPY

157 adenine stabilizes the E conformation of the formamide moiety.

158 Y C5-N(5) bond and the E conformation of the formamide moiety.

159 nstrate that the initial dissociation of the formamide molecule could produce a large amount of highl

160 ttachment of the nucleophile to a protonated formamide molecule is rate determining.

161 A formamide molecule was modeled into the system to mimic

162 A new additive, methyl(phenyl)formamide (MPF), is introduced for the glycosylation of

163 We report gas-phase electronic spectra of formamide, N-methyformamide, acetamide, and N-methylacet

164 n the vicinity of the helix: displacement by formamide of weakly bound hydrate or counterion.

165 t of an extraterrestrial icy body containing formamide on an early Earth atmosphere.

166 icant acceleration and the use of 5 equiv of formamide (optimum amount) gave faster rates than reacti

167 roduct RNAs are structured to 24 M (95% w/w) formamide or 4 M H2O solutions which is equivalent to 4

168 Clear(T) or Clear(T2), which are composed of formamide or formamide/polyethylene glycol, respectively

169 conditions or in solvents, such as dimethyl formamide or N-methylpyrrolidone, to provide the desired

170 ygen from the solvent into the carbonyl-O of formamide or the product, formate ion.

171 sary as the carbon is trapped in the form of formamide (or urea in the case of primary amine).

172 l and [DMF.H(+)](CF3SO3(-))) (DMF = dimethyl-formamide) or electron (decamethylferrocene (Fc*)) sourc

173 vironmentally benign solvents such as water, formamide, or dimethylsulfoxide.

174 elative to the controls (no radiation, or no formamide, or no catalyst), an extremely rich, variegate

175 s but observed no effect on water, glycerol, formamide, or urea permeations.

176 dentical model compounds: N-methylacetamide, formamide, or water.

177 conversion of CO(2) and H(2)O to formate and formamide over Ni-Fe nitride heterostructures in the abs

178 ic pathways indicate that small radicals and formamide play a crucial role, in agreement with a numbe

179 lear(T2), which are composed of formamide or formamide/polyethylene glycol, respectively, embryos, wh

180 them with less potent and readily available formamide precursors, we herein demonstrate an alternati

181 We conclude that formamide preferentially targets RNA related processes i

182 In this study, we have found that formamide preferentially weakens RNA related processes i

183 sion) and replacing one urea function with a formamide (preventing directionality reversal).

184 amino group through the 4-carboxamide to the formamide proceeds in the same transition state.

185 range of readily available sulfonamides and formamides, providing the corresponding products in mode

186 Substituted acetic acids and formamides react in the presence of phosphorus oxychlori

187 insight into the interplay of the different formamide reaction channels and into environment effects

188 most efforts have focused on the analysis of formamide reaction products released in solution, althou

189 w coating medium, N-(2-triethoxysilylpropyl) formamide, recently demonstrated by our laboratory to ne

190 detubulation (by transient exposure to 1.5 m formamide) reduces global acid extrusion on NBC by 40%,

191 ereoselective epoxidation followed by a mild formamide reduction enabled the first total synthesis of

192 ructure in formamide; and (c) DNA analogs of formamide resistant HDV ribozyme sequences lose their st

193 stituted o-halobenzamides with cyanamide and formamide, respectively.

194 Crystalline FAIRs exists solely as the Z-formamide rotamer and exhibits many of the same intramol

195 d by the N-methyl valine-derived Lewis-basic formamide (S)-23 (Sigamide) with high enantioselectivity

196 port growth at 37 degrees C and one was also formamide sensitive (fs) and failed to grow on media con

197 In addition, we have also isolated 35 formamide-sensitive mutants, many of which display remar

198 RSC6 also suppressed the formamide sensitivity of a strain with a C-terminal trun

199 t, its disruption results in slow growth and formamide sensitivity.

200 g reaction of these ionic building blocks in formamide solution results in spontaneous gelation and e

201 The thermophoretic properties of aqueous formamide solutions are studied by means of Infrared The

202 eptylammonium bromide clusters produced from formamide solutions by electrospray ionization (ESI) is

203 We followed the ribozyme structure in formamide solutions by monitoring the amount of bound Et

204 of multiple building units both in water and formamide solutions favors the assembly of mesostructure

205 HDV) ribozyme self-cleaving activity in 20 M formamide solutions is unique.

206 and saturates to highly concentrated aqueous formamide solutions of approximately 85 wt% at large asp

207 metastable polymorph, a hydrate phase, and a formamide solvate.

208 is base, combined with a disilane reagent in formamide solvent, promotes the replacement of a single

209 In general, larger, substituted formamides, such as N-1-ethylheptylformamide, are better

210 Some small formamides, such as N-isopropylformamide, may be useful

211 In formamide the [SnQ4]4- anions undergo condensation-oligo

212 data from the urease-catalyzed hydrolysis of formamide, the commitment factors for semicarbazide and

213 for the anionic form of the sulfhydryl; for formamide, the neutral form is preferred, leading to the

214 in the presence of chaotropic agents such as formamide to allow access to the DNA strands for labeled

215 rogate, reacting with ribo-aminooxazoline in formamide to give ribo-anhydrocytidine - an intermediate

216 ylamide gel contained 3.36 M urea and 19.2 % formamide to lower the DNA melting temperatures.

217 NH radicals, which could further react with formamide to produce adenine, guanine, cytosine, and ura

218 Hexamethyldisilazane was reacted with formamides to generate N,N-disubstituent formimidamide,

219 catalyze the hydrogenation of in situ formed formamides to methanol.

220 ide (DMSO), betaine, polyethylene glycol and formamide, to the reaction mixture.

221 yl formamidines from carbon tetrabromide and formamide under UVA irradiation without any additional c

222 hydrothermal pores leads to accumulation of formamide up to concentrations where nucleobases are for

223 f 5-amino-4-carboxamide imidazole (AICA) and formamide using the B3LYP/6-31G level of theory confirme

224 raightforward synthesis of N,N-disubstituted formamides using a combination of 1,1,1,3,3,3-hexafluoro

225 The pKa for formamide was determined by 15N NMR and found to be abou

226 egeneration solutions; mix of 25 mM NaOH/30% formamide was employed to regenerate the electrode for a

227 Formamide was found to be a superior solvent for obtaini

228 at 454 nm), and chlorophyll a aggregates in formamide/water (rho(v)(90) = 0.23 and 0.32 at 469 and 6

229 ched after 45-90 d, starting with an initial formamide weight fraction of[Formula: see text]wt % that

230 Superelectrophiles: Formamides were designed that when treated with triflic

231 Fourteen new branched chain and chiral formamides were prepared and tested as inhibitors of pur

232 anide complexes, urea, ammonium formate, and formamide) were key reagents for the participation of ph

233 ectivity of the assay was achieved using 20% formamide, which allowed discrimination between a fully

234 w coating medium, N-(2-triethoxysilylpropyl) formamide, which has been shown to diminish electroosmot

235 r three additional substrates: N-(2-propenyl)formamide, (Z)-3-formamido-2-butenenitrile, and (E)-3-fo