ライフサイエンスコーパス: fragile

1 hallenging because such states are extremely fragile.

2 cular dystrophy, limb muscles are especially fragile.

3 pristine matter and coherence was considered fragile.

4 ithout inhibitory feedback is functional but fragile.

5 ith the clinical pipeline is encouraging but fragile.

6 orions that failed to elevate fully and were fragile.

7 Fragile 3D floc samples were successfully captured and s

8 dwide attention, especially on the extremely fragile alpine eco-region of the Tibetan Plateau.

9 culate matter with notable deposition in the fragile alveolar region of the lungs.

10 nal differentiation, the hair is brittle and fragile and contains reduced cysteine content.

11 peptides, building blocks of life, which are fragile and difficult to handle.

12 Xylem in shedding species is less extensive, fragile and highly conductive; its thin-walled tracheids

13 pressures under mechanical load, making them fragile and highly susceptible to abrasion(18).

14 The fragile and jammed states exhibit memory, while the elas

15 leading to ascorbate depletion and a quickly fragile and perishable state.

16 used for these studies, which are large and fragile and remain laboratory instruments.

17 Human cells are fragile and require only mild centrifugation to be disma

18 nd shell of Au(25) nanoclusters becomes more fragile and rigid after ligand addition.

19 osis is a major health problem, making bones fragile and susceptible to fracture.

20 However, these gains are fragile, and coverage is far from optimal.

21 powerful, on average, they tend to be weak, fragile, and fleeting.

22 es in person perception were generally weak, fragile, and fleeting; (2) Social perceptions were often

23 Patients with myeloma with AKI are fragile, and indication for doublet or triplet regimen s

24 face of human cooperation makes it seem more fragile, and its mechanisms more elusive.

25 care randomized controlled trials are often fragile, and study conclusions are frequently affected b

26 ter stress thresholds facilitates protecting fragile aquatic ecosystems in vulnerable catchments.

27 However, the elderly are more fragile because of comorbidities, increased risk of infe

28 nsate of weakly interacting excitons is very fragile, being unstable against a coherent coupling of d

29 To this end, the fragmentation yields of fragile benzylpyridinium "thermometer" ions were monitor

30 nent system in S. sanguinis SK36, produced a fragile biofilm.

31 t these crystalline symmetries can stabilize fragile Bloch bands that challenge our very notion of to

32 and osteoporosis, often leading to extremely fragile bones.

33 n structural networks to identify robust and fragile brain regions in healthy subjects.

34 neration is achieved, even when using highly fragile catalysts such as the enzyme hydrogenase.

35 complex, time-consuming, and destructive to fragile cells.

36 d spectrometer, allowing these expensive and fragile components to remain at the surface while only t

37 Smad4 causes the formation of inappropriate, fragile connections between arteries and veins called ar

38 ical, social, and technological networks are fragile, convincing theories are still lacking to explai

39 lthough individual marketplaces might appear fragile, coordinated user migration guarantees overall s

40 grid express interactions among modules with fragile couplings that amplify even small shocks, thus p

41 f halide perovskites due to their mobile and fragile crystal lattices.

42 probing local structures in these typically fragile crystals.

43 ry suffers from its reliance on increasingly fragile data indicators for "wealth" and its focus on "i

44 ight into why human neoplastic translocation fragile DNA sequences are more prone to enzymes or agent

45 scenarios across a wide range of potentially fragile dryland environments.

46 e neural systems that regulate breathing are fragile early in development, and it is not clear how th

47 ated populations, with restricted resources, fragile ecological and economic systems, and overburdene

48 ace daunting challenges, including small and fragile economies, unequal distribution of resources, we

49 EOF1-deficient mosquitoes have nonmelanized fragile eggshells, and all embryos are nonviable.

50 with development, while differently encoded fragile enhancers are associated with the adaptation of

51 Firstly, fragile enhancers with abundant deM nucleotides are asso

52 s, while tissue-specific TFs are enriched in fragile enhancers.

53 extent usage of heterotypic TFBS clusters in fragile enhancers.

54 ining high initial activities even for quite fragile enzymes.

55 edentary behavior among adolescents from the Fragile Families & Child Wellbeing Study.

56 harides are thought to be transported by the FRAGILE FIBER1 (FRA1) kinesin to facilitate their secret

57 g state exists, in which some regions show a fragile form of superconductivity.

58 Distribution patterns of fragile gelatinous fauna in the open ocean remain scarce

59 ating pan-continental spread in light of the fragile healthcare systems.

60 We discovered FHIT (fragile histidine triad) as a novel BMPR2 modifier.

61 ating common fragile sites (CFS) are equally fragile in response to aphidicolin.

62 fiscal effort is needed to sustain the most fragile individuals and to mitigate the increase in pove

63 on was not possible because of the extremely fragile intestinal tissue perioperatively, and a conserv

64 iving protocol we propose for distinguishing fragile, jammed, and pinned phases should be general to

65 idative damage in lipids and proteins, and a fragile juvenile plumage.

66 is linked to mutations in genes that produce fragile membranes or reduce membrane repair.

67 , preserving the delicate morphology of e.g. fragile, mono-layered three-dimensional organoids.

68 Are you feeling emotionally fragile, moody, unpredictable, even ungenerous to those

69 ouse highly water-repellent and mechanically fragile nanostructures.

70 e of approach curve to prevent damage of the fragile nanotip.

71 generally not paired by toughness, and their fragile nature hinders significantly their widespread ap

72 of an acoustic metamaterial to establish the fragile nature of the low-lying Bloch bands.

73 Yet, because of the inherently fragile nature of the physical computing elements (qubit

74 CO(2)) as a highly efficient means to revert fragile nonporous and amorphous COF polymers into highly

75 damage generates cytosolic DNA species with fragile nuclear envelopes that undergo spontaneous disru

76 n unstable, micrococcal nuclease-sensitive ("fragile") nucleosomal particles.

77 Fragile nucleosomes were defined by nucleosomal DNA frag

78 protein complexes, with little evidence for fragile nucleosomes.

79 tead occupied by easily digested, unstable, "fragile" nucleosomes.

80 t actuators enable tasks such as handling of fragile objects and adapting to unstructured environment

81 nds minimizing destructive sampling of rare, fragile, or small artifacts for molecular identification

82 redictions for exotic superconductivity with fragile pairing symmetries.

83 We find that fragile particles represent the occupancy of the RSC (re

84 To determine the composition of fragile particles, we introduce CUT&RUN.ChIP, in which t

85 reduced PS, the efficacy of this regimen in fragile patients remains unclear.

86 ulators, 4,078 topological semimetals and no fragile phases.

87 ial size, membrane potential and displayed a fragile phenotype during viral infection of cells.

88 y important given the diverse population and fragile political and economic situation.

89 Medically fragile populations, such as cancer survivors, were sign

90 ning taxa whose elimination would jeopardise fragile positive interaction networks.

91 tion, they also highlight how our relatively-fragile Primate order does not possess analogous "surviv

92 lived vertebrate and a widely used model for fragile protein homeostasis, is found to be chaperone li

93 zation, climate change, increased travel and fragile public health systems, epidemics will become mor

94 Quantum entanglement is usually considered a fragile quantity and decoherence through coupling to an

95 ts of quantum networking(2), maintaining the fragile quantum state in such a conversion process with

96 their hemostatic system, which results in a fragile rebalanced status.

97 In the fragile regime, the system organizes into a pinned state

98 However, predictions and estimates often are fragile, resting on unsupported assumptions and limited

99 e loss of dystrophin produces a mechanically fragile sarcolemma, causing muscle membrane disruption a

100 CAG/CTG trinuncleotide repeats are fragile sequences that when expanded form DNA secondary

101 The magnetic structure in GdPd3 is highly fragile since applied magnetic fields of moderate streng

102 Fragile site damage is thought to arise from the aberran

103 ion within the human genome is able to drive fragile site formation under conditions of replication s

104 neous replication stress, however successful fragile site repair cannot be calculated using existing

105 ncogene BCL2 as a replication stress-induced fragile site.

106 RFS), while ERFS and late-replicating common fragile sites (CFS) are equally fragile in response to a

107 Common fragile sites (CFSs) are genomic regions prone to breaka

108 Common fragile sites (CFSs) are regions susceptible to replicat

109 ves late replication intermediates at common fragile sites (CFSs) during early mitosis to trigger DNA

110 le telomeres-structures that resemble common fragile sites (CFSs)-but how they are formed is not know

111 nsitive RFSs share many features with common fragile sites (CFSs; which are found in all individuals)

112 ion induces more breaks at early replicating fragile sites (ERFS), while ERFS and late-replicating co

113 on drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide

114 w-JCN deletions enriched in late-replicating fragile sites and gastrointestinal carcinomas.

115 ication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated dur

116 Chromosomal fragile sites are genomic loci sensitive to replication

117 nderlying most of the known folate-sensitive fragile sites in the genome.

118 dings demonstrate that SCE-FISH frequency at fragile sites is a sensitive indicator of replication st

119 Furthermore, SCEs were suppressed at fragile sites near centromeres in response to replicatio

120 nearest transcription start site, chromosome fragile sites, CpG islands, viral sequences and target s

121 f ssDNA associated with disruption of genome fragile sites, inefficient cell cycle progression, and i

122 romatin, gene dense regions, and chromosomal fragile sites.

123 that we detected correlated with cytogenetic fragile sites.

124 ress generated unrepaired breaks and SCEs at fragile sites.

125 ns in known CFSs and identification of novel fragile sites.

126 ith the presence of previously mapped common fragile sites.

127 ted tissue growth, resulting in a porous and fragile skeleton.

128 Modern humans have more fragile skeletons than other hominins, which may result

129 l remains, microcomputed tomography scans of fragile skull bones (jaws, skull roofs and braincases) a

130 near T (gel) is associated with a remarkably fragile solid-like gel structure, which can form below e

131 ditions is both uncovering and threatening a fragile source of paleoenvironmental and archaeological

132 , precluding their successful application to fragile species including growth factors.

133 ion heating at such fields allows preserving fragile species, in particular the noncovalent complexes

134 Importantly, the usually fragile specimen can remain in the same cuvette from see

135 lose their biological activity due to their fragile structural conformation during formulation, stor

136 s, phenols, and malonates to be present, and fragile structures are also tolerated.

137 counterparts, resulting in foreshortened and fragile structures.

138 rming the parent state out of which the more fragile superconducting and correlated insulating ground

139 BIR also promoted fragile telomere formation in cells with FokI-induced te

140 Targeted telomere analysis revealed fragile telomeres and telomere loss as well as 53BP1-pos

141 Collectively, these findings indicate that fragile telomeres can arise from BIR-mediated repair of

142 reak-induced replication (BIR), resulting in fragile telomeres containing conservatively replicated D

143 We report that analogous to CFSs, fragile telomeres in BLM-deficient cells involved double

144 ll lines, we show that ALT cells harbor more fragile telomeres representing telomere replication prob

145 ng-strand telomeres lacking TRF1 or BLM form fragile telomeres-structures that resemble common fragil

146 d joining (alt-NHEJ), which did not generate fragile telomeres.

147 natural world is more complex, and also more fragile, than it appears.

148 Third, many small businesses are financially fragile: The median business with more than $10,000 in m

149 es of the brain, and provide rigidity to the fragile tissue while eliminating background interference

150 ed over an unprecedentedly broad range, from fragile to strong and even superstrong behavior, by decr

151 e rapid ubiquitylation of the substrate, and fragile, to enable the subsequent functions of cullin-RI

152 The previously reported fragile-to-strong dynamic transition in nanoconfined wat

153 y identify the microstructural origin of the fragile-to-superstrong crossover, which is rooted in the

154 In this work, we discover that strong and fragile topological Dirac semimetals exhibit one-dimensi

155 id microscale actuators, which are typically fragile under external impact.

156 with narrow access to inferior vena cava and fragile venous wall may lead to venous tearing and catac

157 mportant to limit eutrophication to preserve fragile water supplies, but also to avoid acceleration o

158 bust to lesions and other insults, it may be fragile when these take place in specific locations.

159 correlated states in MATBG are particularly fragile with respect to the twist-angle disorder.

160 revious work in the Fmr1(-/y) mouse model of fragile X (FX) suggests that increased constitutive dend

161 enic syndromes highly comorbid with autism - fragile X and tuberous sclerosis types 1 and 2 syndromes

162 Fragile X associated tremor/ataxia syndrome (FXTAS) is a

163 related protein 1 (FXR1P) is a member of the fragile X family of RNA-binding proteins, which includes

164 Fragile X granules (FXGs) are axonal RNPs containing the

165 mutation allele of 55-200 CGG repeats in the Fragile X mental retardation (FMR1) gene.

166 utation carriers (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene.

167 Purkinje neurons (PNs) in the cerebellum of Fragile X Mental Retardation 1 (Fmr1) knockout (KO) mice

168 Using hippocampal tissue from wide type and fragile X mental retardation 1 (Fmr1) knockout mice, we

169 on with the WAVE complex subunit cytoplasmic fragile X mental retardation 1-interacting protein 1 (Cy

170 The expression levels of FXR1 (fragile X mental retardation autosomal homolog 1), an RN

171 nships, we inhibited the RNA-binding protein fragile X mental retardation protein (encoded by Fmr1),

172 Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched

173 Fragile X mental retardation protein (FMRP) binds to and

174 The loss of fragile X mental retardation protein (FMRP) causes fragi

175 Loss of the gene (Fmr1) encoding Fragile X mental retardation protein (FMRP) causes incre

176 ional silencing of the Fmr1 gene and loss of fragile X mental retardation protein (FMRP) expression.

177 ability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons.

178 The Fragile X Mental Retardation Protein (FMRP) is an RNA bi

179 Fragile X mental retardation protein (FMRP) is an RNA-bi

180 Fragile X mental retardation protein (FMRP) is well-stud

181 Whether fragile X mental retardation protein (FMRP) target mRNAs

182 By using the Fragile X Mental Retardation Protein (FMRP), an abundant

183 FXS is caused by the loss of fragile X mental retardation protein (FMRP), an mRNA bin

184 ual impairment that results from the loss of fragile X mental retardation protein (FMRP), an mRNA bin

185 Fragile X mental retardation protein (FMRP), an RNA-bind

186 FXS results from the loss of function of fragile X mental retardation protein (FMRP), which repre

187 FXS is caused by loss of the fragile X mental retardation protein (FMRP), which trans

188 sults from a loss of the RNA-binding protein fragile X mental retardation protein (FMRP).

189 mutation that disrupts the transcription of Fragile X Mental Retardation Protein (FMRP).

190 drome (FXS) with abrogated expression of the Fragile X Mental Retardation Protein (FMRP).

191 Using male mice, we tested whether Fragile X Mental Retardation Protein (FMRPO), the protei

192 e lacking ASD-associated genes such as Fmr1 (fragile X mental retardation protein 1).

193 ritical translation-independent role for the fragile X mental retardation protein as a regulator of n

194 Absence of fragile X mental retardation protein causes fragile X sy

195 rived from disruptions of cytoplasmic CYFIP1-fragile X mental retardation protein complexes.

196 dea that translation-independent function of fragile X mental retardation protein has a major role in

197 These results suggest that Fragile X Mental Retardation Protein regulates dendritic

198 including Y box-binding protein 1 (YB-1) and fragile X mental retardation protein, proteins that func

199 The present study shows that replacing Fragile X Mental Retardation Protein, which is absent in

200 cytoskeletal dynamics and interacts with the fragile X mental retardation protein.

201 ctin-associated protein-like 2 (Cntnap2)(5), fragile X mental retardation-1 (Fmr1)(6) or Sh3 and mult

202 itive phenotypes displayed by the Drosophila fragile X model, and thus reveal a metabolic pathway tha

203 d by new and already approved drugs to treat fragile X patients.

204 Improvements in fragile X phenotypes have been observed following chroni

205 would result in further improvement in these fragile X phenotypes.

206 We generated de novo SGs by expressing the fragile X protein (FMRP) and found that rather than dire

207 anslation play conserved roles in regulating fragile X protein (FMRP) synthesis.

208 ) complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as bindin

209 The fragile X protein family consists of three RNA-binding p

210 We show that the Fragile X proteins FMRP and FXR1P interact with RNA-edit

211 anules (FXGs) are axonal RNPs containing the fragile X related family of RNA binding proteins along w

212 Fragile X related protein 1 (FXR1P) is a member of the f

213 Fragile X related proteins 1 and 2 (FXR1P and FXR2P) are

214 here that in mouse models PFC dysfunction in Fragile X Syndrome (FX) can be attributed to the continu

215 Fragile X Syndrome (FX) is generally considered a develo

216 ptors (mGlu1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially tra

217 ICANCE STATEMENT Sensory hypersensitivity in fragile X syndrome (FXS) and autism patients significant

218 e behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result f

219 ategies.SIGNIFICANCE STATEMENT Patients with fragile X syndrome (FXS) exhibit signs of neuronal and c

220 ontributing to a "leak metabolism." In human Fragile X syndrome (FXS) fibroblasts and in Fmr1(-/y) mo

221 Fragile X syndrome (FXS) is a neurodevelopmental disorde

222 Fragile X syndrome (FXS) is an inherited intellectual im

223 Fragile X syndrome (FXS) is an X chromosome-linked disea

224 Fragile X syndrome (FXS) is caused by inactivation of th

225 Fragile X syndrome (FXS) is characteristically displayed

226 Fragile X syndrome (FXS) is the leading known inherited

227 Fragile X syndrome (FXS) is the leading monogenic cause

228 Fragile X syndrome (FXS) is the most common form of inhe

229 ssing deficits in FXS.SIGNIFICANCE STATEMENT Fragile X Syndrome (FXS) is the most common inheritable

230 elevated basal neuronal protein synthesis in fragile X syndrome (FXS) is unclear.

231 sed diagnostic yield from 1.60% to 1.84% for fragile X syndrome (FXS) using a pooling approach.

232 tion 1 (Fmr1) knockout (KO) mice, a model of Fragile X Syndrome (FXS) with abrogated expression of th

233 ntagious itch behavior in the mouse model of fragile X syndrome (FXS), a common form of inherited int

234 Fragile X Syndrome (FXS), a common inheritable form of i

235 Fragile X syndrome (FXS), an X-chromosome linked intelle

236 autism spectrum disorders (ASDs), including fragile X syndrome (FXS), and frequently leads to tactil

237 tructure and function is a major hallmark of fragile X syndrome (FXS), autism spectrum disorders (ASD

238 Fragile X syndrome (FXS), caused by the loss of function

239 Fragile X syndrome (FXS), due to mutations of the FMR1 g

240 Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inher

241 e X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the most common inherited inte

242 Fragile X syndrome (FXS), the most common monogenetic ca

243 n-enriched RNA-BP, whose deficiency leads to Fragile X Syndrome (FXS), the most prevalent inherited i

244 primary somatosensory cortex (S1) neurons in Fragile X syndrome (FXS), which is a common inherited ca

245 Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a parti

246 ility is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms o

247 fective treatment is currently available for fragile X syndrome (FXS).

248 ual disability and autism spectrum disorder, fragile X syndrome (FXS).

249 ture of neurodevelopmental disorders such as Fragile X Syndrome (FXS).

250 and tactile perception are core problems in fragile X syndrome (FXS).

251 tual deficits and sensory dysfunction in the fragile X syndrome (FXS).

252 dult Fmr1 knock-out mice, the mouse model of fragile X syndrome (FXS).

253 ing causes of abnormal sensory processing in Fragile X syndrome (FXS).

254 t of the neocortex, an area affected in both fragile X syndrome and autism spectrum disorder.

255 n this study, we focused on a mouse model of Fragile X syndrome and demonstrate how dendritic spines

256 ter microstructure has been reported in both fragile X syndrome and psychiatric disorders, we looked

257 rcuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder

258 One classic example is Fragile X syndrome caused by loss of an RNA-binding tran

259 Fragile X syndrome is a neurodevelopmental disorder asso

260 Fragile X syndrome is rare but a prominent cause of inte

261 Fragile X syndrome is the most common form of inherited

262 revious white matter differences reported in fragile X syndrome patients, suggesting common pathogeni

263 rved similar results in neurons derived from Fragile X Syndrome patients.

264 Fragile X syndrome results from a loss of the RNA-bindin

265 Specifically, Fmr1 (fragile X syndrome) and Ube3a (Angelman syndrome) are tr

266 e expansion disorders (Friedreich ataxia and fragile X syndrome), and cancer.

267 (FMRP) is well-studied, as its loss leads to fragile X syndrome, a neurodevelopmental disorder which

268 cation and is the major causative factor for fragile X syndrome, a sex-linked disorder associated wit

269 ic diseases, including Huntington's Disease, Fragile X Syndrome, and hereditary ataxias.

270 in myotonic dystrophy, and (CGG)n repeats in fragile X syndrome, are also subject to double-strand br

271 with a variety of neural diseases, including Fragile X syndrome, autism, and intellectual disability.

272 in multiple neuropsychiatric disorders like fragile X syndrome, autism, and others.

273 tterns of RNA-editing alterations in ASD and Fragile X syndrome, establishing this as a molecular lin

274 We report in a mouse model of fragile X syndrome, glutamate uncaging onto individual d

275 ntal Retardation Protein, which is absent in Fragile X syndrome, in adult CA1 and L5 PFC neurons regu

276 ause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-

277 Loss of function of FMRP causes fragile X syndrome, the most common form of inherited in

278 Fragile X syndrome, the most common known monogenic caus

279 fragile X mental retardation protein causes fragile X syndrome.

280 between FMRP and HTT in the pathogenesis of fragile X syndrome.

281 phase 2 clinical trials for the treatment of Fragile X Syndrome.

282 f many neurodevelopmental diseases including fragile X syndrome.

283 e and behavioural phenotypes associated with fragile X syndrome.

284 cific channelopathies in a mouse of model of Fragile X syndrome.

285 severative grooming states in a rat model of fragile X syndrome.

286 a high-throughput small-molecule screen for fragile X tremor ataxia syndrome.

287 s autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes.

288 tential of modulating CGG RAN translation in fragile X-associated disorders.

289 everal neurodegenerative diseases, including fragile X-associated tremor ataxia syndrome (FXTAS), ALS

290 Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a

291 Fragile X-associated tremor/ataxia syndrome (FXTAS) is a

292 Fragile X-associated tremor/ataxia syndrome (FXTAS) is a

293 eins that contribute to neurodegeneration in fragile X-associated tremor/ataxia syndrome.

294 The Fragile X-related disorders (FXDs) are Repeat Expansion

295 The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upreg

296 Fragile-X mental retardation autosomal homologue-1 (FXR1

297 We identify a novel role for the fragile-X mental retardation protein in the posttranscri

298 nce for differences in PPI in a rat model of Fragile-X Syndrome (FXS) compared with wild-type control

299 suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial memb

300 rtex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory.