ライフサイエンスコーパス: founder

1 ave developed densities sufficiently high to founder.

2 otype of 1 Mb around LMNA suggested a common founder.

3 f the progeny resembles that of the maternal founder.

4 rited, nonunique, and originate from ancient founders.

5 ng that these variants originate from common founders.

6 g for the different genetic contributions of founders.

7 in three RAG1/RAG2 double-gene mutant (DGM) founders.

8 d multiple lines of single-gene mutant (SGM) founders.

9 rid performance in a diallel cross among the founders.

10 ickly and efficiently generate mutant rabbit founders.

11 inter-crossing 24 widely used Chinese maize founders.

12 phical origin and subspecies ancestry of the founders.

13 per-mantle remnant from earlier lithospheric foundering.

14 antitumor efficacy for the anti-HER2 ADCs in Founder 5 was observed with tumor stasis at 0.5-1 mg/kg,

15 rican AHB population, a likely source of the founder AHB on PR.

16 predictions using biological invasions since founder alien populations start small, compiling the lar

17 cated that c.254-649T > G CLRN1 represents a founder allele that may significantly contribute to deaf

18 8% (104 of 142) were due to a BRCA1 or BRCA2 founder allele, 4.9% (7 of 142) to another BRCA1 or BRCA

19 ing mutations other than the BRCA1 and BRCA2 founder alleles among patients of Ashkenazi Jewish ances

20 rent interferon sensitivities of transmitted founder and chronic viruses.

21 E.L. is a scientific co-founder and consultant to IFM Therapeutics.

22 ld have included the following: 'J.D.B. is a founder and Director of the following: Neochromosome, In

23 nd progenitor cells are characterized by key founder and driver mutations and are enriched for cytoge

24 John was the Founder and first Editor-in-Chief of the Journal of Mole

25 potential hybridization with stray dogs, few founders and strong anthropogenic pressures, the genetic

26 blish is determined largely by the number of founders and their genetic background.

27 Phenotypic and genomic characterization of founder animals from these injections revealed a subset

28 Here, we report the isolation of 106 founder animals that show suppression of Mecp2-null trai

29 tablish mutant lines, mosaic gene editing in founder animals, and low homologous recombination rates.

30 Historical specimens show that 1) initial founders are well suited for long-distance movement and

31 minor components (e.g. eclogite) capable of foundering at peak conditions.

32 other organisms, particularly insect pests, foundered because of difficulties in delivering, sustain

33 cipher the pattern and sequence of pericycle founder cell (FC) participation in LR formation.

34 of hESC colonies arising from more than one founder cell and the minimal cell number needed for succ

35 Each Drosophila muscle is seeded by one Founder Cell issued from terminal division of a Progenit

36 onal megaspore, which represents the haploid founder cell of the FG.

37 Not only is visceral founder cell specification not dependent on Pointed or A

38 lerae biofilm as it develops from one single founder cell to a mature biofilm of 10,000 cells, and to

39 e the dynamics of biofilm development from a founder cell to a mature three-dimensional community.

40 ance in growth rate when compared with their founder cell, indicating a dynamic nature in the capacit

41 multicellular structures form from a single founder cell.

42 sting that the epigenetic landscape within a founder-cell population may contribute to tumor formatio

43 oblasts are divided into two distinct pools, founder cells (FC) and fusion competent myoblasts (fcm).

44 Here, we identify human pluripotent founder cells (hPFCs) that initiate, as well as preserve

45 bilateral pairs of A-line primary notochord founder cells and also in the B-line-derived secondary n

46 ntrast, lateral roots emerge from predefined founder cells as an adaptive response to environmental s

47 e variance in growth rate of a population of founder cells compared with the variance in growth rate

48 ation in vivo, our study defines a subset of founder cells critical to the establishment pluripotent

49 derm, Ras pathway signaling specifies muscle founder cells from among the broader population of myobl

50 Primordial germ cells (PGCs), the founder cells of the germline, are specified in pre-gast

51 These neointimal founder cells subsequently undergoing massive clonal exp

52 lly required for the selection of neointimal founder cells, and Notch inhibition significantly improv

53 precedes specification of postembryonic root founder cells, from which roots are initiated through th

54 These are initiated from founder cells, triggering new formative divisions that g

55 so in the B-line-derived secondary notochord founder cells.

56 Quantitative lineage analysis reveals founder clones diminish in frequency and are replaced by

57 the Yangtze descended from a small number of founders colonizing the river from the sea during the la

58 l conditions of plant trait abundance (i.e., founder controlled) due to feedbacks of leaf traits on s

59 let (Panicum miliaceum L.) is not one of the founder crops domesticated in Southwest Asia in the earl

60 Wheat and barley are two of the founder crops domesticated in the Fertile Crescent, and

61 Chickpea (Cicer arietinum) is among the founder crops domesticated in the Fertile Crescent.

62 Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition

63 he Near East around 10,000 years ago several founder crops, flax included, spread to European latitud

64 th in the wild progenitors of both C3 and C4 founder crops.

65 ole-pack death events or broke up when their founders died, irrespective of pack size.

66 nt repertoire of immune genes first due to a founder effect and then as a response to distinct pathog

67 The TNNI3 p.Arg21Cys mutation has a founder effect in South Lebanon and causes malignant hyp

68 is novel repeat expansion configuration is a founder effect in this population, which may indicate th

69 families, and haplotype analysis suggested a founder effect in two of them.

70 The strength of the founder effect is predicted to depend strongly on the de

71 rosatellite genotyping demonstrated a common founder effect shared between 3 Scottish patients with a

72 A founder effect was excluded by linkage analysis.

73 ve advantage but may also be due to a random founder effect.

74 , which can decrease rapidly due to a serial founder effect.

75 e mutation in all individuals, unravelling a founder effect.

76 ve of a variant hotspot region rather than a founder effect.

77 exas and more northern areas and experienced founder effects and genetic bottlenecks resulting in dec

78 To differentiate between founder effects and post polyploidization evolution, we

79 In particular, founder effects and recent strong population size reduct

80 difficult to detect due to rapid evolution; founder effects are more significant than selection pres

81 s are established by few individuals, random founder effects can facilitate rapid phenotypic divergen

82 otracted domestication bottleneck and serial founder effects during post-domestication spread, while

83 tional load in populations undergoing serial founder effects during range expansions.

84 ation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and wi

85 t mutating into derived B types, pointing to founder effects or immunological or environmental resist

86 ies, shaped patterns of collection bias via 'founder effects'.

87 de that neither the eco-evo-devo hypothesis, founder effects, the island rule nor sexual selection th

88 thward, experiencing genetic bottlenecks and founder effects, which left high haplotype endemism in s

89 uctions in genomic diversity consistent with founder effects.

90 lance established in this population through founder effects.

91 as a consequence of separate bottlenecks and founder effects.

92 populations did not support the existence of founder effects: heterozygosity (He = 0.667) and allelic

93 All maintained their founder EGFR mutation, and 15 of 19 with prior EGFR T790

94 c RTK fusions and their fusion partners, the founder EGFR mutations, and their methods of detection.

95 Efforts to model DUX4 myopathy in mice have foundered either in being too severe, or in lacking musc

96 maize, which has experienced a more dramatic founder event compared to other maize populations.

97 land system and data, a model that omits the founder event parameter from biogeographic analysis is l

98 individuals, using models with and without a founder event parameter.

99 This is consistent with a founder event.

100 ss suitable than the equivalent model with a founder event.

101 a colonisation process, involving successive founder events and bottlenecks, may either promote rando

102 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple c

103 es of more than 1 million, that descend from founder events more extreme than those in Ashkenazi Jews

104 We inferred that these founder events removed low frequency alleles, the exact

105 e expansions (REs) occur through a series of founder events that are followed by migration among neig

106 ographic history revealed bottlenecks during founder events, likely promoting ecological divergence a

107 have high rates of recessive disease due to founder events.

108 es in South Asia that are the result of such founder events.

109 The shifts were attributed to founder events.

110 Whilst many of the resulting founder (F0) mice developed motor neuron degeneration, o

111 gh-resolution analysis of the genomes of the founder fibroblast cells without being confounded by the

112 e recipients were used to produce twenty SGM founders for four genes.

113 We also estimated the impact of the founder French-Canadian familial hypercholesterolemia de

114 the risk of hidden inbreeding due to related founders from the same habitat undetectable by pedigree

115 Thus, alarmins and founder gene mutations in MDSs license a common redox-se

116 s consistent with KIR2DP1(F) having been the founder gene.

117 lation level by studying the prevalence of 6 founder genetic variants present in the Dutch population

118 Degradation of oskar in founder granules is temporally and mechanistically disti

119 Founder granules mediate compartmentalized degradation o

120 A second type of RNP granule, here named founder granules, contains oskar mRNA, which encodes the

121 dings are consistent with expansion of small founder groups into novel niches by an initial plastic b

122 ABCA4 variant c.5461-10T-->C is located on a founder haplotype lacking other disease-causing rare seq

123 A founder haplotype was identified for mutation c.919G>A (

124 rge numbers of crossover (CO) events between founder haplotypes, and thus present a unique opportunit

125 lies and gene annotations for the population founders, have allowed the imputation of rich sequence i

126 SHIVs containing primary or transmitted/founder HIV-1 subtype A, B, C, or D Envs with genotypic

127 vpu-env (gp140) sequences from a transmitted/founder HIV-1 subtype C strain, was shown to retain attr

128 Strikingly, the envelope gene from a founder HIV-1 virus is far better at evading these defen

129 Importantly, we find that transmitted founder HIV-1, which establishes de novo infections, is

130 abnormalities) to a single locus in which a founder homozygous truncating variant in FAM149B1 was id

131 conditions and mechanisms required to induce foundering in deep arc crust are assessed using an examp

132 A haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best

133 t of 276 maize hybrids generated by crossing founder inbreds of nested association mapping population

134 Lithospheric foundering induces an asthenospheric drag force, which d

135 discovered that a small number of bacterial founders initially establish colonies deep in the gastri

136 ng essential genes, efficient mutagenesis of founders is often lethal, preventing the acquisition of

137 ficients of n individuals of interest from n founder kinship coefficients and d is the number of samp

138 Formation of epiblast (EPI) - the founder line of all embryonic lineages - and extra-embry

139 epidermidis isolates coalesce into multiple founder lineages rather than a single colonizer.

140 We sequence targeted sites in 632 founder mice and analyse 54 established lines.

141 this study, we generated 18 transgenic (TG) founder mice each carrying a salivary gland specific pro

142 b of DNA 3' to the gene was used to generate founder mice expressing hCFTR.

143 Yet, in another subset of founder mice, we detected aberrant integration events at

144 The protocol takes ~6 weeks to generate the founder mice.

145 takes approximately 2 months to generate the founder mice.

146 The serial founder model of modern human origins predicts that the

147 and patients suggested that gene-edited RTT founder monkeys would be of value for disease mechanisti

148 A multimeric immunogen based on the founder MPER activated B cells bearing the unmutated com

149 xing and recombining the genomes of multiple founders, multi-parent populations combine many commonly

150 The founder mutants exhibited sleep disturbances, motor defi

151 inical characteristics and outcome of MYBPC3 founder mutation (FG+) HCM with nonfounder genotype-posi

152 Based on the likelihood of founder mutation and on the clinical diagnosis, genetic

153 One founder mutation enlarged the leaf-like organs on fruits

154 This has been traced to a single founder mutation from north-west Ireland.

155 ed variants were novel, including a putative founder mutation in ABCA4 (c.3260A>G, p.Glu1087Gly), det

156 ted mutations in 1.8%, including a recessive founder mutation in GDF1 accounting for approximately 5%

157 We have identified a founder mutation in the POLR3A gene that leads to aberra

158 within the coding region of UGT1A1 can be a founder mutation in the Sudanese population.

159 Our data suggest that if a founder mutation is not suspected, adopting whole-exome

160 Due to the Brazilian founder mutation p.R337H, some tumors that have not been

161 followed by whole-exome sequencing (WES) and founder mutation screening revealed two truncating rare

162 eterozygous c.1774C>T (p.Arg592Trp) missense founder mutation that is absent in patients with other A

163 cate that LMNA p.(Arg331Gln) is a pathogenic founder mutation with a phenotype reminiscent of other L

164 tients did not harbour the p.Arg592Trp AARS2 founder mutation.

165 18) and likely represents a Northern Finnish founder mutation.

166 e similar to the patients homozygous for the founder mutation.

167 ntries suggests that the 21-bp deletion is a founder mutation.

168 MYBPC3 (Myosin-binding protein C) founder mutations account for 35% of hypertrophic cardio

169 Results The TTNtv were established as founder mutations and traced to 18th century ancestors.

170 Two founder mutations explain the vast majority of cases: a

171 d PENLs pathogenesis, whereby acquisition of founder mutations in activated B cells favors the develo

172 7 probands in the study, 903 probands had no founder mutations in BRCA1 or BRCA2; of these probands,

173 We find that founder mutations in MSH6 and PMS2 prevail in Iceland un

174 y all affected individuals harbor homozygous founder mutations in WDR73 as well as the closely linked

175 sequencing was performed to detect specific founder mutations known to be prevalent in the AJ popula

176 The six studied founder mutations were found to be more prevalent (1.1%)

177 h respectively mimic the 2 most common BRCA1 founder mutations, BRCA1185delAG and BRCA15382insC.

178 rbid genome of ciliopathies encompasses many founder mutations, the combined carrier frequency of whi

179 breast cancer who do not carry one of these founder mutations, the likelihood of carrying another pa

180 utations was related to case mix, stage, and founder mutations.

181 mosomal deletion and severe apoptosis of the founder neuroepithelial stem cells, accompanied by incre

182 demonstrates highly efficient production of founder NHP with SCID phenotypes, with promises of multi

183 Almost all NPPK patients carry the founder nonsense mutation c.796C>T (p.Arg266Ter) in the

184 's viruses were found to link to the women's founders, nor did the women's env sequences have shorter

185 inal domain that instates fungal Trl1 as the founder of an Rnl6 clade of ATP-dependent RNA ligase.

186 Immunology at the University of Calgary and Founder of Parvus Therapeutics Inc., discuss the opportu

187 ead of its Division of Structural Studies, a Founder of the European Molecular Biology Organization,

188 onal shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa.

189 ltiplano; these patterns are consistent with foundering of mantle lithosphere via Rayleigh-Taylor ins

190 constrained because we cannot know the exact founders of a particular polyploid.

191 s tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse.

192 for molecular breeding, and detection of the founders of genetic effects can be swiftly conducted usi

193 The founders of INRC, meeting together during the Internatio

194 Francois Jacob, would go on to be among the founders of modern cell biology, developmental biology,

195 ers" hypothesis of Pere Alberch - one of the founders of modern evo-devo - emphasized the importance

196 ology and Otolaryngology-are credited as the founders of the ABO.

197 Using the founders of the advanced, high-diversity mouse populatio

198 volutionary progression scale; 3) all of the founders of the groups have emerged in a "deep burst" at

199 He would soon be one of the 4 founders of the Johns Hopkins Hospital along with fellow

200 given here consider the possibility that the founders of the known pedigree may themselves be inbred

201 putative chromosomal complements of the key founders of the main Solanaceae clades and the rearrange

202 identified spa t011 as one of the two group founders of the main spa CC identified across the five y

203 ensive collection of introgressions from the founders of the maize NAM population in a B73 background

204 "Groups"; 2) the order of emergence of the "founders" of all of the groups may be assigned on an evo

205 itness but did not prevent adaptation if the founders originated from genetically diverse populations

206 artially explained by the discovery of three founder pathogenic variants.

207 Through production of F1 progeny from mutant founder pigs, we identified mutations that could reliabl

208 tation to nonnative environments despite the founder population being small.

209 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n

210 Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity f

211 Three strategies for splitting the founder population into two heterotic pools were compare

212 for 170 Nunavik Inuit, a small and isolated founder population of Canadian Arctic indigenous people.

213 Whole genome sequencing in 98 Hutterites, a founder population of European descent, and subsequent i

214 Using in vivo clonal analysis in the founder population of the pancreas here we reveal highly

215 ociations are at lead variants unique to the founder population sequences: chr16:70790626 (high-densi

216 We varied both founder population size and mate encounter rate independ

217 when cannibalism occurred before copulation, founder population size was small and mate encounter rat

218 history describes the island as harboring a founder population that was established largely from the

219 strategies of forming heterotic pools in the founder population.

220 Founder populations are ideally suited for studies on th

221 l numbers of individuals, and reflects known founder populations in the north.

222 acan maize cultivation evolving from reduced founder populations of isolated and perhaps self-pollina

223 opulations, corresponding to several ancient founder populations with little evidence of bottlenecks.

224 y be useful for studies of complex traits in founder populations, where hidden relationships may augm

225 by sequence-based imputation and by studying founder populations.

226 in size in founder pups and genotype offspring in established trans

227 , including tier 2 or 3 strains, transmitted founders, quasispecies, and soluble sdAb JM4-resistant s

228 , including tier 2 or 3 strains, transmitted founders, quasispecies, and soluble single domain antibo

229 e founded separately by genetically distinct founder queens, which appear to have originated from the

230 We identified the noncoding founder region and a nine-nucleotide (9-nt) element ther

231 The earliest odontodes are two longitudinal founder ridges formed at the ossification center.

232 gratory species stop migrating and establish founder sedentary populations, a phenomenon documented i

233 IP trimer, termed AMC009, based on the viral founder sequences of an elite neutralizer.

234 patrilines of the three English Thoroughbred founder stallions and resolved a historic controversy ov

235 in, was differentially expressed in both the founder strain and F6 generation.

236 ics to explain the low frequency of multiple-founder strain infections.

237 ved using both a lab-adapted and transmitted/founder strain of HIV.

238 e human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, th

239 erforming whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single

240 rsity Outbred (DO) stock, and their isogenic founder strains.

241 red mouse strains derived from eight diverse founder strains.

242 ntly remained clonal with rapid outgrowth of founder-, sub-, or even fully independent clones, indica

243 2(b) MHC haplotype of their original C57BL/6 founder, suggesting that the UBC-GFP transgene integrati

244 Reducing mutagenesis levels may improve founder survival, but results in lower, more variable ra

245 e tracked 20 NGS in Env from HIV-transmitted/founder (T/F) and immune escape variants and their mutan

246 studied molecular clones and two transmitted/founder (T/F) clones for their sensitivities to a panel

247 tically recapitulate features of transmitted/founder (T/F) genomes that are of particular interest in

248 s macaques (RMs) infected with a transmitted/founder (T/F) simian-human immunodeficiency virus (SHIV)

249 , we utilized PF74 to identify a transmitted/founder (T/F) strain that shows increased capsid stabili

250 found that a naturally occurring transmitted founder (T/F) variant shares the same properties as the

251 re correlated with the number of transmitted/founder (T/F) variants that established infection, such

252 ere vaginally challenged with a transmission-founder (T/F) virus at 5 x 10(5) TCID(50) inoculation, o

253 Analysis of transmitted/founder (T/F) viruses from this study demonstrates that

254 We identified multiple transmitted/founder (T/F) viruses in six HIV-1-infected subjects by

255 y and productivity of infectious transmitted/founder (TF) (n = 8) and non-transmitted (NT) viruses (n

256 ms race" occurs in which a HIV-1 transmitted/founder (TF) Env induces autologous neutralizing antibod

257 cting SHIVs that bear primary or transmitted/founder (TF) Envs with modifications at Env residue 375

258 Strikingly, we find that transmitted/founder (TF) HIV-1 viruses can resist a late block that

259 t recapitulate key properties of transmitted/founder (TF) or primary HIV-1 isolates, such as CCR5 tro

260 f specific HIV-1 variants called transmitted founder (TF) viruses.

261 rom a single virus particle (the transmitted/founder) that makes it past these defenses and colonizes

262 pendent lineages as autochthonous and likely founders: the major Q-M3 and rarer Q-CTS1780 present thr

263 gests it to be one of the Ashkenazi paternal founders; to have expanded as part of the overall Ashken

264 thyroid carcinoma in Brazilian carriers of a founder TP53 p.R337H mutation.

265 rcinoma may be associated with the Brazilian founder TP53 p.R337H mutation.

266 nfirmed in embryos generated from two of the founder transgenic marmosets that reached sexual maturit

267 VI) was found to co-segregate with the same founder variant in FAM149B1.

268 t location (grouped by 5'-3' quartiles or by founder variant subgroup).

269 n an individual is frequently reduced to one founder variant that initiates infection.

270 of infection increases the risk of multiple-founder variant transmission compared with acquiring inf

271 al disease and to demonstrate a new Scottish founder variant.

272 Three BRCA1/2 founder variants - 185delAG (c.68_69delAG), 5382insC (c.

273 This variant is one of the 3 likely founder variants identified in our Spanish cohort.

274 feasibility for genetic diagnosis using two founder variants in primary screening.

275 ry one or more of the three Ashkenazi Jewish founder variants, evaluating two characteristics that ar

276 the source partner affects the number of HIV founder variants, we developed a phylodynamic model cali

277 ncluding de novo mutation rate and extent of founder versus recurrent variants has implications for v

278 Transmitted founder viral isolates differed in their CD1d downregula

279 protein trimer from a very early transmitted founder virus (CRF01_AE T/F100) complexed with Fab from

280 structures of a soluble clade B transmitted/founder virus B41 SOSIP.664 Env with broadly neutralizin

281 and neutralized RHPA but not the transmitted/founder virus from donor CAP257.

282 Thus, the founder virus is hypothesized to be a relatively interfe

283 ibody-loop lengths and were initiated by the founder virus MPER.

284 In each case, we determined the transmitted founder virus sequence to identify the autologous epitop

285 that causes infection (i.e., the transmitted/founder virus), we sought to generate and characterize i

286 -1 strains, including the CAP257 transmitted/founder virus.

287 revious comparisons of Vpus from transmitted/founder viruses and between viruses isolated during acut

288 be recapitulated for a panel of transmitted founder viruses and laboratory-adapted HIV-1 strains.

289 re able to observe with relevant transmitted/founder viruses in vitro Thus, estradiol plays a key rol

290 The imputed founder viruses in women were genetically similar to bot

291 to SUN1-mediated inhibition, the transmitted founder viruses RHPA and ZM247 are largely resistant.

292 Analysis of a panel of subtype B transmitted/founder viruses showed that splicing patterns are conser

293 d most recent common ancestor of the women's founder viruses showed that they were closer to the seme

294 the calculated means of the total number of founder viruses transmitted were 4.5 and 14.5 in the exp

295 primary HIV-1 clones, including transmitted founder viruses, in contrast to the laboratory-adapted N

296 IV-1 primary isolates, including transmitted founder viruses, is diminished by IFITM3 to various leve

297 ariants, at a dose calculated to transmit 12 founder viruses.

298 obal range, 2) whether initial long-distance founders were particularly suited for migration, and 3)

299 Five founders were produced: one SGM, two DGM, one triple-gen

300 u392Ser variant is likely a newly identified founder YARS2 mutation.