ライフサイエンスコーパス: formidable

1 to modulate the activity of NaV subtypes is formidable.

2 This goal is formidable.

3 tangible clinical endpoint are numerous and formidable.

4 R)-associated (Cas9) technology has proven a formidable addition to our armory of approaches for geno

5 (GAGs) by mass spectrometry has long been a formidable analytical challenge owing to their high stru

6 isecond) stages of folding still represent a formidable analytical challenge.

7 Pancreatic resection remains among the most formidable and complex of abdominal surgical operations.

8 depressive disorder (MDD) had proven to be a formidable and elusive task, with all individual marker-

9 control of emerging infectious diseases are formidable and range from influencing the factors that d

10 e energy requirements for this expansion are formidable, and T-cell activation is accompanied by dram

11 ell types, including erythrocytes, creates a formidable antigen sink that may limit the efficacy of C

12 tegies are urgently needed to overcome these formidable apoptotic blockades.

13 onment adds another mechanism to the already formidable arsenal of immunoevasion tactics used by soli

14 The gastrointestinal tract presents a formidable barrier for pathogens to initiate infection.

15 make an anoxic ocean likely, and would be a formidable barrier to biologic survival.

16 f lipid-based nanoparticles (LNPs) remains a formidable barrier to delivery.

17 However, its complexity presents a formidable barrier to exploring such possibilities.

18 owever, its large genome (~32 Gb) presents a formidable barrier to genetic analyses.

19 formation that implicates the nucleolus as a formidable barrier to interaction between DNA sequences

20 egarding verification requirements remains a formidable barrier to introducing such testing in clinic

21 ity is essential for homeostasis and poses a formidable barrier to pathogen entry.

22 lude that anionic oligosaccharides provide a formidable barrier to the uptake of nucleic acids by mam

23 The sheer number of histone PTMs presents a formidable barrier to understanding the molecular mechan

24 culating oncolytic virus particles remains a formidable barrier.

25 In light of the many formidable barriers against successful NP drug delivery,

26 y epithelial cells is challenging due to the formidable barriers imposed by its specialized and diffe

27 and scar tissue formed after injury present formidable barriers that must be crossed by axons to res

28 intensities and capital/operating costs are formidable barriers to adoption.

29 limiting our current knowledge and providing formidable barriers to further advancement.

30 existing regulatory regime actually creates formidable barriers to research that could provide evide

31 tively suppress antitumor immunity, creating formidable barriers to successful cancer immunotherapy.

32 heart muscle (EHM) may overcome all of these formidable barriers.

33 BAX is a formidable BCL-2 family protein that executes cellular s

34 vely, these data suggest that pregnancy is a formidable biologic barrier for women and contributes un

35 ith formal causal inference approaches." The formidable, but not insurmountable, tensions call for ca

36 paving the way for FUS to become a safe yet formidable cancer treatment option.

37 toma, with therapeutic implications for this formidable cancer.

38 ctivity and long-term stability represents a formidable challenge and has not been extensively addres

39 ing their 110-megadalton structure imposes a formidable challenge and requires in situ structural bio

40 mall iNPs in a controllable manner remains a formidable challenge because of the high temperature gen

41 he development of an HIV-1 vaccine remains a formidable challenge due to multiple circulating strains

42 c-scale metals without aggregation remains a formidable challenge due to thermodynamic stabilization

43 n a micrometer-thick conductive support is a formidable challenge for achieving high reflection loss

44 ons by means of a catalyst species remains a formidable challenge for chemists to face.

45 esent in glycans and glycoconjugates poses a formidable challenge for comprehensive structural analys

46 riously inconsistent terminology, creating a formidable challenge for data integration.

47 pplicable to HIV infections and represents a formidable challenge for developing effective chemoproph

48 , eukaryotic organisms (protists) has been a formidable challenge for ecologists.

49 diverse universe of organic pollutants is a formidable challenge for environmental sciences, enginee

50 Sex-role reversal represents a formidable challenge for evolutionary biologists, since

51 underlying disease remains an important, yet formidable challenge for medical genetics.

52 adult neurogenesis in living human brains-a formidable challenge for now-we cannot establish its fun

53 Obtaining phase information remains a formidable challenge for nucleic acid structure determin

54 ing proteins and natural products presents a formidable challenge for preparing conjugates.

55 Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience bec

56 Adaptation to aquatic habitats is a formidable challenge for terrestrial angiosperms that ha

57 as occurs in the atmosphere and ocean, is a formidable challenge for the following reasons: the comp

58 th sustainable alternatives is a crucial but formidable challenge for the modern society.

59 tly localising sensory stimuli in space is a formidable challenge for the newborn brain.

60 Furthermore, a formidable challenge for the treatment of nicotine addic

61 Alzheimer's disease remains a formidable challenge for therapeutic management.

62 tor to the conductor) transitions presents a formidable challenge for VO(2)-based thin film devices.

63 rganization of the human gut microbiota is a formidable challenge given the number of possible intera

64 China will also have a formidable challenge in achieving UHC, particularly in e

65 o subsequent macroscopic assembly, remains a formidable challenge in artificial synthesis.

66 ree-dimensional structure has proved to be a formidable challenge in biological research, especially

67 ry of biologically active proteins remains a formidable challenge in biomedical research.

68 l molecules, even closely related ones, is a formidable challenge in biomolecular recognition and med

69 ntrolling crystal polymorphism constitutes a formidable challenge in contemporary chemistry.

70 is of Spitzoid melanocytic lesions remains a formidable challenge in dermatopathology.

71 ase of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic poly

72 delivery via vector-based systems remains a formidable challenge in mammalian synthetic biology and

73 ontrolled and rarely reported because of the formidable challenge in measuring trace amounts of often

74 (functionally selective) ligands provides a formidable challenge in medicinal chemistry.

75 A formidable challenge in neural repair in the adult centr

76 ld reaction conditions is a longstanding and formidable challenge in organic chemistry.

77 C-H bonds in complex molecules represents a formidable challenge in organic chemistry.

78 rumentation and analysis techniques, poses a formidable challenge in quantifying regional seismic haz

79 n/annulation/decarboxylative aroylation as a formidable challenge in radical reactions occurs to deli

80 poatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet

81 n acceptors such as fullerene has remained a formidable challenge in the area of organic photovoltaic

82 Human infants face the formidable challenge of learning the structure of their

83 n complex, clinically relevant matrices is a formidable challenge that is complicated by limitations

84 This is, however, a formidable challenge that will demand a new capability t

85 Energy production presents a formidable challenge to axons as their mitochondria are

86 Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which b

87 he crowded intracellular environment poses a formidable challenge to experimental and theoretical ana

88 TF) to the wrong locations on DNA presents a formidable challenge to genomes given the relatively low

89 olving landscape of cancer mutations poses a formidable challenge to identify cancer genes among the

90 al growth of genomics data, yet it remains a formidable challenge to interpret such data for identify

91 reased drought frequency and severity pose a formidable challenge to maintaining soybean yield progre

92 organization of the mammalian genome posed a formidable challenge to molecular evolutionists attempti

93 em make this virus and these glycoproteins a formidable challenge to target by vaccination, requiring

94 nodeficiency virus type 1 (HIV-1) presents a formidable challenge to the generation of an HIV-1 vacci

95 nfection causing end-organ disease remains a formidable challenge to the hematopoietic cell transplan

96 The mammalian brain poses a formidable challenge to the study and treatment of neuro

97 To address this formidable challenge we developed new chemical approache

98 gineering and environmental fluid flows is a formidable challenge with practical significance because

99 and theta-Al(2) O(3) are formed represents a formidable challenge, as both phases accommodate a high

100 he nucleus, and its maintenance represents a formidable challenge, as it harbors regulatory proteins

101 ructural study of the spliceosome presents a formidable challenge, but there has recently been signif

102 hough curing the leukemia is always the most formidable challenge, complications from the disease its

103 rties of ordered organic materials remains a formidable challenge, despite their great potential for

104 unities on host pathophysiology represents a formidable challenge, due to the heterogeneous distribut

105 -doped carbon, metal oxides, etc.) remains a formidable challenge, especially under high-temperature

106 motion in complex molecular structures is a formidable challenge, for both theory and experiment, bu

107 or the oxygen reduction reaction, has been a formidable challenge, mainly due to the vastly different

108 with high ordering temperatures represents a formidable challenge, owing largely to the typically wea

109 wever, sequence-specific detection remains a formidable challenge, particularly when single-nucleotid

110 structure of membrane proteins represents a formidable challenge, particularly when using small-angl

111 ion across the blood-brain barrier remains a formidable challenge, representing a bottleneck for brai

112 hemical "cocktail" on marine ecosystems is a formidable challenge, since 40% of the detected compound

113 While this goal represents a formidable challenge, the modest efficacy of the RV144 t

114 To address this formidable challenge, we developed a supramolecular-synt

115 atical models has been widely perceived as a formidable challenge, which has spurred the development

116 in melting and freezing processes remains a formidable challenge.

117 , at non-cryogenic temperatures represents a formidable challenge.

118 ins assemble into the NPC scaffold imposes a formidable challenge.

119 ion of novel and robust biomarkers remains a formidable challenge.

120 he need for novel strategies to address this formidable challenge.

121 iologically relevant length scales remains a formidable challenge.

122 ill help AVs make these moral decisions is a formidable challenge.

123 ective delivery of therapeutic proteins is a formidable challenge.

124 within the host crystalline matrix remains a formidable challenge.

125 reat frontier is to cure infected persons, a formidable challenge.

126 s of community assembly and composition is a formidable challenge.

127 from large transcriptomic datasets remains a formidable challenge.

128 et the broad range of KRAS mutants remains a formidable challenge.

129 lementation of climate mitigation policies a formidable challenge.

130 of causal regulatory mutations represents a formidable challenge.

131 ARTD family members in a cellular context a formidable challenge.

132 nucleic acid cargo intracellularly remains a formidable challenge.

133 s reactivity in a synthetic system remains a formidable challenge.

134 ges obtained from such microscopes remains a formidable challenge.

135 ancer, yet inhibiting its activity remains a formidable challenge.

136 Few biobased polymers have met this formidable challenge.

137 actical and cost-effective manner has been a formidable challenge.

138 cane-N,O-acetal moiety of sieboldine A was a formidable challenge.

139 owever, resistance to these agents remains a formidable challenge.

140 tations of surrounding residues represents a formidable challenge.

141 of free metal ions in deep tissue remains a formidable challenge.

142 owever, resistance to these agents remains a formidable challenge.

143 fication of bona fide enhancers has proved a formidable challenge.

144 hibiting oncogenic beta-catenin has proven a formidable challenge.

145 ication of their functional impact remains a formidable challenge.

146 active site of this kinase family has been a formidable challenge.

147 ctable stereo-outcomes presents an even more formidable challenge.

148 le diets that are culturally acceptable is a formidable challenge.

149 erials scientists and chemists but remains a formidable challenge.

150 into conventional polyolefins but remains a formidable challenge.

151 possessing very similar properties remains a formidable challenge.

152 samples in ambient mass spectrometry poses a formidable challenge.

153 ontrol of absolute stereochemistry remains a formidable challenge.

154 encountered at high engine loads, remains a formidable challenge.

155 beyond the horizon of Li-ion batteries is a formidable challenge; there are few options.

156 Formidable challenges face health workers who have staye

157 This feedback leads to formidable challenges for causal inference.

158 oronavirus 2 (SARS-CoV-2) pandemic has posed formidable challenges for clinical laboratories seeking

159 cities fueled largely by fossil energy poses formidable challenges for establishing a sustainable rel

160 respective investigational agents, may pose formidable challenges for the development and implementa

161 ore efficiently than classical machines, the formidable challenges in building such devices motivate

162 iomas (PCMs) are regarded as one of the most formidable challenges in neurosurgery.

163 glycosidic linkages remains one of the most formidable challenges in organic chemistry.

164 logical and pharmaceutical samples represent formidable challenges in sample preparation that hold im

165 with their molecular heterogeneity presents formidable challenges in understanding the specific cont

166 Formidable challenges include glycosidic bond formation

167 However, one of the formidable challenges is to develop ultrafast charging L

168 surface via swarming motility is subject to formidable challenges not encountered during swimming.

169 The formidable challenges of controlling site-selectivity, e

170 This has been attributed to the formidable challenges of optimizing drug combinations.

171 egy provides a translational solution to the formidable challenges of overcoming TKI resistance and t

172 ile emphasizing the considerable promise and formidable challenges these advanced composite materials

173 dequate accumulation of therapeutics, remain formidable challenges to drug developers.

174 g rate, providing exciting opportunities and formidable challenges to existing theoretical and modeli

175 demic, and the rise in MDR tuberculosis pose formidable challenges to the global control of tuberculo

176 Although this complexity poses formidable challenges to understanding the underlying mo

177 srael has achieved in health, in the face of formidable challenges, including rapid population growth

178 ral-membrane proteins in general still faces formidable challenges, the minigluzincin soluble minimal

179 the related drug responses currently remain formidable challenges.

180 le-based carrier systems still faces certain formidable challenges.

181 netobacter isolates presents clinicians with formidable challenges.

182 delivery to subcellular compartments remain formidable challenges.

183 Such computations involve formidable challenges.

184 been cultured independently, and this poses formidable challenges.

185 e ocean sustainably requires overcoming many formidable challenges: overfishing, climate change, ocea

186 erica, West Nile virus has and will remain a formidable clinical and public health problem for years

187 Cancer stem cells (CSC) present a formidable clinical challenge by escaping therapeutic in

188 fective treatment of osteomyelitis remains a formidable clinical challenge.

189 declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbi

190 ptive arms of the immune system represents a formidable combinatorial problem but one that needs to b

191 These results not only illustrate the formidable complexity of mechanisms controlling C fluxes

192 t a simple solution to overcome the apparent formidable complexity previously thought to be intrinsic

193 levant native conformation of a protein is a formidable computational challenge given the very large

194 position or size changes) represents such a formidable computational feat that it is widely assumed

195 tural and adaptive locomotor movements poses formidable conceptual and technological challenges.

196 and the corneal epithelium combine to make a formidable defense against P aeruginosa infection of the

197 integrating data from multiple levels remain formidable; developments in this area will significantly

198 Liver failure in newborns can present formidable diagnostic challenges.

199 We also discuss how the nucleoid acts as a formidable diffusion barrier for large bodies in the cel

200 Malignant glioma is a formidable disease that commonly leads to death, mainly

201 become undeniable, at which time in 1993 the formidable drug development resources of large pharmaceu

202 isorders such as anxiety and depression have formidable economic and societal impacts.

203 , small molecules, or cancer cells remains a formidable endeavor.

204 This gain-of-function phenotype provides formidable evidence demonstrating the importance of endo

205 th their liquid reaction environment poses a formidable experimental challenge.

206 ope, without obfuscation by backgrounds is a formidable experimental challenge.

207 Identification is particularly formidable for rare allosteric drivers.

208 at a rate faster than ever before makes it a formidable force and voice.

209 dvanced the field substantially, and promise formidable gains in the years to come as they are applie

210 This is a formidable gap in biomedical knowledge.

211 the coordination of the hand and eye present formidable geometric challenges.

212 ny neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases.

213 or drug-like properties of telaprevir were a formidable hurdle, which the manufacturing and formulati

214 ometric increases in complexity of data make formidable hurdles for exploring, analyzing and presenti

215 Its emerging antibiotic resistance and formidable immune evasion arsenal have emphasized the ne

216 While lending formidable impact to peripheral blood B cells as mediato

217 ation myocardial infarction (STEMI) care are formidable in low- to middle-income countries because of

218 odified thiopeptide antibiotic that displays formidable in vitro activity against a variety of Gram-p

219 or, however, whole parasite vaccines present formidable logistical challenges for production, storage

220 eractions using genome-wide approaches poses formidable methodological problems, and elucidating mole

221 The serum complement machinery is a formidable obstacle for bacteria to overcome if they end

222 of plasticity beyond early development is a formidable obstacle for conventional therapies to stimul

223 The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic rem

224 lantation where the xenoantibodies present a formidable obstacle to advancement of this important the

225 e heterotypic nature of chromatin presents a formidable obstacle to biochemical studies seeking to un

226 These complexities constitute a formidable obstacle to predicting immune responses to pa

227 Rapid clearance from the tears presents a formidable obstacle to the delivery of peptide drugs to

228 offer great promise to safely overcome this formidable obstacle.

229 use proteases to dissolve and traverse this formidable obstacle.

230 eam is promising to this end, but there is a formidable obstacle: either the residual stress and gamm

231 In light of these formidable obstacles, viruses have evolved mechanisms of

232 nce of scale in the signal makes detection a formidable olfactory task.

233 -type strain reveals the contribution of the formidable outer-membrane permeability barrier that redu

234 us is a commensal species that can also be a formidable pathogen.

235 A formidable response to a formidable pathogen.

236 ent patient-to-patient transmission of these formidable pathogens.

237 ors may present elevated IFP, which can be a formidable physical barrier for delivery of cell nutrien

238 Religious leadership in Israel, with its formidable political influence, can be harnessed to prom

239 Despite the formidable potential of aryl methyl ethers as coupling p

240 anus priscus, the largest lizard known, were formidable predators.

241 Designing effective antisense sequences is a formidable problem.

242 les that constitute an ecosystem make this a formidable problem.

243 n interdisciplinary researchers in attacking formidable problems.

244 Recent clinical reports support the formidable promise of this approach but also highlight t

245 prevalence of physical inactivity remains a formidable public health issue, participation in exercis

246 une system and largely responsible for their formidable resistance to antimicrobials, mycobacteria sy

247 s that have increased our knowledge of these formidable respiratory pathogens.

248 A formidable response to a formidable pathogen.

249 ally lifelong and accidental exposure impose formidable risk.

250 ogical systems such as actin filaments are a formidable scientific challenge in attaining future life

251 f innovative molecular designs, it remains a formidable scientific challenge to access Earth-abundant

252 mises the health of future generations, is a formidable scientific challenge worthy of investment.

253 ense, solid-state hydrogen storage remains a formidable scientific challenge.

254 es where glass formation is possible poses a formidable scientific challenge.

255 investigator (PI) or university lecturer are formidable: secure funding, recruit staff and students,

256 This creates a formidable setting from which to isolate the central mec

257 Stigma is a formidable social structural barrier to HIV testing, and

258 is a major international concern that brings formidable socioeconomic and healthcare challenges.

259 A formidable source of noncanonical signal transduction co

260 short intermolecular distances and provides formidable strength for some pi-pi stacking interactions

261 The cervix represents a formidable structural barrier for successful induction o

262 ommunity-empowerment approach, we identified formidable structural barriers to implementation and sca

263 Complex AWR represents a formidable surgical challenge.

264 for a leading clinical candidate that posed formidable synthesis challenges.

265 d environmentally friendly fashion remains a formidable synthetic challenge because of the absence of

266 ination, this class of molecules represent a formidable synthetic challenge.

267 decade-long research effort en route to this formidable target compound.

268 atalysed by an immobilised enzyme is a quite formidable task and observed differences in the performa

269 tion of functional metalloproteins remains a formidable task in biomolecular design.

270 T cells carry out the formidable task of identifying small numbers of foreign

271 c inheritance, plasticity, and learning is a formidable task that demands a more nuanced evolutionary

272 structure-function relationship of IDPs is a formidable task that requires detailed characterization

273 l targeting and monitoring to brain remain a formidable task, the discovery of this dissipation-free,

274 talline phases, like cubic blue phases, is a formidable task.

275 , making de novo riboswitch identification a formidable task.

276 rug delivery and on-demand release remains a formidable task.

277 ation within the adult spinal cord remains a formidable task.

278 for each experimental condition, which is a formidable task.

279 which makes their bioinformatic prediction a formidable task.

280 AFT aqueous emulsion polymerizations poses a formidable technical challenge because the inherently he

281 design of hybrid PET/MR scanners presented a formidable technical challenge, and only recently were t

282 n growing host crystals can be regarded as a formidable technical challenge.

283 technology have been hampered by a number of formidable technical challenges, including the cost and

284 lar mechanisms involved in this process face formidable technical challenges, requiring multiple obse

285 ained difficult to obtain because of several formidable technical challenges, such as poor recording

286 The complexity of this workflow poses formidable technical challenges, thus limiting wider app

287 trology, which exploit this scaling, despite formidable technical difficulties.

288 ome is years away from the clinic because of formidable technical, statutory, regulatory, and societa

289 ose quantitative interpretation represents a formidable theoretical challenge.

290 ameters of biological ion channels remains a formidable theoretical challenge.

291 Besides constituting a formidable therapeutic target, MYC also has an essential

292 This adaptability makes plant pathogens a formidable threat to agriculture and forestry.

293 en identified in mammals, but they are still formidable to be comprehensively identified and characte

294 omic analysis of native viral gp120 is still formidable to date.

295 onsiderable attention as they are becoming a formidable tool in the toolbox of organic synthesis.

296 hat silk fibroin discs can be developed into formidable tools to prevent HIV infection.

297 e this long-range sensory channel makes them formidable top predators.

298 as been elegantly solved by the dragonfly, a formidable visual predator on flying insects.

299 Because viral therapy would be formidable, we examined whether a miR-30c mimic can be u

300 formation Miner, an engine which we see as a formidable workflow editor, and the Grid and User Suppor