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1 ies, shaped patterns of collection bias via 'founder effects'.
2 ve advantage but may also be due to a random founder effect.
3 eir haplotypes (AGXT*LTM), consistent with a founder effect.
4 1600, and that there is a 14484/haplogroup J founder effect.
5               Haplotype analysis indicated a founder effect.
6 ype at the mal de Meleda locus, suggesting a founder effect.
7 e in 1800 in north-west Puerto Rico due to a founder effect.
8 eles arose independently, thus eliminating a founder effect.
9 ence of the disorder occurs as a result of a founder effect.
10  viremia, thereby fixing a novel genotype by founder effect.
11 diately distal to the MET gene, suggesting a founder effect.
12  high frequency in Ashkenazi Jews suggests a founder effect.
13 , which can decrease rapidly due to a serial founder effect.
14  the BS mutation in the Ashkenazim is due to founder effect.
15 rin gene of only one haplotype, indicating a founder effect.
16 ange, which suggests a role for selection or founder effect.
17 riants can be challenging because of a known founder effect.
18 go Basin) possibly underwent a bottleneck or founder effect.
19 uals, likely as the result of a Puerto Rican founder effect.
20 on the same genetic background, suggesting a founder effect.
21 five families from Brazil with evidence of a founder effect.
22 e mutation in all individuals, unravelling a founder effect.
23 rom the same ethnic population, suggesting a founder effect.
24 ited retinal dystrophies and is owing to the founder effect.
25 ions of separate compartments to exploit the founder effect.
26  study population is likely due to a British founder effect.
27 ve of a variant hotspot region rather than a founder effect.
28 ad a homozygous Q289X CARD9 allele, due to a founder effect.
29 ion), which originated as a consequence of a founder effect.
30 r endogamous practices following the initial founder effect.
31 n arise via a selective sweep or through the founder effect.
32 s such as gene flow, self-fertilization, and founder effect.
33 ently old to have recovered from any initial founder effects.
34 lection for regional diets or of independent founder effects.
35 hboring populations and shows no evidence of founder effects.
36 ance, of historic population bottlenecks and founder effects.
37 uctions in genomic diversity consistent with founder effects.
38  also ultimately produce new species through founder effects.
39 ported locus homogeneity, and did not detect founder effects.
40 y have not experienced recent bottlenecks or founder effects.
41 in mapping disease genes and in establishing founder effects.
42 lance established in this population through founder effects.
43 as a consequence of separate bottlenecks and founder effects.
44 Arg417*, and p.Gln336Arg) indicated possible founder effects.
45 single dispersal, accompanied by a series of founder effects.
46 s in additional environmental factors and/or founder effects.
47 ing cave age challenges traditional views on founder effects.
48 t colonization occurred locally and involved founder effects.
49 rent viral lineage and resulting from strong founder effects.
50 ptible to a high false discovery rate due to founder effects.
51 se on other secondary hosts, possibly due to founder effects.
52 localization of genetic defects, even when a founder effect accounts for only a fraction of the disor
53  of hyperuricemia and gout, which suggests a founder effect across the Pacific region.
54 storic perturbation of populations including founder effects, admixture, or incomplete selective swee
55 for an ancestral haplotype consistent with a founder effect and an identical-by-descent mutation.
56 nfirms that the disease is probably due to a founder effect and extends the phenotypic spectrum assoc
57 On the basis of this study, we conclude that founder effect and independent mutational events are res
58 ables than would be expected from the serial founder effect and show signals of environmental adaptat
59 nt repertoire of immune genes first due to a founder effect and then as a response to distinct pathog
60                    The Nama exhibit distinct founder effects and derive 15% of their Y chromosome hap
61                           Models considering founder effects and dispersals were often better fit for
62 exas and more northern areas and experienced founder effects and genetic bottlenecks resulting in dec
63  in neighboring populations, suggesting that founder effects and genetic drift may have had a conside
64                    We tested for evidence of founder effects and genetic isolation in early season po
65                                      We find founder effects and mixed lineages in the northern popul
66 ed experiment in nature, we showed that both founder effects and natural selection jointly determine
67                 The relative contribution of founder effects and natural selection to the observed di
68 To determine the respective contributions of founder effects and natural selection, we conducted an e
69                     To differentiate between founder effects and post polyploidization evolution, we
70 els of haplotype homozygosity, indicative of founder effects and recent population expansion.
71                               In particular, founder effects and recent strong population size reduct
72                           The combination of founder effects and subpopulation turnover can result in
73      The initial mutations may have followed founder effects and/or drift when the virus was introduc
74 ies complex are rarely accompanied by severe founder effects, and multiple founder events and/or long
75 st substantial ancestral variation following founder effects, and subsequent drift and selection.
76 onization of distal tissues, suggesting that founder effects are limited and there is not a strict li
77  difficult to detect due to rapid evolution; founder effects are more significant than selection pres
78 ber of effective founders and indicates that founder effects are weak because island populations are
79 in the spleen and demonstrated the action of founder effects as well as significant variation in the
80  many different mutational events, without a founder effect, as is expected for a disorder with a pre
81 nhanced genetic drift', complementary to the founder effect associated with spatial bottlenecks.
82 oups is probably the result of isolation and founder effects associated with the history of migration
83  an ancient mutation, thus excluding a major founder effect at the OPA1 locus.
84                Haplotype analysis excluded a founder effect at this locus.
85 amily led us to consider the hypothesis of a founder effect being present.
86 e wild can result from bottlenecks (that is, founder effects), biparental inbreeding or self-fertiliz
87 er varying demographic conditions, including founder effects, bottlenecks, and migration, and at vary
88 oexistence and antagonistic effects promoted founder effects (but favored the less exploitative type
89 ombined action of recombination hotspots and founder effects, but cannot be explained by random recom
90                                            A founder effect can account for the presence of an allele
91                                 A pronounced founder effect can be observed among mutations arising i
92 s are established by few individuals, random founder effects can facilitate rapid phenotypic divergen
93     Thus, we conclude that genetic drift and founder effect contribute to diversification of individu
94 he mutational data, as well as the role that founder effect, demographic history, and penetrance play
95 cation that largely follows a clinal "serial founder effect" distribution model.
96  does not follow the predictions of a serial founder effect during human expansion out of Africa.
97 abahan swamp buffalo, likely stemming from a founder effect during introduction to Borneo and minimal
98  decreased phytotoxin production rather than founder effects during introduction and spread.
99 otracted domestication bottleneck and serial founder effects during post-domestication spread, while
100 tional load in populations undergoing serial founder effects during range expansions.
101 nced geographic heterogeneity, likely due to founder effects during the invasions.
102 the high-geotaxis line was probably due to a founder-effect event.
103 s on chromosome 6p2l.23, suggesting a strong founder effect exerted by a common Celtic ancestor.
104 n disease-associated haplotype, suggesting a founder effect for CFEOM2.
105 nce the loss of genetic diversity due to the founder effect for mutations under frequency-dependent s
106               Haplotype analyses suggested a founder effect for the 4 most commonly observed pathogen
107                  This presumably reflected a founder effect for the HPS mutation in Puerto Rico.
108 ance from Africa, as expected under a serial founder effect for the out-of-Africa spread of human pop
109  cohort, suggesting a mutational hot spot or founder effect for those with shared ancestry.
110 ns, while the mutation distribution suggests founder effects for a few mutations, such as c.866A>G in
111 ese TMEM126B variants, including evidence of founder effects for both variants, and establish defects
112 f similar genetic backgrounds, suggesting a "founder effect" for these mutations.
113 habitats, are likely causes of the observed "founder effects" for the two organisms in the Northeast.
114 in studying single-gene disorders, where the founder effect has clearly aided in discovery, and more
115 ciation studies of complex traits, where the founder effect has had less obvious impacts.
116 on, population migration, genetic drift, and founder effects have shaped the world in which we practi
117 , the latter of which likely resulted from a founder effect, have for 60 y restricted the ability of
118 populations did not support the existence of founder effects: heterozygosity (He = 0.667) and allelic
119 e, a statistical test of both aspects of the founder-effect hypothesis is developed.
120 zation events could be localized and involve founder effects, impacting genetic diversity, population
121 ses, this is probably the result of a strong founder effect in a geographically circumscribed populat
122                                   Assuming a founder effect in a large Old Order Amish pedigree, we c
123 cosan body disease mutation explains another founder effect in all Ashkenazi-Jewish cases.
124 mAsh was independently established through a founder effect in Ashkenazic Jews and in immigrants to f
125 disease haplotype associated with a presumed founder effect in families of Mexican-American descent p
126            This pattern is consistent with a founder effect in male lineages, supported by our findin
127  carried the 964del13 mutation, suggesting a founder effect in our population.
128 sides on a common haplotype, indicative of a founder effect in patients of northern European descent.
129 ance to characterize and confirm the Finnish founder effect in sequencing data and to assess its impl
130          The TNNI3 p.Arg21Cys mutation has a founder effect in South Lebanon and causes malignant hyp
131 sequilibrium with the mutation, suggesting a founder effect in the Northern European population.
132 ommon as (GCG)(9), evidence against a strong founder effect in the UK population.
133 is novel repeat expansion configuration is a founder effect in this population, which may indicate th
134 American families analyzed, substantiating a founder effect in this population.
135 segregating disease chromosome, suggesting a founder effect in this population.
136 families, and haplotype analysis suggested a founder effect in two of them.
137 ttleneck during colonization, resulting in a founder effect in which the most successful mutant varie
138 c drift following population bottlenecks and founder effects in arboviral evolution and spread, and t
139 c clustering, reflecting the central role of founder effects in establishing distinct clades.
140                                  Evidence of founder effects in Great Lakes populations by colonizati
141 tic nature of long-distance dispersal causes founder effects in pathogen populations, such that the g
142 ation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and wi
143         The high degree of inbreeding and/or founder effects in some small population isolates result
144 ignal of which has been somewhat blurred via founder effects in the non-African samples.
145 sity, a result of what is called the "serial founder effect." In addition to genomic data, the serial
146                                              Founder effects increase the power to associate function
147                          The strength of the founder effect is predicted to depend strongly on the de
148 shift duplication, the result of an apparent founder effect, is nearly ubiquitous among Puerto Rican
149 but can exhibit low genetic diversity due to founder effects, isolation, or limited outbreeding.
150 d genetic variation due to genetic drift and founder effects limits the ability of a population to ad
151 sm among Hawaiian Drosophila, perhaps due to founder effects, low population sizes, and hitchhiking e
152                                Evidence of a founder effect made if feasible to use a homozygosity ma
153 esponsible for RCDP (PBD CG11) and suggest a founder effect may explain the high frequency of L292ter
154 g isolates in a subpopulation suggested that founder effects might play a role in shaping the genetic
155 ct." In addition to genomic data, the serial founder effect model is now supported by the genetics of
156  patterns and fit to an Out-of-Africa serial founder effect model, which is known to structure neutra
157 ocess of island colonization in the original founder effect model.
158 s is consistent with simulations of a serial founder effects model.
159                       Our findings suggest a founder-effect mutation in the MESP2 gene as a major cau
160 be designed around populations with frequent founder-effect mutations, despite the obvious limitation
161 lotypes, indicating that these were probably founder effects, not public mutations.
162                            Consistent with a founder effect occurring as colonizers moved into these
163 rs and metastatic sites, suggesting a strong founder effect of the primary tumor, their proportions v
164 e Sardinian USH phenotype is the result of a founder effect on a specific pathogenic variant related
165 ing support for random genetic drift (chance founder effects, one approximately 11 centuries ago that
166 languages, perhaps arising from a linguistic founder effect or a desire to establish a distinct socia
167 ng the Upper Palaeolithic, (iii) there was a founder effect or bottleneck associated with the Last Gl
168 er greater loss of language elements through founder effects or drift, or do languages with more spea
169 t mutating into derived B types, pointing to founder effects or immunological or environmental resist
170 ation of new habitats may result from drift (founder effect) or altered selection pressures in the ne
171 s will exhibit linkage disequilibrium due to founder effect over longer distances than a population i
172 imate may have been inflated by inclusion of founder effects peculiar to Finland.
173                                              Founder effects provide a more convincing explanation fo
174        Our findings are a classic example of founder effect, provide evidence for sensitivity of this
175 the Northern Isles of Scotland with multiple founder effects provides a unique opportunity for a tail
176 r transmission in humans or is merely due to founder effects remains unknown.
177 available genetic data are consistent with a founder effect resulting from a severe bottleneck in pop
178 otype analysis identified a common ancestral founder effect RSPH4A mutation present in UK-Pakistani p
179 rosatellite genotyping demonstrated a common founder effect shared between 3 Scottish patients with a
180 cifically, reductions in genetic diversity ('founder effects') should be stronger for species with lo
181 etween these populations as envisioned under founder-effect speciation models.
182 a set is consistent with a model of a serial founder effect starting at a single origin.
183 f divergent SIVsm strains in PCs resulted in founder effects, superinfections, and recombinations.
184 f genetic diversity across China reveal weak founder effects that are driven largely by low-diversity
185                                 In addition, founder effects that occur during the geographic introdu
186 e time of origin of BRCA1 mutations having a founder effect, the interpretation of the significance o
187 de that neither the eco-evo-devo hypothesis, founder effects, the island rule nor sexual selection th
188 tion, dispersal, extinction, vicariance, and founder effects, to describe and reconstruct clone migra
189 e data revealed the substantial influence of founder effects upon viral evolution and HLA association
190                     We measure the extent of founder effects using allozymes and microsatellites, and
191 d age effects; (iii) somatic mosaicism; (iv) founder effects; (v) mutation rates; (vi) the factor IX
192                                            A founder effect was excluded by linkage analysis.
193  frequency of the L292ter allele is due to a founder effect, we identified five polymorphic markers (
194 Recessive inheritance of Naxos disease and a founder effect were demonstrated.
195  the initial expansion and subsequent serial founder effect were determined by demographic and socioc
196 thward, experiencing genetic bottlenecks and founder effects, which left high haplotype endemism in s
197 are larger than in Europe, reflecting strong founder effects whose signatures have been maintained fo
198  However, genetic drift, particularly due to founder effects, will also commonly result in differenti
199 s consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Afric
200 6.5 cM in the candidate region, suggesting a founder effect with an ancestral mutation that occurred
201 d had shown that the ethnic bias is due to a founder effect, with >99.5% of disease alleles sharing a
202     These populations are shaped strongly by founder effects, with limited evidence for positive sele

 
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